TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Haenni, D. R.
T1  - Structure of high-spin states in ¹³⁴ Ce
JF  - Annual report 1981 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: F. Grümmer. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 146)
Y1  - 1982
SP  - 52
PB  - Kernforschungsanlage
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
A1  - Lieder, R. M.
T1  - Side bands in ¹⁷² Hf
JF  - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1977)
Y1  - 1977
SP  - 940
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
A1  - Lieder, R. M.
T1  - Systematic features of isomeric states in Ce, Sm, Nd nuclei
JF  - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1977)
Y1  - 1977
SP  - 892
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
A1  - Lieder, R. M.
T1  - Particle and collective properties of high spin states in heavy nuclei near z=82
JF  - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1977)
Y1  - 1977
SP  - 985
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
A1  - Lieder, R. M.
T1  - The orange-ß-spectrometer at the external beam of the cyclotron
JF  - Annual report 1976 / Institut für Kernphysik Kernforschungsanlage Jülich / Ed. board: A. Fäßler ...
Y1  - 1977
SP  - 124
PB  - Kernforschungsanlage
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
T1  - High-spin states and isomers in light transitional nuclei around n=80
JF  - International Symposium on High-Spin States and Nuclear Structure : held at Dresden from 19-24. Sept. 1977 ; contributed papers / ed.: L. Funke ...
Y1  - 1977
N1  - International Symposium on High Spin States and Nuclear Structure <1977, Dresden> ; (ZfK / Zentralinstitut fuer Kernforschung  ; 336)
SP  - 19
PB  - Zentralinst. fuer Kernforschung
CY  - Rossendorf
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
T1  - Systematics of 10⁺ isomers in the N=78 nuclei
JF  - Annual report 1977 / Institut für Kernphysik Kernforschungsanlage Jülich
Y1  - 1978
N1  - Spezielle Berichte der Kernforschungsanlage Jülich ; 15
SP  - 33
EP  - 34
PB  - Verlag des Forschungszentrums Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
T1  - High spin states and isomers in nuclei with neutron number N=80
JF  - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1978)
Y1  - 1978
SP  - 841
EP  - 842
PB  - Physik-Verlag
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
T1  - Isomeric 10⁺ states in nuclei with N=78
JF  - Proceedings of the International Conference on Nuclear Structure : Tokyo, Sept. 5 - 10, 1977 / ed. by T. Marumori. - Journal of the Physical Society of Japan ; Vol. 44, 1978 : Suppl.
Y1  - 1978
N1  - International Conference on Nuclear Structure <1977, Tokyo>
SP  - 861
PB  - Physical Soc. of Japan
CY  - Tokyo
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Bochev, B.
A1  - Haenni, D. R.
T1  - Study of reactions ²⁰⁹ Bi (a,charged particle Xn) At Ea= 45 Mev and 75 Mev
JF  - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1980)
Y1  - 1980
N1  - Verhandlungen der Deutschen Physikalischen Gesellschaft ; 1980=6.R.15,8
SP  - 1088
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
T1  - Investigation of the preequilibrium reaction mechanism through the study of the isomer ratios ²¹¹,²¹² Po
JF  - Annual report 1979 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 72)
Y1  - 1980
SP  - 32
PB  - Verlag des Forschungszentrums Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
T1  - High-spin level structure of ¹³³ La
JF  - Annual report 1981 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: F. Grümmer. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 146)
Y1  - 1982
SP  - 51
PB  - Kernforschungsanlage
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller, Wolfram
A1  - Jung, Alexander
A1  - Ahammer, Helmut
T1  - Advantages and problems of nonlinear methods applied to analyze physiological time signals: human balance control as an example
JF  - Scientific Reports
Y1  - 2017
SN  - 2045-2322
U6  - http://dx.doi.org/10.1038/s41598-017-02665-5
VL  - 7
IS  - Article number 2464
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Müller, Martin
A1  - Hirschfeld, Julian
A1  - Lambertz, Rita
A1  - Schulze Lohoff, Andreas
A1  - Lustfeld, Hans
A1  - Pfeifer, Heinz
A1  - Reißel, Martin
T1  - Validation of a novel method for detecting and stabilizing malfunctioning areas in fuel cell stacks
JF  - Journal of power sources
N2  - In this paper a setup for detecting malfunctioning areas of MEAs in fuel cell stacks is described. Malfunctioning areas generate electric cross currents inside bipolar plates. To exploit this we suggest bipolar plates consisting not of two but of three layers. The third one is a highly conducting layer and segmented such that the cross currents move along the segments to the surface of the stack where they can be measured by an inductive sensor. With this information a realistic model can be used to detect the malfunctioning area. Furthermore the third layer will prevent any current inhomogeneity of a malfunctioning cell to spread to neighbouring cells in the stack. In this work the results of measurements in a realistic cell setup will be compared with the results obtained in simulation studies with the same configuration. The basis for the comparison is the reliable characterisation of the electrical properties of the cell components and the implication of these results into the simulation model. The experimental studies will also show the limits in the maximum number of segments, which can be used for a reliable detection of cross currents.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.jpowsour.2014.08.045
SN  - 1873-2755 (E-Journal); 0378-7753 (Print)
VL  - 272
SP  - 225
EP  - 232
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Musholt, Petra B.
A1  - Schöndorf, Thomas
A1  - Pfützner, Andreas
A1  - Hohberg, Cloth
A1  - Kleine, Iris
A1  - Fuchs, Winfried
A1  - Hehenwarter, Silvia
A1  - Dikta, Gerhard
A1  - Kerschgens, Benedikt
A1  - Forst, Thomas
T1  - Combined Pioglitazone and Metformin Treatment Maintains the Beneficial Effect of Short-Term Insulin Infusion in Patients with Type 2 Diabetes: Results from a Pilot Study
JF  - Journal of Diabetes Science and Technology. 3 (2009), H. 6
Y1  - 2009
SN  - 1932-2968
SP  - 1442
EP  - 1450
PB  - Sage Publishing
CY  - London
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Molinnus, Denise
A1  - Jablonski, Melanie
A1  - Kipp, Carina Ronja
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
A1  - Siegert, Petra
T1  - Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase
JF  - RSC Advances
N2  - α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated.
Y1  - 2020
U6  - http://dx.doi.org/10.1039/D0RA02066D
SN  - 2046-2069
VL  - 10
SP  - 12206
EP  - 12216
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Molinnus, Denise
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Siegert, Petra
A1  - Selmer, Thorsten
T1  - (R,R)-Butane-2,3-diol Dehydrogenase from Bacillus clausii DSM 8716T: Cloning and Expression of the bdhA-Gene, and Initial Characterization of Enzyme
JF  - Journal of Biotechnology
N2  - The gene encoding a putative (R,R)-butane-2,3-diol dehydrogenase (bdhA) from Bacillus clausii DSM 8716T was isolated, sequenced and expressed in Escherichia coli. The amino acid sequence of the encoded protein is only distantly related to previously studied enzymes (identity 33–43%) and exhibited some uncharted peculiarities. An N-terminally StrepII-tagged enzyme variant was purified and initially characterized. The isolated enzyme catalyzed the (R)-specific oxidation of (R,R)- and meso-butane-2,3-diol to (R)- and (S)-acetoin with specific activities of 12 U/mg and 23 U/mg, respectively. Likewise, racemic acetoin was reduced with a specific activity of up to 115 U/mg yielding a mixture of (R,R)- and meso-butane-2,3-diol, while the enzyme reduced butane-2,3-dione (Vmax 74 U/mg) solely to (R,R)-butane-2,3-diol via (R)-acetoin. For these reactions only activity with the co-substrates NADH/NAD+ was observed. The enzyme accepted a selection of vicinal diketones, α-hydroxy ketones and vicinal diols as alternative substrates. Although the physiological function of the enzyme in B. clausii remains elusive, the data presented herein clearly demonstrates that the encoded enzyme is a genuine (R,R)-butane-2,3-diol dehydrogenase with potential for applications in biocatalysis and sensor development.
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.jbiotec.2017.07.020
SN  - 0168-1656
VL  - 258
SP  - 41
EP  - 50
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Kipp, Carina Ronja
A1  - Recker, Inga
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Gelissen, Melanie
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
A1  - Siegert, Petra
T1  - Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase
JF  - Journal of Biotechnology
N2  - The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.
Y1  - 2020
SN  - 2590-1559
U6  - http://dx.doi.org/10.1016/j.jbiotec.2020.09.016
VL  - 202
IS  - Vol. 324
SP  - 61
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, Mohammed Sharif
A1  - Yeap, Weng-Siang
A1  - Martens, Daan
A1  - Bienstman, Peter
A1  - Ceuninck, Ward de
A1  - Grinsven, Bart van
A1  - Schöning, Michael Josef
A1  - Michiels, Luc
A1  - Haenen, Ken
A1  - Ameloot, Marcel
A1  - Serpengüzel, Ali
A1  - Wagner, Patrick
T1  - Photonic detection and characterization of DNA using sapphire microspheres
JF  - Journal of biomedical optics
N2  - A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants.
Y1  - 2014
U6  - http://dx.doi.org/10.1117/1.JBO.19.9.097006
SN  - 1560-2281 (E-Journal); 1083-3668 (Print)
VL  - 19
IS  - 9
SP  - 097006
PB  - SPIE
CY  - Bellingham
ER  - 
TY  - JOUR
A1  - Murib, Mohammed S.
A1  - Tran, Anh Quang
A1  - Ceuninck, Ward de
A1  - Schöning, Michael Josef
A1  - Nesladek, Milos
A1  - Serpengüzel, Ali
A1  - Wagner, Patrick
T1  - Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres
JF  - Physica Status Solidi A
N2  - Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/pssa.201100795
SN  - 1862-6319
N1  - Special Issue: "Fundamentals and Applications of Diamond"
VL  - 209
IS  - 9
SP  - 1804
EP  - 1810
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Martens, D.
A1  - Liu, X.
A1  - Bienstman, P.
A1  - Fahlman, M.
A1  - Schöning, Michael Josef
A1  - Michiels, L.
A1  - Haenen, K.
A1  - Serpengüzel, A.
A1  - Wagner, Patrick
T1  - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands
JF  - Sensors and actuators A: Physical
N2  - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.sna.2014.11.024
SN  - 1873-3069 (E-Journal); 0924-4247 (Print)
VL  - 222
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Eurlings, Y.
A1  - Grinsven, B. van
A1  - Boyen, H.-G.
A1  - Conings, B.
A1  - Michiels, L.
A1  - Ameloot, M.
A1  - Carleer, R.
A1  - Warmer, J.
A1  - Kaul, P.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Heat-transfer based characterization of DNA on synthetic sapphire chips
JF  - Sensors and Actuators B: Chemical
N2  - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.snb.2016.02.027
SN  - 0925-4005
VL  - 230
IS  - 230
SP  - 260
EP  - 271
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Grinsven, B. van
A1  - Grieten, L.
A1  - Janssens, S. D.
A1  - Vermeeren, V.
A1  - Eersels, K.
A1  - Broeders, J.
A1  - Ameloot, M.
A1  - Michiels, L.
A1  - Ceuninck, W. De
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates
JF  - Physica Status Solidi (A). Vol. 210 (2013), iss. 5
Y1  - 2013
SN  - 0031-8965
SP  - 911
EP  - 917
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Mulhern, Colm
A1  - Bialonski, Stephan
A1  - Kantz, Holger
T1  - Extreme events due to localization of energy
JF  - Physical Review E
Y1  - 2015
U6  - http://dx.doi.org/10.1103/PhysRevE.91.012918
SN  - 2470-0053
VL  - 91
IS  - 1
SP  - 012918
ER  - 
TY  - JOUR
A1  - Muck, A.
A1  - Wang, J.
A1  - Jacobs, M.
A1  - Chen, G.
A1  - Chatrathi, M. P.
A1  - Jurka, V.
A1  - Vyborny, Z.
A1  - Spillmann, S. D.
A1  - Sridharan, G.
A1  - Schöning, Michael Josef
T1  - Fabrication of poly(methyl methacrylate) microfluidic chips by atmospheric molding
JF  - Analytical Chemistry. 76 (2004), H. 8
Y1  - 2004
SN  - 0003-2700
SP  - 2290
EP  - 2297
ER  - 
TY  - JOUR
A1  - Mourzina, Yu.G.
A1  - Schöning, Michael Josef
A1  - Schubert, J.
A1  - Zander, W.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
T1  - Thin film microsensors for fast heavy metal analysis
JF  - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]
Y1  - 2000
SN  - 87-89935-50-0
N1  - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen)
SP  - 839
EP  - 840
PB  - MIC, Mikroelektronik Centret
CY  - Lyngby, Denmark
ER  - 
TY  - JOUR
A1  - Mourzina, Yu. G.
A1  - Schubert, J
A1  - Zander, W.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Development of multisensor systems based on chalcogenide thin film chemical sensors for the simultaneous multicomponent analysis of metal ions in complex solutions
JF  - Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz
Y1  - 2001
SN  - 0-08-044014-2
SP  - 251
EP  - 263
PB  - Elsevier [u.a.]
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Mourzina, Y.G.
A1  - Schöning, Michael Josef
A1  - Schubert, J.
A1  - Zander, W.
A1  - Legin, A. V.
A1  - Vlasov, Y. G.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - A new thin film Pb microsensor based on chalcogenide glasses
JF  - Sensors and Actuators B. 71 (2000), H. 1-2
Y1  - 2000
SN  - 0925-4005
SP  - 13
EP  - 18
ER  - 
TY  - JOUR
A1  - Mourzina, Y.
A1  - Yoshinobu, T.
A1  - Ermelenko, Y.
A1  - Furuichi, K.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Technology of photocurable membranes for ion sensors based on laser scanned semiconductor transducer (LSST)
JF  - Book of abstracts / ed. by J. Saneistr.
Y1  - 2002
SN  - 80-01-02576-4
N1  - Eurosensors ; (16, 2002, Praha)
SP  - 254
EP  - 257
PB  - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement
CY  - Prague
ER  - 
TY  - JOUR
A1  - Mourzina, Y.
A1  - Mai, T.
A1  - Poghossian, Arshak
A1  - Ermolenko, Y.
A1  - Yoshinobu, T.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - K+-selective field-effect sensors as transducers for bioelectronic applications
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3333
EP  - 3339
ER  - 
TY  - JOUR
A1  - Mourzina, Y. G.
A1  - Yoshinobu, T.
A1  - Schubert, J.
A1  - Lüth, H.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - Ion-selective lightaddressable potentiometric sensor (LAPS) with chalcogenide thin film by pulsed laser deposition
JF  - Sensors and Actuators B. 80 (2001), H. 2
Y1  - 2001
SN  - 0925-4005
SP  - 136
EP  - 140
ER  - 
TY  - JOUR
A1  - Mourzina, Y. G.
A1  - Schöning, Michael Josef
A1  - Schubert, J.
A1  - Zander, W.
A1  - Legin, A. V.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
T1  - Copper, cadmium and thallium thin film sensors based on chalcogenide glasses
JF  - Analytica Chimica Acta. 433 (2001)
Y1  - 2001
SN  - 0378-4304
SP  - 103
EP  - 110
ER  - 
TY  - JOUR
A1  - Mourzina, Y. G.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
A1  - Schubert, J.
A1  - Zander, W.
A1  - Lüth, H.
T1  - Thin film chemical sensors based on chalcogenide glasses for „electronic tongue“ applications
JF  - Sensor 2001 : 10th international conference, May 8 - 10, 2001, Exhibition Centre Nuremberg, Germany ; proceedings
Y1  - 2001
N1  - Sensor-Kongress ; (10, 2001, Nürnberg) Sensor 2001 Conference ; (10 : ; 2001.05.08-10 : ; Nuremberg)
SP  - 137
EP  - 141
PB  - AMA Service
CY  - Wunstorf
ER  - 
TY  - JOUR
A1  - Mourzina, Y. G.
A1  - Ermelenko, Y. E.
A1  - Yoshinobu, T.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - Anionselective light-addressable potentiometric sensors (LAPS) for the determination of nitrate and suphate ions
JF  - Sensors and Actuators B. 91 (2003), H. 1-3
Y1  - 2003
SN  - 0925-4005
SP  - 32
EP  - 38
ER  - 
TY  - JOUR
A1  - Mourzina, Ioulia G.
A1  - Yoshinobu, Tatsuo
A1  - Ermolenko, Yuri E.
A1  - Vlasov, Yuri G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors
JF  - Microchimica Acta. 144 (2004), H. 1-3
Y1  - 2004
SN  - 0026-3672
SP  - 41
EP  - 50
ER  - 
TY  - JOUR
A1  - Mourzina, I.G.
A1  - Yoshinobu, T.
A1  - Ermolenko, Y.E.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors
JF  - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors
Y1  - 2004
N1  - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba)
SP  - 788
EP  - 789
PB  - Japan Association of Chemical Sensors
CY  - Fukuoka
ER  - 
TY  - JOUR
A1  - Mosset, J.-B.
A1  - Devroede, O.
A1  - Krieguer, M.
A1  - Rey, M.
A1  - Vieira, J.-M.
A1  - Jung, J. H.
A1  - Kuntner, C.
A1  - Streun, M.
A1  - Ziemons, Karl
A1  - Auffray, E.
A1  - Sempere-Roldan, P.
A1  - Lecoq, P.
A1  - Bruyndonckx, P.
A1  - Loude, J.-F.
A1  - Tavernier, S.
A1  - Morcel, C.
T1  - Development of an optimized LSO/LuYAP phoswich detector head for the Lausanne ClearPET demonstrator
JF  - IEEE Transactions on Nuclear Science
N2  - This paper describes the LSO/LuYAP phoswich detector head developed for the ClearPET small animal PET scanner demonstrator that is under construction in Lausanne within the Crystal Clear Collaboration. The detector head consists of a dual layer of 8×8 LSO and LuYAP crystal arrays coupled to a multi-anode photomultiplier tube (Hamamatsu R7600-M64). Equalistion of the LSO/LuYAP light collection is obtained through partial attenuation of the LSO scintillation light using a thin aluminum deposit of 20-35 nm on LSO and appropriate temperature regulation of the phoswich head between 30°C to 60°C. At 511keV, typical FWHM energy resolutions of the pixels of a phoswich head amounts to (28±2)% for LSO and (25±2)% for LuYAP. The LSO versus LuYAP crystal identification efficiency is better than 98%. Six detector modules have been mounted on a rotating gantry. Axial and tangential spatial resolutions were measured up to 4 cm from the scanner axis and compared to Monte Carlo simulations using GATE. FWHM spatial resolution ranges from 1.3 mm on axis to 2.6 mm at 4 cm from the axis.
Y1  - 2006
SN  - 0018-9499
VL  - 53
IS  - 1
SP  - 25
EP  - 29
ER  - 
TY  - JOUR
A1  - Moseley, Fiona
A1  - Halamek, Jan
A1  - Kramer, Friederike
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible CNOT logic gate realized in a flow system
JF  - Analyst
N2  - An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
Y1  - 2014
U6  - http://dx.doi.org/10.1039/C4AN00133H
SN  - 1364-5528 (E-Journal) ; 0003-2654 (Print)
VL  - 139
IS  - 8
SP  - 1839
EP  - 1842
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - CHAP
A1  - Moritz, Werner
A1  - Yoshinobu, Tatsuo
A1  - Finger, Friedhelm
A1  - Krause, Steffi
A1  - Schöning, Michael Josef
T1  - Amorphous silicon as semiconductor material for high resolution LAPS
T2  - Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimarães, Portugal, September 21 - 24, 2003
Y1  - 2003
SP  - 48
EP  - 49
ER  - 
TY  - JOUR
A1  - Moritz, W.
A1  - Yoshinobu, T.
A1  - Finger, F.
A1  - Krause, S.
A1  - Xu, M.
A1  - Schöning, Michael Josef
T1  - Microscopy of impedance and surface ion concentrations
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1000
EP  - 1001
ER  - 
TY  - JOUR
A1  - Moritz, W.
A1  - Yoshinobu, T.
A1  - Finger, F.
A1  - Krause, S.
A1  - Martin-Fernandez, M.
A1  - Schöning, Michael Josef
T1  - High resolution LAPS using amorphous silicon as the semiconductor material
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 436
EP  - 444
ER  - 
TY  - CHAP
A1  - Moreno, Lia
A1  - Dosev, D.
A1  - Bratov, A.
A1  - Dominguez, C.
A1  - Schöning, Michael Josef
A1  - Kloock, Joachim P.
T1  - Effect of electrical properties of the surrounding medium on the response of an interdigitated electrode array with chalcogenide glass film
T2  - XX Eurosensors : 20th anniversary ; Göteborg, Sweden, 17 - 20 September 2006 ; [proceedings]. - Vol. 1
Y1  - 2006
SN  - 978-91-631-9280-7
N1  - Paper number: T1A-P22
SP  - 384
EP  - 385
CY  - Göteborg
ER  - 
TY  - JOUR
A1  - Moreno i Codinachs, Lia
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
A1  - Baldi, Antoni
A1  - Ipatov, Andrey
A1  - Bratov, Andrey
A1  - Jimenez-Jorquera, Cecilia
T1  - Electronic integrated multisensor tongue applied to grape juice and wine analysis
JF  - Analyst. 133 (2008)
Y1  - 2008
SN  - 1364-5528
SP  - 1440
EP  - 1448
ER  - 
TY  - JOUR
A1  - Moreno i Codinachs, L.
A1  - Birkenstock, C.
A1  - Garma, T.
A1  - Zierold, R.
A1  - Bachmann, J.
A1  - Nielsch, K.
A1  - Schöning, Michael Josef
A1  - Fontcuberta i Morral, A.
T1  - A micron-sized nanoporous multifunction sensing device
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 435
EP  - 441
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Morat, Mareike
A1  - Faude, Oliver
A1  - Hanssen, Henner
A1  - Ludyga, Sebastian
A1  - Zacher, Jonas
A1  - Eibl, Angi
A1  - Albracht, Kirsten
A1  - Donath, Lars
T1  - Agility Training to Integratively Promote Neuromuscular, Cognitive, Cardiovascular and Psychosocial Function in Healthy Older Adults: A Study Protocol of a One-Year Randomized-Controlled Trial
JF  - International Journal of Environmental Research and Public Health
N2  - Exercise training effectively mitigates aging-induced health and fitness impairments. Traditional training recommendations for the elderly focus separately on relevant physiological fitness domains, such as balance, flexibility, strength and endurance. Thus, a more holistic and functional training framework is needed. The proposed agility training concept integratively tackles spatial orientation, stop and go, balance and strength. The presented protocol aims at introducing a two-armed, one-year randomized controlled trial, evaluating the effects of this concept on neuromuscular, cardiovascular, cognitive and psychosocial health outcomes in healthy older adults. Eighty-five participants were enrolled in this ongoing trial. Seventy-nine participants completed baseline testing and were block-randomized to the agility training group or the inactive control group. All participants undergo pre- and post-testing with interim assessment after six months. The intervention group currently receives supervised, group-based agility training twice a week over one year, with progressively demanding perceptual, cognitive and physical exercises. Knee extension strength, reactive balance, dual task gait speed and the Agility Challenge for the Elderly (ACE) serve as primary endpoints and neuromuscular, cognitive, cardiovascular, and psychosocial meassures serve as surrogate secondary outcomes. Our protocol promotes a comprehensive exercise training concept for older adults, that might facilitate stakeholders in health and exercise to stimulate relevant health outcomes without relying on excessively time-consuming physical activity recommendations.
KW  - agility
KW  - prevention
KW  - healthy aging
KW  - community dwelling
KW  - psychosocial
Y1  - 2020
U6  - http://dx.doi.org/10.3390/ijerph17061853
SN  - 1660-4601
VL  - 17
IS  - 6
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Suman, Pedro H.
A1  - Schöning, Michael Josef
A1  - Siqueira Junior, José R.
A1  - Orlandi, Marcelo O.
T1  - Layer-by-layer film based on Sn₃O₄ nanobelts as sensing units to detect heavy metals using a capacitive field-effect sensor platform
JF  - Chemosensors
N2  - Lead and nickel, as heavy metals, are still used in industrial processes, and are classified as “environmental health hazards” due to their toxicity and polluting potential. The detection of heavy metals can prevent environmental pollution at toxic levels that are critical to human health. In this sense, the electrolyte–insulator–semiconductor (EIS) field-effect sensor is an attractive sensing platform concerning the fabrication of reusable and robust sensors to detect such substances. This study is aimed to fabricate a sensing unit on an EIS device based on Sn₃O₄ nanobelts embedded in a polyelectrolyte matrix of polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) using the layer-by-layer (LbL) technique. The EIS-Sn₃O₄ sensor exhibited enhanced electrochemical performance for detecting Pb²⁺ and Ni²⁺ ions, revealing a higher affinity for Pb²⁺ ions, with sensitivities of ca. 25.8 mV/decade and 2.4 mV/decade, respectively. Such results indicate that Sn₃O₄ nanobelts can contemplate a feasible proof-of-concept capacitive field-effect sensor for heavy metal detection, envisaging other future studies focusing on environmental monitoring.
KW  - Sn₃O₄
KW  - nanobelts
KW  - field-effect sensor
KW  - LbL films
KW  - heavy metals
Y1  - 2023
U6  - http://dx.doi.org/10.3390/chemosensors11080436
SN  - 2227-9040
N1  - This article belongs to the Special Issue The Application of Electrochemical Sensors or Biosensors Based on Nanomaterials
VL  - 11
IS  - 8
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Silva, Anielle C. A.
A1  - Dantas, Noelio O.
A1  - Schöning, Michael Josef
A1  - Siqueira, José R., Jr.
T1  - Hybrid Layer‐by‐Layer Film of Polyelectrolytes‐Embedded Catalytic CoFe2O4 Nanocrystals as Sensing Units in Capacitive Electrolyte‐Insulator‐Semiconductor Devices
JF  - physica status solidi a : applications and materials sciences
Y1  - 2019
U6  - http://dx.doi.org/10.1002/pssa.201900044
VL  - 216
IS  - 1900044
SP  - 1
EP  - 9
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Gomes, Vanderley F., Jr.
A1  - Silva, Anielle C. A.
A1  - Dantas, Noelio O.
A1  - Schöning, Michael Josef
A1  - Siqueira, José R., Jr.
T1  - Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices
JF  - Journal of Materials Science
N2  - The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance–voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film’s surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s10853-017-1369-y
SN  - 1573-4803
VL  - 52
IS  - 20
SP  - 12314
EP  - 12325
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Monti, Elena
A1  - Waldvogel, Janice
A1  - Ritzmann, Ramona
A1  - Freyler, Kathrin
A1  - Albracht, Kirsten
A1  - Helm, Michael
A1  - De Cesare, Niccolò
A1  - Pavan, Piero
A1  - Reggiani, Carlo
A1  - Gollhofer, Albert
A1  - Narici, Marco Vincenzo
T1  - Muscle in variable gravity: “I do not know where I am, but I know what to do”
JF  - Frontiers in Physiology
N2  - Performing tasks, such as running and jumping, requires activation of the agonist and antagonist muscles before (motor unit pre-activation) and during movement performance (Santello and Mcdonagh, 1998). A well-timed and regulated muscle activation elicits a stretch-shortening cycle (SSC) response, naturally occurring in bouncing movements (Ishikawa and Komi, 2004; Taube et al., 2012). By definition, the SSC describes the stretching of a pre-activated muscle-tendon complex immediately followed by a muscle shortening in the concentric push-off phase (Komi, 1984).
Given the importance of SSC actions for human movement, it is not surprising that many studies investigated the biomechanics of this phenomenon; in particular, drop jumps (DJs) represent a good paradigm to study muscle fascicle and tendon behavior in ballistic movements involving the SSC.
Within a DJ, three main phases [pre-activation, braking, and push-off (PO; Komi, 2000)] have been recognized and extensively studied in common and challenging conditions, such as changes in load, falling height, or simulated hypo-gravity (Avela et al., 1994; Arampatzis et al., 2001; Fukashiro et al., 2005; Ishikawa et al., 2005; Sousa et al., 2007; Ritzmann et al., 2016; Helm et al., 2020).
These studies show that the timing and amount of triceps-surae muscle-tendon unit pre-activation in DJs are differentially regulated based on the load applied to the muscle, being optimal in normal “Earth” gravity conditions (Avela et al., 1994), but decreased in simulated hypo-gravity, hyper-gravity (Avela et al., 1994; Ritzmann et al., 2016), or unknown conditions (i.e., unknown falling heights; Helm et al., 2020). Some authors indicated that, when falling from heights different from the optimal one [defined as the drop height giving a maximum DJ performance indicated as peak ground reaction force (GRF) or jump high], electromyographic (EMG) activity of the plantar flexors increases from lower than optimal to higher than optimal heights (Ishikawa and Komi, 2004; Sousa et al., 2007).
These findings highlight the ability of the central nervous system to regulate the timing and amount of pre-activation according to different jumping conditions, thus regulating muscle fascicle length, tendon and joint stiffness as well as position, in order to safely land on the ground and quickly re-bounce.
Similarly, to pre-activation, also in the braking phase, the plantar flexors are differentially regulated. In optimal height (i.e., load) jumping conditions, gastrocnemius medialis (GM) fascicles shorten at early ground contact (possibly due to the intervention of the stretch reflex; Gollhofer et al., 1992) and behave quasi-isometrically in the late braking phase, enabling tendon elongation, and storage of elastic energy (Gollhofer et al., 1992; Fukashiro et al., 2005; Sousa et al., 2007). When increasing the falling height (augmenting the impact GRF), the quasi-isometric behavior of fascicles disappears, and fast fascicle lengthening occurs (Ishikawa et al., 2005; Sousa et al., 2007).
In the third and last PO phase, fascicles shorten and the tendon releases the elastic energy previously stored. Bobbert et al. (1987) reported no influence of jumping height on the work done and on the net vertical impulse assessed during PO; this observation suggests that, despite an optimal DJ performance might be achieved only in specific conditions (falling heights, loads), the central nervous system seems to be able to regulate muscle behavior in order to effectively perform the required task also in challenging situations.
Although the regulation of triceps-surae muscle-tendon unit in DJs has been extensively investigated, very few studies focused on sarcomeres behavior during the performance of this SSC movement (Kurokawa et al., 2003; Fukashiro et al., 2005, 2006). Sarcomeres represent muscle contractile units and are known to express different amounts of force depending on their length (Gordon et al., 1966; Walker and Schrodt, 1974); thus, understanding the time course of their responses during DJs is fundamental to gain further insights into muscle force-generating capacity. In vivo measurement of sarcomere length in humans has been so far been performed only in static positions and under highly controlled experimental conditions (Llewellyn et al., 2008; Sanchez et al., 2015). Instead, human sarcomere length estimation (achieved by dividing GM measured fascicle length for a fixed sarcomere number) in dynamic contractions provided an indirect measure of sarcomere operating range during squat jump, countermovement jump, and DJ (Fukashiro et al., 2005, 2006; Kurokawa et al., 2003). The results of these studies showed that sarcomeres operate in the ascending limb of their length-tension (L-T) relationship in all types of jumps, and particularly so in DJ.
However, most of the available observations on sarcomere and muscle fascicle behavior were made in condition of constant gravity. Thus, in order to understand how sarcomere and muscle fascicle length are regulated in variable gravity conditions, we performed experiments in a parabolic flight, involving variable gravity levels, ranging from about zero-g to about double the Earth’s gravity (1 g; Waldvogel et al., 2021).
Specifically, the aims of the present study were as follows:
1. To investigate the ability of the neuromuscular system in regulating fascicle length in response to conditions of variable gravity.
2. To estimate sarcomere operative length in the different DJ phases, in order to calculate its theoretical force production and its possible modulation in conditions of variable gravity.
We hypothesized that muscle fascicles would be differentially regulated in different gravity conditions compared to 1 g, particularly in anticipation of landing and re-bouncing in unknown gravity levels. In addition, we hypothesized that sarcomeres would operate in the upper part of the ascending limb of their L-T relationship, possibly lengthening during the braking phase (especially in hyper-gravity) while operating quasi-isometrically in 1 g.
KW  - parabolic flight
KW  - drop jump
KW  - hypo-gravity
KW  - hyper-gravity
KW  - sarcomere operating length
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fphys.2021.714655
SN  - 1664-042X
VL  - 12
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Sorich, Maren
A1  - Bartz, Alexander
A1  - Siegert, Petra
A1  - Willenberg, Holger S.
A1  - Lisdat, Fred
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate
JF  - Sensors and Actuators B: Chemical
N2  - An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer’s solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.snb.2016.06.064
SN  - 0925-4005
VL  - 237
SP  - 190
EP  - 195
PB  - Elsevier
CY  - Amsterdam
ER  -