TY - JOUR A1 - Enning, Manfred A1 - Baier, M. T1 - Energetic and operational use of FlexCargoRail freight wagons in the single wagon load traffic / Baier, M. ; Enning, M. JF - Towards zero emission : EVS 24, the 24th International Battery, Hybrid and Fuel Cell Electric Vehicle Symposium & Exhibition, Stavanger, Norway, May 13 - 16, 2009 ; symposium proceedings / organised by AVERE ... Robert Stüssi [Hrsg.] Y1 - 2009 N1 - European Association of Electric Road Vehicles ; EVS ; (24 : ; 2009.05.13-16 : ; Stavanger) CY - Stavanger ER - TY - JOUR A1 - Enning, Manfred A1 - Abel, Dirk A1 - Bollig, Alexander T1 - Modellfabrik macht Automatisierungstechnik erlebbar / Abel, D. ; Bollig, A. ; Enning, M. JF - RWTH-Themen (2006) Y1 - 2006 SN - 0179-079X SP - 12 EP - 14 ER - TY - JOUR A1 - Enning, Manfred T1 - Kopplungen ausschalten. Technisch anspruchsvolle Regelungsverfahren vermindern Lageabweichungen bei schnell und genau arbeitenden Robotern. JF - Maschinenmarkt. 98 (1992), H. 46 Y1 - 1992 SN - 0341-5775 SP - 44 EP - 46 ER - TY - JOUR A1 - Enning, Manfred T1 - Grundsätzliche Konzepte bei Lageregelungen für Industrieroboter JF - Maschinenmarkt. 98 (1992), H. 37 Y1 - 1992 SN - 0341-5775 ER - TY - JOUR A1 - Enning, Manfred T1 - FlexCargoRail – Ohne Diesel in die Letzte Meile JF - Schienenverkehr – sicher, leise, effizient : InnoTrans, Berlin 2008 / Hrsg.: Bundesministerium für Wirtschaft und Technologie, Referat Öffentlichkeitsarbeit Y1 - 2008 N1 - Innovationspolitik, Informationsgesellschaft, Telekommunikation SP - 49 EP - 52 CY - Berlin ER - TY - JOUR A1 - Enning, Manfred T1 - Einzelwagenkonzept für die letzte Meile : „FlexCargoRail“ sieht autarke Fahrten von Waggons mit Rangiergeschwindigkeit vor. Massive Effizienzgewinne locken JF - Deutsche Verkehrs-Zeitung : DVZ / Logistik auf der Schiene (2008) Y1 - 2008 SN - 0342-166X N1 - vom 8.11.2008 ER - TY - JOUR A1 - Enning, Manfred T1 - Flexcargorail - ein Fahrzeugsystem für effizienten Einzelwagenverkehr / Baier, Martin ; Enning, Manfred JF - Logistik Management. 8 (2006), H. 3 Y1 - 2006 SN - 1436-6231 SP - 28 EP - 42 ER - TY - JOUR A1 - Enning, Manfred T1 - Vom "König der Landstraße" zur "Ameise 4.0" JF - ETR - Eisenbahntechnische Rundschau N2 - Auf Eisenbahn- und Logistikkonferenzen werden gelegentlich Videos von Blattschneiderameisen gezeigt, die effizient und selbstorganisiert große Mengen Material durch den Dschungel transportieren. Daran sollen wir uns ein Beispiel nehmen. Y1 - 2017 SN - 0013-2845 VL - 66 IS - 1/2 SP - 3 PB - DVV Media Group CY - Hamburg ER - TY - CHAP A1 - Engländer, Jacques A1 - Kaminski, Lars A1 - Schuba, Marko T1 - Informationssicherheitsmanagement T2 - Digitalisierungs- und Informationsmanagement N2 - Daten und Informationen sind die wichtigsten Ressourcen vieler Unternehmen und müssen daher entsprechend geschützt werden. Getrieben durch die erhöhte Vernetzung von Informationstechnologie, die höhere Offenheit infolge datengetriebener Dienstleistungen und eine starke Zunahme an Datenquellen, rücken die Gefahren von Informationsdiebstahl, -manipulation und -verlust in den Fokus von produzierenden Unternehmen. Auf dem Weg zum lern- und wandlungsfähigen Unternehmen kann dies zu einem großen Hindernis werden, da einerseits zu hohe Sicherheitsanforderungen neue Entwicklungen beschränken, andererseits wegen des Mangels an ausreichenden Informationssicherheitskonzepten Unternehmen weniger Innovationen wagen. Deshalb bedarf es individuell angepasster Konzepte für die Bereiche IT-Security, IT-Safety und Datenschutz für vernetzte Produkte, Produktion und Arbeitsplätze. Bei der Entwicklung und Durchsetzung dieser Konzepte steht der Faktor Mensch im Zentrum aller Überlegungen. In diesem Kapitel wird dargestellt, wie der Faktor Mensch bei der Erstellung von Informationssicherheitskonzepten in verschiedenen Phasen zu beachten ist. Beginnend mit der Integration von Informationssystemen und damit verbundenen Sicherheitsmaßnahmen, über die Administration, bis hin zur Anwendung durch den Endnutzer, werden Methoden beschrieben, die den Menschen, verbunden mit seinem Mehrwert wie auch den Risiken, einschließen. Dabei werden sowohl Grundlagen aufgezeigt als auch Konzepte vorgestellt, mit denen Entscheider in der Unternehmens-IT Leitlinien für die Informationssicherheit festlegen können. KW - Informationssicherheitsmanagement KW - Cybersicherheit KW - Cybersecurity KW - Informationssicherheit KW - IT-Sicherheit Y1 - 2022 SN - 978-3-662-63757-9 SN - 978-3-662-63758-6 U6 - https://doi.org/10.1007/978-3-662-63758-6_15 SP - 373 EP - 398 PB - Springer Vieweg CY - Berlin ER - TY - CHAP A1 - Englhard, Markus A1 - Weber, Tobias A1 - Arent, Jan-Christoph T1 - Efficiency enhancement for CFRP-Prepregautoclave manufacturing by means of simulation-assisted loading optimization T2 - Proceedings of SAMPE Europe Conference 2021 N2 - A new method for improved autoclave loading within the restrictive framework of helicopter manufacturing is proposed. It is derived from experimental and numerical studies of the curing process and aims at optimizing tooling positions in the autoclave for fast and homogeneous heat-up. The mold positioning is based on two sets of information. The thermal properties of the molds, which can be determined via semi-empirical thermal simulation. The second information is a previously determined distribution of heat transfer coefficients inside the autoclave. Finally, an experimental proof of concept is performed to show a cycle time reduction of up to 31% using the proposed methodology. Y1 - 2021 N1 - SAMPE Europe Conference 2021, Baden/Zürich, Schweiz, 29. bis 30. September 2021 ER - TY - CHAP A1 - Engemann, Heiko A1 - Wiesen, Patrick A1 - Kallweit, Stephan A1 - Deshpande, Harshavardhan A1 - Schleupen, Josef T1 - Autonomous mobile manipulation using ROS T2 - Advances in Service and Industrial Robotics Y1 - 2018 SN - 978-3-319-61276-8 U6 - https://doi.org/10.1007/978-3-319-61276-8_43 N1 - International Conference on Robotics in Alpe-Adria Danube Region RAAD 2017; Mechanisms and Machince Science book series, Vol 49. SP - 389 EP - 401 PB - Springer CY - Cham ER - TY - CHAP A1 - Engemann, Heiko A1 - Du, Shengzhi A1 - Kallweit, Stephan A1 - Ning, Chuanfang A1 - Anwar, Saqib T1 - AutoSynPose: Automatic Generation of Synthetic Datasets for 6D Object Pose Estimation T2 - Machine Learning and Artificial Intelligence. Proceedings of MLIS 2020 N2 - We present an automated pipeline for the generation of synthetic datasets for six-dimension (6D) object pose estimation. Therefore, a completely automated generation process based on predefined settings is developed, which enables the user to create large datasets with a minimum of interaction and which is feasible for applications with a high object variance. The pipeline is based on the Unreal 4 (UE4) game engine and provides a high variation for domain randomization, such as object appearance, ambient lighting, camera-object transformation and distractor density. In addition to the object pose and bounding box, the metadata includes all randomization parameters, which enables further studies on randomization parameter tuning. The developed workflow is adaptable to other 3D objects and UE4 environments. An exemplary dataset is provided including five objects of the Yale-CMU-Berkeley (YCB) object set. The datasets consist of 6 million subsegments using 97 rendering locations in 12 different UE4 environments. Each dataset subsegment includes one RGB image, one depth image and one class segmentation image at pixel-level. Y1 - 2020 SN - 978-1-64368-137-5 U6 - https://doi.org/10.3233/FAIA200770 N1 - Frontiers in Artificial Intelligence and Applications. Vol 332 SP - 89 EP - 97 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Engemann, Heiko A1 - Du, Shengzhi A1 - Kallweit, Stephan A1 - Cönen, Patrick A1 - Dawar, Harshal T1 - OMNIVIL - an autonomous mobile manipulator for flexible production JF - Sensors Y1 - 2020 SN - 1424-8220 U6 - https://doi.org/10.3390/s20247249 N1 - Special issue: Sensor Networks Applications in Robotics and Mobile Systems VL - 20 IS - 24, art. no. 7249 SP - 1 EP - 30 PB - MDPI CY - Basel ER - TY - CHAP A1 - Engemann, Heiko A1 - Badri, Sriram A1 - Wenning, Marius A1 - Kallweit, Stephan T1 - Implementation of an Autonomous Tool Trolley in a Production Line T2 - Advances in Service and Industrial Robotics. RAAD 2019. Advances in Intelligent Systems and Computing, vol 980 Y1 - 2019 SN - 978-3-030-19648-6 U6 - https://doi.org/10.1007/978-3-030-19648-6_14 SP - 117 EP - 125 PB - Springer CY - Cham ER - TY - JOUR A1 - Engels, Elmar A1 - Wiendahl, H.-P. A1 - Doege, E. T1 - Universelle hydraulische Try-Out Presse / Teilprojekt A6 / Wiendahl, H.-P. ; Doege, E. ; Engels, E. JF - Tagungsband : 12. Oktober 1999, Leibnizhaus Hannover / Sonderforschungsbereich 384 Verfügbarkeitssicherung Reaktionsschneller Produktionssysteme, Universität Hannover. Hrsg.: H.-P. Wiendahl ; M. Röhrig Y1 - 1999 SN - 3-00-005495-2 N1 - Industriekolloquium Verfügbarkeit <1999, Hannover> ; Sonderforschungsbereich Verfügbarkeitssicherung Reaktionsschneller Produktionssysteme CY - Hannover ER - TY - CHAP A1 - Engels, Elmar A1 - Schnabel, Holger T1 - Rapid-control-prototyping of industrial drives for the sercos automation bus T2 - 13th International Workshop on Mechatronics (MECATRONICS), 2012 9th France-Japan & 7th Europe-Asia Congress on and Research and Education in Mechatronics (REM) N2 - This article describes the functionality of a MATLAB® library that can be used to develop motion-logic applications in MATLAB programming language for industrial drive and control systems using the well known sercos automation bus. Therewith MATLAB's functionality is extended to designing automation applications from single axis machines up to multi-kinematic robots. KW - MATLAB , MLPI , Motion control , Open Core , industrial drives , rapid control prototypin , sercos automation bus Y1 - 2012 UR - http://dx.doi.org/10.1109/MECATRONICS.2012.6451005 SN - 978-1-4673-4771-6 SP - 177 EP - 181 ER - TY - JOUR A1 - Engels, Elmar A1 - Krauskopf, S. T1 - Innovation in Motion-Logic programming - a versatile interface JF - Proceedings to the 12th International Workshop on Research and Education in Mechatronics, REM 2011, Kocaeli, Turkey, 15.09.-16.09.2011 Y1 - 2011 SN - 978-975-8047-96-3 PB - - ER - TY - CHAP A1 - Engels, Elmar A1 - Gabler, T. T1 - Universelle Programmierschnittstelle für Motion-Logic Systeme T2 - Tagungsband zur AALE-Tagung 2012 : 9. Fachkonferenz Y1 - 2012 SN - 978-3-8356-3305-6 N1 - AALE 2012 SP - 37 EP - 46 PB - Oldenbourg Industrieverlag CY - München ER - TY - JOUR A1 - Engels, Elmar A1 - Doege, Eckhart T1 - Pressen - Vergleich zwischen Raumlenker- und Exzenterantrieb / Doege, Eckhart ; Engels, Elmar JF - Blech, Rohre, Profile : Herstellen, Verarbeiten und Veredeln von Band, Blech, Rohren und Profilen. 46 (1999), H. 7-8 Y1 - 1999 SN - 0006-4688 SP - 31 EP - 37 ER - TY - JOUR A1 - Engels, Elmar A1 - Doege, Eckhart T1 - Pressen - Hubzahlregelung an Schnelläuferpressen mit Fuzzy-Reglern / Doege, Eckhart ; Engels, Elmar JF - Blech, Rohre, Profile : Herstellen, Verarbeiten und Veredeln von Band, Blech, Rohren und Profilen. 45 (1998), H. 11 Y1 - 1998 SN - 0006-4688 SP - 47 EP - 49 ER - TY - BOOK A1 - Engels, Elmar A1 - Doege, E. A1 - Lierath, F. A1 - Meyer, F. T1 - Automatisierte Maximierung der Produktionshubzahl bei Schnelläuferpressen mittels Fuzzy-Regler : [Abschlußbericht] / Verf.: Friedhelm Lierath ... ; Doege, E. ; Meyer, F. ; Engels, E. Y1 - 1998 N1 - EFB-Forschungsbericht ; Nr. 113 ; Forschungsvorhaben EFB/AiF-Nr. 10425B. PB - EFB CY - Hannover ER - TY - JOUR A1 - Engels, Elmar A1 - Doege, E. A1 - Elend, L. E. T1 - Modifizierte Ziehkissenklemmung erweitert Pressen-Arbeitsbereich / Doege, E. ; Elend, L. E. ; Engels, E. JF - Maschinenmarkt. 106 (2000), H. 7 Y1 - 2000 SN - 0341-5775 SP - 30 EP - 33 ER - TY - JOUR A1 - Engels, Elmar A1 - Doege, E. T1 - Optimizing the number of strokes for punching machines using a fuzzy controlled electrohydraulic damping system / Doege, E. ; Engels, E. JF - ICME 98, CIRP International Seminar on Intelligent Computation in Manufacturing Engineering, Proceedings, Capri, IT, Jul 1-3, 1998 Y1 - 1998 SP - 471 EP - 478 CY - Capri ER - TY - JOUR A1 - Engels, Elmar T1 - Reduzierung der horizontalen Massenkräfte bei Pressen mit Raumlenkerantrieb JF - UTF-science : Forschungsmagazin für die Produktionstechnik. 1 (2000), H. 3 Y1 - 2000 SP - 17 S. ER - TY - BOOK A1 - Engels, Elmar T1 - Einsparpotentiale und Anwendungserweiterungen mitfahrender Ziehtechniken : Abschlussbericht AiF/EFB 11158 B / Neugebauer, R. ; Henning, W. ; Doege, E. ; Elend, L.E. ; Engels, E. Y1 - 1999 N1 - EFB-Forschungsbericht, Europäische Forschungsgesellschaft für Blechverarbeitung ; Band 144 PB - EFB CY - Hannover ER - TY - PAT A1 - Engels, Elmar T1 - Tastatur mit einem magnetisch sensitiven Element : Offenlegungsschrift : DE102007052146A1 ; Offenlegungstag: 07.05.2009 Y1 - 2009 N1 - Volltext über Datenbank: http://publikationen.dpma.de/ PB - Deutsches Patent- und Markenamt CY - München ER - TY - PAT A1 - Engels, Elmar T1 - Magnetlesekopf, Magnetspeicherleseeinrichtung und Verfahren zum abgesicherten Auslesen und Verarbeiten von magnetisch gespeicherten Daten : Offenlegungsschrift : DE102006049162A1 ; Offenlegungstag: 24.04.2008 Y1 - 2008 N1 - Volltext über Datenbank: http://publikationen.dpma.de/ PB - Deutsches Patent- und Markenamt CY - München ER - TY - PAT A1 - Engels, Elmar T1 - Tastatur mit gegen Manipulation geschützten Tasten : Offenlegungsschrift : DE102006047331A1 ; Offenlegungstag: 10.04.2008 Y1 - 2008 N1 - Volltext über Datenbank: http://publikationen.dpma.de/ PB - Deutsches Patent- und Markenamt CY - München ER - TY - PAT A1 - Engels, Elmar T1 - Sicherungseinrichtung mit einem ein leitfähiges Muster aufweisenden Sicherungsring : Offenlegungsschrift : DE102006019811A1 ; Offenlegungstag: 31.07.2007 Y1 - 2007 N1 - Volltext über Datenbank: http://publikationen.dpma.de/ PB - Deutsches Patent- und Markenamt CY - München ER - TY - PAT A1 - Engels, Elmar T1 - Sicherungseinrichtung und Sicherheitskappe mit mehrlagigem leitfähigem Muster : Offenlegungsschrift : DE102006017506A1 ; Offenlegungstag: 18.10.2007 Y1 - 2007 N1 - Volltext über Datenbank: http://publikationen.dpma.de/ PB - Deutsches Patent- und Markenamt CY - München ER - TY - BOOK A1 - Engels, Elmar T1 - Entwicklung und Einsatz einer prozeßgeführten Hubzahlsteuerung für Schnelläuferpressen Y1 - 2000 SN - 3-18-383508-8 N1 - Fortschrittberichte VDI : Reihe 8, Meß-, Steuerungs- und Regelungstechnik ; 835 PB - VDI-Verl. CY - Düsseldorf ER - TY - CHAP A1 - Engels, Elmar T1 - Industrieantriebe mit sercos Schnittstelle über MATLAB steuern T2 - Tagungsband AALE 2013 : das Forum für Fachleute der Automatisierungstechnik aus Hochschulen und Wirtschaft ; 10. Fachkonferenz, Stralsund Y1 - 2013 SN - 978-3-8356-3364-3 SP - 223 EP - 232 PB - DIV Dt. Industrieverl. CY - München ER - TY - CHAP A1 - Engels, Elmar T1 - A field bus library for MATLAB based on open core engineering T2 - Proceedings to the 14th International Workshop on Research and Education in Mechatronics, REM 2013, Wien, 05.06.-06.06.2013. Y1 - 2013 SN - 978-3-90275-907-8 ER - TY - BOOK A1 - Engeln-Müllges, Gisela A1 - Zimmermann, Hans-Jürgen T1 - Methoden und Modelle des Operations Research : für Ingenieure, Ökonomen und Informatiker / Hans-Jürgen Zimmermann. [Hrsg. von Gisela Engeln-Müllges] - 2., überarb. Aufl. Y1 - 1992 SN - 3-528-18917-7 PB - Vieweg CY - Braunschweig ; Wiesbaden ER - TY - BOOK A1 - Engeln-Müllges, Gisela A1 - Uhlig, Frank T1 - Numerical algorithms with C Y1 - 1996 SN - 3-540-60530-0 PB - Springer CY - Berlin [u.a.] ER - TY - BOOK A1 - Engeln-Müllges, Gisela A1 - Uhlig, Frank T1 - Numeric Algorithms with Fortran Y1 - 1996 SN - 3-540-60529-0 PB - Springer CY - Berlin [u.a.] ER - TY - BOOK A1 - Engeln-Müllges, Gisela A1 - Schäfer, Wolfgang A1 - Trippler, Gisela T1 - Kompaktkurs Ingenieurmathematik mit Wahrscheinlichkeitsrechnung und Statistik. - 3., neu bearb. und erw. Aufl. Y1 - 2004 SN - 3-446-22864-0 PB - Fachbuchverl. Leipzig im Carl-Hanser-Verl. CY - München [u.a.] ER - TY - BOOK A1 - Engeln-Müllges, Gisela A1 - Reutter, Fritz T1 - Formelsammlung zur numerischen Mathematik mit Quick-BASIC-Programmen. Anh. Quick-BASIC-Programme / von Jürgen Dietel ... / von Gisela Engeln-Müllges und Fritz Reutter Y1 - 1991 SN - 3-411-14312-6 PB - BI-Wiss.-Verl. CY - Mannheim, Wien , Zürich ER - TY - BOOK A1 - Engeln-Müllges, Gisela A1 - Niederdrenk, Klaus A1 - Wodicka, Reinhard T1 - Numerik-Algorithmen : Verfahren, Beispiele, Anwendungen. - 9., vollst. überarb. und erw. Aufl. Y1 - 2005 SN - 3-540-62669-7 PB - Springer CY - Berlin [u.a.] ER - TY - BOOK A1 - Engeln-Müllges, Gisela A1 - Niederdrenk, Klaus T1 - Fortran 90 mit Fortran 95 Y1 - 1996 SN - 3-499-19826-6 PB - Rowohlt CY - Reinbek bei Hamburg ER - TY - BOOK A1 - Engeln-Müllges, Gisela T1 - Numerische Mathematik und Statistik : NUMAS ; multimediales Lehr- und Lernsystem zur Numerischen Mathematik und Statistik ; Abschlussbericht ; Gemeinschaftsprojekt Y1 - 2004 N1 - Bd. 1 - 3 PB - Projektbüro NUMAS, FH [u.a.] CY - Aachen ER - TY - JOUR A1 - Engeln-Müllges, Gisela T1 - Entartungsbedingungen für Gleitflächennomogramme und Nomographierbarkeitsbedingungen für Fluchtebenennomogramme JF - ZAMM ‐ Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik Y1 - 1982 U6 - https://doi.org/10.1002/zamm.19820620203 SN - 1521-4001 VL - 62 IS - 2 SP - 77 EP - 93 ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Simsek, Beril A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study JF - Sensors N2 - Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled Néel–Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays. KW - key performance indicators KW - magnetic biosensing KW - coupled Néel–Brownian relaxation dynamics KW - frequency mixing magnetic detection KW - magnetic relaxation KW - micromagnetic simulation KW - magnetic nanoparticles Y1 - 2024 U6 - https://doi.org/10.3390/s24061945 SN - 1424-8220 N1 - This article belongs to the Special Issue "Advances in Magnetic Sensors and Their Applications" VL - 24 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shasha, Carolyn A1 - Teeman, Eric A1 - Slabu, Iona A1 - Krishnan, Kannan M. T1 - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation JF - Journal of Magnetism and Magnetic Materials Y1 - 2019 U6 - https://doi.org/10.1016/j.jmmm.2018.09.041 SN - 0304-8853 VL - 471 IS - 1 SP - 450 EP - 456 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Engelmann, Ulrich M. A1 - Shasha, Carolyn A1 - Slabu, Ioana T1 - Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating T2 - Magnetic nanoparticles in human health and medicine Y1 - 2021 SN - 978-1-119-75467-1 SP - 327 EP - 354 PB - Wiley-Blackwell CY - Hoboken, New Jeersey ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shalaby, Ahmed A1 - Shasha, Carolyn A1 - Krishnan, Kannan M. A1 - Krause, Hans-Joachim T1 - Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory JF - Nanomaterials N2 - Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90% of the frequency mixing magnetic response signal is generated by the largest 10% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory. KW - Magnetic nanoparticles KW - Frequency mixing magnetic detection KW - Langevin theory KW - Micromagnetic simulation KW - Nonequilibrium dynamics Y1 - 2021 SN - 2079-4991 U6 - https://doi.org/10.3390/nano11051257 N1 - This article belongs to the Special Issue Applications and Properties of Magnetic Nanoparticles VL - 11 IS - 5 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Seifert, Julian A1 - Mues, Benedikt A1 - Roitsch, Stefan A1 - Ménager, Christine A1 - Schmidt, Annette M. A1 - Slabu, Ioana T1 - Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels JF - Journal of Magnetism and Magnetic Materials Y1 - 2019 U6 - https://doi.org/10.1016/j.jmmm.2018.09.113 SN - 0304-8853 VL - 471 IS - 1 SP - 486 EP - 494 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Roeth, Anjali A.J. A1 - Eberbeck, Dietmar A1 - Buhl, Eva Miriam A1 - Neumann, Ulf Peter A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells JF - Scientific Reports N2 - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells. Y1 - 2018 U6 - https://doi.org/10.1038/s41598-018-31553-9 SN - 2045-2322 VL - 8 IS - 1 SP - Article number 13210 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Pourshahidi, Mohammad Ali A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation JF - Journal of Magnetism and Magnetic Materials N2 - Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing. Y1 - 2022 U6 - https://doi.org/10.1016/j.jmmm.2022.169965 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Draack, Sebastian A1 - Viereck, Thilo A1 - Frank, A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications JF - IEEE Magnetic Letters N2 - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy. Y1 - 2018 U6 - https://doi.org/10.1109/LMAG.2018.2879034 SN - 1949-307X VL - 9 IS - Article number 8519617 PB - IEEE CY - New York, NY ER -