TY  - JOUR
A1  - Scheer, Nico
A1  - Wilson, Ian D.
T1  - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
JF  - Drug Discovery Today
N2  - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.
Y1  - 2016
U6  - https://doi.org/10.1016/j.drudis.2015.09.002
SN  - 1359-6446
VL  - 21
IS  - 2
SP  - 250
EP  - 263
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Steinbauer, Gerald
T1  - 20 Years of RoboCup -  A Subjective Retrospection
JF  - KI - Künstliche Intelligenz
N2  - This summer, RoboCup competitions were held for the 20th time in Leipzig, Germany. It was the second time that RoboCup took place in Germany, 10 years after the 2006 RoboCup in Bremen. In this article, we give an overview on the latest developments of RoboCup and what happened in the different leagues over the last decade. With its 20th edition, RoboCup clearly is a success story and a role model for robotics competitions. From our personal view point, we acknowledge this by giving a retrospection about what makes RoboCup such a success.
Y1  - 2016
U6  - https://doi.org/10.1007/s13218-016-0449-5
SN  - 1610-1987
VL  - 30
IS  - 3
SP  - 225
EP  - 232
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Steinbauer, Gerald
A1  - Ferrein, Alexander
T1  - 20 Years of RoboCup
JF  - KI - Künstliche Intelligenz
Y1  - 2016
U6  - https://doi.org/10.1007/s13218-016-0442-z
SN  - 1610-1987
VL  - 30
IS  - 3-4
SP  - 221
EP  - 224
PB  - Springer
CY  - Berlin
ER  -