TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roikaew, Wipa
A1  - Ulber, Roland
A1  - Hoffmann, Alexander
A1  - Denzler, Hans-Jörg
A1  - Buchholz, Heinrich
T1  - Paracoccus denitrificans for the effluent recycling during continuous denitrification of liquid food
JF  - Biotechnology Progress
N2  - Nitrate is an undesirable component of several foods. A typical case of contamination with high nitrate contents is whey concentrate, containing nitrate in concentrations up to 25 l. The microbiological removal of nitrate by Paracoccus denitrificans under formation of harmless nitrogen in combination with a cell retention reactor is described here. Focus lies on the resource-conserving design of a microbal denitrification process. Two methods are compared. The application of polyvinyl alcohol-immobilized cells, which can be applied several times in whey feed, is compared with the implementation of a two step denitrification system. First, the whey concentrate's nitrate is removed by ion exchange and subsequently the eluent regenerated by microorganisms under their retention by crossflow filtration. Nitrite and nitrate concentrations were determined by reflectometric color measurement with a commercially available Reflectoquant® device. Correction factors for these media had to be determined. During the pilot development, bioreactors from 4 to 250 mg·L-1 and crossflow units with membrane areas from 0.02 to 0.80 m2 were examined. Based on the results of the pilot plants, a scaling for the exemplary process of denitrifying 1,000 tons per day is discussed.
Y1  - 2010
U6  - http://dx.doi.org/10.1002/btpr.384
SN  - 8756-7938
VL  - 26
IS  - 3
SP  - 756
EP  - 762
PB  - Wiley
CY  - Hoboken, NJ
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Li, D. X.
A1  - Riekert, Lothar
T1  - Partial oxidation of o-xylene to phthalic anhydride in a structured fixed bed containing a sequence of catalysts
JF  - New developments in selective oxidation : proceedings of an international symposium ; Rimini, Italy, Sept. 18 - 22, 1989 / eds.: G. Centi ... - (Studies in surface science and catalysis ; 55)
Y1  - 1990
SN  - 0-444-88694-X
SP  - 267
EP  - 274
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Goetze, Sandra
A1  - Baer, Alexandra
A1  - Winkelmann, Silke
A1  - Nehlsen, Kristina
A1  - Seibler, Jost
A1  - Maass, Karin
A1  - Bode, Jürgen
T1  - Performance of genomic bordering elements at predefined genomic loci
JF  - Molecular and Cellular Biology
Y1  - 2005
U6  - http://dx.doi.org/10.1128/MCB.25.6.2260-2272.2005
SN  - 1098-5549
VL  - 25
IS  - 6
SP  - 2260
EP  - 2272
ER  - 
TY  - JOUR
A1  - Feuerriegel, Uwe
A1  - Stahlberg, R.
T1  - Performance of the Thermoselect Demonstration Plant at Fondotoce, Italy: Product Quality and Distribution of Chemical Elements in the Material Flow. Stahlberg, R. ; Feuerriegel, U.
JF  - Solid waste management: thermal treatment & waste-to-energy technologies : proceedings of an international specialty conference sponsored by the Air & Waste Management Association, [Washington, DC, April 18 - 21, 1995] / comp. by James D. Kilgroe
Y1  - 1996
N1  - International Conference on Solid Waste Management, Thermal Treatment and Waste to Energy ; <1995, Washington, DC>
PB  - Air & Waste Management Assoc.
CY  - Pittsburgh, Pa.
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Corvinus, Florian M.
A1  - Orth, Carina
A1  - Moriggl, Richard
T1  - Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth / Corvinus, Florian, Moriggl, Richard ; Tsareva, Svetlana A. ; Wagner, Stefan ; Pfitzner, Edith B. ; Baus, Daniela ; Kaufmann, Roland : Huber, Luka
JF  - Neoplasia. 7 (2005), H. 6
Y1  - 2005
SN  - 1476-5586
SP  - 545
EP  - 555
ER  - 
TY  - JOUR
A1  - Luisier, Raphaëlle
A1  - Lempiäinen, Harri
A1  - Scherbichler, Nina
A1  - Braeuning, Albert
A1  - Geissler, Miriam
A1  - Dubost, Valerie
A1  - Müller, Arne
A1  - Scheer, Nico
A1  - Chibout, Salah-Dine
A1  - Hara, Hisanori
A1  - Picard, Frank
A1  - Theil, Diethilde
A1  - Couttet, Philippe
A1  - Vitobello, Antonio
A1  - Grenet, Olivier
A1  - Grasl-Kraupp, Bettina
A1  - Ellinger-Ziegelbauer, Heidrung
A1  - Thomson, John P.
A1  - Meehan, Richard R.
A1  - Elcombe, Clifford R.
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Remi
A1  - Moggs, Jonathan G.
T1  - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF  - Toxicological Sciences
N2  - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1  - 2014
U6  - http://dx.doi.org/https://doi.org/10.1093/toxsci/kfu038
SN  - 1094-2025
VL  - 139
IS  - 2
SP  - 501
EP  - 511
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Falkenberg, Fabian
A1  - Bott, Michael
A1  - Bongaerts, Johannes
A1  - Siegert, Petra
T1  - Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae
JF  - Frontiers in Microbiology
N2  - The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions. Subtilases are divided in several groups and especially subtilisins are of interest as they are used in various industrial sectors. Therefore, we searched for new subtilisin sequences of the family Bacillaceae using a data mining approach. The obtained 1,400 sequences were phylogenetically classified in the context of the subtilase family. This required an updated comprehensive overview of the different groups within this family. To fill this gap, we conducted a phylogenetic survey of the S8 family with characterised holotypes derived from the MEROPS database. The analysis revealed the presence of eight previously uncharacterised groups and 13 subgroups within the S8 family. The sequences that emerged from the data mining with the set filter parameters were mainly assigned to the subtilisin subgroups of true subtilisins, high-alkaline subtilisins, and phylogenetically intermediate subtilisins and represent an excellent source for new subtilisin candidates.
Y1  - 2022
U6  - http://dx.doi.org/10.3389/fmicb.2022.1017978
SN  - 1664-302X
VL  - 2022
IS  - 13
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Aggarwal, Prerna
A1  - Singh, Virendra
A1  - Singh, Arjun
A1  - Scherer, Ulrich W.
A1  - Singh, Tejvir
A1  - Singla, Madan L.
A1  - Srivastava, Alok
T1  - Physico-chemical transformations in swift heavy ion modified poly(ethyleneterephthalate)
JF  - Radiation Physics and Chemistry
Y1  - 2011
SN  - 0969-806X
N1  - In Press, Accepted Manuscript
SP  - 1
EP  - 28
PB  - Pergamon Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Smith, Walker O.
A1  - Baumann, Marcus
A1  - Wilson, David L.
A1  - Aletsee, Ludwig
T1  - Phytoplankton biomass and productivity in the marginal ice zone of the Fram Strait during summer 1984
JF  - Journal of geophysical research
Y1  - 1987
SN  - 2156-2202 (E-Journal); 2169-9291 (E-Journal); 0148-0227 (Print); 2169-9275 (Print)
VL  - Vol. 92
IS  - Iss. C7
SP  - 6777
EP  - 6786
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Goeyens, L.
A1  - Semeneh, M.
A1  - Elskens, M.
T1  - Phytoplankton nutrient utilisation and nutrient signature in the Southern Ocean / Goeyens, L. ; Semeneh, M. ; Baumann, M.E.M. ; Elskens, M. ; Shopova, D. ; Dehairs, F.
JF  - Journal of Marine Systems. 17 (1998), H. 1-4
Y1  - 1998
SN  - 0924-7963
SP  - 143
EP  - 157
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Zeng, Steffen
A1  - Dinter, Andre
A1  - Eisenkrätzer, Detlef
T1  - Pilot Scale Expression and Purification of Soluble Protein A Tagged &#946;1,6N-Acetylglucosaminyltransferase in CHO Cells / Zeng, Steffen ; Dinter, Andre ; Eisenkrätzer, Detlef ; Biselli, Manfred ; Wandrey, Christian ; Berger, Eric G.
JF  - Biochemical and Biophysical Research Communications. 237 (1997), H. 3
Y1  - 1997
SN  - 0006-291X
SP  - 653
EP  - 658
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Hirche, H.-J.
A1  - Kattner, G.
A1  - Gradinger, R.
T1  - Plankton distribution and the impact of copepod grazing on primary production in Fram Strait, Greenland Sea / Hirche, H.-J. ; Baumann, M.E.M. ; Kattner, G.; Gradinger, R.
JF  - Journal of Marine Systems. 2 (1991), H. 3-4
Y1  - 1991
SN  - 0924-7963
SP  - 477
EP  - 494
ER  - 
TY  - JOUR
A1  - Michalak, Ewa Malgorzata
A1  - Nacerddine, Karim
A1  - Pietersen, Alexandra
A1  - Beuger, Vincent
A1  - Pawlitzky, Inka
A1  - Cornelissen-Steijger, Paulien
A1  - Wientjens, Ellen
A1  - Tanger, Ellen
A1  - Seibler, Jost
A1  - Lohuizen, Maarten van
A1  - Jonkers, Jos
T1  - Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool
JF  - Stem Cells
Y1  - 2013
U6  - http://dx.doi.org/10.1002/stem.1437
SN  - 1549-4918
VL  - Vol 31
IS  - 9
SP  - 1910
EP  - 1920
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Kricheldorf, Hans R.
A1  - Jonté, J. Michael
T1  - Polylactones, 2. Copolymerization of glycolide with &#946;-propiolactone,  &#967;-butyrolactone or &#948;-valerolactone / Kricheldorf, Hans R. ; Mang, Thomas ; Jonté, J. Michael
JF  - Die makromolekulare Chemie. 186 (1985), H. 5
Y1  - 1985
SN  - 1022-1352
SP  - 955
EP  - 976
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Kricheldorf, Hans R.
A1  - Jonté, J. Michael
T1  - Polylactones. 1. Copolymerizations of glycolide and &beta-caprolactone / Kricheldorf, Hans R. ; Mang, Thomas ; Jonté, J. Michael
JF  - Macromolecules. 17 (1984), H. 10
Y1  - 1984
SN  - 0024-9297
SP  - 2173
EP  - 2181
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Polymer Magnetic Particles for Isolating Biomolecules, Especially Nucleic Acids
JF  - Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2
Y1  - 2004
SN  - 0013-5585
SP  - 1008
EP  - 1009
ER  - 
TY  - JOUR
A1  - Oosterhuis, Koen
A1  - Öhlschläger, Peter
A1  - Berg, Joost H. van den
A1  - Toebes, Mireille
A1  - Gomez, Raquel
A1  - Schumacher, Ton N.
A1  - Haanen, John B.
T1  - Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7
JF  - International Journal of Cancer
Y1  - 2011
SN  - 1097-0215
VL  - 129
IS  - 2
SP  - 397
EP  - 406
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Henken, F. E.
A1  - Oosterhuis, K.
A1  - Öhlschläger, Peter
A1  - Bosch, L.
A1  - Hooijberg, E.
A1  - Haanen, J. B. A. G.
A1  - Steenbergen, R. D. M.
T1  - Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7
JF  - Vaccine
N2  - Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.vaccine.2012.04.013
SN  - 0264-410X
VL  - 30
IS  - 28
SP  - 4259
EP  - 4266
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Schmid, Georg
A1  - Wandrey, Christian
T1  - Preparation of cellodextrins and isolation of oligomeric side components and their characterization / Schmid, Georg ; Biselli, Manfred ; Wandrey, Christian
JF  - Analytical Biochemistry. 175 (1988)
Y1  - 1988
SN  - 0003-2697
SP  - 573
EP  - 583
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Hammon, U.
T1  - Preparation of pellets with well-defined pore structure / U. Hammon ; A. Kotter
JF  - International chemical engineering. 26 (1986), H. 4
Y1  - 1986
SN  - 0020-6318
SP  - 563
EP  - 573
ER  - 
TY  - JOUR
A1  - Naithani, V. K
A1  - Klostermeyer, Henning
A1  - Lange, H. R.
A1  - [u.a.], 
A1  - Berndt, Heinz
A1  - [u.a.], 
T1  - Preparation of peptide derivatives for porcine proinsulin-synthesis
JF  - Biological Chemistry
Y1  - 1971
U6  - http://dx.doi.org/10.1515/bchm2.1971.352.1.1
SN  - 1437-4315
VL  - 352
IS  - 1
SP  - 2
EP  - 3
PB  - De Gruyter
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Woznyj, M.
A1  - Lüdemann, H.-D.
T1  - Pressure Dependence of the Melting and Self Diffusion in 2,2-Dimethylpropane, 2,2-Dimethylpropionitrile, and 2-Methylpropanol-2 / M. Woznyj, F. X. Prielmeier, H.-D. Lüdemann
JF  - Zeitschrift für Naturforschung A, Journal of Physical Sciences. 39 (1984)
Y1  - 1984
SN  - 0932-0784
SP  - 800
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Lang, E. W.
A1  - Lüdemann, H.-D.
T1  - Pressure dependence of the self-diffusion in liquid trifluoromethane / F. X. Prielmeier; E. W. Lang; H.-D. Lüdemann
JF  - Molecular Physics. 52 (1984), H. 5
Y1  - 1984
SN  - 0026-8976
SP  - 1105
EP  - 1113
ER  - 
TY  - JOUR
A1  - Tüg, Helmut
A1  - Baumann, Marcus
T1  - Problems of UV-B radiation measurements in biological research : critical remarks on current techniques and suggestions for improvements
JF  - Geophysical research letters
Y1  - 1994
SN  - 1944-8007 (E-Journal); 0094-8276 (Print)
VL  - Vol. 21
IS  - Iss. 8
SP  - 689
EP  - 692
ER  - 
TY  - JOUR
A1  - Gerigk, M.
A1  - Bujnicki, R.
A1  - Ganpo-Nkwenkwa, E.
A1  - Bongaerts, Johannes
A1  - Sprenger, G.
A1  - Takors, Ralf
T1  - Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains
JF  - Biotechnology and bioengineering
Y1  - 2002
SN  - 1097-0290 (E-Journal); 0006-3592 (Print)
VL  - Vol. 80
IS  - Iss. 7
SP  - 746
EP  - 754
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Born, C.
A1  - Wandrey, C.
T1  - Production of monoclonal antibodies in a pilot scale fluidized bed bioreactor / Born, C.; Biselli, M.; Wandrey, C.
JF  - Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery
Y1  - 1995
SN  - 0-7923-3736-0
N1  - Meeting "Animal Cell Technology, Developments towards the 21st Century" ; <1994.09.12-16 : ; Veldhoven>
SP  - 515
EP  - 519
PB  - Kluwer Acad. Press
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Hoehr, Cornelia
A1  - Hou, Xinchi
A1  - Hanemaayer, Victoire
A1  - Zeisler, Stefan
A1  - Adam, Michael J.
A1  - Ruth, Thomas J.
A1  - Celler, Anna
A1  - Buckley, Ken
A1  - Benard, Francois
A1  - Schaffer, Paul
T1  - Production of Y-86 and other radiometals for research purposes using a solution target system
JF  - Nuclear medicine and biology
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.nucmedbio.2015.06.005
SN  - 1872-9614
VL  - 42
IS  - 11
SP  - 842
EP  - 849
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Achebach, Stephanie
A1  - Unden, Gottfried
T1  - Properties and significance of apoFNR as a second form of air-inactivated [4Fe-4S]·FNR of Escherichia coli / Achebach, S. ; Selmer, T. ; Unden, G.
JF  - The FEBS Journal. 272 (2005), H. 16
Y1  - 2005
SN  - 1742-464X
SP  - 4260
EP  - 4269
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Willanzheimer, Angela
A1  - Hetzel, Marc
T1  - Propionate CoA-transferase from Clostridium propionicum. Cloning of the gene and identification of glutamate 324 at the active site
JF  - European Journal of Biochemistry. 269 (2002), H. 1
Y1  - 2002
SN  - 0014-2956
SP  - 372
EP  - 380
ER  - 
TY  - JOUR
A1  - Dellmann, Sophia Florence
A1  - Glorius, J.
A1  - Litvinov, Yu A.
A1  - Reifarth, R.
A1  - Al-Khasawneh, Kafa
A1  - Aliotta, M.
A1  - Bott, L.
A1  - Brückner, Benjamin
A1  - Bruno, C. G.
A1  - Chen, Ruijiu
A1  - Davinson, T.
A1  - Dickel, T.
A1  - Dillmann, Iris
A1  - Dmytriev, D.
A1  - Erbacher, P.
A1  - Freire-Fernández, D.
A1  - Forstner, Oliver
A1  - Geissel, H.
A1  - Göbel, K.
A1  - Griffin, Christopher J.
A1  - Grisenti, R.
A1  - Gumberidze, Alexandre
A1  - Haettner, Emma
A1  - Hagmann, Siegbert
A1  - Heil, M.
A1  - Heß, R.
A1  - Hillenbrand, P.-M.
A1  - Joseph, R.
A1  - Jurado, B.
A1  - Kozhuharov, Christophor
A1  - Kulikov, I.
A1  - Löher, Bastian
A1  - Langer, Christoph
A1  - Leckenby, Guy
A1  - Lederer-Woods, C.
A1  - Lestinsky, M.
A1  - Litvinov, S. A.
A1  - Lorenz, B. A.
A1  - Lorenz, E.
A1  - Marsh, J.
A1  - Menz, Esther Babette
A1  - Morgenroth, T.
A1  - Petridis, N.
A1  - Pibernat, Jerome
A1  - Popp, U.
A1  - Psaltis, Athanasios
A1  - Sanjari, Shahab
A1  - Scheidenberger, C.
A1  - Sguazzin, M.
A1  - Sidhu, Ragandeep Singh
A1  - Spillmann, Uwe
A1  - Steck, M.
A1  - Stöhlker, T.
A1  - Surzhykov, A.
A1  - Swartz, J. A.
A1  - Törnqvist, H.
A1  - Varga, L.
A1  - Vescovi, Diego
A1  - Weick, H.
A1  - Weigand, M.
A1  - Woods, P.
A1  - Xing, Y.
A1  - Yamaguchi, Taiyo
T1  - Proton capture on stored radioactive ¹¹⁸Te ions
JF  - EPJ Web of Conferences
N2  - Experimental determination of the cross sections of proton capture on radioactive nuclei is extremely difficult. Therefore, it is of substantial interest for the understanding of the production of the p-nuclei. For the first time, a direct measurement of proton-capture cross sections on stored, radioactive ions became possible in an energy range of interest for nuclear astrophysics. The experiment was performed at the Experimental Storage Ring (ESR) at GSI by making use of a sensitive method to measure (p,γ) and (p,n) reactions in inverse kinematics. These reaction channels are of high relevance for the nucleosyn-thesis processes in supernovae, which are among the most violent explosions in the universe and are not yet well understood. The cross section of the ¹¹⁸Te(p,γ) reaction has been measured at energies of 6 MeV/u and 7 MeV/u. The heavy ions interacted with a hydrogen gas jet target. The radiative recombination process of the fully stripped ¹¹⁸Te ions and electrons from the hydrogen target was used as a luminosity monitor. An overview of the experimental method and preliminary results from the ongoing analysis will be presented.
Y1  - 2023
U6  - http://dx.doi.org/10.1051/epjconf/202327911018
SN  - 2100-014X
N1  - Volume 279, 2023. Nuclear Physics in Astrophysics – X (NPA-X 2022).
VL  - 279
IS  - Article Number: 11018
SP  - 1
EP  - 5
PB  - EDP Sciences
ER  - 
TY  - JOUR
A1  - Schmitz, M.
A1  - Hirsch, E.
A1  - Bongaerts, Johannes
A1  - Takors, Ralf
T1  - Pulse experiments as a prerequisite for the quantification of in vivo enzyme kinetics in aromatic amino acid pathway of Eschericia coli
JF  - Biotechnology progress
Y1  - 2002
SN  - 1520-6033 (E-Journal); 8756-7938 (Print)
VL  - Vol. 18
IS  - Iss. 5
SP  - 935
EP  - 941
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Thömmes, J.
A1  - Born, C.
A1  - Wandrey, C.
T1  - Purification of monoclonal antibodies by fluidized bed adsorption / Thömmes, J. ; Born, C.  Biselli, M. ; Wandrey, C. ; Kula, M.-R.
JF  - Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery
Y1  - 1995
SN  - 0-7923-3736-0
N1  - Meeting "Animal Cell Technology, Developments towards the 21st Century" ; <1994.09.12-16 : ; Veldhoven>
SP  - 515
EP  - 519
PB  - Kluwer Acad. Press
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roth, Jasmine
T1  - Purified Butanol from Lignocellulose – Solvent‐Impregnated Resins for an Integrated Selective Removal
JF  - Chemie Ingenieur Technik
N2  - In traditional microbial biobutanol production, the solvent must be recovered during fermentation process for a sufficient space-time yield. Thermal separation is not feasible due to the boiling point of n-butanol. As an integrated and selective solid-liquid separation alternative, solvent impregnated resins (SIRs) were applied. Two polymeric resins were evaluated and an extractant screening was conducted. Vacuum application with vapor collection in fixed-bed column as bioreactor bypass was successfully implemented as butanol desorption step. In course of further increasing process economics, fermentation with renewable lignocellulosic substrates was conducted using Clostridium acetobutylicum. Utilization of SIR was shown to be a potential strategy for solvent removal from fermentation broth, while application of a bypass column allows for product removal and recovery at once.
KW  - Biofuel
KW  - Biorefinery
KW  - Butanol
KW  - Clostridium acetobutylicum
KW  - Lignocellulose
Y1  - 2020
U6  - http://dx.doi.org/10.1002/cite.202000200
SN  - 1522-2640
VL  - 92
IS  - 11
SP  - 1741
EP  - 1751
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hasegawa, Maki
A1  - Kapelyukh, Yury
A1  - Tahara, Harunobu
A1  - Seibler, Jost
A1  - Rode, Anja
A1  - Krueger, Sylvia
A1  - Lee, Dongtao N.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
T1  - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
JF  - Molecular Pharmacology
Y1  - 2011
U6  - http://dx.doi.org/10.1124/mol.111.071845
SN  - 1521-0111
VL  - 80
IS  - 33
SP  - 518
EP  - 528
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Soboleva, Polina M.
A1  - Fedotova, Elena S.
A1  - Musina, Kristina T.
A1  - Burmistrova, Natalia A.
T1  - Quantum chemical calculations of IR spectra of heparin disaccharide subunits
JF  - Computational and Theoretical Chemistry
N2  - Heparin is a natural polysaccharide, which plays essential role in many biological processes. Alterations in building blocks can modify biological roles of commercial heparin products, due to significant changes in the conformation of the polymer chain. The variability structure of heparin leads to difficulty in quality control using different analytical methods, including infrared (IR) spectroscopy. In this paper molecular modelling of heparin disaccharide subunits was performed using quantum chemistry. The structural and spectral parameters of these disaccharides have been calculated using RHF/6-311G. In addition, over-sulphated chondroitin sulphate disaccharide was studied as one of the most widespread contaminants of heparin. Calculated IR spectra were analyzed with respect to specific structure parameters. IR spectroscopic fingerprint was found to be sensitive to substitution pattern of disaccharide subunits. Vibrational assignments of calculated spectra were correlated with experimental IR spectral bands of native heparin. Chemometrics was used to perform multivariate analysis of simulated spectral data.
KW  - IR spectroscopy
KW  - Chemometrics
KW  - Quantum chemistry
KW  - Molecular modelling
KW  - Quality control
Y1  - 2022
SN  - 2210-271X
U6  - http://dx.doi.org/10.1016/j.comptc.2022.113891
VL  - 1217
IS  - Article number: 113891
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Voigt, B.
A1  - Gabriel, B.
A1  - Ghod, Mumin M.
T1  - Quaternary events  at the Horn of Africa / Voigt, B., B. Gabriel,  B. Lassonczyk and Mumin M. Ghod
JF  - Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Paläontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universität Berlin. 120 A (1990)
Y1  - 1990
SN  - 0172-8784
SP  - 679
EP  - 694
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Tomasberger, T.
A1  - Veltkamp, T. C.
A1  - Booij, A. S.
T1  - Radiocesium Removal from High Level Liquid Waste and Immobilisation in Sodium SilicoTitanate for Geological Disposal / T. Tomasberger, T.C. Veltkamp, A.S. Booij, U.W. Scherer
JF  - Radiochimica Acta. 89 (2001), H. 3
Y1  - 2001
SN  - 0033-8230
SP  - 145
EP  - 150
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Zevnik, Branko
A1  - Küter-Luks, Birgit
A1  - Andreas, Susanne
A1  - Kern, Heidrun
A1  - Hennek, Thomas
A1  - Rode, Anja
A1  - Heimann, Cornelia
A1  - Faust, Nicole
A1  - Kauselmann, Gunther
A1  - Schoor, Michael
A1  - Jaenisch, Rudolf
A1  - Rajewsky, Klaus
A1  - Kühn, Ralf
A1  - Schwenk, Frieder
T1  - Rapid generation of inducible mouse mutants
JF  - Nucleic Acids Research
Y1  - 2003
U6  - http://dx.doi.org/10.1093/nar/gng012
SN  - 1362-4962
VL  - 33
IS  - 4
SP  - e12
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Kragl, U.
A1  - Wandrey, C.
T1  - Reaction Engineering for Enzyme-Catalyzed Biotransformations
JF  - Enzyme catalysis in organic synthesis : a comprehensive handbook. Bd. 1. -  2., completely rev. and enl. ed. / ed. by Karlheinz Drauz.
Y1  - 2002
SN  - 3-527-29949-1
N1  - erschienen: Vol. 1-3
SP  - 185
EP  - 257
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Kragl, U.
A1  - Wandrey, C.
T1  - Reaction Engineering for Enzyme-Catalyzed Biotransformations
JF  - Enzyme catalysis in organic synthesis : a comprehensive handbook. Bd. 1.  / ed. by Karlheinz Drauz.
Y1  - 1995
SN  - 3-527-28479-6
N1  - erschienen: Vol. 1-2
SP  - 89
EP  - 155
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Wandrey, Christian
T1  - Reaction Mechanism of an Endoglucanase of Trichoderma Reesei QM 9414 using Cellodextrins as Substrate
JF  - Technology of biological processes, safety in biotechnology, applied genetic engineering : lectures held at the 5th DECHEMA Annual Meeting of Biotechnologists, May 12 - 13, 1987, [Frankfurt, Main] / [hrsg. von Dieter Behrens ...]
Y1  - 1988
N1  - Jahrestagung der Biotechnologen ; <5, 1987, Frankfurt, Main> ; DECHEMA Biotechnology Conferences series ; 1
SP  - 425
EP  - 429
PB  - VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Brüchle, W.
A1  - Brügger, M.
A1  - Frink, C.
T1  - Reactions of 40Ar with 233U,,235U, and 238U at the Barrier / U.W. Scherer, W. Brüchle, M. Brügger, C. Frink, H. Gäggeler, G. Herrmann, J.V. Kratz, K.J. Moody, M. Schädel, K. Sümmerer, N. Trautmann, G. Wirth
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 335 (1990), H. 4
Y1  - 1990
SN  - 0939-7922
SP  - 421
EP  - 430
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Schweighöfer, Philip V.
A1  - Abram, Ulrich
T1  - Reactions of [ReOX3(PPh3)2] Complexes (X = Cl, Br) with Phenylacetylene and the Structures of the Products
JF  - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry
N2  - Oxorhenium(V) complexes [ReOX3(PPh3)2] (X = Cl, Br) react with phenylacetylene under formation of complexes with ylide-type ligands. Compounds of the compositions [ReOCl3(PPh3){C(Ph)C(H)(PPh3)}] (1), [ReOBr3(OPPh3){C(Ph)C(H)(PPh3)}] (2), and [ReOBr3(OPPh3){C(H)C(Ph)(PPh3)}] (3) were isolated and characterized by X-ray diffraction. They contain a ligand, which was formed by a nucleophilic attack of released PPh3 at coordinated phenylacetylene. The structures of the products show that there is no preferable position for this attack. Cleavage of the Re–C bond in 3 and dimerization of the organic ligand resulted in the formation of the [{(PPh3)(H)CC(Ph)}2]2+ cation, which crystallized as its [(ReOBr4)(OReO3)]2– salt.
Y1  - 2010
U6  - http://dx.doi.org/10.1002/zaac.200900478
SN  - 1521-3749
VL  - 636
IS  - 5
SP  - 779
EP  - 783
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
T1  - Recycling of Polymeric Composites
JF  - Invited and contributing lectures presented at the 38th Microsymposium on Recycling of Polymers : held in Prague, Czech Republic, July 14 - 17, 1997 / International Union of Pure and Applied Chemistry, Macromolecular Division. Symposium ed. J. Kahovec.
Y1  - 1998
N1  - Macromolecular symposia ; 135 ; Microsymposium on Recycling of Polymers <38, 1997, Praha>
SP  - 147
EP  - 156
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Wollny, Steffen
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense
JF  - Engineering in Life Sciences
N2  - A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/elsc.201300113
SN  - 1618-2863
VL  - 14
IS  - 4
SP  - 425
EP  - 432
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Tüg, Helmut
A1  - Baumann, Marcus
T1  - Reply to the comments by R.L. McKenzie and P.V. Johnston on our paper “Problems of UV-B radiation measurements in biological research: Critical Remarks on current techniques and suggestions for improvements”
JF  - Geophysical research letters
Y1  - 1995
SN  - 1944-8007 (E-Journal); 0094-8276 (Print)
VL  - Vol. 22
IS  - Iss. 9
SP  - 1159
EP  - 1160
ER  - 
TY  - JOUR
A1  - Tran, Quang Hon
A1  - Bongaerts, Johannes
A1  - Vlad, Dorina
A1  - Unden, Gottfried
T1  - Requirement for the proton-pumping NADH dehydrogenase I of Escherichia coli in respiration of NADH to fumarate and its bioenergetic implications
JF  - European journal of biochemistry
Y1  - 1997
SN  - 0014-2956
VL  - Vol. 244
IS  - Iss. 1
SP  - 155
EP  - 160
ER  - 
TY  - JOUR
A1  - Berndt, Heinz
A1  - Krüger, Götz
T1  - Resolution of enantiomeric amino acid derivatives by high-performance liquid chromatography on chiral stationary phases
JF  - Journal of chromatography A
Y1  - 1985
U6  - http://dx.doi.org/10.1016/S0021-9673(01)92461-6
SN  - 0021-9673
VL  - 1985
IS  - 348
SP  - 275
EP  - 279
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Kleinridders, Andre
A1  - Küter-Luks, Birgit
A1  - Niehaves, Sandra
A1  - Brüning, Jens C.
A1  - Schwenk, Frieder
T1  - Reversible gene knockdown in mice using a tight, inducible shRNA expression system
JF  - Nucleic Acids Research
Y1  - 2007
U6  - http://dx.doi.org/10.1093/nar/gkm122
SN  - 1362-4962
VL  - 35
IS  - 7
SP  - e54
ER  - 
TY  - JOUR
A1  - Wiegand, Sandra
A1  - Dietrich, Sascha
A1  - Hertel, Robert
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Volland, Sonja
A1  - Daniel, Rolf
A1  - Liesegang, Heiko
T1  - RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation
JF  - BMC genomics
Y1  - 2013
SN  - 1471-2164
VL  - Vol. 14
SP  - 667
PB  - BioMed Central
CY  - London
ER  -