TY  - JOUR
A1  - Hackl, Michael
A1  - Leschinger, T.
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
A1  - Wegmann, Kilian
T1  - Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.
Y1  - 2016
U6  - https://doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 130
EP  - 131
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Capri, Miriam
A1  - Morsiani, Cristina
A1  - Santoro, Aurelia
A1  - Moriggi, Manuela
A1  - Conte, Maria
A1  - Martucci, Morena
A1  - Bellavista, Elena
A1  - Fabbri, Cristina
A1  - Giampieri, Enrico
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Canepari, Monica
A1  - Longa, Emanuela
A1  - Giulio, Irene Di
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Salvioli, Stefano
A1  - Gelfi, Cecilia
A1  - Franceschi, Claudio
A1  - Narici, Marco
A1  - Rittweger, Jörn
T1  - Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
JF  - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Y1  - 2019
U6  - https://doi.org/10.1096/fj.201801625R
VL  - 33
IS  - 4
SP  - 5168
EP  - 5180
ER  - 
TY  - JOUR
A1  - Stäudle, Benjamin
A1  - Seynnes, Olivier
A1  - Laps, Guido
A1  - Göll, Fabian
A1  - Brüggemann, Gert-Peter
A1  - Albracht, Kirsten
T1  - Recovery from achilles tendon repair: a combination of Postsurgery Outcomes and Insufficient remodeling of muscle and tendon
JF  - Medicine & Science in Sports & Exercise
N2  - Achilles tendon rupture (ATR) patients have persistent functional deficits in the triceps surae muscle–tendon unit (MTU). The complex remodeling of the MTU accompanying these deficits remains poorly understood. The purpose of the present study was to associate in vivo and in silico data to investigate the relations between changes inMTU properties and strength deficits inATR patients. Methods: Elevenmale subjects who had undergone surgical repair of complete unilateral ATR were examined 4.6 ± 2.0 (mean ± SD) yr after rupture. Gastrocnemius medialis (GM) tendon stiffness, morphology, and muscle architecture were determined using ultrasonography. The force–length relation of the plantar flexor muscles was assessed at five ankle joint angles. In addition, simulations (OpenSim) of the GM MTU force–length properties were performed with various iterations of MTU properties found between the unaffected and the affected side. Results: The affected side of the patients displayed a longer, larger, and stiffer GM tendon (13% ± 10%, 105% ± 28%, and 54% ± 24%, respectively) compared with the unaffected side. The GM muscle fascicles of the affected side were shorter (32% ± 12%) and with greater pennation angles (31% ± 26%). A mean deficit in plantarflexion moment of 31% ± 10% was measured. Simulations indicate that pairing an intact muscle with a longer tendon shifts the optimal angular range of peak force outside physiological angular ranges, whereas the shorter muscle fascicles and tendon stiffening seen in the affected side decrease this shift, albeit incompletely. Conclusions: These results suggest that the substantial changes in MTU properties found in ATR patients may partly result from compensatory remodeling, although this process appears insufficient to fully restore muscle function.
KW  - Tendon Rupture
KW  - Stiffness
KW  - Simulation
KW  - Muscle Force
KW  - Muscle Fascicle
Y1  - 2021
U6  - https://doi.org/10.1249/MSS.0000000000002592
SN  - 1530-0315
VL  - 53
IS  - 7
SP  - 1356
EP  - 1366
PB  - American College of Sports Medicine
CY  - Philadelphia, Pa.
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Baskurt, O. K.
A1  - Meiselman, H. J.
T1  - Red blood cell aggregation in experimental sepsis . Baskurt, O. K.; Temiz, A.; Meiselman, H. J.
JF  - Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2
Y1  - 1997
SN  - 0022-2143
SP  - 183
EP  - 190
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - Reliability Analysis of Elasto-Plastic Structures under Variable Loads
JF  - Inelastic analysis of structures under variable loads : theory and engineering applications / Maier, G.; Weichert, D. [ed]
Y1  - 2000
SN  - 0-7923-6645-X
SP  - 269
EP  - 288
PB  - Kluwer Academic Publ.
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Pham, Phu Tinh
A1  - Vu, D. K.
A1  - Staat, Manfred
T1  - Reliability Analysis of Inelastic Shell Structures Under Variable Loads
JF  - Limit States of Materials and Structures : Direct Methods / Hrsg. Dieter Weichert; Hrsg. Alan Ponter
Y1  - 2009
SN  - 978-1-4020-9633-4
SP  - 135
EP  - 156
PB  - Springer Netherland
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Fiorini, G. L.
A1  - Lensa, W. von
A1  - Burgazzi, L.
T1  - Reliability Methods for Passive Safety Functions
JF  - Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations
Y1  - 1997
CY  - Pisa
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Reliability of an HTR-module primary circuit pressure boundary Influences, sensitivity, and comparison with a PWR
JF  - Nuclear Engineering and Design. 158 (1995), H. 2-3
Y1  - 1995
SN  - 0029-5493
SP  - 333
EP  - 340
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Abel, Thomas
A1  - Albracht, Kirsten
A1  - Strüder, Heiko K.
T1  - Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants
JF  - Sports Biomechanics
Y1  - 2019
U6  - https://doi.org/10.1080/14763141.2019.1593496
SN  - 1752-6116
IS  - Article in press
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Reliability of the Primary Circuit Pressure Boundary of an HTR-Module under Accident Conditions
JF  - Safety and reliability assessment : an integral approach ; ESREL'93 ; proceedings of the European Safety and Reliability Conference, Munich, Germany, May 10th - 12th 1993 / Kafka, P. [ed]
Y1  - 1993
SN  - 0-444-81561-9
SP  - 331
EP  - 342
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Aggeloussis, Nickos
A1  - Giannakou, Erasmia
A1  - Albracht, Kirsten
A1  - Arampatzis, Adamantios
T1  - Reproducibility of fascicle length and pennation angle of gastrocnemius medialis in human gait in vivo
JF  - Gait and Posture
N2  - The purpose of the current study was to examine the reproducibility of fascicle length and pennation angle of gastrocnemius medialis while human walking. To the best of our knowledge, this is the first study of the reproducibility of fascicle length and pennation angle of gastrocnemius medialis in vivo during human gait. Twelve males performed 10 gait trials on a treadmill, in 2 separate days. B-mode ultrasonography, with the ultrasound probe firmly adjusted in the transverse and frontal planes using a special cast, was used to measure the fascicle length and the pennation angle of the gastrocnemius medialis (GM). A Vicon 624 system with three cameras operating at 120 Hz was also used to record the ankle and knee joint angles. The results showed that measurements of fascicle length and pennation angle showed high reproducibility during the gait cycle, both within the same day and between different days. Moreover, the root mean square differences between the repeated waveforms of both variables were very small, compared with their ranges (fascicle length: RMS = ∼3 mm, range: 38–63 mm; pennation angle: RMS = ∼1.5°, range: 22–32°). However, their reproducibility was lower compared to the joint angles. It was found that representative data have to be derived by a wide number of gait trials (fascicle length ∼six trials, pennation angle more than 10 trials), to assure the reliability of the fascicle length and pennation angle in human gait.
Y1  - 2010
U6  - https://doi.org/10.1016/j.gaitpost.2009.08.249
SN  - 0966-6362
VL  - 31
IS  - 1
SP  - 73
EP  - 77
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Pourshahidi, Ali Mohammad
A1  - Engelmann, Ulrich M.
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
T1  - Resolving ambiguities in core size determination of magnetic nanoparticles from magnetic frequency mixing data
JF  - Journal of Magnetism and Magnetic Materials
N2  - Frequency mixing magnetic detection (FMMD) has been widely utilized as a measurement technique in magnetic immunoassays. It can also be used for the characterization and distinction (also known as “colourization”) of different types of magnetic nanoparticles (MNPs) based on their core sizes. In a previous work, it was shown that the large particles contribute most of the FMMD signal. This leads to ambiguities in core size determination from fitting since the contribution of the small-sized particles is almost undetectable among the strong responses from the large ones. In this work, we report on how this ambiguity can be overcome by modelling the signal intensity using the Langevin model in thermodynamic equilibrium including a lognormal core size distribution fL(dc,d0,σ) fitted to experimentally measured FMMD data of immobilized MNPs. For each given median diameter d0, an ambiguous amount of best-fitting pairs of parameters distribution width σ and number of particles Np with R2 > 0.99 are extracted. By determining the samples’ total iron mass, mFe, with inductively coupled plasma optical emission spectrometry (ICP-OES), we are then able to identify the one specific best-fitting pair (σ, Np) one uniquely. With this additional externally measured parameter, we resolved the ambiguity in core size distribution and determined the parameters (d0, σ, Np) directly from FMMD measurements, allowing precise MNPs sample characterization.
Y1  - 2022
U6  - https://doi.org/10.1016/j.jmmm.2022.169969
SN  - 0304-8853
VL  - 563
IS  - In progress, Art. No. 169969
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schäfer, Horst
A1  - Uebbing, H.
A1  - Stolz, H.
A1  - von der Osten, W. (u.a.)
T1  - Resonance Brillouin Scattering from Quantized Exciton-Polaritons in Ultrathin Epitaxial Layers of ZnSe
JF  - Il nuovo Cimento D. 17 (1995)
Y1  - 1995
SN  - 0392-6737
SP  - 1753
EP  - 1757
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Trzewik, Jürgen
A1  - Demirci, Taylan
A1  - Temiz Artmann, Aysegül
T1  - Response of fibroblasts to cyclic mechanical stress : a proteome approach / Digel, I. ; Trzewik, J. ; Demirci, T. ; Temiz Artmann, A. ; Artmann, G. M.
JF  - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1042
EP  - 1043
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Grebe, R.
A1  - Homrighausen, A.
A1  - Wolff, H.
A1  - Teitel, P.
A1  - Schmid-Schönbein, H.
T1  - Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Schönbein, H.
JF  - 12. Jahrestagung der Gesellschaft für Mikrozirkulation
Y1  - 1988
SP  - 196
EP  - 200
PB  - Karger [u.a.]
CY  - Basel [u.a.]
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schmid-Schönbein, H.
A1  - Grebe, R.
A1  - Teitel, P. [u.a.]
T1  - Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Schönbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schröder, Susanne
JF  - Drug Development Research. 14 (1988), H. 3-4
Y1  - 1988
SN  - 1098-2299
N1  - Abstracts frei unter:
SP  - 205
EP  - 211
ER  - 
TY  - JOUR
A1  - Streese, Lukas
A1  - Kotliar, Konstantin
A1  - Deiseroth, Arne
A1  - Infanger, Denis
A1  - Gugleta, Konstantin
A1  - Schmaderer, Christoph
A1  - Hanssen, Henner
T1  - Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial
JF  - Scandinavian Journal of Medicine and Science in Sports
N2  - The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1%, post: 3.0 ± 2.2%, P = .018) and AFarea (pre: 32.6 ± 28.4%*s, post: 37.7 ± 30.6%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8%, post: 2.9 ± 1.8%, P = .254; AFarea, pre: 41.6 ± 28.5%*s, post: 37.8 ± 27.0%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.
Y1  - 2020
U6  - https://doi.org/10.1111/sms.13560
SN  - 1600-0838
VL  - 30
IS  - 2
SP  - 272
EP  - 280
PB  - Wiley
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Ramoshaba, Nthai E.
A1  - Huisman, Hugo W.
A1  - Lammertyn, Leandi
A1  - Kotliar, Konstantin
A1  - Schutte, Aletta E.
A1  - Smith, Wayne
T1  - Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study
JF  - Hypertension Research
N2  - Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20–30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = −0.097 (95% CI = −0.165; −0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.
Y1  - 2020
U6  - https://doi.org/10.1038/s41440-020-0487-0
SN  - 1348-4214
IS  - 43
SP  - 1231
EP  - 1238
PB  - Springer Nature
CY  - Osaka
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hanssen, Henner
A1  - Eberhardt, Karla
A1  - Vilser, Walthard
A1  - Schmaderer, Christoph
A1  - Halle, Martin
A1  - Heemann, Uwe
A1  - Baumann, M.
T1  - Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects
JF  - Microcirculation
Y1  - 2013
SN  - 1549-8719
N1  - Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
PB  - Wiley
CY  - Malden
ER  - 
TY  - JOUR
A1  - Albanna, W.
A1  - Conzen, C.
A1  - Weiss, M.
A1  - Clusmann, H.
A1  - Fuest, M.
A1  - Mueller, M.
A1  - Brockmann, M.A.
A1  - Vilser, W.
A1  - Schmidt-Trucksäss, A.
A1  - Hoellig, A.
A1  - Seiz, M.
A1  - Thomé, C.
A1  - Kotliar, Konstantin
A1  - Schubert, G.A.
T1  - Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study
JF  - PLoS ONE
N2  - Background
Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH.

Methods
In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling.

Results
Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion.

Conclusion
RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.
Y1  - 2016
U6  - https://doi.org/10.1371/journal.pone.0158781
SN  - 1932-6203
VL  - 11
IS  - 7
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Vilser, Walthatd
A1  - Nagel, Edgar
A1  - Lanzl, Ines M.
T1  - Retinal vessel reaction in response to chromatic flickering light / Kotliar, Konstantin E. ; Vilser, Walthard ; Nagel, Edgar ; Lanzl, Ines M.
JF  - Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5
Y1  - 2004
SN  - 1435-702X
SP  - 377
EP  - 392
PB  - -
ER  - 
TY  - JOUR
A1  - Neumaier, Felix
A1  - Kotliar, Konstantin
A1  - Haeren, Roel Hubert Louis
A1  - Temel, Yasin
A1  - Lüke, Jan Niklas
A1  - Seyam, Osama
A1  - Lindauer, Ute
A1  - Clusmann, Hans
A1  - Hescheler, Jürgen
A1  - Schubert, Gerrit Alexander
A1  - Schneider, Toni
A1  - Albanna, Walid
T1  - Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA)
JF  - Frontiers in Neurology
Y1  - 2021
U6  - https://doi.org/10.3389/fneur.2021.659890
VL  - 12
SP  - 1
EP  - 11
PB  - Frontiers
ER  - 
TY  - JOUR
A1  - Rhoden, Imke
A1  - Ball, Christopher Stephen
A1  - Grajewski, Matthias
A1  - Kuckshinrich, Wilhelm
T1  - Reverse engineering of stakeholder preferences – A multi-criteria assessment of the German passenger car sector
JF  - Renewable and Sustainable Energy Reviews
N2  - Germany is a frontrunner in setting frameworks for the transition to a low-carbon system. The mobility sector plays a significant role in this shift, affecting different people and groups on multiple levels. Without acceptance from these stakeholders, emission targets are out of reach. This research analyzes how the heterogeneous preferences of various stakeholders align with the transformation of the mobility sector, looking at the extent to which the German transformation paths are supported and where stakeholders are located.

Under the research objective of comparing stakeholders' preferences to identify which car segments require additional support for a successful climate transition, a status quo of stakeholders and car performance criteria is the foundation for the analysis. Stakeholders' hidden preferences hinder the derivation of criteria weightings from stakeholders; therefore, a ranking from observed preferences is used. This study's inverse multi-criteria decision analysis means that weightings can be predicted and used together with a recalibrated performance matrix to explore future preferences toward car segments.

Results show that stakeholders prefer medium-sized cars, with the trend pointing towards the increased potential for alternative propulsion technologies and electrified vehicles. These insights can guide the improved targeting of policy supporting the energy and mobility transformation. Additionally, the method proposed in this work can fully handle subjective approaches while incorporating a priori information. A software implementation of the proposed method completes this work and is made publicly available.
KW  - Regionalization
KW  - Multi-criteria decision analysis
KW  - Preference assessment
KW  - E-Mobility
KW  - Mobility transition
Y1  - 2023
U6  - https://doi.org/10.1016/j.rser.2023.113352
SN  - 1364-0321
VL  - 181
IS  - July 2023
SP  - Article number: 113352
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kurulgan Demirci, Eylem
A1  - Demirci, Taylan
A1  - Linder, Peter
A1  - Trzewik, Jürgen
A1  - Gierkowski, Jessica Ricarda
A1  - Gossmann, Matthias
A1  - Kayser, Peter
A1  - Porst, Dariusz
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells
JF  - Journal of Bioscience and Bioengineering
N2  - All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.
KW  - Cell permeability
KW  - Cellular force
KW  - Endothelial cells
KW  - Recombinant activated protein C
KW  - Lipopolysaccharide
KW  - Contractile tension
KW  - CellDrum
Y1  - 2012
U6  - https://doi.org/10.1016/j.jbiosc.2012.03.019
SN  - 1347-4421
VL  - 113
IS  - 2
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - RHO-RHO production by two photon scattering. TASSO Collaboration
JF  - Physics Letters B. 97 (1980), H. 3-4
Y1  - 1980
SN  - 0370-2693
SP  - 448
EP  - 452
ER  - 
TY  - JOUR
A1  - Vögele, Stefan
A1  - Josyabhatla, Vishnu Teja
A1  - Ball, Christopher
A1  - Rhoden, Imke
A1  - Grajewski, Matthias
A1  - Rübbelke, Dirk
A1  - Kuckshinrichs, Wilhelm
T1  - Robust assessment of energy scenarios from stakeholders' perspectives
JF  - Energy
N2  - Using scenarios is vital in identifying and specifying measures for successfully transforming the energy system. Such transformations can be particularly challenging and require the support of a broader set of stakeholders. Otherwise, there will be opposition in the form of reluctance to adopt the necessary technologies. Usually, processes for considering stakeholders' perspectives are very time-consuming and costly. In particular, there are uncertainties about how to deal with modifications in the scenarios. In principle, new consulting processes will be required. In our study, we show how multi-criteria decision analysis can be used to analyze stakeholders' attitudes toward transition paths. Since stakeholders differ regarding their preferences and time horizons, we employ a multi-criteria decision analysis approach to identify which stakeholders will support or oppose a transition path. We provide a flexible template for analyzing stakeholder preferences toward transition paths. This flexibility comes from the fact that our multi-criteria decision aid-based approach does not involve intensive empirical work with stakeholders. Instead, it involves subjecting assumptions to robustness analysis, which can help identify options to influence stakeholders' attitudes toward transitions.
Y1  - 2023
U6  - https://doi.org/10.1016/j.energy.2023.128326
SN  - 1873-6785 (Online)
SN  - 0360-5442 (Print)
IS  - In Press, Article 128326
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wedrowski, M.
A1  - Bruyndonckx, P.
A1  - Tavernier, S.
A1  - Zhi, L.
A1  - Dang, J.
A1  - Mendes, P. R.
A1  - Perez, J. M.
A1  - Ziemons, Karl
T1  - Robustness of neural networks algorithm for gamma detection in monolithic block detector, positron emission tomography
JF  - 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)
N2  - The monolithic scintillator block approach for gamma detection in the Positron Emission Tomography (PET) avoids estimating Depth of Interaction (DOI), reduces dead zones in detector and diminishes costs of detector production. Neural Networks (NN) are very efficient to determine the entrance point of a gamma incident on a scintillator block. This paper presents results on the robustness of the spatial resolution as a function of the random fraction in the data, temperature and HV fluctuations. This is important when implementing the method in a real scanner. Measurements were done with two Hamamatsu S8550 APD arrays, glued on a 20 × 20 × 10 mm3 monolithic LSO crystal block.
Y1  - 2009
SN  - 1082-3654
SP  - 2625
EP  - 2628
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Lieder, R. M.
A1  - Neskakis, A
T1  - Rotational bands in ¹⁹⁵,¹⁹⁷ Tl
JF  - Nuclear physics / A. 299 (1978), H. 2
Y1  - 1978
SN  - 0375-9474
SP  - 255
EP  - 284
ER  - 
TY  - JOUR
A1  - Gaigall, Daniel
T1  - Rothman–Woodroofe symmetry test statistic revisited
JF  - Computational Statistics & Data Analysis
N2  - The Rothman–Woodroofe symmetry test statistic is revisited on the basis of independent but not necessarily identically distributed random variables. The distribution-freeness if the underlying distributions are all symmetric and continuous is obtained. The results are applied for testing symmetry in a meta-analysis random effects model. The consistency of the procedure is discussed in this situation as well. A comparison with an alternative proposal from the literature is conducted via simulations. Real data are analyzed to demonstrate how the new approach works in practice.
Y1  - 2020
U6  - https://doi.org/10.1016/j.csda.2019.106837
SN  - 0167-9473
VL  - 2020
IS  - 142
SP  - Artikel 106837
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Frotscher, Ralf
A1  - Muanghong, Danita
A1  - Dursun, Gözde
A1  - Goßmann, Matthias
A1  - Temiz Artmann, Aysegül
A1  - Staat, Manfred
T1  - Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue
JF  - Journal of Biomechanics
N2  - We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.
KW  - hiPS cardiomyocytes
KW  - Homogenization
KW  - Hodgkin–Huxley models
KW  - Frequency adaption
KW  - Electromechanical modeling
KW  - Drug simulation
KW  - Computational biomechanics
KW  - Cardiac tissue
Y1  - 2016
U6  - https://doi.org/10.1016/j.jbiomech.2016.01.039
SN  - 0021-9290 (Print)
SN  - 1873-2380 (Online)
VL  - 49
IS  - 12
SP  - 2428
EP  - 2435
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Rittweger, Jörn
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Longa, Emanuela
A1  - Moriggi, Manuela
A1  - Seynnes, Olivier
A1  - Di Giulio, Irene
A1  - Tenori, Leonardo
A1  - Vignoli, Alessia
A1  - Capri, Miriam
A1  - Gelfi, Cecilia
A1  - Luchinat, Claudio
A1  - Franceschi, Claudio
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Narici, Marco
T1  - Sarcolab pilot study into skeletal muscle’s adaptation to longterm spaceflight
JF  - npj Microgravity
Y1  - 2018
U6  - https://doi.org/10.1038/s41526-018-0052-1
SN  - 2373-8065
VL  - 4
IS  - 1
SP  - 1
EP  - 9
PB  - Nature Portfolio
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - Scale braking in inclusive charged particle production by e--e+ annihilation. TASSO Collaboration
JF  - Physics Letters B. 114 (1982), H. 1
Y1  - 1982
SN  - 0370-2693
SP  - 65
EP  - 70
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Garbe, S.
A1  - Nour, Y.
A1  - Wolf, K.
T1  - Scattered dose determination using the semiconductor diodes for a mask based whole brain radiotherapy (WBRT) with high-energy photons
JF  - Biomedizinische Technik. 50 (2005), H. 2
Y1  - 2005
SN  - 0932-4666
SP  - 1069
EP  - 1070
ER  - 
TY  - JOUR
A1  - Schäfer, Horst
A1  - Shanjia, Xu
A1  - Xinzhang, Wu
A1  - Boege, P.
T1  - Scattering Characteristics of 3-D Discontinuity Consisting of Semiconductor Sample Filled in Waveguide with Gaps
JF  - International Journal of Infrared and Millimeter Waves. 14 (1993), H. 10
Y1  - 1993
SN  - 0195-9271
SP  - 2155
EP  - 2190
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Screen-printed carbon electrodes modified with graphene oxide for the design of a reagent-free NAD+-dependent biosensor array
JF  - Analytical Chemistry
Y1  - 2019
U6  - https://doi.org/10.1021/acs.analchem.9b04481
VL  - 91
IS  - 23
SP  - 15293
EP  - 15299
PB  - ACS Publications
CY  - Washington
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Kilthau, G.
A1  - Spies, K. H.
T1  - Sealing mechanism of lip seals
JF  - Eleventh 11th International Conference on Fluid Sealing : proceedings of the 11th Internat. Conference on Fluid Sealing, held at Cannes, France 8 - 10 April, 1987 / organised and sponsored by BHRA, the Fluid Engineering Centre. Ed. B. S. Nau
Y1  - 1987
SN  - 3-540-51383-3
N1  - International Conference on Fluid Sealing <11, 1987, Cannes>
SP  - 748
EP  - 772
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - Search for new sequential leptons in e+e- annihilation at petra energies. TASSO Collaboration
JF  - Physics Letters B. 99 (1981), H. 2
Y1  - 1981
SN  - 0370-2693
SP  - 163
EP  - 168
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Lieder, R. M.
A1  - Didelez, J. P.
T1  - Search for the yrast traps through the study of the α-decay after (α,Xn) reactions
JF  - Annual report 1977 / Institut für Kernphysik Kernforschungsanlage Jülich
Y1  - 1978
N1  - Spezielle Berichte der Kernforschungsanlage Jülich ; 15
SP  - 50
PB  - Verlag des Forschungszentrums Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Lieder, R. M.
A1  - Beuscher, H.
A1  - Gono, Y.
T1  - Search for yrast traps trough the study of and a decay after(a,xn) reactions
JF  - Annual report 1976 / Institut für Kernphysik Kernforschungsanlage Jülich
Y1  - 1977
SP  - 32
PB  - Verlag des Forschungszentrums Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Givanoudi, Stella
A1  - Cornelis, Peter
A1  - Rasschaert, Geertrui
A1  - Wackers, Gideon
A1  - Iken, Heiko
A1  - Rolka, David
A1  - Yongabi, Derick
A1  - Robbens, Johan
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source
JF  - Sensors and Actuators B: Chemical
Y1  - 2021
U6  - https://doi.org/10.1016/j.snb.2021.129484
SN  - 0925-4005
IS  - In Press, Journal Pre-proof
SP  - Article 129484
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Haenni, D. R.
A1  - Beuscher, H.
A1  - Bochev, B.
T1  - Selectivity of a sum spectrometer for (a,xn) reaction
JF  - Annual report 1979 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 72)
Y1  - 1980
SP  - 49
PB  - Kernforschungsanlage
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Self-Adjoint Operator
JF  - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.
Y1  - 2009
SN  - 978-3-540-70622-9
SP  - 692
EP  - 697
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Self-aligned nanogaps and nanochannels via conventional photolithography and pattern-size reduction technique
JF  - Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI
Y1  - 2009
SN  - 0013-4686
SP  - 6010
EP  - 6014
ER  - 
TY  - JOUR
A1  - Pawelke, Siegfried
A1  - Butzer, Paul L.
T1  - Semi-groups and resolvent operators
JF  - Archive for Rational Mechanics and Analysis
KW  - Resolvent Operator
KW  - Electromagnetism
KW  - Complex System
KW  - Neural Network
KW  - Nonlinear Dynamics
Y1  - 1968
U6  - https://doi.org/10.1007/BF00250941
SN  - 0003-9527
VL  - 30
IS  - 2
SP  - 127
EP  - 147
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Dikta, Gerhard
T1  - Semi-parametric random censorship models
JF  - From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute
Y1  - 2017
SN  - 978-3-319-50986-0
U6  - https://doi.org/10.1007/978-3-319-50986-0_3
SP  - 43
EP  - 56
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Dikta, Gerhard
A1  - Reißel, Martin
A1  - Harlaß, Carsten
T1  - Semi-parametric survival function estimators deduced from an identifying Volterra type integral equation
JF  - Journal of multivariate analysis
N2  - Based on an identifying Volterra type integral equation for randomly right censored observations from a lifetime distribution function F, we solve the corresponding estimating equation by an explicit and implicit Euler scheme. While the first approach results in some known estimators, the second one produces new semi-parametric and pre-smoothed Kaplan–Meier estimators which are real distribution functions rather than sub-distribution functions as the former ones are. This property of the new estimators is particular useful if one wants to estimate the expected lifetime restricted to the support of the observation time.

Specifically, we focus on estimation under the semi-parametric random censorship model (SRCM), that is, a random censorship model where the conditional expectation of the censoring indicator given the observation belongs to a parametric family. We show that some estimated linear functionals which are based on the new semi-parametric estimator are strong consistent, asymptotically normal, and efficient under SRCM. In a small simulation study, the performance of the new estimator is illustrated under moderate sample sizes. Finally, we apply the new estimator to a well-known real dataset.
KW  - Volterra integral equation
KW  - Product-integration
KW  - Asymptotic efficiency
KW  - Semi-parametric random censorship model
KW  - Censored data
KW  - Survival analysis
Y1  - 2016
U6  - https://doi.org/10.1016/j.jmva.2016.02.008
IS  - 147
SP  - 273
EP  - 284
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Lüth, Hans
T1  - Semiconductor-based field-effect structures for chemical sensing
Y1  - 2001
SP  - 188
EP  - 198
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors
JF  - Journal of Contemporary Physics. 43 (2008), H. 2
Y1  - 2008
SN  - 1934-9378
N1  - Armenian Academy of Sciences
SP  - 77
EP  - 81
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Poghossian, Arshak
A1  - Bronder, Thomas
A1  - Schöning, Michael Josef
T1  - Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor
JF  - Sensors and Actuators B: Chemical
N2  - A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.
KW  - Layer-by-layer adsorption
KW  - Poly(allylamine hydrochloride)
KW  - Label-free detection
KW  - DNA biosensor
KW  - LAPS
KW  - Field effect
Y1  - 2016
U6  - https://doi.org/10.1016/j.snb.2016.02.004
SN  - 0925-4005
IS  - 229
SP  - 506
EP  - 512
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Neuendorf, Christian
A1  - Faßbender, Tobias
A1  - Nölke, Greta
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
A1  - Schröper, Florian
T1  - Sensitive and rapid detection of cholera toxin subunit B using magnetic frequency mixing detection
JF  - Plos One
N2  - Cholera is a life-threatening disease caused by the cholera toxin (CT) as produced by some Vibrio cholerae serogroups. In this research we present a method which directly detects the toxin’s B subunit (CTB) in drinking water. For this purpose we performed a magnetic sandwich immunoassay inside a 3D immunofiltration column. We used two different commercially available antibodies to capture CTB and for binding to superparamagnetic beads. ELISA experiments were performed to select the antibody combination. The beads act as labels for the magnetic frequency mixing detection technique. We show that the limit of detection depends on the type of magnetic beads. A nonlinear Hill curve was fitted to the calibration measurements by means of a custom-written python software. We achieved a sensitive and rapid detection of CTB within a broad concentration range from 0.2 ng/ml to more
than 700 ng/ml.
Y1  - 2019
U6  - https://doi.org/10.1371/journal.pone.0219356
SN  - 1932-6203
VL  - 14
IS  - 7
PB  - Plos
CY  - San Francisco
ER  -