TY - JOUR A1 - Förster, Arnold A1 - Rose, D. A1 - Pietsch, U. A1 - Metzger, H. T1 - Depth resolved investigation of the relaxation behaviour in strained GaInAs/GaAs superlattices / Rose, D. ; Pietsch, U. ; Förster, A. ; Metzger, H.... JF - Physica B: condensed matter. 198 (1994), H. 1-3 Y1 - 1994 SN - 0921-4526 SP - 256 EP - 258 ER - TY - JOUR A1 - Förster, Arnold A1 - Rose, D. A1 - Pietsch, U. A1 - Metzger, T. H. T1 - Depth resolved investigations of the relaxation behaviour in strained GaInAs/GaAs superlattices using grazing incidence X-ray diffraction / Rose, D. ; Pietsch, U. ; Förster, A. ; Metzger, T. H. JF - Nuclear instruments and methods in physics research / Section B, Beam interactions with materials and atoms. 97 (1995), H. 1-4 Y1 - 1995 SN - 0168-583X SP - 333 EP - 336 ER - TY - JOUR A1 - Schmitz, Günter A1 - Damann, H. A1 - Schmit, H. J. T1 - Design and Analysis of a Waveguide Isolator with a Form-Birefringent Top Layer JF - ECOC '84 : Conference proceedings ; 10th European Conference on Optical Communication, September 3 - 6, 1984 Liederhalle Stuttgart, Federal Republic of Germany / Organized by Nachrichtentechn. Ges. im VDE (NTG). Y1 - 1984 SN - 3-8007-1383-7 SP - 42 PB - VDE-Verl. CY - Berlin [u.a.] ER - TY - JOUR A1 - Hoffstadt, Kevin A1 - Cheenakula, Dheeraja A1 - Nikolausz, Marcell A1 - Krafft, Simone A1 - Harms, Hauke A1 - Kuperjans, Isabel T1 - Design and construction of a new reactor for flexible biomethanation of hydrogen JF - Fermentation N2 - The increasing share of renewable electricity in the grid drives the need for sufficient storage capacity. Especially for seasonal storage, power-to-gas can be a promising approach. Biologically produced methane from hydrogen produced from surplus electricity can be used to substitute natural gas in the existing infrastructure. Current reactor types are not or are poorly optimized for flexible methanation. Therefore, this work proposes a new reactor type with a plug flow reactor (PFR) design. Simulations in COMSOL Multiphysics ® showed promising properties for operation in laminar flow. An experiment was conducted to support the simulation results and to determine the gas fraction of the novel reactor, which was measured to be 29%. Based on these simulations and experimental results, the reactor was constructed as a 14 m long, 50 mm diameter tube with a meandering orientation. Data processing was established, and a step experiment was performed. In addition, a kLa of 1 h−1 was determined. The results revealed that the experimental outcomes of the type of flow and gas fractions are in line with the theoretical simulation. The new design shows promising properties for flexible methanation and will be tested. KW - methanation KW - plug flow reactor KW - bubble column KW - bio-methane KW - power-to-gas Y1 - 2023 U6 - http://dx.doi.org/10.3390/fermentation9080774 SN - 2311-5637 N1 - The article belongs to the Special Issue Fermentation Processes: Modeling, Optimization and Control VL - 9 IS - 8 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - JOUR A1 - Beer, S. A1 - Streun, M. A1 - Hombach, T. A1 - Buehler, J. A1 - Jahnke, S. A1 - Khodaverdi, M. A1 - Larue, H. A1 - Minwuyelet, S. A1 - Parl, C. A1 - Roeb, G. A1 - Schurr, U. A1 - Ziemons, Karl T1 - Design and initial performance of PlanTIS: a high-resolution positron emission tomograph for plants JF - Physics in Medicine and Biology N2 - Positron emitters such as 11C, 13N and 18F and their labelled compounds are widely used in clinical diagnosis and animal studies, but can also be used to study metabolic and physiological functions in plants dynamically and in vivo. A very particular tracer molecule is 11CO2 since it can be applied to a leaf as a gas. We have developed a Plant Tomographic Imaging System (PlanTIS), a high-resolution PET scanner for plant studies. Detectors, front-end electronics and data acquisition architecture of the scanner are based on the ClearPET™ system. The detectors consist of LSO and LuYAP crystals in phoswich configuration which are coupled to position-sensitive photomultiplier tubes. Signals are continuously sampled by free running ADCs, and data are stored in a list mode format. The detectors are arranged in a horizontal plane to allow the plants to be measured in the natural upright position. Two groups of four detector modules stand face-to-face and rotate around the field-of-view. This special system geometry requires dedicated image reconstruction and normalization procedures. We present the initial performance of the detector system and first phantom and plant measurements. Y1 - 2010 U6 - http://dx.doi.org/10.1088/0031-9155/55/3/006 SN - 1361-6560 VL - 55 IS - 3 SP - 635 EP - 646 PB - IOP CY - Bristol ER - TY - JOUR A1 - Robinson, A. E. A1 - Funke, Harald A1 - Hendrick, P. T1 - Design and Testing of a Micromix Combustor With Recuperative Wall Cooling for a Hydrogen Fueled µ-Scale Gas Turbine JF - Journal of engineering for gas turbines and power Y1 - 2011 SN - 1528-8919 VL - 133 IS - 8 PB - ASME CY - New York ER - TY - JOUR A1 - Funke, Harald A1 - Robinson, A. E. A1 - Hendrick, P. A1 - Wagemakers, R. T1 - Design and Testing of a Micromix Combustor With Recuperative Wall Cooling for a Hydrogen Fuelled µ-Scale Gas Turbine JF - Proceedings of the ASME Turbo Expo 2010 : presented at the 2010 ASME Turbo Expo, June 14 - 18, 2010, Glasgow, UK / sponsored by the International Gas Turbine Institute / Vol. 5: Industrial and cogeneration ; microturbines and small turbomachinery ; oil and gas applications ; wind turbine technology Y1 - 2010 SN - 978-0-7918-4400-7 N1 - GT2010-23453 ; ASME Turbo Expo ; (Glasgow) : 2010.06.14-18 SP - 587 EP - 596 PB - ASME CY - New York, NY ER - TY - JOUR A1 - Staat, Manfred A1 - Schwartz, M. A1 - Lang, H. A1 - Wirtz, K. A1 - Heitzer, M. T1 - Design by Analysis of Pressure Components by non-linear Optimization JF - The 10th International Conference on Pressure Vessel Technology, July 7-10, 2003, Vienna, Austria, Proceedings ICPVT-10 / Zeman, J. L. [ed] Y1 - 2003 SN - 3950152814 SP - 59 EP - 65 PB - ÖGS, Österreichische Gesellschaft für Schweißtechnik CY - Wien ER - TY - JOUR A1 - Grundmann, Reinhard T1 - Design Criteria for Aeroacoustic Wind Tunnels Y1 - 1992 N1 - Konferenzeinzelbericht : DGLR-workshop : Joint meeting of the Specialists Groups Test Facilities/Aeroacoustics - Flight Noise . Deutsche Gesellschaft für Luft- und Raumfahrt. Test Facilities Specialist Group ; Deutsche Gesellschaft für Luft- und Raumfahr ER - TY - JOUR A1 - Gerhardt, Hans Joachim T1 - Design methods of smoke and heat exhaust systems in construction works JF - V Mie̜dzynarodowa Konferencja Bezpieczeństwo Pożarowe Budowli, Warszawa-Miedzeszyn, 14 - 16 listopada 2005 r. = : Vth International Conference Fire Safety of Buildings / ITB ... [Ed. Mirosław Kosiorek] Y1 - 2005 SN - 83-7413-810-6 N1 - Mie̜dzynarodowa Konferencja Bezpieczeństwo Pożarowe Budowli <5, 2005, Warszawa> ; International Conference Fire Safety of Buildings <5, 2005, Warszawa-Miedzeszyn> SP - 127 EP - 140 PB - ITB CY - Warszawa ER - TY - JOUR A1 - Almajhdi, Fahad N. A1 - Senger, Tilo A1 - Amer, Haitham M. A1 - Gissmann, Lutz A1 - Öhlschläger, Peter T1 - Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling) JF - PLOS one N2 - Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism. Y1 - 2014 U6 - http://dx.doi.org/10.1371/journal.pone.0113461 SN - 1932-6203 VL - 11 IS - 9 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Hillgärtner, Michael A1 - Peier, Dirk T1 - Design of a Measurement Setup for the Impedance of Low-Resistance Plate-Conductors in the RF-Range JF - Proceedings of the 10th International Conference on Optimization of Electrical and Electronic Equipment, OPTIM '06, Braşov, May 18 - 20, 2006 / ed. by The Transilvania University of Braşov, Faculty of Electrical Engineering and Computer Science. [Ed. Mihai Cernat .̤] . - Vol. 1: Keynote addresses, electrotechnics Y1 - 2006 SN - 978-973-635703-9 N1 - International Conference on Optimization of Electrical and Electronic Equipment <10, 2006, Braşov>; OPTIM <10, 2006, Braşov> SP - 59 EP - 64 CY - Braşov ER - TY - JOUR A1 - Franko, Josef A1 - Du, Shengzhi A1 - Kallweit, Stephan A1 - Duelberg, Enno Sebastian A1 - Engemann, Heiko T1 - Design of a Multi-Robot System for Wind Turbine Maintenance JF - Energies N2 - The maintenance of wind turbines is of growing importance considering the transition to renewable energy. This paper presents a multi-robot-approach for automated wind turbine maintenance including a novel climbing robot. Currently, wind turbine maintenance remains a manual task, which is monotonous, dangerous, and also physically demanding due to the large scale of wind turbines. Technical climbers are required to work at significant heights, even in bad weather conditions. Furthermore, a skilled labor force with sufficient knowledge in repairing fiber composite material is rare. Autonomous mobile systems enable the digitization of the maintenance process. They can be designed for weather-independent operations. This work contributes to the development and experimental validation of a maintenance system consisting of multiple robotic platforms for a variety of tasks, such as wind turbine tower and rotor blade service. In this work, multicopters with vision and LiDAR sensors for global inspection are used to guide slower climbing robots. Light-weight magnetic climbers with surface contact were used to analyze structure parts with non-destructive inspection methods and to locally repair smaller defects. Localization was enabled by adapting odometry for conical-shaped surfaces considering additional navigation sensors. Magnets were suitable for steel towers to clamp onto the surface. A friction-based climbing ring robot (SMART— Scanning, Monitoring, Analyzing, Repair and Transportation) completed the set-up for higher payload. The maintenance period could be extended by using weather-proofed maintenance robots. The multi-robot-system was running the Robot Operating System (ROS). Additionally, first steps towards machine learning would enable maintenance staff to use pattern classification for fault diagnosis in order to operate safely from the ground in the future. Y1 - 2020 U6 - http://dx.doi.org/10.3390/en13102552 SN - 1996-1073 VL - 13 IS - 10 SP - Article 2552 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kalbe, Jochen A1 - Höcker, Hartwig A1 - Berndt, Heinz T1 - Design of enzyme reactors as chromatographic columns for racemic resolution of amino acid esters JF - Chromatographia Y1 - 1989 SN - 0009-5893 U6 - http://dx.doi.org/10.1007/BF02319646 VL - 28 IS - 3-4 SP - 193 EP - 196 ER - TY - JOUR A1 - Hillgärtner, Michael A1 - Stonies, R. A1 - Peier, D. A1 - Voges, E. T1 - Design of Low Cost Antennas for Reverberation Chambers JF - Proceedings of the 16th International Zurich Symposium on Electromagnetic Compatibility : [EMC Week 2005, Zurich, Switzerland, February 13 - 18 ; technical exhibition on EMC and RF/microwave Measurements and Instrumentation (February 15 - 17)] / [Laboratory for Electromagnetic Fields and Microwave Electronics, Swiss Federal Institute of Technology Zurich] Y1 - 2005 SN - 3-9521199-9-7 N1 - Nebent.: EMC Zurich 2005 Symposium proceedings. - International Zurich Symposium and Technical Exhibition on Electromagnetic Compatibility <16, 2005, Zürich> Institut für Feldtheorie und Höchstfrequenztechnik PB - ETH-Zentrum-IFH CY - Zürich ER - TY - JOUR A1 - Kürten, Sylvia A1 - Mottaghy, Darius A1 - Ziegler, Martin T1 - Design of plane energy geostructures based on laboratory tests and numerical modelling JF - Energy and Buildings Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.enbuild.2015.08.039 SN - 0378-7788 VL - 107 SP - 434 EP - 444 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Heinrichs, U. A1 - Pietrzyk, U. A1 - Ziemons, Karl T1 - Design optimization of the PMT-ClearPET prototypes based on simulation studies with GEANT3 JF - 2002 IEEE Nuclear Science Symposium Conference Record, Vol. 3 N2 - Within the Crystal Clear Collaboration four centres are developing 2nd generation high performance small animal PET scanners for different kinds of animals and medical applications. The first prototypes are PMT-based systems including depth of interaction (DOI) detection by using a phoswich layer of LSO and LuYAP. The aim of these simulation studies is to optimize sensitivity and spatial resolution of given designs, which vary in FOVs caused by different detector configurations (ring/octagon) and sizes. For this purpose the simulation tool GEANT3 (CERN) was used. The simulations have shown that all PMT designs with one-to-one coupling of crystals have a very nonlinear axial sensitivity profile. By shifting every other PMT 1/4 of a PMT length in axial direction the sampling of the FOVs became more homogeneous. At an energy threshold of 350keV the regression coefficient increases from 0.818 for the non-shifted to 0.993 for the shifted design. Simulations of a point source centred in the FOV (threshold: 350keV) resulted in sensitivities of 4.2% for a 4×20PMT (LSO/LuYAP a 10mm) and 3.8% for a 4×16PMT (LSO/LuYAP a 8mm) ring design. The 3D-MLEM reconstruction of a point source shows the enormous improvement of resolution using a crystal double layer with DOI (3.1mm at 40mm from CFOV) instead of a 20mm single layer (11.9mm). Y1 - 2003 SN - 1082-3654 SP - 682 EP - 686 ER - TY - JOUR A1 - Heinrichs, U. A1 - Pietrzyk, U. A1 - Ziemons, Karl T1 - Design optimization of the PMT-ClearPET prototypes based on simulation studies with GEANT3 JF - IEEE Transactions on Nuclear Science N2 - Within the Crystal Clear Collaboration (CCC), four centers are developing second generation high performance small animal positron emission tomography (PET) scanners for different kinds of animals and medical applications. The first prototypes are photomultiplier tube (PMT)-based systems including depth of interaction (DOI) detection by using a phoswich layer of lutetium oxyorthosilicate (LSO) and lutetium yttrium aluminum perovskite (LuYAP). The aim of these simulation studies is to optimize sensitivity and spatial resolution of given designs, which vary in fields of view (FOVs) caused by different detector configurations (ring/octagon) and sizes. For this purpose the simulation tool GEANT3 (CERN, Geneva, Switzerland) was used. Y1 - 2003 SN - 0018-9499 VL - 50 IS - 5 SP - 1428 EP - 1432 ER - TY - JOUR A1 - Niemüller, Tim A1 - Ferrein, Alexander A1 - Beck, Daniel A1 - Lakemeyer, Gerhard T1 - Design Principles of the Component-Based Robot Software Framework Fawkes JF - Simulation, Modeling, and Programming for Autonomous Robots Y1 - 2010 N1 - Lecture Notes in Computer Science ; 6472 ; Second International Conference, SIMPAR 2010, Darmstadt, Germany, November 15-18, 2010. Proceedings SP - 300 EP - 311 ER - TY - JOUR A1 - Choi, Chang-Hoon A1 - Felder, Tim A1 - Felder, Jörg A1 - Tellmann, Lutz A1 - Hong, Suk-Min A1 - Wegener, Hans-Peter A1 - Shah, N Jon A1 - Ziemons, Karl T1 - Design, evaluation and comparison of endorectal coils for hybrid MR-PET imaging of the prostate JF - Physics in Medicine & Biology N2 - Prostate cancer is one of the most common cancers among men and its early detection is critical for its successful treatment. The use of multimodal imaging, such as MR-PET, is most advantageous as it is able to provide detailed information about the prostate. However, as the human prostate is flexible and can move into different positions under external conditions, it is important to localise the focused region-of-interest using both MRI and PET under identical circumstances. In this work, we designed five commonly used linear and quadrature radiofrequency surface coils suitable for hybrid MR-PET use in endorectal applications. Due to the endorectal design and the shielded PET insert, the outer face of the coils investigated was curved and the region to be imaged was outside the volume of the coil. The tilting angles of the coils were varied with respect to the main magnetic field direction. This was done to approximate the various positions from which the prostate could be imaged. The transmit efficiencies and safety excitation efficiencies from simulations, together with the signal-to-noise ratios from the MR images were calculated and analysed. Overall, it was found that the overlapped loops driven in quadrature were superior to the other types of coils we tested. In order to determine the effect of the different coil designs on PET, transmission scans were carried out, and it was observed that the differences between attenuation maps with and without the coils were negligible. The findings of this work can provide useful guidance for the integration of such coil designs into MR-PET hybrid systems in the future. Y1 - 2020 U6 - http://dx.doi.org/10.1088/1361-6560/ab87f8 SN - 0031-9155 VL - 65 IS - 11 PB - IOP CY - Bristol ER - TY - JOUR A1 - Leurs, Ulrike A1 - Mezo, Gabor A1 - Öhlschläger, Peter A1 - Orban, Erika A1 - Marquard, Andrea A1 - Manea, Marilena T1 - Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety JF - Peptide Science N2 - Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect. Y1 - 2012 U6 - http://dx.doi.org/10.1002/bip.21640 SN - 1097-0282 VL - 98 IS - 1 SP - 1 EP - 10 PB - Wiley CY - New York, NY ER - TY - JOUR A1 - Bitz, Andreas A1 - Felder, Jorg A1 - Wittig, Tilmann T1 - Designing MRI Coils with Aid of Simulation JF - Microwaves & RF Y1 - 2013 SN - 0745-2993 VL - 52 IS - 7 SP - 56 PB - Penton CY - Cleveland, Ohio ER - TY - JOUR A1 - Bindal, Gaurav A1 - Sharma, Sparsh A1 - Janser, Frank A1 - Neu, Eugen T1 - Detailed analysis of variables affecting wing kinematics of bat flight JF - SAE International Journal of Aerospace Y1 - 2013 U6 - http://dx.doi.org/10.4271/2013-01-9003 SN - 1946-3901 VL - 6 IS - 2 SP - 811 EP - 818 ER - TY - JOUR A1 - Rochefort, E. de A1 - Verver, M. A1 - Grunendahl, A. A1 - Mooi, H. A1 - Butenweg, Christoph T1 - Detailed modelling of the lumbar spine for investigations of low back pain JF - SAE transactions : papers presented at Society and Section meetings / Society of Automotive Engineers Y1 - 2005 SN - 0096-736X VL - Volume 114 IS - Part 7 SP - 788 EP - 796 ER - TY - JOUR A1 - Grajewski, Matthias A1 - Kleefeld, Andreas T1 - Detecting and approximating decision boundaries in low-dimensional spaces JF - Numerical Algorithms N2 - A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch’s factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms. KW - MCDA KW - Inverse scattering problem KW - Fault approximation KW - Fault detection Y1 - 2023 SN - 1572-9265 N1 - Corresponding author: Matthias Grajewski VL - 93 IS - 4 PB - Springer Science+Business Media CY - Dordrecht ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Detecting Both Physical and (Bio-)Chemical Parameters by Means of ISFET Devices JF - Electroanalysis. 16 (2004), H. 22 Y1 - 2004 SN - 1040-0397 SP - 1863 EP - 1872 ER - TY - JOUR A1 - Allefeld, Carsten A1 - Bialonski, Stephan T1 - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains JF - Physical Review E Y1 - 2007 U6 - http://dx.doi.org/10.1103/PhysRevE.76.066207 SN - 2470-0053 VL - 76 IS - 6 SP - 066207 ER - TY - JOUR A1 - Schmich, Peter A1 - Ederer, Hanns J. A1 - Ebert, Klaus H. T1 - Detection and identification of free radicals in hydrocarbon pyrolysis by an iodine trapping method JF - Industrial & Engineering Chemistry Research. 31 (1992), H. 1 Y1 - 1992 SN - 1520-5045 SP - 29 EP - 37 ER - TY - JOUR A1 - Welden, Melanie A1 - Severins, Robin A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Bongaerts, Johannes A1 - Siegert, Petra A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor JF - Chemosensors N2 - Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte–insulator–semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin–streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage–current, capacitance–voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution. Y1 - 2022 U6 - http://dx.doi.org/10.3390/chemosensors10060218 SN - 2227-9040 N1 - This article belongs to the Special Issue "Nanostructured Devices for Biochemical Sensing" VL - 10 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Molinnus, Denise A1 - Bäcker, Matthias A1 - Siegert, Petra A1 - Willenberg, H. A1 - Poghossian, Arshak A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Detection of Adrenaline Based on Substrate Recycling Amplification JF - Procedia Engineering N2 - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.708 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 540 EP - 543 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Molinnus, Denise A1 - Hardt, Gabriel A1 - Siegert, Petra A1 - Willenberg, Holger S. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling JF - Electroanalysis N2 - An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5–1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma. Y1 - 2018 U6 - http://dx.doi.org/10.1002/elan.201800026 SN - 1521-4109 VL - 30 IS - 5 SP - 937 EP - 942 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Detection of charged macromolecules by means of field-effect devices (FEDs): possibilities and limitations JF - Electrochemical sensors, biosensors and their biomedical applications / ed. by Xueji Zhang ... Y1 - 2008 SN - 978-0-12-373738-0 SP - 187 EP - 212 PB - Elsevier Acad. Press CY - Amsterdam ER - TY - JOUR A1 - Herber, R. A1 - Ernst, S. A1 - Buß, G. A1 - Schöning, Michael Josef A1 - Baltruschat, H. T1 - Detection of hydrocarbons in air and water by adsorption on Pt electrodes using continuous impedance measurements JF - Proceedings of the Symposium on New Directions in Electroanalytical Chemistry II : [held at the 195th Meeting of the Electrochemical Society in Seattle, Washington on May 3 and 4, 1999] / Physical Electrochemistry, Sensor, and Organic and Biological Electrochemistry Divisions. Ed.: J. Leddy, P. Vanysek, M.D. Porter Y1 - 1999 SN - 1-56677-227-3 N1 - Symposium on New Directions in Electroanalytical Chemistry ; (2, 1999, Seattle, Wash.) SP - 168 EP - 177 PB - Electrochemical Society CY - Pennington, NJ ER - TY - JOUR A1 - Oberländer, Jan A1 - Kirchner, Patrick A1 - Boyen, Hans-Gerd A1 - Schöning, Michael Josef T1 - Detection of hydrogen peroxide vapor by use of manganese(IV) oxide as catalyst for calorimetric gas sensors JF - Physica status solidi A: Applications and materials science N2 - In this work, the catalyst manganese(IV) oxide (MnO2), of calorimetric gas sensors (to monitor the sterilization agent vaporized hydrogen peroxide) has been investigated in more detail. Chemical analyses by means of X-ray-induced photoelectron spectroscopy have been performed to unravel the surface chemistry prior and after exposure to hydrogen peroxide vapor at elevated temperature, as applied in the sterilization processes of beverage cartons. The surface characterization reveals a change in oxidation states of the metal oxide catalyst after exposure to hydrogen peroxide. Additionally, a cleaning effect of the catalyst, which itself is attached to the sensor surface by means of a polymer interlayer, could be observed. Y1 - 2014 U6 - http://dx.doi.org/10.1002/pssa.201330359 SN - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print) VL - 211 IS - 6 SP - 1372 EP - 1376 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kassab, T. A1 - Han, Y. A1 - Poghossian, Arshak A1 - Ingebrandt, S. A1 - Offenhäusser, A. A1 - Schöning, Michael Josef T1 - Detection of layerby-layer adsorbed polyelectrolytes by means of field-effect based capacitive EIS structures JF - Biomedizinische Technik. 49 (2004), H. 2 Y1 - 2004 SN - 0932-4666 SP - 1034 EP - 1035 ER - TY - JOUR A1 - Emons, H. A1 - Hüllenkremer, B. A1 - Schöning, Michael Josef T1 - Detection of metal ions in aqueous solutions by voltohmmetry JF - Fresenius' Journal of Analytical Chemistry. 369 (2001), H. 1 Y1 - 2001 SN - 0937-0633 SP - 42 EP - 46 ER - TY - JOUR A1 - Bronder, Thomas A1 - Jessing, Max P. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors JF - Analytical Chemistry N2 - Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results. Y1 - 2018 U6 - http://dx.doi.org/10.1021/acs.analchem.8b01807 SN - 0003-2700 VL - 90 IS - 12 SP - 7747 EP - 7753 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Jablonski, Melanie A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Detection of plant virus particles with a capacitive field-effect sensor JF - Analytical and Bioanalytical Chemistry N2 - Plant viruses are major contributors to crop losses and induce high economic costs worldwide. For reliable, on-site and early detection of plant viral diseases, portable biosensors are of great interest. In this study, a field-effect SiO2-gate electrolyte-insulator-semiconductor (EIS) sensor was utilized for the label-free electrostatic detection of tobacco mosaic virus (TMV) particles as a model plant pathogen. The capacitive EIS sensor has been characterized regarding its TMV sensitivity by means of constant-capacitance method. The EIS sensor was able to detect biotinylated TMV particles from a solution with a TMV concentration as low as 0.025 nM. A good correlation between the registered EIS sensor signal and the density of adsorbed TMV particles assessed from scanning electron microscopy images of the SiO2-gate chip surface was observed. Additionally, the isoelectric point of the biotinylated TMV particles was determined via zeta potential measurements and the influence of ionic strength of the measurement solution on the TMV-modified EIS sensor signal has been studied. KW - Plant virus KW - Capacitive field-effect sensor KW - Tobacco mosaic virus (TMV) KW - Label-free detection KW - Zeta potential Y1 - 2021 U6 - http://dx.doi.org/10.1007/s00216-021-03448-8 SN - 1618-2650 N1 - Corresponding authors: Arshak Poghossian & Michael J. Schöning VL - 413 SP - 5669 EP - 5678 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Warmer, Johannes A1 - Wagner, Patrick A1 - Schöning, Michael Josef A1 - Kaul, Peter T1 - Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors JF - Physica status solidi (a) Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431882 SN - 1862-6319 VL - 212 IS - 6 SP - 1289 EP - 1298 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Schopp, Christoph A1 - Rohrbach, Felix A1 - Langer, Luc A1 - Heuermann, Holger T1 - Detection of welding wire length by active S11 measurement JF - IEEE Transactions on Plasma Science N2 - A novel method to determine the extruded length of a metallic wire for a directed energy deposition (DED) process using a microwave (MW) plasma jet with a straight-through wire feed is presented. The method is based on the relative comparison of the measured frequency response obtained by the large-signal scattering parameter (Hot-S) technique. In the practical working range, repeatability of less than 6% for a nonactive plasma and 9% for the active plasma state is found. Measurements are conducted with a focus on a simple solution to decrease the processing time and reduce the integration time of the process into the existing hardware. It is shown that monitoring a single frequency for magnitude and phase changes is sufficient to achieve good accuracy. A combination of different measurement values to determine the length is possible. The applicability to different diameter of the same material is shown as well as a contact detection of the wire and metallic substrate. KW - Circuit simulation KW - Hot S-parameter KW - Modeling KW - Plasma KW - Plasma diagnostics Y1 - 2024 U6 - http://dx.doi.org/10.1109/TPS.2024.3356659 SN - 0093-3813 (Print) SN - 1939-9375 (Online) IS - Early Access SP - 1 EP - 6 PB - IEEE ER - TY - JOUR A1 - Tippkötter, Nils A1 - Deterding, A. A1 - Ulber, Roland T1 - Determination of acetic acid in fermentation broth by gas-diffusion technique JF - Engineering in Life Sciences N2 - Due to the interfering effects of acetic acid in many fermentation processes, a gas-diffusion technique was developed for the online determination of acetic acid. The measurements were accomplished with a flow diffusion analysis (FDA) unit from the TRACE Analytics GmbH, Braunschweig, Germany. The diffusion analysis is based on the UV-absorbance of acetic acid at 205 nm. The measurement was achieved by the separation of an acceptor and a carrier stream (acidified fermentation broth) using a gas permeable polytetrafluoroethylene (PTFE) membrane, whereby broth constituents that would otherwise disturb the UV-measurement of acetic acid, are held back efficiently. Merely, the fermentation by-products, e.g. formic acid, is capable of diffusing through the membrane. While formic acid can disturb the measurement, carbon dioxide does not absorb at 205 nm. The method operates with time-dependent sample enrichment. During the analysis, a small volume of the acceptor stream is stopped for a defined time interval in the acceptor chamber. During this period, the gaseous acetic acid diffuses through the membrane and is enriched in the acceptor chamber. Subsequently after the enrichment, the acceptor stream flows through a UV-detector. The intensity of the signal is proportional to the acetic acid concentration. Online measurements in bioreactors via a sterile filtration probe have been accomplished. A linear calibration in the range of 0.5–5.0 g/L acetic acid with a relative standard deviation of <5 % was obtained. A sampling rate of 8 samples per hour was possible. The system was applied for the determination of acetic acid in E. coli fermentation broth. The instrument is easy to clean, very user-friendly and does not require any toxic or expensive reagents. Y1 - 2008 U6 - http://dx.doi.org/10.1002/elsc.200820227 VL - 8 IS - 1, Special Issue: Technical Systems for the Use in Life Sciences SP - 62 EP - 67 ER - TY - JOUR A1 - Wagner, Torsten A1 - Kloock, Joachim P. A1 - Schöning, Michael Josef T1 - Determination of cadmium concentration and pH value in aqueous solutions by means of a handheld light-addressable potentiometric sensor (LAPS) device JF - Electrochemical sensor analysis / edited by S. Alegret ... Y1 - 2007 SN - 978-0-444-53133-9 N1 - Wilson & Wilson's comprehensive analytical chemistry ; 49 SP - e35 EP - e44 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Helsper, Christoph A1 - Fißan, H. J. A1 - Thielen, H. J. T1 - Determination of Particle Size Distributions by Means of an Electrostatic Classifier / Fißan, H. J.; Helsper, C. ; Thielen, H. J. JF - Journal of Aerosol Science. 14 (1983), H. 3 Y1 - 1983 SN - 0021-8502 SP - 354 EP - 357 ER - TY - JOUR A1 - Förster, Arnold A1 - Tillmann, K. A1 - Thust, M. T1 - Determination of segregation, elastic strain and thin-foil relaxation in InxGa-1-x As islands on GaAs(001) by high resolution transmission electron microscopy / K. Tillmann ; A. Thust ; M. Lentzen ... A. Förster ... JF - Philosophical magazine / Letters. 74 (1996), H. 5 Y1 - 1996 SN - 1362-3036 SP - 309 EP - 315 ER - TY - JOUR A1 - Helsper, Christoph A1 - Wiedensohler, A. A1 - Weise, W. A1 - Lütkemeier, E. T1 - Determination of the Bipolar Charge Equilibrium in Pure Gases / Wiedensohler, A. ; Weise, W. ; Helsper, C. ; Lütkemeier, E. JF - Aerosols : formation and reactivity ; proceedings of the second International Aerosol Conference, 22-26 Sept. 1986, Berlin (West) / Gesellschaft für Aerosolforschung (GAeF) ; American Association for Aerosol Research (AAAR) Y1 - 1986 N1 - International Aerosol Conference ; (2, 1986, Berlin (West)) SP - 383 EP - 386 PB - Pergamon Press CY - Oxford [u.a.] ER - TY - JOUR A1 - Maggakis-Kelemen, Christina A1 - Biselli, Manfred A1 - Artmann, Gerhard T1 - Determination of the elastic shear modulus of cultured human red blood cells JF - Biomedizinische Technik. 47 (2002), H. Suppl. 1 Pt. 1 Y1 - 2002 SN - 0013-5585 N1 - Druckausgabe unter 63 Z 471 vorhanden SP - 106 EP - 109 ER - TY - JOUR A1 - Werner, Frederik A1 - Krumbe, Christoph A1 - Schumacher, Katharina A1 - Groebel, Simone A1 - Spelthahn, Heiko A1 - Stellberg, Michael A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Selmer, Thorsten A1 - Keusgen, Michael A1 - Baumann, Marcus A1 - Schöning, Michael Josef T1 - Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1340 EP - 1344 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Dantism, Shahriar A1 - Takenaga, Shoko A1 - Wagner, Patrick A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system JF - Physica status solidi (a) N2 - On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable “down times” during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements. Y1 - 2016 U6 - http://dx.doi.org/10.1002/pssa.201533043 SN - 1862-6300 VL - 213 IS - 6 SP - 1479 EP - 1485 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Hasan, Istabrak A1 - Keil, Ludger A1 - Staat, Manfred A1 - Wahl, Gerhard A1 - Bourauel, Christoph T1 - Determination of the frictional coefficient of the implant-antler interface : experimental approach JF - Biomedical Engineering / Biomedizinische Technik N2 - The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5–0.7 and 0.3–0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens. Y1 - 2012 SN - 1862-278X VL - 57 IS - 5 SP - 359 EP - 363 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Arpshofen, Ingo A1 - Pool, M. J. A1 - Sommer, Ferdinand A1 - Gerling, Ulrich A1 - Predel, Bruno A1 - Schultheiss, Emil T1 - Determination of the integral mixing enthalpies in the Cu-Pd-Si liquid ternary alloy system at 1600 K JF - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 1 Y1 - 1983 SN - 0044-3093 ; 0179-4841 SP - 25 EP - 32 ER -