TY - JOUR A1 - Roth, Jasmine A1 - Tippkötter, Nils T1 - Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium JF - Cellulose Chemistry and Technology N2 - Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹. Y1 - 2016 VL - 50 IS - 3-4 SP - 405 EP - 410 PB - Editura Academiei Romane CY - Bukarest ER - TY - JOUR A1 - Ngamga, Eulalie Joelle A1 - Bialonski, Stephan A1 - Marwan, Norbert A1 - Kurths, Jürgen A1 - Geier, Christian A1 - Lehnertz, Klaus T1 - Evaluation of selected recurrence measures in discriminating pre-ictal and inter-ictal periods from epileptic EEG data JF - Physics Letters A N2 - We investigate the suitability of selected measures of complexity based on recurrence quantification analysis and recurrence networks for an identification of pre-seizure states in multi-day, multi-channel, invasive electroencephalographic recordings from five epilepsy patients. We employ several statistical techniques to avoid spurious findings due to various influencing factors and due to multiple comparisons and observe precursory structures in three patients. Our findings indicate a high congruence among measures in identifying seizure precursors and emphasize the current notion of seizure generation in large-scale epileptic networks. A final judgment of the suitability for field studies, however, requires evaluation on a larger database. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.physleta.2016.02.024 SN - 0375-9601 VL - 380 IS - 16 SP - 1419 EP - 1425 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Leingartner, Max A1 - Maurer, Johannes A1 - Ferrein, Alexander A1 - Steinbauer, Gerald T1 - Evaluation of Sensors and Mapping Approaches for Disasters in Tunnels JF - Journal of Field Robotics N2 - Ground or aerial robots equipped with advanced sensing technologies, such as three-dimensional laser scanners and advanced mapping algorithms, are deemed useful as a supporting technology for first responders. A great deal of excellent research in the field exists, but practical applications at real disaster sites are scarce. Many projects concentrate on equipping robots with advanced capabilities, such as autonomous exploration or object manipulation. In spite of this, realistic application areas for such robots are limited to teleoperated reconnaissance or search. In this paper, we investigate how well state-of-the-art and off-the-shelf components and algorithms are suited for reconnaissance in current disaster-relief scenarios. The basic idea is to make use of some of the most common sensors and deploy some widely used algorithms in a disaster situation, and to evaluate how well the components work for these scenarios. We acquired the sensor data from two field experiments, one from a disaster-relief operation in a motorway tunnel, and one from a mapping experiment in a partly closed down motorway tunnel. Based on these data, which we make publicly available, we evaluate state-of-the-art and off-the-shelf mapping approaches. In our analysis, we integrate opinions and replies from first responders as well as from some algorithm developers on the usefulness of the data and the limitations of the deployed approaches, respectively. We discuss the lessons we learned during the two missions. These lessons are interesting for the community working in similar areas of urban search and rescue, particularly reconnaissance and search. Y1 - 2016 U6 - http://dx.doi.org/10.1002/rob.21611 SN - 1556-4967 VL - 33 IS - 8 SP - 1037 EP - 1057 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Niemueller, Tim A1 - Reuter, Sebastian A1 - Ferrein, Alexander A1 - Jeschke, Sabina A1 - Lakemeyer, Gerhard ED - Almeida, Luis T1 - Evaluation of the RoboCup Logistics League and Derived Criteria for Future Competitions T2 - RoboCup 2015: Robot World Cup XIX Y1 - 2016 SN - 978-3-319-29339-4 U6 - http://dx.doi.org/10.1007/978-3-319-29339-4_3 N1 - Lecture Notes in Computer Science ; 9513 SP - 31 EP - 43 PB - Springer International Publishing CY - Cham ER - TY - JOUR A1 - Funke, Harald A1 - Keinz, Jan A1 - Kusterer, Karsten A1 - Ayed, Anis Haj A1 - Kazari, Masahide A1 - Kitajima, Junichi A1 - Horikawa, Atsushi A1 - Okada, Kunio T1 - Experimental and Numerical Study on Optimizing the Dry Low NOₓ Micromix Hydrogen Combustion Principle for Industrial Gas Turbine Applications JF - Journal of Thermal Science and Engineering Applications N2 - Combined with the use of renewable energy sources for its production, hydrogen represents a possible alternative gas turbine fuel for future low-emission power generation. Due to the difference in the physical properties of hydrogen compared to other fuels such as natural gas, well-established gas turbine combustion systems cannot be directly applied to dry low NOₓ (DLN) hydrogen combustion. The DLN micromix combustion of hydrogen has been under development for many years, since it has the promise to significantly reduce NOₓ emissions. This combustion principle for air-breathing engines is based on crossflow mixing of air and gaseous hydrogen. Air and hydrogen react in multiple miniaturized diffusion-type flames with an inherent safety against flashback and with low NOₓ emissions due to a very short residence time of the reactants in the flame region. The paper presents an advanced DLN micromix hydrogen application. The experimental and numerical study shows a combustor configuration with a significantly reduced number of enlarged fuel injectors with high-thermal power output at constant energy density. Larger fuel injectors reduce manufacturing costs, are more robust and less sensitive to fuel contamination and blockage in industrial environments. The experimental and numerical results confirm the successful application of high-energy injectors, while the DLN micromix characteristics of the design point, under part-load conditions, and under off-design operation are maintained. Atmospheric test rig data on NOₓ emissions, optical flame-structure, and combustor material temperatures are compared to numerical simulations and show good agreement. The impact of the applied scaling and design laws on the miniaturized micromix flamelets is particularly investigated numerically for the resulting flow field, the flame-structure, and NOₓ formation. Y1 - 2016 U6 - http://dx.doi.org/10.1115/1.4034849 SN - 1948-5093 N1 - TSEA-15-1227 VL - 9 IS - 2 SP - 021001 EP - 021001-10 PB - ASME CY - New York, NY ER - TY - CHAP A1 - Leicht-Scholten, Carmen A1 - Steuer-Dankert, Linda A1 - Bouffier, Anna T1 - Facing Future Challenges: Building Engineers for Tomorrow T2 - Conference proceedings : new perspectives in science education : 5th Conference edition, Florence, Italy, 17-18 March 2016 N2 - Future engineers are increasingly confronted with the so-called Megatrends which are the big social challenges society has to cope with. These Megatrends, such as “Silver Society”, “Globalization”, “Mobility” and “Female Shift” require an application-oriented perspective on Diversity especially in the engineering field. Therefore, it is necessary to enable future engineers not only to look at the technical perspectives of a problem, but also to be able to see the related questions within societies they are developing their artefacts for. The aim of teaching engineering should be to prepare engineers for these requirements and to draw attention to the diverse needs in a globalized world. Bringing together technical knowledge and social competences which go beyond a mere training of the so-called “soft skills”, is a new approach followed at RWTH Aachen University, one of the leading technical universities in Germany. RWTH Aachen University has established the bridging professorship “Gender and Diversity in Engineering” (GDI) which educates engineers with an interdisciplinary approach to expand engineering limits. In the frame of a sustainable teaching concept the research group under the leadership of Prof. Carmen Leicht-Scholten has developed an approach which imparts a supplication-specific Gender and Diversity expertise to engineers. In workshops students gain theoretical knowledge about Gender and Diversity and learn how to transfer their knowledge in their special field of study and later work. To substantiate this, the course participants have to solve case studies from real life. The cases which are developed in collaboration with non-profit organizations and enterprises from economy rise the students to challenges which are inspired by professional life. Evaluation shows the success of this approach as well as an increasing demand for such teaching formats. KW - Diversity KW - Engineering Education KW - Gender KW - Higher Education Y1 - 2016 SN - 978-886292-705-5 SP - 32 EP - 37 ER - TY - CHAP A1 - Niemueller, Tim A1 - Reuter, Sebastian A1 - Ferrein, Alexander ED - Almeida, Luis T1 - Fawkes for the RoboCup Logistics League T2 - RoboCup 2015: Robot World Cup XIX Y1 - 2016 SN - 978-3-319-29339-4 U6 - http://dx.doi.org/10.1007/978-3-319-29339-4_31 N1 - Lecture Notes in Computer Science ; 9513 SP - 365 EP - 373 PB - Springer International Publishing CY - Cham ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Tran, Thanh Ngoc A1 - Matthies, Hermann G. A1 - Stavroulakis, Georgios Eleftherios A1 - Staat, Manfred T1 - FEM Shakedown of uncertain structures by chance constrained programming T2 - PAMM Proceedings in Applied Mathematics and Mechanics Y1 - 2016 U6 - http://dx.doi.org/10.1002/pamm.201610346 SN - 1617-7061 N1 - Special Issue: Joint 87th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) and Deutsche Mathematiker-Vereinigung VL - 16 IS - 1 SP - 715 EP - 716 ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Erni, Daniel T1 - Female pelvic floor dysfunction: progress weakening of the support system T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders. Y1 - 2016 U6 - http://dx.doi.org/10.17185/duepublico/40821 SP - 11 EP - 12 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Feldmann, M. A1 - Döring, Bernd A1 - Pyschny, D. T1 - Floor systems; Sustainabilty analyses and assessments of steel bridges T2 - Sustainable steel buildings : a practical guide for structures and envelopes Y1 - 2016 SN - 978-1-118-74079-8 (PDF) SN - 978-1-118-74111-5 SP - 198 EP - 223 PB - Wiley Blackwell CY - Chichester, West Sussex ER - TY - BOOK A1 - Tünnemann, Thomas ED - Tünnemann, Thomas T1 - Formine : Neo Style : Workshop 2016 N2 - Leitung und Konzeption: Thomas Tünnemann, Professor für Gestalten, FB Architektur, FH Aachen: Mit Beiträgen von Miriam Azzab, Larissa Rohr, Janna Steinhart, Felix Reymann, Kevin Osterkamp, Mark Kieckhefer, Pia Bienert, Sarah Schuhmann, Hermann Stuzmann, Silvana Hecklinger, Thorsten, Köllen, Jesse Dilworth, Silke Wanders, Tomas Tünnemann und Jan Waschinzki Y1 - 2016 SN - 978-3-9811003-7-2 CY - Aachen ER - TY - JOUR A1 - Schwab, Lukas A1 - Hojdis, Nils A1 - Lacayo, Jorge A1 - Wilhelm, Manfred T1 - Fourier-Transform Rheology of Unvulcanized, Carbon Black Filled Styrene Butadiene Rubber JF - Macromolecular Materials and Engineering N2 - Rubber materials filled with reinforcing fillers display nonlinear rheological behavior at small strain amplitudes below γ0 < 0.1. Nevertheless, rheological data are analyzed mostly in terms of linear parameters, such as shear moduli (G′, G″), which loose their physical meaning in the nonlinear regime. In this work styrene butadiene rubber filled with carbon black (CB) under large amplitude oscillatory shear (LAOS) is analyzed in terms of the nonlinear parameter I3/1. Three different CB grades are used and the filler load is varied between 0 and 70 phr. It is found that I3/1(φ) is most sensitive to changes of the total accessible filler surface area at low strain amplitudes (γ0 = 0.32). The addition of up to 70 phr CB leads to an increase of I3/1(φ) by a factor of more than ten. The influence of the measurement temperature on I3/1 is pronounced for CB levels above the percolation threshold. Y1 - 2016 U6 - http://dx.doi.org/10.1002/mame.201500356 SN - 1439-2054 VL - 301 IS - 4 SP - 457 EP - 468 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Matcha, Heike ED - Herneoja, Aulikki ED - Österlund, Toni ED - Markkanen, Piia T1 - From Designing Buildings from Systems to Designing Systems for Buildings T2 - Complexity & Simplicity - Proceedings of the 34th eCAADe Conference - Volume 1 N2 - We study the novel possibilities computer aided design and production open up for the design of building systems. Such systems today can, via individualized mass production, consist of a larger number and more complex parts than previously and therefore be assembled into more complex wholes. This opens up the possibility of designing specialized systems specifically for single buildings. The common order of starting with a building system and designing a building using this system can be reversed to designing a building first and then developing a system specifically for that building. We present and discuss research that incorporates students design projects into research work and fosters links between research and teaching. KW - Building Systems KW - Parametric Design KW - Parametric Modelling KW - Structuralist Architecture Y1 - 2016 U6 - http://dx.doi.org/10.52842/conf.ecaade.2016.1.237 N1 - Proceedings of the 34th eCAADe Conference, University of Oulu, Oulu, Finland, 22-26 August 2016. SP - 237 EP - 240 PB - ECAADe CY - Oulu, Finland ER - TY - CHAP A1 - Hafner, David A1 - Ochs, Peter A1 - Weickert, Joachim A1 - Reißel, Martin ED - Rosenhahn, Bodo T1 - FSI Schemes : Fast Semi-Iterative Solvers for PDEs and Optimisation Methods T2 - Pattern Recognition : 38th German Conference, GCPR 2016, Hannover, Germany, September 12-15, 2016, Proceedings Y1 - 2016 SN - 978-3-319-45886-1 U6 - http://dx.doi.org/10.1007/978-3-319-45886-1_8 N1 - Lecture Notes in Computer Science; Vol. 9796 SP - 91 EP - 102 PB - Springer ER - TY - BOOK A1 - Siedenbiedel, Georg T1 - Führung international operierender Unternehmen T3 - Schriftenreihe innovative betriebswirtschaftliche Forschung und Praxis ; Band 457 Y1 - 2016 SN - 978-3-8300-9164-6 PB - Kovac CY - Hamburg ER - TY - JOUR A1 - König, Johannes Alexander A1 - Völker, Veronika A1 - Wolf, Martin A1 - Schuba, Marko T1 - Gamified Hacking Offence Simulation-based Training (GHOST) JF - Crisis Prevention Y1 - 2016 VL - 2016 IS - 3 SP - 44 EP - 46 PB - Beta CY - Bonn ER - TY - JOUR A1 - Dallas, Shannon A1 - Salphati, Laurent A1 - Gomez-Zepeda, David A1 - Wanek, Thomas A1 - Chen, Liangfu A1 - Chu, Xiaoyan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Menet, Marie-Claude A1 - Chasseigneaux, Stephanie A1 - Declèves, Xavier A1 - Langer, Oliver A1 - Pierre, Esaie A1 - DiLoreto, Karen A1 - Hoft, Carolin A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Pereira, Tony A1 - Andonian, Clara A1 - Simic, Damir A1 - Rode, Anja A1 - Yabut, Jocelyn A1 - Zhang, Xiaolin A1 - Scheer, Nico T1 - Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model JF - Molecular Pharmacology N2 - Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp−/−) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP. Y1 - 2016 U6 - http://dx.doi.org/10.1124/mol.115.102079 SN - 1521-0111 VL - 89 IS - 5 SP - 492 EP - 504 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Thomas, Axel T1 - Genussrechte als Instrument der Unternehmensfinanzierung von kommunalen Wohnungs- baugesellschaften JF - VM Verwaltung und Management N2 - Die kommunalen Wohnungsbaugesellschaften und ihr Geschäftszweck bzw. Versorgungsauftrag erfahren aus gesamtgesellschaftlichen Gründen aktuell einen erheblichen Bedeutungszuwachs. Der kommunale Wohnungsbau soll und muss intensiviert werden, da z.B. zunehmend Wohnungsbindungen auslaufen. Bezahlbare Neubauten fehlen speziell Familien, Senioren, Studenten und Flüchtlingen. Um das Investitionsvolumen zu bewältigen, bedarf es nicht nur der Förderkredite, sondern auch der Zuführung „frischen Kapitals“. Der Beitrag stellt dar, dass Genussrechte ein interessantes und oft unbekanntes Finanzierungsinstrument für kommunale Wohnungsbaugesellschaften mit passgenauen Ausgestaltungsmöglichkeiten sind. Mit Hilfe von Genussrechten können die notwendigen Neubau-Investitionen solide mit Quasi-Eigenkapital unterlegt werden und den sozialen Wohnungsbau wiederbeleben. Genussrechte als Hybridkapital lassen sich mangels gesetzlicher Eingrenzung exakt und individuell ebenso an die Bedürfnisse der kommunalen Wohnungsbaugesellschaft anpassen wie an die der Gesellschafter und des jeweiligen Neubauvorhabens. Y1 - 2016 U6 - http://dx.doi.org/10.5771/0947-9856-2016-6-322 SN - 0947-9856 VL - 22 IS - 6 SP - 322 EP - 327 PB - Nomos CY - Baden-Baden ER - TY - CHAP A1 - Tippkötter, Nils ED - Kaltschmidt, Martin T1 - Grundlagen der bio-chemischen Umwandlung T2 - Energie aus Biomasse : Grundlagen, Techniken und Verfahren Y1 - 2016 SN - 978-3-662-47437-2 (Print) SN - 978-3-662-47438-9 (Online) U6 - http://dx.doi.org/10.1007/978-3-662-47438-9 SP - 1447 EP - 1500 PB - Springer Vieweg CY - Berlin ; Heidelberg ET - 3., aktualisierte, erweiterte Auflage ER - TY - BOOK A1 - Schmidt, Bernd T1 - Grundlagen der Elektrotechnik und Elektronik für Ingenieure der Schienenfahrzeugtechnik und anderer Fachrichtungen Y1 - 2016 SN - 978-3-944131-02-3 PB - B. Schmidt, Fachverlag für Elektro- und Informationstechnik CY - Bielefeld ET - 1. Aufl. ER - TY - CHAP A1 - Martin, Joachim A1 - Martin, Angelika T1 - Größen, Formeln, Bemessung T2 - Zahlentafeln für den Baubetrieb N2 - Das Kapitel 1 vermittelt eine Übersicht für den schnellen Gebrauch von Größen, Einheiten und Zeichen. Es folgt die Darstellung wichtiger Grundlagen der Mathematik, Lastannahmen und einfacher statischer Systeme. Schließlich werden Hinweise zu charakteristischen Festigkeiten und Tragfähigkeitsnachweisen für Berechnungen im Mauerwerk, Holz- und Stahlbau sowie Stahlbetonbau gegeben. Für eine weitere Vertiefung des Themas empfiehlt sich der Wendehorst Bautechnische Zahlentafel Y1 - 2016 SN - 978-3-658-02838-1 (Online) SN - 978-3-658-02837-4 (Print) U6 - http://dx.doi.org/10.1007/978-3-658-02838-1_1 SP - 1 EP - 61 PB - Springer Vieweg CY - Wiesbaden ET - 9., überarb. und aktual. Aufl. ER - TY - CHAP A1 - Hallmann, Marcus A1 - Heidecker, Ansgar A1 - Schlotterer, Markus A1 - Dachwald, Bernd T1 - GTOC8: results and methods of team 15 DLR T2 - 26th AAS/AIAA Space Flight Mechanics Meeting, Napa, CA N2 - This paper describes the results and methods used during the 8th Global Trajectory Optimization Competition (GTOC) of the DLR team. Trajectory optimization is crucial for most of the space missions and usually can be formulated as a global optimization problem. A lot of research has been done to different type of mission problems. The most demanding ones are low thrust transfers with e.g. gravity assist sequences. In that case the optimal control problem is combined with an integer problem. In most of the GTOCs we apply a filtering of the problem based on domain knowledge. Y1 - 2016 N1 - 26th AAS/AIAA Space Flight Mechanics Meeting, February 14-18, 2016, Napa, California, U.S.A. Napa, CA ER - TY - JOUR A1 - Murib, M. S. A1 - Yeap, W. S. A1 - Eurlings, Y. A1 - Grinsven, B. van A1 - Boyen, H.-G. A1 - Conings, B. A1 - Michiels, L. A1 - Ameloot, M. A1 - Carleer, R. A1 - Warmer, J. A1 - Kaul, P. A1 - Haenen, K. A1 - Schöning, Michael Josef A1 - Ceuninck, W. de A1 - Wagner, P. T1 - Heat-transfer based characterization of DNA on synthetic sapphire chips JF - Sensors and Actuators B: Chemical N2 - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.snb.2016.02.027 SN - 0925-4005 VL - 230 IS - 230 SP - 260 EP - 271 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Barnat, Miriam A1 - Billerbeck, Katrin T1 - Hochschuldidaktisches Qualitätsmanagement - Ideen für die Ermöglichung guter Lehre T2 - Professionalisierung der Hochschuldidaktik: [42. Jahrestagung der Gesellschaft für Hochschuldidaktik im März 2013 an der Hochschule Magdeburg-Stendal] Y1 - 2016 SN - 978-3-7639-5533-6 N1 - Blickpunkt Hochschuldidaktik ; 127 : Tagung SP - 261 EP - 269 PB - Bertelsmann CY - Bielefeld ER - TY - JOUR A1 - Breuer, Lars A1 - Raue, Markus A1 - Strobel, M. A1 - Mang, Thomas A1 - Schöning, Michael Josef A1 - Thoelen, R. A1 - Wagner, Torsten T1 - Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems JF - Physica status solidi (a) N2 - Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium. Y1 - 2016 U6 - http://dx.doi.org/10.1002/pssa.201533056 SN - 1862-6300 VL - 213 IS - 6 SP - 1520 EP - 1525 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Bung, Daniel B. A1 - Valero, Daniel ED - Dewals, Benjamin T1 - Image processing techniques for velocity estimation in highly aerated flows: bubble image velocimetry vs. optical flow T2 - Sustainable Hydraulics in the Era of Global Change : Proceedings of the 4th IAHR Europe Congress (Liege, Belgium, 27-29 July 2016) Y1 - 2016 SN - 978-1-138-02977-4 SN - 978-1-4987-8149-7 (eBook) U6 - http://dx.doi.org/10.1201/b21902-31 SP - 151 EP - 157 PB - CRC Press ER - TY - CHAP A1 - Kahmann, Stephanie A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Müller, Lars-Peter A1 - Staat, Manfred ED - Erni, Daniel T1 - Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient’s quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student ́s t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly. Y1 - 2016 U6 - http://dx.doi.org/10.17185/duepublico/40821 SP - 7 EP - 8 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Neu, Eugen A1 - Janser, Frank A1 - Khatibi, Akbar A. A1 - Orifici, Adrian C. T1 - In-flight vibration-based structural health monitoring of aircraft wings T2 - 30th Congress of the internatonal council of the aeronautical sciences : 25.-30. September 2016, Daejeon, Korea N2 - This work presents a methodology for automated damage-sensitive feature extraction and anomaly detection under multivariate operational variability for in-flight assessment of wings. The method uses a passive excitation approach, i. e. without the need for artificial actuation. The modal system properties (natural frequencies and damping ratios) are used as damage-sensitive features. Special emphasis is placed on the use of Fiber Bragg Grating (FBG) sensing technology and the consideration of Operational and Environmental Variability (OEV). Measurements from a wind tunnel investigation with a composite cantilever equipped with FBG and piezoelectric sensors are used to successfully detect an impact damage. In addition, the feasibility of damage localisation and severity estimation is evaluated based on the coupling found between damageand OEV-induced feature changes. Y1 - 2016 ER - TY - JOUR A1 - Wollert, Jörg T1 - Industrial Internet of Things : Seifenblase oder Revolution JF - Elektronik Y1 - 2016 SN - 0013-5658 N1 - gedruckt in der Bereichsbibliothek Eupener Str. unter der Signatur Z 263 IS - 7 SP - 39 EP - 45 PB - WEKA-Fachmedien CY - München ER - TY - CHAP A1 - Wollert, Jörg T1 - Industrie 4.0 - warten bis die Revolution vorbei ist? T2 - Automatisierung im Fokus von Industrie 4.0 : Tagungsband AALE 2016 ; 13. Fachkonferenz, Lübeck Y1 - 2016 SN - 978-3-8356-7312-0 N1 - AALE-Konferenz <13., 2016, Lübeck> SP - 127 EP - 136 PB - DIV Deutscher Industrieverlag GmbH CY - München ER - TY - JOUR A1 - Hamad, E. M. A1 - Bilatto, S. E. R. A1 - Adly, N. Y. A1 - Correa, D. S. A1 - Wolfrum, B. A1 - Schöning, Michael Josef A1 - Offenhäusser, A. A1 - Yakushenko, A. T1 - Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices JF - Lab on a Chip N2 - Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing. Y1 - 2016 U6 - http://dx.doi.org/10.1039/C5LC01195G SN - 1473-0189 VL - 16 IS - 1 SP - 70 EP - 74 PB - Royal Society of Chemistry CY - Cambridge ER - TY - BOOK A1 - Janser, Frank A1 - Havermann, Marc A1 - Hoeveler, Bastian A1 - Hertz, Cyril T1 - Inkompressible Profil- und Tragflügelaerodynamik T3 - Strömungslehre und Aerodynamik ; Band 2 Y1 - 2016 SN - 978-3-8107-0261-6 N1 - Signatur in der Bibliothek: 21 ZSE 118 PB - Verlagshaus Mainz GmbH CY - Aachen ET - 1. Auflage ER - TY - BOOK A1 - Wilke, Thomas T1 - Innendekoration : graphische Vorlagen und theoretische Vorgaben für die wandfeste Dekoration von Appartement im 17. und 18. Jahrhundert in Frankreich Y1 - 2016 SN - 978-3-89235-233-4 N1 - Schriftenreihe des Kunsthistorischen Instituts der Universität Stuttgart ; 3. Band; Dissertation: Universität Stuttgart, 2012 PB - scaneg Verlag CY - München ER - TY - JOUR A1 - Lind, Thorsten Patric T1 - Insolvenzanfechtung: Keine Gläubigerbenachteiligung bei Ablösezahlung gegen Forderungsverzicht JF - Der Betrieb N2 - Schwerpunkt einer vorinsolvenzlichen Sanierung ist i.d.R., dass einzelne Gläubiger gegen Teilzahlungen auf ihre Forderungen verzichten und somit dem Unternehmen den notwendigen finanziellen Freiraum für einen Turnaround geben. Die Motivation der Gläubiger für einen Verzicht ist dabei auch die Überlegung, dass eine quotale Befriedigung im Rahmen eines Insolvenzverfahrens oft wesentlich geringer ausfallen würde als die durch den Vergleich realisierte Teilzahlung. Das Risiko, im Falle der Insolvenz eine Teilzahlung im Rahmen der Insolvenzanfechtung aber wieder zurückgewähren zu müssen, macht einen Forderungsverzicht weniger attraktiv. Mit Urteil vom 28.01.2016 hat der BGH nun entschieden, dass eine Insolvenzanfechtung mangels Gläubigerbenachteiligung ausscheidet, wenn der in der Teilzahlung liegende Vermögensverlust durch den damit verbundenen Verzicht auf die Restforderung voll ausgeglichen wird. Im Folgenden wird untersucht, ob dieses Urteil als Blaupause für eine anfechtungsfeste Restrukturierung einzelner Verbindlichkeiten dienen kann. Y1 - 2016 SN - 0005-9935 N1 - Printausgabe in der Bibliothek Eupener Str. vorhanden: 43 Z 364 VL - 69 IS - 17 SP - 999 EP - 1001 PB - Fachmedien Otto Schmidt CY - Düsseldorf ER - TY - CHAP A1 - Valero, Daniel A1 - Bung, Daniel B. T1 - Interfacial velocity estimation in highly aerated stepped spillway flows with a single tip fibre optical probe and Artificial Neural Networks T2 - 6th IAHR International Junior Researcher and Engineer Workshop on Hydraulic Structures, May 30th to June 1st 2016. Lübeck, Germany N2 - Air-water flows can be found in different engineering applications: from nuclear engineering to huge hydraulic structures. In this paper, a single tip fibre optical probe has been used to record high frequency (over 1 MHz) phase functions at different locations of a stepped spillway. These phase functions have been related to the interfacial velocities by means of Artificial Neural Networks (ANN) and the measurements of a classical double tip conductivity probe. Special attention has been put to the input selection and the ANN dimensions. Finally, ANN have shown to be able to link the signal rising times and plateau shapes to the air-water interfacial velocity. Y1 - 2016 U6 - http://dx.doi.org/10.15142/T3Q590 ER - TY - JOUR A1 - Wollert, Jörg A1 - Booke, Andreas T1 - IoT von der Stange JF - elektronik N2 - Heute sollte am besten jedes Gerät in die große Rechnerwolke eingebettet werden. Doch so einfach ist das nicht, denn Cloud ist viel mehr als nur das Internet der Dinge. Als Anwender muss man sich also fragen, welche Dienste man möchte und welchem Anbieter man sein Vertrauen schenkt. KW - Einbetten in das Internet der Dinge Y1 - 2016 IS - 21 (2016) SP - 30 EP - 37 PB - WEKA-Fachmedien CY - München ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Albracht, Kirsten A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk T1 - Isokinematic leg extension training with an industrial robot T2 - 6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore Y1 - 2016 U6 - http://dx.doi.org/10.1109/BIOROB.2016.7523750 SP - 950 EP - 955 ER - TY - CHAP A1 - Becker, Sebastian A1 - Höfken, Hans-Wilhelm A1 - Schütz, Philip A1 - Schuba, Marko ED - Schartner, P. T1 - IT-forensische Erkennung modifizierter Android-Apps T2 - Proceedings of DACH Security 2016, Klagenfurt, Austria, September 2016 N2 - Malware auf Smartphones ist ein Problem, dem auch Strafverfolgungsbehörden immer häufiger gegenüberstehen. Insbesondere Telefone, bei denen potentiell schadhafte Apps zu einem finanziellen Schaden geführt haben, finden sich auf den Schreibtischen der Polizei wieder. Dabei müssen die Ermittler möglichst schnell und gezielt erkennen können, ob eine App tatsächlich schadhaft manipuliert wurde, was manipuliert wurde und mit wem die App kommuniziert. Klassische Malware-Erkennungsverfahren helfen zwar bei der generellen Erkennung schadhafter Software, sind aber für die polizeiliche Praxis nicht geeignet. Dieses Paper stellt ein Programm vor, welches gerade die forensischen Fragestellungen berücksichtigt und so für den Einsatz in der Strafverfolgung in Frage kommt. Y1 - 2016 SP - 120 EP - 125 ER - TY - CHAP A1 - Streit, Wilfried T1 - Kalkulation T2 - Zahlentafeln für den Baubetrieb N2 - Das Kapitel behandelt die Kosten- und Preisermittlung, die Kostenvorgabe und Kostenkontrolle. Der Angebotspreis wird aufgeschlüsselt in die Einzelkosten der Teilleistungen, die Baustellengemeinkosten, die Allgemeinen Geschäftskosten und einen Zuschlag für Wagnis und Gewinn. Auf der Basis der Angebotskalkulation werden die Vorgaben für die Kostenkontrolle entwickelt. Y1 - 2016 SN - 978-3-658-02838-1 (Online) SN - 978-3-658-02837-4 (Print) U6 - http://dx.doi.org/10.1007/978-3-658-02838-1_13 SP - 1391 EP - 1501 PB - Springer Vieweg CY - Wiesbaden ET - 9., überarb. und aktual. Aufl. ER - TY - RPRT A1 - Damm, Marc André A1 - Anthrakidis, Anette A1 - Fend, Thomas T1 - Keramische Porenkörpersysteme als SCR-Mischer und Hydrolysekatalysator : BMBF-Projekt: Hydromix : Schlussbericht : Laufzeit: 01.10.2011 bis 31.03.2015 Y1 - 2016 CY - Aachen ER - TY - CHAP A1 - Bagheri, Mohsen A1 - Schleupen, Josef A1 - Dahmann, Peter A1 - Kallweit, Stephan T1 - Kletternde Wartungsplattform für die wetterunabhängige Instandhaltung von Rotorblättern an Windenergieanlagen - SMART T2 - AKIDA 2016 Aachener Kolloquium für Instandhaltung, Diagnose und Anlagenüberwachung (AKIDA) am 15. und 16.11.2016, Technologiezentrum Aachen N2 - In Deutschland liegt der Anteil der Windkraft an der Gesamtstromerzeugung bei 13,3% mit mehr als 25.000 installierten Windenergieanlagen (WEA). Weltweit erfährt die Windbranche ein rasantes Wachstum. Indien und China berichten eine jährliche Wachstumsrate an Neuinstallationen von 45%. Die Technologie zur Erzeugung elektrischer Energie aus Windkraft ist noch vergleichsweise jung. Durch die weltweit steigende Anzahl an Windenergieanlagen wächst zunehmend der Bedarf an innovativen Wartungslösungen. Komponenten wie Generator oder Getriebe sind inzwischen weitestgehend ausgereift. Der Fokus richtet sich zunehmend auf die wesentliche Kernkomponente - die Rotorblätter. Industriekletterer inspizieren die Rotorblätter oder Türme i.d.R. in einem zwei Jahres Rhythmus. Sie werden zunehmend durch Seilarbeitsbühnen unterstützt. Für größere Reparaturen kommen Kräne zum Einsatz, mit denen das Rotorblatt für die Instandhaltung demontiert wird. Die Standardinspektion besteht aus Sicht- und Klopfprüfung der Rotorblattoberfläche und ist nur bei sehr ruhiger Wetterlage durchführbar. Seit September 2014 wird das Forschungsprojekt SMART (Scanning, Monitoring, Analysis, Repair and Transportation), Entwicklung einer Wartungsplattform für WEA, vom BMWi gefördert. Das Konsortium besteht aus zwei Firmen und der Fachhochschule Aachen. Die SMART-Anlage klettert reibschlüssig am Turm der WEA mittels speziellen Kettenfahrwerken (Abbildung) auf- und abwärts. Ein ringförmiges Spannsystems, basierend auf dem Konzept der „Nürnberger“-Schere, erzeugt die erforderliche Anpresskraft für den Kletterprozess. Wettergeschützte Arbeitskabinen ermöglichen die ganzjährige Instandhaltung von Rotorblättern und ebenso Türmen. Dadurch können Wartungsarbeiten auf 24 Stunden am Tag ausgeweitet werden. Der kombinierte Einsatz (Sensorfusion) bildgebender Messtechnik wie Thermografie, Ultraschall, und Terahertz in der Arbeitskabine kann die Dokumentation, Effizienz und Qualität der Instandhaltungsarbeiten erheblich verbessern. Langfristiges Ziel von SMART ist ein Condition Monitoring für Rotorblätter und Türme auf Basis digitalisierter dreidimensionaler Volumenscans. Der kooperative Einsatz mit UAVs erweitert die Instandhaltungsstrategie. UAVs ermöglichen die schnelle, kostengünstige globale optische Inspektion von Rotorblattoberflächen zur Detektion potentieller Fehlstellen. Der „Proof-of-Concept“ Meilenstein wurde mit der Demonstration eines funktionsfähigen Modells im Dezember 2015 erfolgreich abgeschlossen. Y1 - 2016 ER - TY - CHAP A1 - Scheer, Nico A1 - Chu, Xiaoyan A1 - Salphati, Laurent A1 - Zamek-Gliszczynski, Maciej J. ED - Nicholls, Glynis T1 - Knockout and humanized animal models to study membrane transporters in drug development T2 - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development Y1 - 2016 SN - 978-1-78262-379-3 U6 - http://dx.doi.org/10.1039/9781782623793-00298 SP - 298 EP - 332 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Billerbeck, Katrin A1 - Barnat, Miriam A1 - Knutzen, Sönke T1 - Kompetenzorientierung auf dem Prüfstand. Erprobung von Indikatoren für den Kulturwandel JF - Die Hochschullehre N2 - Der Beitrag fokussiert die Frage nach dem Stand des durch die Bologna-Reform angestoßenen Kulturwandels im Hinblick auf Kompetenzorientierung am Beispiel der Technischen Universität Hamburg (TUHH). An der TUHH wird bereits seit einigen Jahren daran gearbeitet, die Lehre grundlegend neu auszurichten. Hierfür setzt das hochschuldidaktische "Zentrum für Lehre und Lernen" (ZLL) verschiedene Maßnahmen ein, wie z.B. eine finanzielle und didaktische Unterstützung von Lehrenden bei der Umstellung ihrer Veranstaltungen, Weiterqualifizierungsangebote und Informationsmaterial. Die Maßnahmen ebenso wie die innovierten Veranstaltungen werden von Lehrenden und Studierenden gut evaluiert. Nach dem Ansatz des Constructive Alignments lässt sich jedoch davon ausgehen, dass der Bereich der Prüfungen für eine Einschätzung des Status Quo der Kompetenzorientierung besonders relevant ist. Dieser wird deshalb anhand der beiden Kriterien Prüfungsformate und Schwierigkeitsstufen von Prüfungsaufgaben näher beleuchtet, die eng mit der Kompetenzorientierung zusammen hängen. Ergebnisse hierzu aus einer universitätsweiten Datenbank zur Studienorganisation sowie aus einer Online-Umfrage unter Studierenden weisen darauf hin, dass das Prüfungsformat "Klausur" nach wie vor am stärksten verbreitet ist; zugleich sind die Studierenden nach einer Selbsteinschätzung in Prüfungen vorrangig mit Aufgaben auf den Taxonomieniveaus "Wiedergeben" und "Anwenden" konfrontiert. Dies lässt sich als Hinweis darauf interpretieren, dass es im Hinblick auf eine Kompetenzorientierung in den Prüfungen noch weiteren Veränderungsbedarf gibt. Y1 - 2016 U6 - http://dx.doi.org/10.3278/HSL1616W SN - 2199-8825 VL - 2016 IS - 16 PB - WBV Media CY - Bielefeld ER - TY - CHAP A1 - Poghossian, Arshak A1 - Bronder, Thomas A1 - Scheja, S. A1 - Wu, Chunsheng A1 - Metzger-Boddien, C. A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices T2 - Procedia Engineering N2 - A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.proeng.2016.11.512 SN - 1877-7058 N1 - Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary VL - Vol. 168 SP - 514 EP - 517 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Vergé, Angela A1 - Pöttgen, Philipp A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Pelz, Peter F. ED - Greuloch, Ivo ED - Weber, Manfred ED - Meier, Miles T1 - Lebensdauer als Optimierungsziel: Algorithmische Struktursynthese am Beispiel eines hydrostatischen Getriebes JF - O+P – Ölhydraulik und Pneumatik N2 - Verfügbarkeit und Nachhaltigkeit sind wichtige Anforderungen bei der Planung langlebiger technischer Systeme. Meist werden bei Lebensdaueroptimierungen lediglich einzelne Komponenten vordefinierter Systeme untersucht. Ob eine optimale Lebensdauer eine gänzlich andere Systemvariante bedingt, wird nur selten hinterfragt. Technical Operations Research (TOR) erlaubt es, aus Obermengen technischer Systeme automatisiert die lebensdaueroptimale Systemstruktur auszuwählen. Der Artikel zeigt dies am Beispiel eines hydrostatischen Getriebes. Y1 - 2016 SN - 1614-9602 VL - 60 IS - 1-2 SP - 114 EP - 121 PB - Vereinigte Fachverl. CY - Mainz ER - TY - CHAP A1 - Schlösser, Karl Helmut T1 - Leistungsbeschreibung und Bauvertrag T2 - Zahlentafeln für den Baubetrieb N2 - Das Gesetz gegen Wettbewerbsbeschränkungen bildet die Grundlage für die Verordnung über die Vergabe öffentlicher Aufträge, aus der sich die Vergabe- und Vertragsordnungen für Freiberufliche Leistungen (VOF), für Lieferungen und Leistungen (VOL) und für Bauleistungen (VOB) ableiten. Die dabei in Frage kommenden Vergabeverfahren und die einzelnen Schwellenwerte gemäß EU-Recht werden detailliert aufbereitet und im Zusammenhang dargestellt. Die für die Ausgestaltung von Bauverträgen notwendigen Grundlagen des Werkvertragsrecht nach BGB sowie die branchenspezifischen Allgemeinen Geschäftsbedingungen in Form der Vertragsordnung für Bauleistungen (VOB) mit ihren Zusätzlichen und Besonderen Vertragsbedingungen werden intensiv aufbereitet. Das Zustandekommen eines Bauvertrages ergibt sich dann aus der notwendigen Leistungsbeschreibung mit einem Leistungsverzeichnis und verschiedenen Positionen oder in Form einer Funktionalen Leistungsbeschreibung (Beschreibung mit Leistungsprogramm). Das Auslandsgeschäft der Baubranche (Bauausführende Unternehmen sowie Beratende Ingenieure und Consultants) wird von den jeweils vorliegenden Internationalen Wettbewerbsbedingungen bestimmt, deren Zusammenhänge anhand umfangreicher statistischer Daten und anhand von Beispielen dargestellt werden. Y1 - 2016 SN - 978-3-658-02838-1 (Online) SN - 978-3-658-02837-4 (Print) U6 - http://dx.doi.org/10.1007/978-3-658-02838-1_6 SP - 635 EP - 961 PB - Springer Vieweg CY - Wiesbaden ET - 9., überarb. und aktual. Aufl. ER - TY - JOUR A1 - Wagner, Torsten A1 - Vornholt, Wolfgang A1 - Werner, Frederik A1 - Yoshinobu, Tatsuo A1 - Miyamoto, Ko-Ichiro A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening JF - Physics in medicine N2 - The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.phmed.2016.03.001 SN - 2352-4510 VL - 2016 IS - 1 SP - 2 EP - 7 ER - TY - JOUR A1 - Miyamoto, Ko-Ichiro A1 - Sato, Takuya A1 - Abe, Minami A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices JF - Micromachines N2 - A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement. KW - light-addressable potentiometric sensor KW - plug-based microfluidic device KW - chemical sensor Y1 - 2016 U6 - http://dx.doi.org/10.3390/mi7070111 SN - 2072-666X N1 - This article belongs to the Special Issue "Micro/Nano Devices for Chemical Analysis" VL - 7 IS - 7 SP - 111 PB - MDPI CY - Basel ER - TY - JOUR A1 - Ferrein, Alexander A1 - Steinbauer, Gerald T1 - Looking back on 20 Years of RoboCup JF - KI - Künstliche Intelligenz Y1 - 2016 U6 - http://dx.doi.org/10.1007/s13218-016-0443-y SN - 1610-1987 VL - 30 IS - 3-4 SP - 321 EP - 323 PB - Springer CY - Berlin ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinkovic, Marko A1 - Kubalski, Thomas A1 - Klinkel, Sven T1 - Masonry infilled reinforced concrete frames under horizontal loading T1 - Stahlbetonrahmen mit Ausfachungen aus Mauerwerk unter horizontalen Belastungen JF - Mauerwerk N2 - The behaviour of infilled reinforced concrete frames under horizontal load has been widely investigated, both experimentally and numerically. Since experimental tests represent large investments, numerical simulations offer an efficient approach for a more comprehensive analysis. When RC frames with masonry infill walls are subjected to horizontal loading, their behaviour is highly non-linear after a certain limit, which makes their analysis quite difficult. The non-linear behaviour results from the complex inelastic material properties of the concrete, infill wall and conditions at the wall-frame interface. In order to investigate this non-linear behaviour in detail, a finite element model using a micro modelling approach is developed, which is able to predict the complex non-linear behaviour resulting from the different materials and their interaction. Concrete and bricks are represented by a non-linear material model, while each reinforcement bar is represented as an individual part installed in the concrete part and behaving elasto-plastically. Each brick is modelled individually and connected taking into account the non-linearity of a brick mortar interface. The same approach is followed using two finite element software packages and the results are compared with the experimental results. The numerical models show a good agreement with the experiments in predicting the overall behaviour, but also very good matching for strength capacity and drift. The results emphasize the quality and the valuable contribution of the numerical models for use in parametric studies, which are needed for the derivation of design recommendations for infilled frame structures. Y1 - 2016 U6 - http://dx.doi.org/10.1002/dama.201600703 SN - 1437-1022 VL - 20 IS - 4 SP - 305 EP - 312 PB - Ernst & Sohn CY - Berlin ER -