TY  - JOUR
A1  - Digel, Ilya
A1  - Kayser, Peter
A1  - Artmann, Gerhard
T1  - Molecular processes in biological thermosensation
JF  - Journal of Biophysics. 2008 (2008)
Y1  - 2008
SN  - 1687-8000
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael
JF  - Biorheology. 32 (1995), H. 5
Y1  - 1995
SN  - 0006-355x
SP  - 553
EP  - 570
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Sung, K.-L. Paul
A1  - Horn, Thomas
A1  - Whittemore, Darren [u.a.]
T1  - Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu
JF  - Biophysical journal. 72 (1997), H. 3
Y1  - 1997
SN  - 1542-0086
SP  - 1434
EP  - 1441
ER  - 
TY  - THES
A1  - Artmann, Gerhard
T1  - Methodische und experimentelle Beiträge zur Analyse der Ruheform, der Verformung und der Integrität humaner Erythrozyten
Y1  - 1999
N1  - Ilmenau, Techn. Univ., Habil.-Schr., 1999
ER  - 
TY  - JOUR
A1  - Becker, C.
A1  - Wallang, C.
A1  - Artmann, Gerhard
A1  - Jakse, G.
T1  - Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis
JF  - International Journal of Artificial Organs, The
Y1  - 2008
SN  - 0391-3988
N1  - Abstracts from the XXXV Congress of the European Society for Artificial Organs: 'Towards Future Biomedical Technologies' - ORAL PRESENTATIONS
VL  - 31
IS  - 7
SP  - 583
EP  - 583
ER  - 
TY  - JOUR
A1  - Bayer, Robin
A1  - Temiz Artmann, Aysegül
A1  - Digel, Ilya
A1  - Falkenstein, Julia
A1  - Artmann, Gerhard
A1  - Creutz, Till
A1  - Hescheler, Jürgen
T1  - Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model
JF  - Cellular Physiology and Biochemistry
N2  - Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.
Y1  - 2020
U6  - http://dx.doi.org/10.33594/000000225
SN  - 1421-9778
VL  - 54
SP  - 371
EP  - 383
PB  - Cell Physiol Biochem Press
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Goßmann, Matthias
A1  - Frotscher, Ralf
A1  - Linder, Peter
A1  - Bayer, Robin
A1  - Epple, U.
A1  - Staat, Manfred
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells
JF  - Cellular physiology and biochemistry
N2  - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
KW  - Inotropic compounds
KW  - Pharmacology
KW  - Ion channels
KW  - CellDrum
KW  - Heart tissue culture
KW  - Induced pluripotent stem cells
KW  - Cardiac myocytes
Y1  - 2016
U6  - http://dx.doi.org/10.1159/000443124
SN  - 1421-9778 (Online)
SN  - 1015-8987 (Print)
VL  - 38
IS  - 3
SP  - 1182
EP  - 1198
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Linder, Peter
A1  - Porst, Dariusz
T1  - Mechanism of haemoglobin sensing body temperature
JF  - Tissue Engineering Part A. 14 (2008), H. 5
Y1  - 2008
SN  - 1937-3341
N1  - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal
SP  - 754
EP  - 754
ER  - 
TY  - JOUR
A1  - Demirci, T.
A1  - Trzewik, J.
A1  - Linder, Peter
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison
JF  - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1046
EP  - 1047
ER  - 
TY  - JOUR
A1  - Demirci, T.
A1  - Trzewik, J.
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level
JF  - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1030
EP  - 1031
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Grosse, Joachim O.
A1  - Grossmann, Matthias
A1  - Janke, Heinz Peter
A1  - Arndt, Patrick
A1  - Koch, Sabine
A1  - Epple, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation
JF  - Journal of Biomaterials Applications
Y1  - 2017
U6  - http://dx.doi.org/10.1177/0885328217723178
SN  - 1530-8022
VL  - 32
IS  - 3
SP  - 321
EP  - 330
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Eijck, Lambert van
A1  - Demmel, Franz
A1  - Artmann, Gerhard
A1  - Stadtler, Andreas Maximilian
T1  - Macromolecular dynamics in red blood cells investigated using neutron spectroscopy
JF  - Journal of the Royal Society Interface
Y1  - 2011
SN  - 1742-5689
VL  - 8
IS  - 57
SP  - 590
EP  - 600
PB  - The Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Trzewik, J.
A1  - Schmid-Schönbein, G. W.
T1  - Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Schönbein, G. W.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 521
EP  - 522
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zhou-Stache, J.
A1  - Buettner, R.
A1  - Mittermayer, C. [u.a.]
T1  - Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.
JF  - Medical and Biological Engineering and Computing. 40 (2002), H. 6
Y1  - 2002
SN  - 0140-0118
SP  - 698
EP  - 703
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schmid-Schönbein, H.
A1  - Schröder, Susanne
A1  - Grebe, R. [u.a.]
T1  - Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Schönbein, H.; Schröder, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.
JF  - Arzneimittelforschung. 38 (1988), H. 5
Y1  - 1988
SN  - 0004-4172
SP  - 710
EP  - 716
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Leimena, W.
A1  - Dachwald, Bernd
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Funke, O.
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - In-situ biological decontamination of an ice melting probe : [abstract]
N2  - The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.
KW  - Sonde
KW  - Dekontamination
KW  - Wasserstoffperoxid
KW  - Natriumhypochlorit
Y1  - 2010
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Gorbatenkova, E. A.
A1  - Panasenko, O. M.
T1  - Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M.
JF  - Membrane and cell biology. 13 (2000), H. 4
Y1  - 2000
SN  - 1023-6597
SP  - 537
EP  - 546
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
T1  - HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten für die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "Förderung von innovativen Netzwerken" (InnoNet) des Bundesministerium für Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010
Y1  - 2011
U6  - http://dx.doi.org/10.2314/GBV:68757076X
N1  - Förderkennzeichen BMWi 16IN0536. - Verbund-Nr. 01056220
PB  - Technische Informationsbibliothek u. Universitätsbibliothek
CY  - Aachen [u.a.]
ER  - 
TY  - JOUR
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Kayser, Peter
A1  - Porst, Dariusz
A1  - Artmann, Gerhard
T1  - High-throughput testing of mechanical forces generated in thin cell and tissue layers
JF  - Tissue Engineering. 13 (2007), H. 7
Y1  - 2007
SN  - 1076-3279
N1  - Meeting abstract 433
SP  - 1778
EP  - 1778
ER  - 
TY  - JOUR
A1  - Li, Anlan
A1  - Shi, Young de
A1  - Landsmann, B.
A1  - Schankowski-Bouvier, P.
A1  - Dikta, Gerhard
A1  - Bauer, U.
A1  - Artmann, Gerhard
T1  - Hemorheology and walking distance of Peripheral Arterial Occlusive Disease patients during treatment with Ginkgo-biloba extract
JF  - Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5
Y1  - 1998
SN  - 1745-7254
N1  - ISSN der parallelen Ausgabe 1671-4083; China-Zs.-Code: CN31-1347 abstract frei unter
SP  - 417
EP  - 421
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
T1  - Hemoglobin Senses Body Temperature
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 415
EP  - 447
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Maggakis-Kelemen, Christina
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Stadler, David
A1  - Dikta, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Hemoglobin senses body temperature
JF  - European Biophysics Journal
Y1  - 2009
SN  - 0175-7571
VL  - 38
IS  - 5
SP  - 589
EP  - 600
ER  - 
TY  - JOUR
A1  - Stadler, A.  M.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Embs, Jan P.
A1  - Zaccai, Joe
A1  - Büldt, Georg
T1  - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature
JF  - Biophysical Journal. 95 (2008), H. 11
Y1  - 2008
SN  - 1542-0086
SP  - 5449
EP  - 5461
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Seifarth, Volker
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Staat, Manfred
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.
KW  - Mechanical simulation
KW  - Growth modelling
KW  - Ureter
KW  - Bladder
KW  - Reconstruction
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - http://dx.doi.org/10.1007/978-981-10-7904-7_9
SP  - 209
EP  - 232
PB  - Springer
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schikarsky, C.
T1  - Ginkgo Biloba extract (EGb 761) protects red blood cells from oxidative damage. Artmann, Gerhard Michael; Schikarsky, C.
JF  - Clinical Hemorheology. 13 (1993), H. 4
Y1  - 1993
SN  - 0271-5198
SP  - 529
EP  - 539
ER  - 
TY  - JOUR
A1  - Kurulgan Demirci, Eylem
A1  - Demirci, T.
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Karakulah, G.
A1  - Artmann, Gerhard
A1  - Sakizli, M.
A1  - Temiz Artmann, Aysegül
T1  - Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation
JF  - Cellular and molecular bioengineering. 4 (2011), H. 1
Y1  - 2011
SN  - 1865-5025
SP  - 46
EP  - 55
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Demirci, Taylan
A1  - Kurulgan Demirci, Eylem
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Sakizli, Meral
A1  - Temiz Artmann, Aysegül
T1  - Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress
JF  - IUBMB Life. 61 (2009), H. 3
Y1  - 2009
SN  - 1521-6543
N1  - Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey
SP  - 311
EP  - 312
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Meruvu, Haritha
A1  - Kizildag, Sefa
A1  - Temiz Artmann, Aysegül
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - http://dx.doi.org/10.1007/978-981-10-7904-7_7
SP  - 157
EP  - 192
PB  - Springer
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zang, Werner
T1  - Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen
JF  - Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3
Y1  - 1990
SN  - 0013-5585
SP  - 94
EP  - 96
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Digel, Ilya
A1  - Embs, Jan P.
A1  - Unruh, Tobias
A1  - Tehei, M.
A1  - Zaccai, G.
A1  - Büldt, G.
A1  - Artmann, Gerhard
T1  - From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature
JF  - Biophysical Journal. 96 (2009), H. 12
Y1  - 2009
SN  - 0006-3495
SP  - 5073
EP  - 5081
PB  - Cell Press
CY  - Cambridge, Mass.
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Hueck, Isgard S.
A1  - Rossiter, Katharine
A1  - Schmid-Schönbein, Geert W.
T1  - Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Schönbein, Geert W.
JF  - Microcirculation. 15 (2008), H. 6
Y1  - 2008
SN  - 1549-8719
SP  - 531
EP  - 542
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
T1  - FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten für die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010
Y1  - 2011
U6  - http://dx.doi.org/10.2314/GBV:782964621
N1  - Förderkennzeichen BMBF 1760X07
PB  - Technische Informationsbibliothek u. Universitätsbibliothek
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Leimena, W.
A1  - Artmann, Gerhard
A1  - Dachwald, Bernd
A1  - Temiz Artmann, Aysegül
A1  - Gossmann, Matthias
A1  - Digel, Ilya
T1  - Feasibility of an in-situ microbial decontamination of an ice-melting probe
JF  - Eurasian Chemico-Technological Journal. 12 (2010), H. 2
Y1  - 2010
SN  - 1562-3920
SP  - 145
EP  - 150
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Witte, Ch.
T1  - Expertensystem für Personal Computer zur Strukturbestimmung des Circulus Arteriosus Willisii mittels transkranieller Dopplersonografie. Witte, Ch.; Artmann, Gerhard Michael
JF  - Biomedizinische Technik = Biomedical engineering. 36 (1991)
Y1  - 1991
SN  - 0013-5585
SP  - 228
EP  - 230
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Trzewik, Jürgen
A1  - Mallipattu, S. K.
A1  - Delano, F. A. [u.a.]
T1  - Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, Jürgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W
JF  - The FASEB Journal. 15 (2001)
Y1  - 2001
SN  - 1530-6860
SP  - 1711
EP  - 1717
ER  - 
TY  - JOUR
A1  - Trzewik, Jürgen
A1  - Temiz Artmann, Aysegül
A1  - Linder, Peter
A1  - Demirci, T.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Evaluation of lateral mechanical tension in thin-film tissue constructs
JF  - Annals of Biomedical Engineering. 32 (2004), H. 9
Y1  - 2004
SN  - 1573-9686
SP  - 1243
EP  - 1251
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
T1  - Escherichia Coli Infektion und Zellschädigung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701
Y1  - 2004
U6  - http://dx.doi.org/10.2314/GBV:482527137
PB  - Technische Informationsbibliothek u. Universitätsbibliothek
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Vogel, A.
A1  - Zink, S.
A1  - Stache, O.
T1  - Entwicklung eines automatisierten, computergesteuerten Permeabilitätsanalysators zur Messung an Endothelzellen / Vogel, A. ; Zinke, S. ; Stache, O. ; Königsfeld, J. ; Artmann, G.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 479
EP  - 480
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Hovav, T.
A1  - Goldfarb, A.
A1  - Yedgar, S. [u.a.]
T1  - Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G.
JF  - British Journal of Haematology. 106 (1999), H. 1
Y1  - 1999
SN  - 1365-2141
SP  - 178
EP  - 181
ER  - 
TY  - JOUR
A1  - Preiß, C.
A1  - Linder, Peter
A1  - Wendt, K.
A1  - Krystek, M.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Bassam, Rasha
A1  - Artmann, Gerhard
T1  - Engineering technology for plant physiology and plant stress research
N2  - Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.
KW  - Pflanzenphysiologie
KW  - Pflanzenstress
KW  - Pflanzenscanner
KW  - plant stress
KW  - plant scanner
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Bassam, Rasha
A1  - Hescheler, Jürgen
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Digel, Ilya
T1  - Effects of spermine NONOate and ATP on the thermal stability of hemoglobin
JF  - BMC Biophysics
N2  - Background
Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min.

Results
Major results were:
1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment,
2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and
3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature.

Conclusion
The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.
KW  - Nitric Oxide Donor
KW  - NONOate
KW  - Circular Dichroism
KW  - Nitric Oxide
Y1  - 2012
U6  - http://dx.doi.org/10.1186/2046-1682-5-16
SN  - 2046-1682
VL  - 5
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Bassam, Rasha
A1  - Digel, Ilya
A1  - Hescheler, Jürgen
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences
JF  - BMC Biophysics
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?10.1186/2046-1682-6-1
SN  - 2046-1682
SP  - 1
EP  - 14
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Li, Anlan
A1  - Seipelt, H.
A1  - Müller, C. [u.a.]
T1  - Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; Müller, C.;Shi, Yong de; Artmann, Gerhard Michael
JF  - Pharmacology and Toxicology. 85 (1999)
Y1  - 1999
SN  - 0902-9938
SP  - 206
EP  - 211
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - Effects of plasma generated ions on bacteria : [poster]
N2  - Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.
KW  - Clusterion
KW  - Bakterien
KW  - plasma generated ions
Y1  - 2003
ER  - 
TY  - CHAP
A1  - Schlemmer, Katharina
A1  - Porst, Dariusz
A1  - Bassam, Rasha
A1  - Artmann, Gerhard
A1  - Digel, Ilya
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 100
EP  - 101
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Bassam, Rasha
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Effect of nitric oxide on protein thermal stability : [abstract]
N2  - As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.
KW  - Stickstoffmonoxid
KW  - Proteine
KW  - Hämoglobin
KW  - nitric oxide gas
KW  - protein
KW  - hemoglobin
Y1  - 2009
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Büldt, Georg
A1  - Zaccai, Guiseppe
A1  - Artmann, Gerhard
T1  - Dynamics and interactions of hemoglobin in red blood cells
JF  - Tissue Engineering Part A. 14 (2008), H. 5
Y1  - 2008
SN  - 1937-3341
N1  - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal
SP  - 724
EP  - 724
ER  - 
TY  - JOUR
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Stadler, Andreas M.
A1  - Büldt, Georg
A1  - Zaccai, Guiseppe
A1  - Artmann, Gerhard
T1  - Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions
JF  - Regenerative medicine. 2 (2007), H. 5
Y1  - 2007
SN  - 1746-0751
N1  - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany
SP  - 573
EP  - 573
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Li, Anlan
T1  - Dihydroergocryptine maintains erythrocyte fluidity in acidotic and hyperosmolar suspensions modelling hypoxic and ischemic microcirculation. Li, Anlan; Artmann, Gerhard Michael
JF  - Clinical Hemorheology. 15 (1994), H. 2
Y1  - 1994
SN  - 0271-5198
SP  - 133
EP  - 146
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Montanus, M.
A1  - Teitel, P.
T1  - Die photometrische Kapillaraggregation- ein neues Verfahren zur Messung der Erythrozytenaggregation. Montanus, M.; Artmann, Gerhard Michael; Teitel, P.
JF  - Biomedizinische Technik = Biomedical engineering. 36 (1991)
Y1  - 1991
SN  - 0013-5585
SP  - 213
EP  - 215
ER  -