TY  - JOUR
A1  - Tippkötter, Nils
A1  - Deterding, A.
A1  - Ulber, Roland
T1  - Determination of acetic acid in fermentation broth by gas-diffusion technique
JF  - Engineering in Life Sciences
N2  - Due to the interfering effects of acetic acid in many fermentation processes, a gas-diffusion technique was developed for the online determination of acetic acid. The measurements were accomplished with a flow diffusion analysis (FDA) unit from the TRACE Analytics GmbH, Braunschweig, Germany. The diffusion analysis is based on the UV-absorbance of acetic acid at 205 nm. The measurement was achieved by the separation of an acceptor and a carrier stream (acidified fermentation broth) using a gas permeable polytetrafluoroethylene (PTFE) membrane, whereby broth constituents that would otherwise disturb the UV-measurement of acetic acid, are held back efficiently. Merely, the fermentation by-products, e.g. formic acid, is capable of diffusing through the membrane. While formic acid can disturb the measurement, carbon dioxide does not absorb at 205 nm. The method operates with time-dependent sample enrichment. During the analysis, a small volume of the acceptor stream is stopped for a defined time interval in the acceptor chamber. During this period, the gaseous acetic acid diffuses through the membrane and is enriched in the acceptor chamber. Subsequently after the enrichment, the acceptor stream flows through a UV-detector. The intensity of the signal is proportional to the acetic acid concentration. Online measurements in bioreactors via a sterile filtration probe have been accomplished. A linear calibration in the range of 0.5–5.0 g/L acetic acid with a relative standard deviation of <5 % was obtained. A sampling rate of 8 samples per hour was possible. The system was applied for the determination of acetic acid in E. coli fermentation broth. The instrument is easy to clean, very user-friendly and does not require any toxic or expensive reagents.
Y1  - 2008
U6  - http://dx.doi.org/10.1002/elsc.200820227
VL  - 8
IS  - 1, Special Issue: Technical Systems for the Use in Life Sciences
SP  - 62
EP  - 67
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Determination of cadmium concentration and pH value in aqueous solutions by means of a handheld light-addressable potentiometric sensor (LAPS) device
JF  - Electrochemical sensor analysis / edited by S. Alegret ...
Y1  - 2007
SN  - 978-0-444-53133-9
N1  - Wilson & Wilson's comprehensive analytical chemistry ; 49
SP  - e35
EP  - e44
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Helsper, Christoph
A1  - Fißan, H. J.
A1  - Thielen, H. J.
T1  - Determination of Particle Size Distributions by Means of an Electrostatic Classifier / Fißan, H. J.; Helsper, C. ; Thielen, H. J.
JF  - Journal of Aerosol Science. 14 (1983), H. 3
Y1  - 1983
SN  - 0021-8502
SP  - 354
EP  - 357
ER  - 
TY  - JOUR
A1  - Förster, Arnold
A1  - Tillmann, K.
A1  - Thust, M.
T1  - Determination of segregation, elastic strain and thin-foil relaxation in InxGa-1-x As islands on GaAs(001) by high resolution transmission electron microscopy / K. Tillmann ; A. Thust ; M. Lentzen ... A. Förster ...
JF  - Philosophical magazine / Letters. 74 (1996), H. 5
Y1  - 1996
SN  - 1362-3036
SP  - 309
EP  - 315
ER  - 
TY  - JOUR
A1  - Helsper, Christoph
A1  - Wiedensohler, A.
A1  - Weise, W.
A1  - Lütkemeier, E.
T1  - Determination of the Bipolar Charge Equilibrium in Pure Gases / Wiedensohler, A. ; Weise, W. ; Helsper, C. ; Lütkemeier, E.
JF  - Aerosols : formation and reactivity ; proceedings of the second International Aerosol Conference, 22-26 Sept. 1986, Berlin (West) / Gesellschaft für Aerosolforschung (GAeF) ; American Association for Aerosol Research (AAAR)
Y1  - 1986
N1  - International Aerosol Conference ; (2, 1986, Berlin (West))
SP  - 383
EP  - 386
PB  - Pergamon Press
CY  - Oxford [u.a.]
ER  - 
TY  - JOUR
A1  - Maggakis-Kelemen, Christina
A1  - Biselli, Manfred
A1  - Artmann, Gerhard
T1  - Determination of the elastic shear modulus of cultured human red blood cells
JF  - Biomedizinische Technik. 47 (2002), H. Suppl. 1 Pt. 1
Y1  - 2002
SN  - 0013-5585
N1  - Druckausgabe unter 63 Z 471 vorhanden
SP  - 106
EP  - 109
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Krumbe, Christoph
A1  - Schumacher, Katharina
A1  - Groebel, Simone
A1  - Spelthahn, Heiko
A1  - Stellberg, Michael
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1340
EP  - 1344
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Takenaga, Shoko
A1  - Wagner, Patrick
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system
JF  - Physica status solidi (a)
N2  - On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable “down times” during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements.
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201533043
SN  - 1862-6300
VL  - 213
IS  - 6
SP  - 1479
EP  - 1485
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hasan, Istabrak
A1  - Keil, Ludger
A1  - Staat, Manfred
A1  - Wahl, Gerhard
A1  - Bourauel, Christoph
T1  - Determination of the frictional coefficient of the implant-antler interface : experimental approach
JF  - Biomedical Engineering / Biomedizinische Technik
N2  - The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5–0.7 and 0.3–0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.
Y1  - 2012
SN  - 1862-278X
VL  - 57
IS  - 5
SP  - 359
EP  - 363
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Arpshofen, Ingo
A1  - Pool, M. J.
A1  - Sommer, Ferdinand
A1  - Gerling, Ulrich
A1  - Predel, Bruno
A1  - Schultheiss, Emil
T1  - Determination of the integral mixing enthalpies in the Cu-Pd-Si liquid ternary alloy system at 1600 K
JF  - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 1
Y1  - 1983
SN  - 0044-3093 ; 0179-4841
SP  - 25
EP  - 32
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Türler, A.
A1  - Gäggeler, H. W.
A1  - Jost, D. T.
T1  - Determination of the Partial Electron-Capture- and Spontaneous-Fission Half-Lives of 254No / A. Türler, H.W. Gäggeler, D.T. Jost, P. Armbruster, W. Brüchle, H. Folger, F.P. Heßberger,  S. Hofmann,
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 331 (1988), H. 3
Y1  - 1988
SN  - 0939-7922
SP  - 363
EP  - 364
ER  - 
TY  - JOUR
A1  - Grap, Rolf Dietmar
T1  - Determining manpower requirements in a spinning mill
JF  - Chemical fibers international : CFI ; fiber polymers, fibers, texturing, and spunbonds (2003)
Y1  - 2003
SN  - 0340-3343
SP  - 455
EP  - 458
ER  - 
TY  - JOUR
A1  - Sousa, Marcos A. M.
A1  - Siqueira, Jose R. Jr.
A1  - Vercik, Andres
A1  - Schöning, Michael Josef
A1  - Oliveira, Osvaldo N. Jr.
T1  - Determining the optimized layer-by-layer film architecture with dendrimer/carbon nanotubes for field-effect sensors
JF  - IEEE Sensors Journal
N2  - The capacitive electrolyte–insulator–semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte–insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors.
Y1  - 2017
U6  - http://dx.doi.org/10.1109/JSEN.2017.2653238
SN  - 1558-1748
VL  - 17
IS  - 6
SP  - 1735
EP  - 1740
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Pöttgen, Philipp
A1  - Ederer, Thorsten
A1  - Altherr, Lena
A1  - Pelz, Peter F.
T1  - Developing a control strategy for booster stations under uncertain load
JF  - Applied Mechanics and Materials
N2  - Booster stations can fulfill a varying pressure demand with high energy-efficiency, because individual pumps can be deactivated at smaller loads. Although this is a seemingly simple approach, it is not easy to decide precisely when to activate or deactivate pumps. Contemporary activation controls derive the switching points from the current volume flow through the system. However, it is not measured directly for various reasons. Instead, the controller estimates the flow based on other system properties. This causes further uncertainty for the switching decision. In this paper, we present a method to find a robust, yet energy-efficient activation strategy.
KW  - Technical Operations Research (TOR)
KW  - Booster Station
KW  - Pump System
KW  - Discrete Optimization
Y1  - 2015
SN  - 1662-7482
U6  - http://dx.doi.org/10.4028/www.scientific.net/AMM.807.241
N1  - Ebenfalls weltweit einsehbar unter:
http://wl.fst.tu-darmstadt.de/wl/publications/paper_151123_SFB805_
ICUME_Developing_a_Control_Strategy_for_Booster_Stations_under_Uncertain_Load_poettgen_ederer_pelz_altherr.pdf
VL  - 807
IS  - 807
SP  - 241
EP  - 246
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Küppers, Tobias
A1  - Steffen, Victoria
A1  - Hellmuth, Hendrik
A1  - O'Connell, Timothy
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Wiechert, Wolfgang
T1  - Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer
JF  - Microbial cell factories
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1475-2859-13-46
SN  - 1475-2859 (E-Journal)
VL  - 13
SP  - Article No. 46
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Bung, Daniel B.
T1  - Developing flow in skimming flow regime on embankment stepped spillways
JF  - Journal of hydraulic research
Y1  - 2011
SN  - 1814-2079 (E-Journal); 0022-1686 (Print)
VL  - Vol. 49
IS  - Iss. 5
SP  - 639
EP  - 648
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, Ko-Ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging
JF  - Sensors and Actuators B: Chemical
N2  - Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach to read out light-addressable potentiometric sensors (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device, which allows fast and flexible generation of light patterns. With the help of these light patterns, the sensor surface of the LAPS device can be addressed. The DLP approach has several advantages compared to conventional LAPS set-ups, e.g., the spot size and the shape of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of the measurement. In addition, the modulation frequency and intensity of the light beam are important parameters of the LAPS set-up. Within this work, the authors will discuss two different ways of light modulation by the DLP set-up, investigate the influence of different modulation frequencies and different light intensities as well as demonstrate the scanning capabilities of the new set-up by pH mapping on the sensor surface.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2010.12.003
SN  - 0925-4005
N1  - Part of special issue "Eurosensors XXIV, 2010"
VL  - 170
SP  - 34
EP  - 39
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Muschallik, Lukas
A1  - Gonzalez, Laura Osorio
A1  - Bongaerts, Johannes
A1  - Wagner, Torsten
A1  - Selmer, Thorsten
A1  - Siegert, Petra
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Development and characterization of a field-effect biosensor for the detection of acetoin
JF  - Biosensors and Bioelectronics
N2  - A capacitive electrolyte-insulator-semiconductor (EIS) field-effect biosensor for acetoin detection has been presented for the first time. The EIS sensor consists of a layer structure of Al/p-Si/SiO₂/Ta₂O₅/enzyme acetoin reductase. The enzyme, also referred to as butane-2,3-diol dehydrogenase from B. clausii DSM 8716T, has been recently characterized. The enzyme catalyzes the (R)-specific reduction of racemic acetoin to (R,R)- and meso-butane-2,3-diol, respectively. Two different enzyme immobilization strategies (cross-linking by using glutaraldehyde and adsorption) have been studied. Typical biosensor parameters such as optimal pH working range, sensitivity, hysteresis, linear concentration range and long-term stability have been examined by means of constant-capacitance (ConCap) mode measurements. Furthermore, preliminary experiments have been successfully carried out for the detection of acetoin in diluted white wine samples.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.bios.2018.05.023
VL  - 115
SP  - 1
EP  - 6
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Turek, Monika
A1  - Ketterer, Lothar
A1  - Claßen, Melanie
A1  - Berndt, Heinz
A1  - Elbers, Gereon
A1  - Krüger, Peter
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Development and Electrochemical Investigations of an EIS-(Electrolyte-Insulator-Semiconductor) based Biosensor for Cyanide Detection
JF  - Sensors
Y1  - 2007
SN  - 1424-8220
VL  - 7
IS  - 8
SP  - 1415
EP  - 1426
ER  - 
TY  - JOUR
A1  - Rietsch, Stefan H. G.
A1  - Brunheim, Sascha
A1  - Orzada, Stephan
A1  - Voelker, Maximilian N.
A1  - Maderwald, Stefan
A1  - Bitz, Andreas
A1  - Gratz, Marcel
A1  - Ladd, Mark E.
A1  - Quick, Harald H.
T1  - Development and evaluation of a 16-channel receive-only RF coil to improve 7T ultra-high field body MRI with focus on the spine
JF  - Magnetic Resonance in Medicine
Y1  - 2019
U6  - http://dx.doi.org/10.1002/mrm.27731
SN  - 1522-2594
IS  - Early view
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wolf, Martin
A1  - Foltz, Christian
A1  - Schlick, Christopher
A1  - Luczak, Holger
T1  - Development and evaluation of a groupware system to support chemical design processes / Wolf, Martin ; Foltz, Christian ; Schlick, Christopher ; Luczak, Holger
JF  - International Journal of Human-Computer Interaction . 14 (2002), H. 2
Y1  - 2002
SN  - 1044-7318
SP  - 181
EP  - 198
PB  - -
ER  - 
TY  - JOUR
A1  - Krämer, Stefan
A1  - Daab, Dominique Jonas
A1  - Müller, Brigitte
A1  - Wagner, Tobias
A1  - Baader, Fabian
A1  - Hessel, Joana
A1  - Gdalewitsch, Georg
A1  - Plescher, Engelbert
A1  - Dachwald, Bernd
A1  - Wahle, Michael
A1  - Gierse, Andreas
A1  - Vetter, Rudolf
A1  - Pfützenreuter, Lysan
T1  - Development and flight-testing of a system to isolate vibrations for microgravity experiments on sounding rockets
JF  - 21st ESA Symposium on Rocket and Balloon Research
Y1  - 2013
SP  - 1
EP  - 8
ER  - 
TY  - JOUR
A1  - Enning, Manfred
A1  - Jenayeh, I.
A1  - Müller, C.
A1  - Rake, Heinrich
T1  - Development and realization of a manipulator for automatic decoupling of freight cars in marshalling yards /  Jenayeh, I. ; Müller, C. ; Enning, Manfred ; Rake, Heinrich ; Peter, J.
Y1  - 1997
N1  - World Congress on Railway Research, Florenz, 16.-19.11.1997, 1997
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Rönna, Uwe
A1  - Robinson, A. E.
T1  - Development and testing of a 10 kW diffusive micromix combustor for hydrogen-fuelled μ-scale gas turbines
JF  - Proceedings of ASME Turbo Expo 2008: Power for Land, Sea and Air ; GT2008 ; June 9-13, 2008, Berlin, Germany
Y1  - 2008
N1  - GT2008-50418
SP  - 1
EP  - 8
PB  - ASME
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Starke, Günther
A1  - Drews, P.
T1  - Development approaches for advanced control in automated arc welding
Y1  - 1985
N1  - Konferenz-Einzelbericht: Automation and robotisation in welding and allied processes. International conference on automation and robotisation in welding and allied processes, Strasbourg, FR, 02.09.1985-03.09.1985
SP  - 115
EP  - 124
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Goßmann, Matthias
A1  - Grosse, J. O.
A1  - Becker, C.
A1  - Heschel, I.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds
JF  - Urologia Internationalis
Y1  - 2015
U6  - http://dx.doi.org/10.1159/000368419
SN  - 0042-1138
VL  - 2015
IS  - 95
SP  - 106
EP  - 113
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Keusgen, M.
A1  - Jünger, M.
A1  - Krest, I.
A1  - Schöning, Michael Josef
T1  - Development of a biosensor specific for cysteine sulfoxides
JF  - Biosensors & Bioelectronics. 18 (2003), H. 5-6
Y1  - 2003
SN  - 0956-5663
SP  - 805
EP  - 812
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Bronder, Thomas
A1  - Goretzki, Alexander
A1  - Kriesel, Jana
A1  - Ahlborn, Kristina
A1  - Gerlach, Frank
A1  - Vonau, Winfried
A1  - Zander, Willi
A1  - Schubert, Jürgen
A1  - Schöning, Michael Josef
T1  - Development of a Combined pH- and Redox-Sensitive Bi-Electrode Glass Thin-Film Sensor
JF  - physica status solidi a : applications and materials sciences
Y1  - 2019
U6  - http://dx.doi.org/10.1002/pssa.201900114
SN  - 1862-6319
VL  - 216
IS  - 12
SP  - 1
EP  - 8
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dünkelmann, Pascal
A1  - Kolter-Jung, Doris
A1  - Nitsche, Adam
A1  - Demir, Ayhan S.
A1  - Siegert, Petra
A1  - Lingen, Bettina
A1  - Baumann, Martin
A1  - Pohl, Martina
A1  - Müller, Michael
T1  - Development of a donor-acceptor concept for enzymatic cross-coupling reactions of adehydes : the first asymmetric cross-benzoin condensation
JF  - Journal of the American Chemical Society
Y1  - 2002
SN  - 1520-5126 (E-Journal); 0002-7863 (Print)
VL  - Vol. 124
SP  - 12084
EP  - 12085
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Meissner, Petra
A1  - Schröder, Bernd
A1  - Herfurth, Cornelia
T1  - Development of a fixed bed bioreactor for the expansion of human hematopoietic progenitor cells / Meissner, Petra ; Schröder, Bernd ; Herfurth, Cornelia ; Biselli, Manfred
JF  - Cytotechnology. 30 (1999), H. 1
Y1  - 1999
SN  - 0920-9069
SP  - 227
EP  - 234
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
A1  - Wang, C.
A1  - Otto, R.
A1  - Yoshinobu, T.
T1  - Development of a handheld 16 channel pen-type LAPS for electrochemical sensing
JF  - Sensors and Actuators B. 108 (2005)
Y1  - 2005
SN  - 0925-4005
SP  - 808
EP  - 814
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
A1  - Wang, C.
A1  - Otto, R.
A1  - Yoshinobu, T.
T1  - Development of a handheld 16 channel pen-type LAPS for electrochemical sensing
JF  - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors
Y1  - 2004
N1  - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba)
SP  - 136
EP  - 137
PB  - Japan Association of Chemical Sensors
CY  - Fukuoka
ER  - 
TY  - JOUR
A1  - Reisert, Steffen
A1  - Henkel, Hartmut
A1  - Schneider, Andreas
A1  - Schäfer, Daniel
A1  - Friedrich, Peter
A1  - Berger, Jörg
A1  - Schöning, Michael Josef
T1  - Development of a handheld sensor system for the online measurement of hydrogen peroxide in aseptic filling systems
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 913
EP  - 918
ER  - 
TY  - JOUR
A1  - Trilla, Joan
A1  - Grossen, Jürgen
A1  - Robinson, Alexander
A1  - Funke, Harald
A1  - Bosschaerts, Walter
A1  - Hendrick, Patrick
T1  - Development of a hydrogen combustion chamber for an ultra micro gas turbine
JF  - PowerMEMS 2008, 8th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications, microEMS 2008, 2nd Symposium on Micro Environmental Machine Systems, Sendai, JP, Nov 9-12, 2008
Y1  - 2008
SP  - 101
EP  - 104
ER  - 
TY  - JOUR
A1  - Robinson, A. E.
A1  - Funke, Harald
A1  - Hendrick, P.
A1  - Recker, E.
A1  - Peirs, J.
T1  - Development of a hydrogen fuelled 1 kW ultra micro gas turbine with special respect to designing, testing and mapping of the µ-scale combustor
JF  - IEEE International Conference on Sustainable Energy Technologies, 2008 : ICSET 2008 ; Singapore, 24 - 27 Nov. 2008.
Y1  - 2008
SN  - 978-1-4244-1887-9
SP  - 656
EP  - 660
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Iken, Heiko
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Development of a multi‐parameter sensor chip for the simultaneous detection of organic compounds in biogas processes
JF  - Physica status solidi (a)
N2  - An enzyme-based multi-parameter biosensor is developed for monitoring the concentration of formate, d-lactate, and l-lactate in biological samples. The sensor is based on the specific dehydrogenation by an oxidized β-nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenase (formate dehydrogenase, d-lactic dehydrogenase, and l-lactic dehydrogenase, respectively) in combination with a diaphorase from Clostridium kluyveri (EC 1.8.1.4). The enzymes are immobilized on a platinum working electrode by cross-linking with glutaraldehyde (GA). The principle of the determination scheme in case of l-lactate is as follows: l-lactic dehydrogenase (l-LDH) converts l-lactate into pyruvate by reaction with NAD+. In the presence of hexacyanoferrate(III), the resulting reduced β-nicotinamide adenine dinucleotide (NADH) is then regenerated enzymatically by diaphorase. The electrochemical detection is based on the current generated by oxidation of hexacyanoferrate(II) at an applied potential of +0.3 V vs. an Ag/AgCl reference electrode. The biosensor will be electrochemically characterized in terms of linear working range and sensitivity. Additionally, the successful practical application of the sensor is demonstrated in an extract from maize silage.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431894
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1306
EP  - 1312
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Robinson, A. E.
T1  - Development of a new test rig for a micro scale hydrogen combustion chamber
JF  - Proceedings of the 2nd European Conference for Aero-Space Sciences : July 1 - 6, 2007, Brussels, Belgium
Y1  - 2007
N1  - European Conference for Aerospace Sciences <2, 2007, Brüssel> ; EUCASS <2, 2007, Brüssel> ; Paper No. 22
SP  - 1
EP  - 8
PB  - -
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Vahidpour, Farnoosh
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Development of a package-sterilization process for aseptic filling machines: A numerical approach and validation for surface treatment with hydrogen peroxide
JF  - Sensor and Actuators A: Physical
N2  - Within the present work a sterilization process by a heated gas mixture that contains hydrogen peroxide (H₂O₂) is validated by experiments and numerical modeling techniques. The operational parameters that affect the sterilization efficacy are described alongside the two modes of sterilization: gaseous and condensed H₂O₂. Measurements with a previously developed H₂O₂ gas sensor are carried out to validate the applied H₂O₂ gas concentration during sterilization. We performed microbiological tests at different H₂O₂ gas concentrations by applying an end-point method to carrier strips, which contain different inoculation loads of Geobacillus stearothermophilus spores. The analysis of the sterilization process of a pharmaceutical glass vial is performed by numerical modeling. The numerical model combines heat- and advection-diffusion mass transfer with vapor–pressure equations to predict the location of condensate formation and the concentration of H₂O₂ at the packaging surfaces by changing the gas temperature. For a sterilization process of 0.7 s, a H₂O₂ gas concentration above 4% v/v is required to reach a log-count reduction above six. The numerical results showed the location of H₂O₂ condensate formation, which decreases with increasing sterilant-gas temperature. The model can be transferred to different gas nozzle- and packaging geometries to assure the absence of H₂O₂ residues.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.sna.2019.111691
SN  - 0924-4247
VL  - 303
IS  - 111691
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Aboulnaga, E. A.
A1  - Zou, H.
A1  - Selmer, Thorsten
A1  - Xian, M.
T1  - Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16
JF  - Journal of Biotechnology
N2  - Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism. As applications of the expression system in C. necator H16, the growth ability on glycerol was enhanced by constitutively expressing the E. coli glpk gene-encoding for glycerol kinase. Likewise, we used the system to overcome the expression toxicity of mevalonate pathway in C. necator H16. With this system, the mevalonate-genes were successfully introduced in the host and the recombinant strains could produce about 200 mg/l mevalonate.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.jbiotec.2018.03.007
SN  - 0168-1656
VL  - 274
SP  - 15
EP  - 27
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Hambach, B.
A1  - Runstadler, P. W.
A1  - Wandrey, Christian
T1  - Development of a reactor-integrated aeration system for cultivation of animal cells in fluidized beds / Hambach, B. ; Biselli, M. ; Runstadler, P.W. ; Wandrey, C.
JF  - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier
Y1  - 1992
SN  - 0750604212
SP  - 381
EP  - 385
PB  - Butterworth-Heinemann
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Wert, Stefan
A1  - Iken, Heiko
A1  - Schöning, Michael Josef
A1  - Matysik, Frank-Michael
T1  - Development of a temperature‐pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy
JF  - Electroanalysis
N2  - Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.
Y1  - 2021
U6  - http://dx.doi.org/10.1002/elan.202100089
SN  - 1521-4109
IS  - Early View
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hailer, Benjamin
A1  - Weber, Tobias
A1  - Neveling, Sebastian
A1  - Dera, Samuel
A1  - Arent, Jan-Christoph
A1  - Middendorf, Peter
T1  - Development of a test device to determine the frictional behavior between honeycomb and prepreg layers under realistic manufacturing conditions
JF  - Journal of Sandwich Structures & Materials
N2  - In the friction tests between honeycomb with film adhesive and prepreg, the relative displacement occurs between the film adhesive and the prepreg. The film adhesive does not shift relative to the honeycomb. This is consistent with the core crush behavior where the honeycomb moves together with the film adhesive, as can be seen in Figure 2(a). The pull-through forces of the friction measurements between honeycomb and prepreg at 1 mm deformation are plotted in Figure 17(a). While the friction at 100°C is similar to the friction at 120°C, it decreases significantly at 130°C and exhibits a minimum at 140°C. At 150°C, the friction rises again slightly and then sharply at 160°C. Since the viscosity of the M18/1 prepreg resin drops significantly before it cures [23], the minimum friction at 140°C could result from a minimum viscosity of the mixture of prepreg resin and film adhesive before the bond subsequently cures. Figure 17(b) shows the mean value curve of the friction measurements at 140°C. The error bars, which represent the standard deviation, reveal the good repeatability of the tests. The force curve is approximately horizontal between 1 mm and 2 mm. The friction then slightly rises. As with interlaminar friction measurements, this could be due to the fact that resin is removed by friction and the proportion of boundary lubrication increases. Figure 18 shows the surfaces after the friction measurement. The honeycomb cell walls are clearly visible in the film adhesive. There are areas where the film adhesive is completely removed and the carrier material of the film adhesive becomes visible. In addition, the viscosity of the resin changes as the curing progresses during the friction test. This can also affect the force-displacement curve.
Y1  - 2020
U6  - http://dx.doi.org/10.1177/1099636220923986
SN  - 1530-7972
IS  - Volume 23, Issue 7
SP  - 3017
EP  - 3043
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Kirsanov, Dmitry
A1  - Legin, Andrey
A1  - Osterrath, Thomas
A1  - Schubert, Jürgen
A1  - Zander, Willi
A1  - Schöning, Michael Josef
T1  - Development of a thin-film sensor array for analytical monitoring of heavy metals in aqueous solutions
JF  - Physica Status Solidi (a)
N2  - In industrial processes there is a variety of heavy metals (e.g., copper, zinc, cadmium, and lead) in use for wires, coatings, paints, alloys, batteries, etc. Since the application of these transition metals for industry is inevitable, it is a vital task to develop proper analytical techniques for their monitoring at low activity levels, especially because most of these elements are acutely toxic for biological organisms. The determination of ions in solution by means of a simple and inexpensive sensor array is, therefore, a promising task. In this work, a sensor array with heavy metal-sensitive chalcogenide glass membranes for the simultaneous detection of the four ions Ag⁺, Cu2⁺, Cd2⁺, and Pb2⁺ in solution is realized. The results of the physical characterization by means of microscopy, profilometry, Rutherford backscattering spectroscopy (RBS), and scanning electron microscopy (SEM) as well as the electrochemical characterization by means of potentiometric measurements are presented. Additionally, the possibility to expand the sensor array by polymeric sensor membranes is discussed.
Y1  - 2012
SN  - 1862-6319
U6  - http://dx.doi.org/10.1002/pssa.201100733
VL  - 209
IS  - 5
SP  - 885
EP  - 891
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
T1  - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid
JF  - Applied Biochemistry and Biotechnology
N2  - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s12010-017-2578-1
SN  - 1559-0291
VL  - 183
SP  - 566
EP  - 581
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Schaffrath, Sophie
A1  - Coppe, Thomas
A1  - Rufi, Frederic
A1  - Schöning, Michael Josef
T1  - Development of an electrolyte-insulator-semiconductor (EIS) based capacitive heavy metal sensor for the detection of Pb2+ und Cd2+ ions
JF  - Physica status solidi (a) : applications and material science. 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 930
EP  - 934
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Van der Pol, Jens J.
A1  - Joksch, B.
A1  - Eberhardt, R.
T1  - Development of an enzymatic multichannel flow injection analysis system for monitoring mammalian cell fermentations / Van der Pol, J.J.; Joksch, B.; Eberhardt, R.; Biselli, M.; Wandrey, C., Tramper, J.
JF  - Biosensors : fundamentals, technologies and applications ; contributions to the BMFT status seminar with international participation May, 12 to 14, 1991, Internationales Bildungs-Centrum Bogensee/Brandenburg, Germany / org. by ZIM-Zentralinstitut für Molekularbiologie, Berlin-Buch and GBF, Braunschweig. Ed. by F. Scheller
Y1  - 1992
SN  - 3527284370
N1  - GBF Monographs ; 17
SP  - 349
EP  - 352
PB  - VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Baltes, Klaus
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Development of an in-line evaporation unit for the production of gas mixtures containing hydrogen peroxide – numerical modeling and experimental results
JF  - International Journal of Heat and Mass Transfer
N2  - Hydrogen peroxide (H2O2) is a typical surface sterilization agent for packaging materials used in the pharmaceutical, food and beverage industries. We use the finite-elements method to analyze the conceptual design of an in-line thermal evaporation unit to produce a heated gas mixture of air and evaporated H2O2 solution. For the numerical model, the required phase-transition variables of pure H2O2  solution and of the aerosol mixture are acquired from vapor-liquid equilibrium (VLE) diagrams derived from vapor-pressure formulations. This work combines homogeneous single-phase turbulent flow with heat-transfer physics to describe the operation of the evaporation unit. We introduce the apparent heat-capacity concept to approximate the non-isothermal phase-transition process of the H2O2-containing aerosol. Empirical and analytical functions are defined to represent the temperature- and pressure-dependent material properties of the aqueous H2O2 solution, the aerosol and the gas mixture. To validate the numerical model, the simulation results are compared to experimental data on the heating power required to produce the gas mixture. This shows good agreement with the deviations below 10%. Experimental observations on the formation of deposits due to the evaporation of stabilized H2O2 solution fits the prediction made from simulation results.
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.118519
SN  - 0017-9310
VL  - 143
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Mosset, J.-B.
A1  - Devroede, O.
A1  - Krieguer, M.
A1  - Rey, M.
A1  - Vieira, J.-M.
A1  - Jung, J. H.
A1  - Kuntner, C.
A1  - Streun, M.
A1  - Ziemons, Karl
A1  - Auffray, E.
A1  - Sempere-Roldan, P.
A1  - Lecoq, P.
A1  - Bruyndonckx, P.
A1  - Loude, J.-F.
A1  - Tavernier, S.
A1  - Morcel, C.
T1  - Development of an optimized LSO/LuYAP phoswich detector head for the Lausanne ClearPET demonstrator
JF  - IEEE Transactions on Nuclear Science
N2  - This paper describes the LSO/LuYAP phoswich detector head developed for the ClearPET small animal PET scanner demonstrator that is under construction in Lausanne within the Crystal Clear Collaboration. The detector head consists of a dual layer of 8×8 LSO and LuYAP crystal arrays coupled to a multi-anode photomultiplier tube (Hamamatsu R7600-M64). Equalistion of the LSO/LuYAP light collection is obtained through partial attenuation of the LSO scintillation light using a thin aluminum deposit of 20-35 nm on LSO and appropriate temperature regulation of the phoswich head between 30°C to 60°C. At 511keV, typical FWHM energy resolutions of the pixels of a phoswich head amounts to (28±2)% for LSO and (25±2)% for LuYAP. The LSO versus LuYAP crystal identification efficiency is better than 98%. Six detector modules have been mounted on a rotating gantry. Axial and tangential spatial resolutions were measured up to 4 cm from the scanner axis and compared to Monte Carlo simulations using GATE. FWHM spatial resolution ranges from 1.3 mm on axis to 2.6 mm at 4 cm from the axis.
Y1  - 2006
SN  - 0018-9499
VL  - 53
IS  - 1
SP  - 25
EP  - 29
ER  - 
TY  - JOUR
A1  - Hoffschmidt, Bernhard
A1  - Fernandez, V.
A1  - Konstandopoulus, A. G.
T1  - Development of ceramic volumetric receiver technology
JF  - Forschungsbericht : DLR FB. 10 (2001)
Y1  - 2001
SN  - 0939-2963
N1  - 2. ISSN: 1434-8454 ; Kölner Sonnenkolloquium <5, 2001, Köln> ; Solar thermal power plants and solar chemical processes : advances and perspectives for international cooperation
SP  - 51
EP  - 61
ER  - 
TY  - JOUR
A1  - Edip, K.
A1  - Sesov, V.
A1  - Butenweg, Christoph
A1  - Bojadjieva, J.
T1  - Development of coupled numerical model for simulation of multiphase soil
JF  - Computers and Geotechnics
N2  - In this paper, a coupled multiphase model considering both non-linearities of water retention curves and solid state modeling is proposed. The solid displacements and the pressures of both water and air phases are unknowns of the proposed model. The finite element method is used to solve the governing differential equations. The proposed method is demonstrated through simulation of seepage test and partially consolidation problem. Then, implementation of the model is done by using hypoplasticity for the solid phase and analyzing the fully saturated triaxial experiments. In integration of the constitutive law error controlling is improved and comparisons done accordingly. In this work, the advantages and limitations of the numerical model are discussed.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.compgeo.2017.08.016
SN  - 0266-352X
VL  - 96
SP  - 118
EP  - 131
PB  - Elsevier
CY  - Amsterdam
ER  -