TY  - JOUR
A1  - Gligorevic, Snjezana
T1  - Joint channel estimation and equalisation of fast time-varying frequency-selective channels
JF  - European transactions on telecommunications
Y1  - 2008
SN  - 1541-8251; 2161-3915; 1120-3862; 1124-318X
VL  - Vol. 19
IS  - Iss. 1
SP  - 1
EP  - 13
ER  - 
TY  - JOUR
A1  - Kempt, Hendrik
A1  - Freyer, Nils
A1  - Nagel, Saskia K.
T1  - Justice and the normative standards of explainability in healthcare
JF  - Philosophy & Technology
N2  - Providing healthcare services frequently involves cognitively demanding tasks, including diagnoses and analyses as well as complex decisions about treatments and therapy. From a global perspective, ethically significant inequalities exist between regions where the expert knowledge required for these tasks is scarce or abundant. One possible strategy to diminish such inequalities and increase healthcare opportunities in expert-scarce settings is to provide healthcare solutions involving digital technologies that do not necessarily require the presence of a human expert, e.g., in the form of artificial intelligent decision-support systems (AI-DSS). Such algorithmic decision-making, however, is mostly developed in resource- and expert-abundant settings to support healthcare experts in their work. As a practical consequence, the normative standards and requirements for such algorithmic decision-making in healthcare require the technology to be at least as explainable as the decisions made by the experts themselves. The goal of providing healthcare in settings where resources and expertise are scarce might come with a normative pull to lower the normative standards of using digital technologies in order to provide at least some healthcare in the first place. We scrutinize this tendency to lower standards in particular settings from a normative perspective, distinguish between different types of absolute and relative, local and global standards of explainability, and conclude by defending an ambitious and practicable standard of local relative explainability.
KW  - Clinical decision support systems
KW  - Justice
KW  - Medical AI
KW  - Explainability
KW  - Normative standards
Y1  - 2022
U6  - https://doi.org/10.1007/s13347-022-00598-0
VL  - 35
IS  - Article number: 100
SP  - 1
EP  - 19
PB  - Springer Nature
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Mourzina, Y.
A1  - Mai, T.
A1  - Poghossian, Arshak
A1  - Ermolenko, Y.
A1  - Yoshinobu, T.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - K+-selective field-effect sensors as transducers for bioelectronic applications
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3333
EP  - 3339
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - K0 production in e+e− annihilations at 30 GeV center of mass energy. TASSO Collaboration
JF  - Physics Letters B. 94 (1980), H. 1
Y1  - 1980
SN  - 0370-2693
SP  - 91
EP  - 95
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Simsek, Beril
A1  - Shalaby, Ahmed
A1  - Krause, Hans-Joachim
T1  - Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study
JF  - Sensors
N2  - Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled Néel–Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays.
KW  - key performance indicators
KW  - magnetic biosensing
KW  - coupled Néel–Brownian relaxation dynamics
KW  - frequency mixing magnetic detection
KW  - magnetic relaxation
KW  - micromagnetic simulation
KW  - magnetic nanoparticles
Y1  - 2024
U6  - https://doi.org/10.3390/s24061945
SN  - 1424-8220
N1  - This article belongs to the Special Issue "Advances in Magnetic Sensors and Their Applications"
VL  - 24
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Ulamec, Stephan
A1  - Postberg, Frank
A1  - Sohl, Frank
A1  - Vera, Jean-Pierre de
A1  - Christoph, Waldmann
A1  - Lorenz, Ralph D.
A1  - Hellard, Hugo
A1  - Biele, Jens
A1  - Rettberg, Petra
T1  - Key technologies and instrumentation for subsurface exploration of ocean worlds
JF  - Space Science Reviews
N2  - In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter’s moon Europa and Saturn’s moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or – in the case of Enceladus – plume-fly-through missions.
Y1  - 2020
U6  - https://doi.org/10.1007/s11214-020-00707-5
SN  - 1572-9672
N1  - Corresponding author: Bernd Dachwald
VL  - 216
IS  - Art. 83
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Pietschmann, Bernd P.
A1  - Ruhtz, Vanessa
T1  - Knowledge Management
JF  - Personal : Zeitschrift für Human Resource Management. 53 (2001), H. 5
Y1  - 2001
SN  - 0031-5605
SP  - 242
EP  - 249
ER  - 
TY  - JOUR
A1  - Goedhuys, Micheline
A1  - Janz, Norbert
A1  - Mohnen, Pierre
T1  - Knowledge-based productivity in “low-tech” industries: evidence from firms in developing countries
JF  - Industrial and corporate change
N2  - Using firm-level data from five developing countries—Brazil, Ecuador, South Africa, Tanzania, and Bangladesh—and three industries—food processing, textiles, and the garments and leather products—this article examines the importance of various sources of knowledge for explaining productivity and formally tests whether sector- or country-specific characteristics dominate these relationships. Knowledge sources driving productivity appear mainly sector specific. Also differences in the level of development affect the effectiveness of knowledge sources. In the food processing sector, firms with higher educated managers are more productive, and in least-developed countries, additionally those with technology licenses and imported machinery and equipment. In the capital-intensive textiles sector, productivity is higher in firms that conduct R&D. In the garments and leather products sector, higher education of the managers, licensing, and R&D raise productivity.
Y1  - 2014
U6  - https://doi.org/10.1093/icc/dtt006
SN  - 1464-3650 (E-Journal); 0960-6491 (Print)
VL  - 23
IS  - 1
SP  - 1
EP  - 23
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Hoyler, Friedrich
A1  - Corminboeuf, F.
A1  - Jolie, J.
T1  - Kp=4+ double-gvibration in 164Dy / F. Corminboeuf ; J. Jolie ... F. Hoyler ...
JF  - Physical review / C. 56 (1997), H. 3
Y1  - 1997
SN  - 0556-2813
SP  - R1201
ER  - 
TY  - JOUR
A1  - Svaneborg, Carsten
A1  - Karimi-Varzaneh, Hossein Ali
A1  - Hojdis, Nils
A1  - Fleck, Franz
A1  - Everaers, Ralf
T1  - Kremer-Grest Models for Universal Properties of Specific Common Polymer Species
JF  - Soft Condensed Matter
N2  - The Kremer-Grest (KG) bead-spring model is a near standard in Molecular Dynamic simulations of generic polymer properties. It owes its popularity to its computational efficiency, rather than its ability to represent specific polymer species and conditions. Here we investigate how to adapt the model to match the universal properties of a wide range of chemical polymers species. For this purpose we vary a single parameter originally introduced by Faller and Müller-Plathe, the chain stiffness. Examples include polystyrene, polyethylene, polypropylene, cis-polyisoprene, polydimethylsiloxane, polyethyleneoxide and styrene-butadiene rubber. We do this by matching the number of Kuhn segments per chain and the number of Kuhn segments per cubic Kuhn volume for the polymer species and for the Kremer-Grest model. We also derive mapping relations for converting KG model units back to physical units, in particular we obtain the entanglement time for the KG model as function of stiffness allowing for a time mapping. To test these relations, we generate large equilibrated well entangled polymer melts, and measure the entanglement moduli using a static primitive-path analysis of the entangled melt structure as well as by simulations of step-strain deformation of the model melts. The obtained moduli for our model polymer melts are in good agreement with the experimentally expected moduli.
Y1  - 2018
IS  - 1606.05008
ER  - 
TY  - JOUR
A1  - Everaers, Ralf
A1  - Karimi-Varzaneh, Hossein Ali
A1  - Fleck, Franz
A1  - Hojdis, Nils
A1  - Svaneborg, Carsten
T1  - Kremer–Grest Models for Commodity Polymer Melts: Linking Theory, Experiment, and Simulation at the Kuhn Scale
JF  - Macromolecules
N2  - The Kremer–Grest (KG) polymer model is a standard model for studying generic polymer properties in molecular dynamics simulations. It owes its popularity to its simplicity and computational efficiency, rather than its ability to represent specific polymers species and conditions. Here we show that by tuning the chain stiffness it is possible to adapt the KG model to model melts of real polymers. In particular, we provide mapping relations from KG to SI units for a wide range of commodity polymers. The connection between the experimental and the KG melts is made at the Kuhn scale, i.e., at the crossover from the chemistry-specific small scale to the universal large scale behavior. We expect Kuhn scale-mapped KG models to faithfully represent universal properties dominated by the large scale conformational statistics and dynamics of flexible polymers. In particular, we observe very good agreement between entanglement moduli of our KG models and the experimental moduli of the target polymers.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.macromol.9b02428
SN  - 1520-5835
VL  - 53
IS  - 6
SP  - 1901
EP  - 1916
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Schulte-Zurhausen, Manfred
A1  - Poznanska, K.
T1  - Kryteria klasyfikacji malych i srednich przedsiebiorstw = Kriterien zur Klassifizierung von kleinen und mittleren Unternehmen
JF  - Przeglad Organizacji (1994)
Y1  - 1994
SP  - 24
EP  - 27
ER  - 
TY  - JOUR
A1  - Mischke, Winfried
T1  - Kurzkommentierung der §§ 433, 436, 446 - 453, 474 - 479 BGB
JF  - LexisNexis : Elektronische Ressource / Recht  (2009)
Y1  - 2009
ER  - 
TY  - JOUR
A1  - Meyer, Carolin
A1  - Gaalen, Kerstin van
A1  - Leschinger, Tim
A1  - Scheyerer, Max J.
A1  - Neiss, Wolfram F.
A1  - Staat, Manfred
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement
JF  - BioMed Research International
Y1  - 2019
U6  - https://doi.org/10.1155/2019/9232813
SP  - Article ID 9232813
ER  - 
TY  - JOUR
A1  - Mayer, Claudia
T1  - L'Estétique et le pouvoir: Le discours chaotique de l'Allemagne unifiée
JF  - Canadian review of comparative literature : CRCL = Revue canadienne de littérature comparée : RCLC / Canadian Comparative Literature Association. 24 (1997), H. 2
Y1  - 1997
SN  - 0319-051X
SP  - 297
EP  - 317
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
T1  - Label-free detection of charged macromolecules by using a field-effect-based sensor platform: Experiments and possible mechanisms of signal generation
JF  - Applied Physics A: Materials Science & Processing. 87 (2007), H. 3
Y1  - 2007
SN  - 0947-8396
N1  - Special Issue “From Surface Science to Nanoscale Devices”
SP  - 517
EP  - 524
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Wu, Chunsheng
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Label-free detection of DNA hybridization with light-addressable potentiometric sensors: comparison of various DNA-immobilization strategies
JF  - Procedia Engineering
N2  - Light-addressable potentiometric sensors (LAPS) consisting of a p-Si-SiO2 and p-Si-SiO2-Au structure, respectively, have been tested for a label-free electrical detection of DNA (deoxyribonucleic acid) hybridization. Three different strategies for immobilizing single-stranded probe DNA (ssDNA) molecules on a LAPS surface have been studied and compared: (a) immobilization of thiol-modified ssDNA on the patterned Au surface via gold-thiol bond, (b) covalent immobilization of amino-modified ssDNA onto the SiO2 surface functionalized with 3-aminopropyltriethoxysilane and (c) layer-by-layer adsorption of negatively charged ssDNA on a positively charged weak polyelectrolyte layer of poly(allylamine hydrochloride).
KW  - LAPS
KW  - lable-free detection
KW  - DNA hybridization
KW  - field-effect sensor
Y1  - 2014
U6  - https://doi.org/10.1016/j.proeng.2014.11.647
SN  - 1877-7058
N1  - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014>
VL  - 87
SP  - 755
EP  - 758
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
T1  - Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer
JF  - Nanoscale
N2  - A multi-spot (16 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure modified with a weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. To achieve a preferentially flat orientation of DNA strands and thus, to reduce the distance between the DNA charge and MLAPS surface, the negatively charged probe single-stranded DNAs (ssDNA) were electrostatically adsorbed onto the positively charged PAH layer using a simple layer-by-layer (LbL) technique. In this way, more DNA charge can be positioned within the Debye length, yielding a higher sensor signal. The surface potential changes in each spot induced due to the surface modification steps (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), non-specific adsorption of mismatched ssDNA) were determined from the shifts of photocurrent–voltage curves along the voltage axis. A high sensor signal of 83 mV was registered after immobilization of probe ssDNA onto the PAH layer. The hybridization signal increases from 5 mV to 32 mV with increasing the concentration of cDNA from 0.1 nM to 5 μM. In contrast, a small signal of 5 mV was recorded in the case of non-specific adsorption of fully mismatched ssDNA (5 μM). The obtained results demonstrate the potential of the MLAPS in combination with the simple and rapid LbL immobilization technique as a promising platform for the future development of multi-spot light-addressable label-free DNA chips with direct electrical readout.
Y1  - 2015
U6  - https://doi.org/10.1039/C4NR07225A
VL  - 14
IS  - 7
SP  - 6143
EP  - 6150
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors
T1  - Markierungsfreie Detektion doppelsträngiger DNA Moleküle mit Hilfe von Polyelektrolyt-modifizierten kapazitiven Feldeffekt-Sensoren
JF  - tm - Technisches Messen
N2  - In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.
Y1  - 2017
U6  - https://doi.org/10.1515/teme-2017-0015
VL  - 84
IS  - 10
SP  - 628
EP  - 634
PB  - De Gruyter
CY  - Oldenbourg
ER  - 
TY  - JOUR
A1  - Ingebrandt, S.
A1  - Han, Y.
A1  - Nakamura, F.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Offenhäusser, A.
T1  - Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors
JF  - Biosensors and Bioelectronics. 22 (2007), H. 12
Y1  - 2007
SN  - 0956-5663
SP  - 2834
EP  - 2840
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Bronder, Thomas
A1  - Wu, Chunsheng
A1  - Scheja, Sabrina
A1  - Jessing, Max
A1  - Metzger-Boddien, Christoph
A1  - Keusgen, Michael
A1  - Poghossian, Arshak
T1  - Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities
JF  - Proceedings
N2  - Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.
Y1  - 2017
U6  - https://doi.org/10.3390/proceedings1080719
SN  - 2504-3900
N1  - This article belongs to the Proceedings of "Proceedings of the 5th International Symposium on Sensor Science (I3S 2017)"
VL  - 1
IS  - 8
SP  - Artikel 719
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Pedraza, A. M.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Proc. Eurosensors XXIV, September 5–8, 2010, Linz, Austria
SP  - 918
EP  - 921
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Cherstvy, Andrey G.
A1  - Pedraza, Angela M.
A1  - Ingebrandt, Sven
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
JF  - Physica Status Solidi (a)
N2  - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100710
SN  - 1862-6319
VL  - 209
SP  - 925
EP  - 934
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Bäcker, Matthias
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips
JF  - Physica status solidi A : Applications and materials science
N2  - A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent–voltage (I–V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I–V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.
Y1  - 2014
U6  - https://doi.org/10.1002/pssa.201330442
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1423
EP  - 1428
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Label-free sensing of biomolecules with field-effect devices for clinical applications
JF  - Electroanalysis
N2  - Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.
Y1  - 2014
U6  - https://doi.org/10.1002/elan.201400073
SN  - 1521-4109 (E-Journal); 1040-0397 (Print)
VL  - 26
IS  - 6
SP  - 1197
EP  - 1213
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Zischank, Wolfgang J.
A1  - Heidler, Fridolin
A1  - Wiesinger, J.
A1  - Metwally, I.
A1  - Kern, Alexander
A1  - Seevers, M.
T1  - Laboratory simulation of direct lightning strokes to a modeled building : measurement of magnetic fields and included voltages
JF  - Journal of electrostatics. 60 (2004), H. 2 - 4
Y1  - 2004
SN  - 0304-3886
N1  - ISSN der E-Ausg.: 0304-3886
SP  - 223
EP  - 232
ER  - 
TY  - JOUR
A1  - Schwarzer, Klemens
A1  - Werner, M.
A1  - Hartz, T.
T1  - Lacasa - an instrument for the energy analysis and optimisation of buildings including technical equipment
JF  - Proceedings / organised by: ISES Europe ... [Ed.: Deutsche Gesellschaft für Sonnenenergie e.V. - DGS, Munich ; PSE GmbH - Forschung Entwicklung Marketing, Freiburg]. - Vol. 2
Y1  - 2004
SN  - 3-9809656-2-7
N1  - EuroSun <5, 2004, Freiburg, Breisgau> ; Internationales Sonnenforum <14, 2004, Freiburg, Breisgau> ; Deutsche Gesellschaft für Sonnenenergie ; CD-ROM-Ausg.: ISBN 3-9809656-4-3
SP  - 2-489-2-494
PB  - PSE
CY  - Freiburg [Breisgau]
ER  - 
TY  - JOUR
A1  - Mertens, Josef
T1  - Laminar flow for supersonic transports
JF  - Proceedings : March 16 - 18, 1992, Congress Centrum, Hamburg, Federal Republic of Germany / organized jointly by: Deutsche Gesellschaft für Luft- und Raumfahrt e.V. ... [Programme committee J. Szodruch ...]
Y1  - 1992
SN  - 3-922010-73-3
N1  - DGLR-Bericht ; 92,06
SP  - 319
EP  - 323
PB  - DGLR
CY  - Bonn
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Ulamec, S
A1  - Richter, L
T1  - Lander Systems for Planetary Missions
JF  - Laboratory astrophysics and space research / ed. by P. Ehrenfreund
Y1  - 1999
SN  - 0-7923-5338-2
N1  - Serie Astrophysics and space science library 236
SP  - 597
EP  - 621
PB  - Kluwer
CY  - Dordrecht [u.a.]
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Beck, Daniel
A1  - Lakemeyer, Gerhard
T1  - Landmark-Based Representations for Navigating Holonomic Soccer Robots / Beck, Daniel ; Ferrein, Alexander ; Lakemeyer, Gerhard
JF  - RoboCup 2008 : robot soccer world cup XII / Luca Iocchi ... (eds.)
Y1  - 2009
SN  - 978-3-642-02921-9
N1  - Lecture Notes in Computer Science ; 5399
SP  - 25
EP  - 36
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Dahmen, Markus
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - LAPS-based monitoring of metabolic responses of bacterial cultures in a paper fermentation broth
JF  - Sensors and Actuators B: Chemical
N2  - As an alternative renewable energy source, methane production in biogas plants is gaining more and more attention. Biomass in a bioreactor contains different types of microorganisms, which should be considered in terms of process-stability control. Metabolically inactive microorganisms within the fermentation process can lead to undesirable, time-consuming and cost-intensive interventions. Hence, monitoring of the cellular metabolism of bacterial populations in a fermentation broth is crucial to improve the biogas production, operation efficiency, and sustainability. In this work, the extracellular acidification of bacteria in a paper-fermentation broth is monitored after glucose uptake, utilizing a differential light-addressable potentiometric sensor (LAPS) system. The LAPS system is loaded with three different model microorganisms (Escherichia coli, Corynebacterium glutamicum, and Lactobacillus brevis) and the effect of the fermentation broth at different process stages on the metabolism of these bacteria is studied. In this way, different signal patterns related to the metabolic response of microorganisms can be identified. By means of calibration curves after glucose uptake, the overall extracellular acidification of bacterial populations within the fermentation process can be evaluated.
Y1  - 2020
U6  - https://doi.org/10.1016/j.snb.2020.128232
SN  - 0925-4005
VL  - 320
IS  - Art. 128232
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Roesner, Andreas
A1  - Scheik, Sven
A1  - Olowinsky, Alexander
A1  - Gillner, Arnold
A1  - Reisgen, Uwe
A1  - Schleser, Markus
T1  - Laser assisted joining of plastic metal hybrids
JF  - Lasers in manufacturing 2011 : proceedings of the sixth International WLT Conference on Lasers in Manufacturing, Munich, May 23 - 26 2011. (Physics procedia ; Vol. 12 (2011), Part B)
Y1  - 2011
SN  - 1875-3892 (E-Journal); 1875-3884 (Print)
SP  - 370
EP  - 377
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Olschok, Simon
A1  - Jakobs, Stefan
A1  - Schleser, Markus
A1  - Mokrov, Oleg
A1  - Rossiter, Eduardo
T1  - Laser beam submerged arc hybrid welding
JF  - Physics procedia
N2  - The laser beam-submerged arc hybrid welding method originates from the knowledge that, with increasing penetration depth, the laser beam process has a tendency to pore formation in the lower weld regions. The coupling with the energy-efficient submerged-arc process improves degassing and reduces the tendency to pore formation. The high deposition rate of the SA process in combination with the laser beam process offers, providing the appropriate choice of weld preparation, the possibility of welding plates with a thickness larger than 20° mm in a single pass, and also of welding thicker plates with the double-sided single pass technique.
Y1  - 2012
U6  - https://doi.org/10.1016/j.phpro.2012.10.016
SN  - 1875-3892
N1  - Part of special issue "Laser assisted net shape engineering 7 (LANE 2012)"
VL  - 39
SP  - 75
EP  - 83
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Strack, Andreas
A1  - Lakemeyer, Gerhard
T1  - Laser-Based Localization with Sparse Landmarks  / Strack, Andreas ; Ferrein, Alexander ; Lakemeyer, Gerhard
JF  - RoboCup 2005: Robot Soccer World Cup IX
Y1  - 2006
SN  - 978-3-540-35437-6
N1  - Lecture Notes in Computer Science ; 4020
SP  - 569
EP  - 576
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ermolenko, Y. E.
A1  - Yoshinobu, T.
A1  - Mourzina, Y. G.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Laserscanned transducer (LSST) as a multisensor system
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 457
EP  - 462
ER  - 
TY  - JOUR
A1  - Gebhardt, Andreas
T1  - Laserwelding with fillerwire
JF  - LIA handbook of laser material processing / Laser Institute of America
Y1  - 2001
SN  - 3-540-41770-2
N1  - Chapter 11.2.12
CY  - Orlando, Florida
ER  - 
TY  - JOUR
A1  - Mottaghy, Darius
A1  - Rath, Volker
T1  - Latent heat effects in subsurface heat transport modelling and their impact on palaeotemperature reconstructions
JF  - Geophysical Journal International
Y1  - 2006
U6  - https://doi.org/10.1111/j.1365-246X.2005.02843.x
SN  - 1365-246X
VL  - 164
IS  - 1
SP  - 236
EP  - 245
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor
JF  - Sensor and Actuators B: Chemical
N2  - To study chemical and biological processes, spatially resolved determination of the concentrations of one or more analyte species is of distinct interest. With a light-addressable potentiometric sensor (LAPS), chemical images can be created, which visualize the concentration distribution above the sensor plate. One important challenge is to achieve a good lateral resolution in order to detect events that take place in a small and limited region. LAPS utilizes a focused light spot to address the measurement region. By moving this light spot along the semiconductor sensor plate, the concentration distribution can be observed. In this study, we show that utilizing a pulse as light excitation instead of a traditionally used continuously modulated light excitation, the lateral resolution can be improved by a factor of 6 or more.
KW  - Chemical images
KW  - LAPS
KW  - Light-addressable potentiometric sensor
Y1  - 2017
U6  - https://doi.org/10.1016/j.snb.2017.02.057
SN  - 0925-4005
VL  - 248
SP  - 961
EP  - 965
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bialonski, Stephan
A1  - Schindler, K.
A1  - Elger, C. E.
A1  - Lehnertz, Klaus
T1  - Lateralized characteristics of the evolution of EEG correlation during focal onset seizures: a mechanism to prevent secondary generalization?
JF  - Epilepsia
N2  - Rationale: Previous studies [Topolnik et al., Cereb Cortex 2003; 13: 883; Schindler et al., Brain 2007; 130: 65] indicate that the termination of focal onset seizures may be causally related to an increase of global neuronal correlation during the second half of the seizures. This increase was observed to occur earlier in complex partial seizures than in secondarily generalized seizures. We here address the question whether such an increase of neuronal correlation prior to seizure end is indeed a global phenomenon, involving both hemispheres or whether there are side-specific differences. Methods: We analyzed 20 focal onset seizures (10 complex partial, 10 secondarily generalized seizures) recorded in 13 patients who underwent presurgical evaluation of focal epilepsies of different origin. EEG was recorded intracranially from bilaterally implanted subdural strip and intrahippocampal depth electrodes. Utilizing a moving window approach, we investigated the evolution of the maximum cross correlation for all channel combinations during seizures. For each moving window the mean value of the maximum cross correlation (MCC) between all electrode contacts was computed separately for each hemisphere. After normalization of seizure durations, MCC values of the ipsi- and contralateral hemisphere for all seizures were determined. Results: We observed that the MCC of the contralateral hemisphere in complex partial seizures increased during the first half of the seizure, whereas, for the same time interval, the MCC of the ipsilateral hemisphere even declined below the level of the pre-seizure period. In contrast, no significant differences between both hemispheres could be observed for secondarily generalized seizures where both hemispheres showed a simultaneous increase of MCC during the second half of the seizures. The level of MCC for the contralateral hemisphere was higher for complex partial seizures than for secondarily generalized seizures during the first half of the seizure. Conclusions: Our findings indicate that there are indeed lateralized differences in the evolution of global neuronal correlation during complex partial and secondarily generalized seizures. The observed contralateral increase of neuronal correlation during complex partial seizures might indicate an emerging self-organizing mechanism for preventing the spread of seizure activity.
Y1  - 2008
SN  - 0013-9580
VL  - 49
SP  - 11
EP  - 11
ER  - 
TY  - JOUR
A1  - Morandi, Paolo
A1  - Butenweg, Christoph
A1  - Breis, Khaled
A1  - Beyer, Katrin
A1  - Magenes, Guido
ED  - Ansal, Atilla
T1  - Latest findings on the behaviour factor q for the seismic design of URM buildings
JF  - Bulletin of Earthquake Engineering
N2  - Recent earthquakes as the 2012 Emilia earthquake sequence showed that recently built unreinforced masonry (URM) buildings behaved much better than expected and sustained, despite the maximum PGA values ranged between 0.20–0.30 g, either minor damage or structural damage that is deemed repairable. Especially low-rise residential and commercial masonry buildings with a code-conforming seismic design and detailing behaved in general very well without substantial damages. The low damage grades of modern masonry buildings that was observed during this earthquake series highlighted again that codified design procedures based on linear analysis can be rather conservative. Although advances in simulation tools make nonlinear calculation methods more readily accessible to designers, linear analyses will still be the standard design method for years to come. The present paper aims to improve the linear seismic design method by providing a proper definition of the q-factor of URM buildings. These q-factors are derived for low-rise URM buildings with rigid diaphragms which represent recent construction practise in low to moderate seismic areas of Italy and Germany. The behaviour factor components for deformation and energy dissipation capacity and for overstrength due to the redistribution of forces are derived by means of pushover analyses. Furthermore, considerations on the behaviour factor component due to other sources of overstrength in masonry buildings are presented. As a result of the investigations, rationally based values of the behaviour factor q to be used in linear analyses in the range of 2.0–3.0 are proposed.
KW  - Unreinforced masonry buildings
KW  - Modern constructions
KW  - Seismic design
KW  - Linear elastic analysis
KW  - Behaviour factor q
Y1  - 2022
U6  - https://doi.org/10.1007/s10518-022-01419-7
SN  - 1573-1456
SN  - 1570-761X
VL  - 20
IS  - 11
SP  - 5797
EP  - 5848
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Schädel, M.
A1  - Brüchle, W.
T1  - Lawrencium Chemistry: No Evidence for Oxidation States Lower than 3+ in Aqueous Solution / U.W. Scherer, J.V. Kratz, M. Schädel, W. Brüchle, K.E. Gregorich, R.A. Henderson, D. Lee, M. Nurmia, D.C. Hoffman
JF  - Inorganica Chimica Acta. 146 (1988)
Y1  - 1988
SN  - 0020-1693
SP  - 249
EP  - 254
ER  - 
TY  - JOUR
A1  - Förster, Arnold
T1  - Layer Deposition I
JF  - Fundamentals of nanoelectronics / Stefan Blügel ... (ed.). - (Lecture manuscripts of the ... Spring School of the Department of Solid State Research ; 34). - (Schriften des Forschungszentrums Jülich : Materie und Material ; 14 ; 34)
Y1  - 2003
SN  - 3-89336-319-X
SP  - C2.1
EP  - C2.13
PB  - Forschungszentrum, Zentralbibliothek
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Werner, Frederik
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Layer-by-Layer Assembly of Carbon Nanotubes Incorporated in Light-Addressable Potentiometric Sensors
JF  - Journal of Physical Chemistry C. 113 (2009), H. 33
Y1  - 2009
SN  - 1932-7455
SP  - 14765
EP  - 14770
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Suman, Pedro H.
A1  - Schöning, Michael Josef
A1  - Siqueira Junior, José R.
A1  - Orlandi, Marcelo O.
T1  - Layer-by-layer film based on Sn₃O₄ nanobelts as sensing units to detect heavy metals using a capacitive field-effect sensor platform
JF  - Chemosensors
N2  - Lead and nickel, as heavy metals, are still used in industrial processes, and are classified as “environmental health hazards” due to their toxicity and polluting potential. The detection of heavy metals can prevent environmental pollution at toxic levels that are critical to human health. In this sense, the electrolyte–insulator–semiconductor (EIS) field-effect sensor is an attractive sensing platform concerning the fabrication of reusable and robust sensors to detect such substances. This study is aimed to fabricate a sensing unit on an EIS device based on Sn₃O₄ nanobelts embedded in a polyelectrolyte matrix of polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) using the layer-by-layer (LbL) technique. The EIS-Sn₃O₄ sensor exhibited enhanced electrochemical performance for detecting Pb²⁺ and Ni²⁺ ions, revealing a higher affinity for Pb²⁺ ions, with sensitivities of ca. 25.8 mV/decade and 2.4 mV/decade, respectively. Such results indicate that Sn₃O₄ nanobelts can contemplate a feasible proof-of-concept capacitive field-effect sensor for heavy metal detection, envisaging other future studies focusing on environmental monitoring.
KW  - Sn₃O₄
KW  - nanobelts
KW  - field-effect sensor
KW  - LbL films
KW  - heavy metals
Y1  - 2023
U6  - https://doi.org/10.3390/chemosensors11080436
SN  - 2227-9040
N1  - This article belongs to the Special Issue The Application of Electrochemical Sensors or Biosensors Based on Nanomaterials
VL  - 11
IS  - 8
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Bhattarai, Aroj
A1  - May, Charlotte Anabell
A1  - Staat, Manfred
A1  - Kowalczyk, Wojciech
A1  - Tran, Thanh Ngoc
T1  - Layer-specific damage modeling of porcine large intestine under biaxial tension
JF  - Bioengineering
N2  - The mechanical behavior of the large intestine beyond the ultimate stress has never been investigated. Stretching beyond the ultimate stress may drastically impair the tissue microstructure, which consequently weakens its healthy state functions of absorption, temporary storage, and transportation for defecation. Due to closely similar microstructure and function with humans, biaxial tensile experiments on the porcine large intestine have been performed in this study. In this paper, we report hyperelastic characterization of the large intestine based on experiments in 102 specimens. We also report the theoretical analysis of the experimental results, including an exponential damage evolution function. The fracture energies and the threshold stresses are set as damage material parameters for the longitudinal muscular, the circumferential muscular and the submucosal collagenous layers. A biaxial tensile simulation of a linear brick element has been performed to validate the applicability of the estimated material parameters. The model successfully simulates the biomechanical response of the large intestine under physiological and non-physiological loads.
KW  - biaxial tensile experiment
KW  - anisotropy
KW  - hyperelastic
KW  - constitutive modeling
KW  - damage
Y1  - 2022
U6  - https://doi.org/10.3390/bioengineering9100528
SN  - 2306-5354
N1  - Der Artikel gehört zum Sonderheft "Computational Biomechanics"
VL  - 9
IS  - 10, Early Access
SP  - 1
EP  - 17
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Starke, Günther
A1  - Drews, P.
T1  - Le soudage au siecle de l'informatique
JF  - Souder. 18 (1994), H. 6
Y1  - 1994
SN  - 0246-1900
SP  - 33
EP  - 44
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - De Nardo, L.
A1  - Balbinot, G.
A1  - Colautti, P.
T1  - Leak Microstructures Operation at low pressure of propane: application at the Trigger&Anti-Trigger system of the STARTRACK Experiment
JF  - Annual report / Istituto Nazionale di Fisica Nucleare, LNL, Laboratori Nazionali di Legnaro. 2004 (2005)
Y1  - 2005
SN  - 88-7337-008-X
N1  - LNL-INFN(REP)-204/2005
SP  - 242
EP  - 243
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Konur, Savas
A1  - Lakemeyer, Gerhard
T1  - Learning Decision Trees for Action Selection in Soccer Agents / Konur, Savas ; Ferrein, Alexander ; Lakemeyer, Gerhard
Y1  - 2004
N1  - Proceedings of Workshop on Agents in dynamic and real-time environments
SP  - 1
EP  - 7
ER  - 
TY  - JOUR
A1  - Fabo, Sabine
T1  - Learning from Brachelen
JF  - Freistil (Boxhorn ; 8)
Y1  - 2002
SP  - 2,1
EP  - 2,31
PB  - FH Aachen, Fachbereich Gestaltung
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Blome, Hans-Joachim
A1  - Kundt, Wolfgang
T1  - Leptonic jets from young stellar objects?
JF  - Astrophysics and Space Science. 148 (1988), H. 2
Y1  - 1988
SN  - 0004-640X
SP  - 343
EP  - 361
ER  -