TY - JOUR A1 - Kahmann, Stephanie L. A1 - Rausch, Valentin A1 - Plümer, Jonathan A1 - Müller, Lars P. A1 - Pieper, Martin A1 - Wegmann, Kilian T1 - The automized fracture edge detection and generation of three-dimensional fracture probability heat maps JF - Medical Engineering & Physics N2 - With proven impact of statistical fracture analysis on fracture classifications, it is desirable to minimize the manual work and to maximize repeatability of this approach. We address this with an algorithm that reduces the manual effort to segmentation, fragment identification and reduction. The fracture edge detection and heat map generation are performed automatically. With the same input, the algorithm always delivers the same output. The tool transforms one intact template consecutively onto each fractured specimen by linear least square optimization, detects the fragment edges in the template and then superimposes them to generate a fracture probability heat map. We hypothesized that the algorithm runs faster than the manual evaluation and with low (< 5 mm) deviation. We tested the hypothesis in 10 fractured proximal humeri and found that it performs with good accuracy (2.5 mm ± 2.4 mm averaged Euclidean distance) and speed (23 times faster). When applied to a distal humerus, a tibia plateau, and a scaphoid fracture, the run times were low (1–2 min), and the detected edges correct by visual judgement. In the geometrically complex acetabulum, at a run time of 78 min some outliers were considered acceptable. An automatically generated fracture probability heat map based on 50 proximal humerus fractures matches the areas of high risk of fracture reported in medical literature. Such automation of the fracture analysis method is advantageous and could be extended to reduce the manual effort even further. KW - Fracture classification KW - Shoulder KW - Probability distribution mapping KW - Morphing KW - Imaging Y1 - 2022 SN - 1350-4533 VL - 2022 IS - 110 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - Testing marginal homogeneity in Hilbert spaces with applications to stock market returns JF - Test N2 - This paper considers a paired data framework and discusses the question of marginal homogeneity of bivariate high-dimensional or functional data. The related testing problem can be endowed into a more general setting for paired random variables taking values in a general Hilbert space. To address this problem, a Cramér–von-Mises type test statistic is applied and a bootstrap procedure is suggested to obtain critical values and finally a consistent test. The desired properties of a bootstrap test can be derived that are asymptotic exactness under the null hypothesis and consistency under alternatives. Simulations show the quality of the test in the finite sample case. A possible application is the comparison of two possibly dependent stock market returns based on functional data. The approach is demonstrated based on historical data for different stock market indices. Y1 - 2022 U6 - http://dx.doi.org/10.1007/s11749-022-00802-5 SN - 1863-8260 VL - 2022 IS - 31 SP - 749 EP - 770 PB - Springer ER - TY - CHAP A1 - Mahdi, Zahra A1 - Dersch, Jürgen A1 - Schmitz, Pascal A1 - Dieckmann, Simon A1 - Caminos, Ricardo Alexander Chico A1 - Teixeira Boura, Cristiano José A1 - Herrmann, Ulf A1 - Schwager, Christian A1 - Schmitz, Mark A1 - Gielen, Hans A1 - Gedle, Yibekal A1 - Büscher, Rauno T1 - Technical assessment of Brayton cycle heat pumps for the integration in hybrid PV-CSP power plants T2 - SOLARPACES 2020 N2 - The hybridization of Concentrated Solar Power (CSP) and Photovoltaics (PV) systems is a promising approach to reduce costs of solar power plants, while increasing dispatchability and flexibility of power generation. High temperature heat pumps (HT HP) can be utilized to boost the salt temperature in the thermal energy storage (TES) of a Parabolic Trough Collector (PTC) system from 385 °C up to 565 °C. A PV field can supply the power for the HT HP, thus effectively storing the PV power as thermal energy. Besides cost-efficiently storing energy from the PV field, the power block efficiency of the overall system is improved due to the higher steam parameters. This paper presents a technical assessment of Brayton cycle heat pumps to be integrated in hybrid PV-CSP power plants. As a first step, a theoretical analysis was carried out to find the most suitable working fluid. The analysis included the fluids Air, Argon (Ar), Nitrogen (N2) and Carbon dioxide (CO2). N2 has been chosen as the optimal working fluid for the system. After the selection of the ideal working medium, different concepts for the arrangement of a HT HP in a PV-CSP hybrid power plant were developed and simulated in EBSILON®Professional. The concepts were evaluated technically by comparing the number of components required, pressure losses and coefficient of performance (COP). KW - Solar thermal technologies KW - Hybrid energy system KW - Concentrated solar power KW - Power plants KW - Energy storage Y1 - 2022 SN - 978-0-7354-4195-8 U6 - http://dx.doi.org/10.1063/5.0086269 SN - 1551-7616 (online) SN - 0094-243X (print) N1 - 26th International Conference on Concentrating Solar Power and Chemical Energy Systems 28 September–2 October 2020 Freiburg, Germany IS - 2445 / 1 PB - AIP conference proceedings / American Institute of Physics CY - Melville, NY ER - TY - CHAP A1 - Welden, Melanie A1 - Severins, Robin A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Siegert, Petra A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors T2 - 2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) N2 - A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy. KW - Tobacco mosaic virus KW - acetoin KW - capacitive field-effect biosensor KW - enzyme immobilization Y1 - 2022 SN - 978-1-6654-5860-3 (Online) SN - 978-1-6654-5861-0 (Print) U6 - http://dx.doi.org/10.1109/ISOEN54820.2022.9789657 N1 - IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 29 May 2022 - 01 June 2022, Aveiro, Portugal. PB - IEEE ER - TY - CHAP A1 - Staat, Manfred A1 - Tran, Ngoc Trinh T1 - Strain based brittle failure criteria for rocks T2 - Proceedings of (NACOME2022) The 11th National Conference on Mechanics, Vol. 1. Solid Mechanics, Rock Mechanics, Artificial Intelligence, Teaching and Training, Hanoi, December 2-3, 2022 N2 - When confining pressure is low or absent, extensional fractures are typical, with fractures occurring on unloaded planes in rock. These “paradox” fractures can be explained by a phenomenological extension strain failure criterion. In the past, a simple empirical criterion for fracture initiation in brittle rock has been developed. But this criterion makes unrealistic strength predictions in biaxial compression and tension. A new extension strain criterion overcomes this limitation by adding a weighted principal shear component. The weight is chosen, such that the enriched extension strain criterion represents the same failure surface as the Mohr–Coulomb (MC) criterion. Thus, the MC criterion has been derived as an extension strain criterion predicting failure modes, which are unexpected in the understanding of the failure of cohesive-frictional materials. In progressive damage of rock, the most likely fracture direction is orthogonal to the maximum extension strain. The enriched extension strain criterion is proposed as a threshold surface for crack initiation CI and crack damage CD and as a failure surface at peak P. Examples show that the enriched extension strain criterion predicts much lower volumes of damaged rock mass compared to the simple extension strain criterion. KW - Extension fracture KW - Extension strain criterion KW - Mohr–Coulomb criterion KW - Evolution of damage Y1 - 2023 SN - 978-604-357-084-7 SP - 500 EP - 509 PB - Nha xuat ban Khoa hoc tu nhien va Cong nghe (Verlag Naturwissenschaft und Technik) CY - Hanoi ER - TY - CHAP A1 - Butenweg, Christoph ED - Vacareanu, Radu ED - Ionescu, Constantin T1 - Seismic design and evaluation of industrial facilities T2 - Progresses in European Earthquake Engineering and Seismology. Third European Conference on Earthquake Engineering and Seismology – Bucharest, 2022 N2 - Industrial facilities must be thoroughly designed to withstand seismic actions as they exhibit an increased loss potential due to the possibly wideranging damage consequences and the valuable process engineering equipment. Past earthquakes showed the social and political consequences of seismic damage to industrial facilities and sensitized the population and politicians worldwide for the possible hazard emanating from industrial facilities. However, a holistic approach for the seismic design of industrial facilities can presently neither be found in national nor in international standards. The introduction of EN 1998-4 of the new generation of Eurocode 8 will improve the normative situation with specific seismic design rules for silos, tanks and pipelines and secondary process components. The article presents essential aspects of the seismic design of industrial facilities based on the new generation of Eurocode 8 using the example of tank structures and secondary process components. The interaction effects of the process components with the primary structure are illustrated by means of the experimental results of a shaking table test of a three story moment resisting steel frame with different process components. Finally, an integrated approach of digital plant models based on building information modelling (BIM) and structural health monitoring (SHM) is presented, which provides not only a reliable decision-making basis for operation, maintenance and repair but also an excellent tool for rapid assessment of seismic damage. KW - Industrial facilities KW - Seismic design KW - Tanks KW - EN 1998-4 KW - Structural health monitoring Y1 - 2022 SN - 978-3-031-15103-3 SN - 978-3-031-15106-4 SN - 978-3-031-15104-0 U6 - http://dx.doi.org/10.1007/978-3-031-15104-0 SN - 2524-342X SN - 2524-3438 N1 - Third European Conference on Earthquake Engineering and Seismology. 04-09.09 Bucharest, Romania. SP - 449 EP - 464 PB - Springer CY - Cham ER - TY - CHAP A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Razzaque, Mohammed S. T1 - Role of vitamins in maintaining structure and function of intestinal microbiome T2 - Comprehensive Gut Microbiota N2 - The recent advances in microbiology have shed light on understanding the role of vitamins beyond the nutritional range. Vitamins are critical in contributing to healthy biodiversity and maintaining the proper function of gut microbiota. The sharing of vitamins among bacterial populations promotes stability in community composition and diversity; however, this balance becomes disturbed in various pathologies. Here, we overview and analyze the ability of different vitamins to selectively and specifically induce changes in the intestinal microbial community. Some schemes and regularities become visible, which may provide new insights and avenues for therapeutic management and functional optimization of the gut microbiota. KW - Vitamin A KW - Vitamin B KW - Thiamine KW - Riboflavin KW - Niacin Y1 - 2022 SN - 978-0-12-822036-8 U6 - http://dx.doi.org/10.1016/B978-0-12-819265-8.00043-7 SP - 320 EP - 334 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Allal, D. A1 - Bannister, R. A1 - Buisman, K. A1 - Capriglione, D. A1 - Di Capua, G. A1 - García-Patrón, M. A1 - Gatzweiler, Thomas A1 - Gellersen, F. A1 - Harzheim, Thomas A1 - Heuermann, Holger A1 - Hoffmann, J. A1 - Izbrodin, A. A1 - Kuhlmann, K. A1 - Lahbacha, K. A1 - Maffucci, A. A1 - Miele, G. A1 - Mubarak, F. A1 - Salter, M. A1 - Pham, T.D. A1 - Sayegh, A. A1 - Singh, D. A1 - Stein, F. A1 - Zeier, M. T1 - RF measurements for future communication applications: an overview T2 - 2022 IEEE International Symposium on Measurements & Networking (M&N) N2 - In this paper research activities developed within the FutureCom project are presented. The project, funded by the European Metrology Programme for Innovation and Research (EMPIR), aims at evaluating and characterizing: (i) active devices, (ii) signal- and power integrity of field programmable gate array (FPGA) circuits, (iii) operational performance of electronic circuits in real-world and harsh environments (e.g. below and above ambient temperatures and at different levels of humidity), (iv) passive inter-modulation (PIM) in communication systems considering different values of temperature and humidity corresponding to the typical operating conditions that we can experience in real-world scenarios. An overview of the FutureCom project is provided here, then the research activities are described. KW - FPGA KW - signal integrity KW - power integrity KW - passive inter-modulation KW - metrological characterization Y1 - 2022 SN - 978-1-6654-8362-9 SN - 978-1-6654-8363-6 U6 - http://dx.doi.org/10.1109/MN55117.2022.9887740 SN - 2639-5061 SN - 2639-507X N1 - 2022 IEEE International Symposium on Measurements & Networking (M&N), 18-20 July 2022, Padua, Italy. SP - 1 EP - 6 PB - IEEE ER - TY - JOUR A1 - Pourshahidi, Ali Mohammad A1 - Engelmann, Ulrich M. A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Resolving ambiguities in core size determination of magnetic nanoparticles from magnetic frequency mixing data JF - Journal of Magnetism and Magnetic Materials N2 - Frequency mixing magnetic detection (FMMD) has been widely utilized as a measurement technique in magnetic immunoassays. It can also be used for the characterization and distinction (also known as “colourization”) of different types of magnetic nanoparticles (MNPs) based on their core sizes. In a previous work, it was shown that the large particles contribute most of the FMMD signal. This leads to ambiguities in core size determination from fitting since the contribution of the small-sized particles is almost undetectable among the strong responses from the large ones. In this work, we report on how this ambiguity can be overcome by modelling the signal intensity using the Langevin model in thermodynamic equilibrium including a lognormal core size distribution fL(dc,d0,σ) fitted to experimentally measured FMMD data of immobilized MNPs. For each given median diameter d0, an ambiguous amount of best-fitting pairs of parameters distribution width σ and number of particles Np with R2 > 0.99 are extracted. By determining the samples’ total iron mass, mFe, with inductively coupled plasma optical emission spectrometry (ICP-OES), we are then able to identify the one specific best-fitting pair (σ, Np) one uniquely. With this additional externally measured parameter, we resolved the ambiguity in core size distribution and determined the parameters (d0, σ, Np) directly from FMMD measurements, allowing precise MNPs sample characterization. Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.jmmm.2022.169969 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169969 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Zähl, Philipp M. A1 - Biewendt, Marcel A1 - Wolf, Martin A1 - Eggert, Mathias T1 - Requirements for Competence Developing Games in the Environment of SE Competence Development T2 - Angewandte Forschung in der Wirtschaftsinformatik 2022 N2 - Many of today’s factors make software development more and more complex, such as time pressure, new technologies, IT security risks, et cetera. Thus, a good preparation of current as well as future software developers in terms of a good software engineering education becomes progressively important. As current research shows, Competence Developing Games (CDGs) and Serious Games can offer a potential solution. This paper identifies the necessary requirements for CDGs to be conducive in principle, but especially in software engineering (SE) education. For this purpose, the current state of research was summarized in the context of a literature review. Afterwards, some of the identified requirements as well as some additional requirements were evaluated by a survey in terms of subjective relevance. KW - software engineering KW - requirements KW - competence developing games KW - systematic literature review Y1 - 2022 SN - 978-3-95545-409-8 U6 - http://dx.doi.org/10.30844/AKWI_2022_05 N1 - Tagungsband zur 35. Jahrestagung des Arbeitskreises Wirtschaftsinformatik an Hochschulen für Angewandte Wissenschaften im deutschsprachigen Raum (AKWI) vom 11.09. bis 13.09.2022, ausgerichtet von der Hochschule für Technik und Wirtschaft Berlin (HTW Berlin) und der Hochschule für Wirtschaft und Recht Berlin (HWR Berlin) SP - 73 EP - 88 PB - GITO CY - Berlin ER - TY - CHAP A1 - Chavez Bermudez, Victor Francisco A1 - Cruz Castanon, Victor Fernando A1 - Ruchay, Marco A1 - Wollert, Jörg ED - Leipzig, Hochschule für Technik, Wirtschaft und Kultur T1 - Rapid prototyping framework for automation applications based on IO-Link T2 - Tagungsband AALE 2022 N2 - The development of protype applications with sensors and actuators in the automation industry requires tools that are independent of manufacturer, and are flexible enough to be modified or extended for any specific requirements. Currently, developing prototypes with industrial sensors and actuators is not straightforward. First of all, the exchange of information depends on the industrial protocol that these devices have. Second, a specific configuration and installation is done based on the hardware that is used, such as automation controllers or industrial gateways. This means that the development for a specific industrial protocol, highly depends on the hardware and the software that vendors provide. In this work we propose a rapid-prototyping framework based on Arduino to solve this problem. For this project we have focused to work with the IO-Link protocol. The framework consists of an Arduino shield that acts as the physical layer, and a software that implements the IO-Link Master protocol. The main advantage of such framework is that an application with industrial devices can be rapid-prototyped with ease as its vendor independent, open-source and can be ported easily to other Arduino compatible boards. In comparison, a typical approach requires proprietary hardware, is not easy to port to another system and is closed-source. KW - Rapid-prototyping KW - Arduino KW - IO-Link KW - Industrial Communication Y1 - 2022 SN - 978-3-910103-00-9 U6 - http://dx.doi.org/10.33968/2022.28 N1 - 18. AALE-Konferenz, Pforzheim, 09.03.-11.03.2022. CY - Leipzig ER - TY - JOUR A1 - Monakhova, Yulia A1 - Soboleva, Polina M. A1 - Fedotova, Elena S. A1 - Musina, Kristina T. A1 - Burmistrova, Natalia A. T1 - Quantum chemical calculations of IR spectra of heparin disaccharide subunits JF - Computational and Theoretical Chemistry N2 - Heparin is a natural polysaccharide, which plays essential role in many biological processes. Alterations in building blocks can modify biological roles of commercial heparin products, due to significant changes in the conformation of the polymer chain. The variability structure of heparin leads to difficulty in quality control using different analytical methods, including infrared (IR) spectroscopy. In this paper molecular modelling of heparin disaccharide subunits was performed using quantum chemistry. The structural and spectral parameters of these disaccharides have been calculated using RHF/6-311G. In addition, over-sulphated chondroitin sulphate disaccharide was studied as one of the most widespread contaminants of heparin. Calculated IR spectra were analyzed with respect to specific structure parameters. IR spectroscopic fingerprint was found to be sensitive to substitution pattern of disaccharide subunits. Vibrational assignments of calculated spectra were correlated with experimental IR spectral bands of native heparin. Chemometrics was used to perform multivariate analysis of simulated spectral data. KW - IR spectroscopy KW - Chemometrics KW - Quantum chemistry KW - Molecular modelling KW - Quality control Y1 - 2022 SN - 2210-271X U6 - http://dx.doi.org/10.1016/j.comptc.2022.113891 VL - 1217 IS - Article number: 113891 PB - Elsevier CY - New York, NY ER - TY - CHAP A1 - Schopen, Oliver A1 - Shabani, Bahman A1 - Esch, Thomas A1 - Kemper, Hans A1 - Shah, Neel ED - Rahim, S.A. ED - As'arry, A. ED - Zuhri, M.Y.M. ED - Harmin, M.Y. ED - Rezali, K.A.M. ED - Hairuddin, A.A. T1 - Quantitative evaluation of health management designs for fuel cell systems in transport vehicles T2 - 2nd UNITED-SAIG International Conference Proceedings N2 - Focusing on transport vehicles, mainly with regard to aviation applications, this paper presents compilation and subsequent quantitative evaluation of methods aimed at building an optimum integrated health management solution for fuel cell systems. The methods are divided into two different main types and compiled in a related scheme. Furthermore, different methods are analysed and evaluated based on parameters specific to the aviation context of this study. Finally, the most suitable method for use in fuel cell health management systems is identified and its performance and suitability is quantified. KW - aviation application KW - health management systems KW - fuel cell systems Y1 - 2022 N1 - 2nd UNITED-SAIG International Conference, 23-24 May 2022, Putrajaya, Malaysia SP - 1 EP - 3 ER - TY - JOUR A1 - Coll-Perales, Baldomero A1 - Schulte-Tigges, Joschua A1 - Rondinone, Michele A1 - Gozalvez, Javier A1 - Reke, Michael A1 - Matheis, Dominik A1 - Walter, Thomas T1 - Prototyping and evaluation of infrastructure-assisted transition of control for cooperative automated vehicles JF - IEEE Transactions on Intelligent Transportation Systems N2 - Automated driving is now possible in diverse road and traffic conditions. However, there are still situations that automated vehicles cannot handle safely and efficiently. In this case, a Transition of Control (ToC) is necessary so that the driver takes control of the driving. Executing a ToC requires the driver to get full situation awareness of the driving environment. If the driver fails to get back the control in a limited time, a Minimum Risk Maneuver (MRM) is executed to bring the vehicle into a safe state (e.g., decelerating to full stop). The execution of ToCs requires some time and can cause traffic disruption and safety risks that increase if several vehicles execute ToCs/MRMs at similar times and in the same area. This study proposes to use novel C-ITS traffic management measures where the infrastructure exploits V2X communications to assist Connected and Automated Vehicles (CAVs) in the execution of ToCs. The infrastructure can suggest a spatial distribution of ToCs, and inform vehicles of the locations where they could execute a safe stop in case of MRM. This paper reports the first field operational tests that validate the feasibility and quantify the benefits of the proposed infrastructure-assisted ToC and MRM management. The paper also presents the CAV and roadside infrastructure prototypes implemented and used in the trials. The conducted field trials demonstrate that infrastructure-assisted traffic management solutions can reduce safety risks and traffic disruptions. KW - Automated driving KW - automated vehicles KW - connected automated vehicles KW - CAV KW - experimental evaluation Y1 - 2021 U6 - http://dx.doi.org/10.1109/TITS.2021.3061085 SN - 1524-9050 (Print) SN - 1558-0016 (Online) VL - 23 IS - 7 SP - 6720 EP - 6736 PB - IEEE ER - TY - CHAP A1 - Striebing, Clemens A1 - Müller, Jörg A1 - Schraudner, Martina A1 - Gewinner, Irina Valerie A1 - Guerrero Morales, Patricia A1 - Hochfeld, Katharina A1 - Hoffman, Shekinah A1 - Kmec, Julie A. A1 - Nguyen, Huu Minh A1 - Schneider, Jannick A1 - Sheridan, Jennifer A1 - Steuer-Dankert, Linda A1 - Trimble O'Connor, Lindsey A1 - Vandevelde-Rougale, Agnès T1 - Promoting diversity and combatting discrimination in research organizations: a practitioner’s guide T2 - Diversity and discrimination in research organizations N2 - The essay is addressed to practitioners in research management and from academic leadership. It describes which measures can contribute to creating an inclusive climate for research teams and preventing and effectively dealing with discrimination. The practical recommendations consider the policy and organizational levels, as well as the individual perspective of research managers. Following a series of basic recommendations, six lessons learned are formulated, derived from the contributions to the edited collection on “Diversity and Discrimination in Research Organizations.” KW - Inclusive work climate KW - lessons learned KW - policy recommendations KW - recommendations for actions KW - bullying Y1 - 2022 SN - 978-1-80117-959-1 (Print) SN - 978-1-80117-956-0 (Online) U6 - http://dx.doi.org/10.1108/978-1-80117-956-020221012 SP - 421 EP - 442 PB - Emerald Publishing Limited CY - Bingley ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Pourshahidi, Mohammad Ali A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation JF - Journal of Magnetism and Magnetic Materials N2 - Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing. Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.jmmm.2022.169965 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Funke, Harald A1 - Esch, Thomas A1 - Roosen, Petra T1 - Powertrain Adaptions for LPG Usage in General Aviation JF - MTZ worldwide N2 - In general aviation, too, it is desirable to be able to operate existing internal combustion engines with fuels that produce less CO₂ than Avgas 100LL being widely used today It can be assumed that, in comparison, the fuels CNG, LPG or LNG, which are gaseous under normal conditions, produce significantly lower emissions. Necessary propulsion system adaptations were investigated as part of a research project at Aachen University of Applied Sciences. Y1 - 2022 U6 - http://dx.doi.org/10.1007/s38313-021-0756-6 VL - 2022 IS - 83 SP - 58 EP - 62 PB - Springer Nature CY - Basel ER - TY - CHAP A1 - Gkatzogias, Konstantinos A1 - Veljkoviv, Ana A1 - Pohoryles, Daniel A. A1 - Tsionis, Georgios A1 - Bournas, Dionysios A. A1 - Crowley, Helen A1 - Norlén, Hedvig A1 - Butenweg, Christoph A1 - Gervasio, Helena A1 - Manfredi, Vincenzo A1 - Masi, Angelo A1 - Zaharieva, Roumiana ED - Gkatzogias, Konstantinos ED - Tsionis, Georgios T1 - Policy practice and regional impact assessment for building renovation T2 - REEBUILD Integrated Techniques for the Seismic Strengthening & Energy Efficiency of Existing Buildings N2 - The work presented in this report provides scientific support to building renovation policies in the EU by promoting a holistic point of view on the topic. Integrated renovation can be seen as a nexus between European policies on disaster resilience, energy efficiency and circularity in the building sector. An overview of policy measures for the seismic and energy upgrading of buildings across EU Member States identified only a few available measures for combined upgrading. Regulatory framework, financial instruments and digital tools similar to those for energy renovation, together with awareness and training may promote integrated renovation. A framework for regional prioritisation of building renovation was put forward, considering seismic risk, energy efficiency, and socioeconomic vulnerability independently and in an integrated way. Results indicate that prioritisation of building renovation is a multidimensional problem. Depending on priorities, different integrated indicators should be used to inform policies and accomplish the highest relative or most spread impact across different sectors. The framework was further extended to assess the impact of renovation scenarios across the EU with a focus on priority regions. Integrated renovation can provide a risk-proofed, sustainable, and inclusive built environment, presenting an economic benefit in the order of magnitude of the highest benefit among the separate interventions. Furthermore, it presents the unique capability of reducing fatalities and energy consumption at the same time and, depending on the scenario, to a greater extent. Y1 - 2022 SN - 978-92-76-60454-9 U6 - http://dx.doi.org/10.2760/883122 SN - 1831-9424 SP - 1 EP - 68 PB - Publications Office of the European Union CY - Luxembourg ER - TY - JOUR A1 - Falkenberg, Fabian A1 - Bott, Michael A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae JF - Frontiers in Microbiology N2 - The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions. Subtilases are divided in several groups and especially subtilisins are of interest as they are used in various industrial sectors. Therefore, we searched for new subtilisin sequences of the family Bacillaceae using a data mining approach. The obtained 1,400 sequences were phylogenetically classified in the context of the subtilase family. This required an updated comprehensive overview of the different groups within this family. To fill this gap, we conducted a phylogenetic survey of the S8 family with characterised holotypes derived from the MEROPS database. The analysis revealed the presence of eight previously uncharacterised groups and 13 subgroups within the S8 family. The sequences that emerged from the data mining with the set filter parameters were mainly assigned to the subtilisin subgroups of true subtilisins, high-alkaline subtilisins, and phylogenetically intermediate subtilisins and represent an excellent source for new subtilisin candidates. Y1 - 2022 U6 - http://dx.doi.org/10.3389/fmicb.2022.1017978 SN - 1664-302X VL - 2022 IS - 13 PB - Frontiers CY - Lausanne ER - TY - GEN A1 - Feldmann, Marco A1 - Francke, Gero A1 - Espe, Clemes A1 - Chen, Qian A1 - Baader, Fabian A1 - Boxberg, Marc S. A1 - Sustrate, Anna-Marie A1 - Kowalski, Julia A1 - Dachwald, Bernd T1 - Performance data of an ice-melting probe from field tests in two different ice environments N2 - This dataset was acquired at field tests of the steerable ice-melting probe "EnEx-IceMole" (Dachwald et al., 2014). A field test in summer 2014 was used to test the melting probe's system, before the probe was shipped to Antarctica, where, in international cooperation with the MIDGE project, the objective of a sampling mission in the southern hemisphere summer 2014/2015 was to return a clean englacial sample from the subglacial brine reservoir supplying the Blood Falls at Taylor Glacier (Badgeley et al., 2017, German et al., 2021). The standardized log-files generated by the IceMole during melting operation include more than 100 operational parameters, housekeeping information, and error states, which are reported to the base station in intervals of 4 s. Occasional packet loss in data transmission resulted in a sparse number of increased sampling intervals, which where compensated for by linear interpolation during post processing. The presented dataset is based on a subset of this data: The penetration distance is calculated based on the ice screw drive encoder signal, providing the rate of rotation, and the screw's thread pitch. The melting speed is calculated from the same data, assuming the rate of rotation to be constant over one sampling interval. The contact force is calculated from the longitudinal screw force, which es measured by strain gauges. The used heating power is calculated from binary states of all heating elements, which can only be either switched on or off. Temperatures are measured at each heating element and averaged for three zones (melting head, side-wall heaters and back-plate heaters). KW - Ocean Worlds KW - Icy Moons KW - Cryobot KW - Analogue Environments KW - Melting Efficiency KW - Melting Performance KW - Melting Probe KW - Ice Melting Y1 - 2022 U6 - http://dx.doi.org/10.5281/zenodo.6094866 N1 - Forschungsdaten zu "Field-test performance of an ice-melting probe in a terrestrial analogue environment" (https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/10889) ER - TY - JOUR A1 - Fiedler, Thomas M. A1 - Orzada, Stephan A1 - Flöser, Martina A1 - Rietsch, Stefan H. G. A1 - Schmidt, Simon A1 - Stelter, Jonathan K. A1 - Wittrich, Marco A1 - Quick, Harald H. A1 - Bitz, Andreas A1 - Ladd, Mark E. T1 - Performance and safety assessment of an integrated transmitarray for body imaging at 7 T under consideration of specificabsorption rate, tissue temperature, and thermal dose JF - NMR in Biomedicine N2 - In this study, the performance of an integrated body-imaging array for 7 T with 32 radiofrequency (RF) channels under consideration of local specific absorption rate (SAR), tissue temperature, and thermal dose limits was evaluated and the imaging performance was compared with a clinical 3 T body coil. Thirty-two transmit elements were placed in three rings between the bore liner and RF shield of the gradient coil. Slice-selective RF pulse optimizations for B1 shimming and spokes were performed for differently oriented slices in the body under consideration of realistic constraints for power and local SAR. To improve the B1+ homogeneity, safety assessments based on temperature and thermal dose were performed to possibly allow for higher input power for the pulse optimization than permissible with SAR limits. The results showed that using two spokes, the 7 T array outperformed the 3 T birdcage in all the considered regions of interest. However, a significantly higher SAR or lower duty cycle at 7 T is necessary in some cases to achieve similar B1+ homogeneity as at 3 T. The homogeneity in up to 50 cm-long coronal slices can particularly benefit from the high RF shim performance provided by the 32 RF channels. The thermal dose approach increases the allowable input power and the corresponding local SAR, in one example up to 100 W/kg, without limiting the exposure time necessary for an MR examination. In conclusion, the integrated antenna array at 7 T enables a clinical workflow for body imaging and comparable imaging performance to a conventional 3 T clinical body coil. KW - body imaging at 7 T MRI KW - thermal dose KW - tissue temperature KW - transmit antenna arrays Y1 - 2022 U6 - http://dx.doi.org/10.1002/nbm.4656 SN - 0952-3480 (Print) SN - 1099-1492 (Online) VL - 35 IS - 5 SP - 1 EP - 17 PB - Wiley ER - TY - CHAP A1 - Steuer-Dankert, Linda A1 - Leicht-Scholten, Carmen T1 - Perceiving diversity : an explorative approach in a complex research organization. T2 - Diversity and discrimination in research organizations N2 - Diversity management is seen as a decisive factor for ensuring the development of socially responsible innovations (Beacham and Shambaugh, 2011; Sonntag, 2014; López, 2015; Uebernickel et al., 2015). However, many diversity management approaches fail due to a one-sided consideration of diversity (Thomas and Ely, 2019) and a lacking linkage between the prevailing organizational culture and the perception of diversity in the respective organization. Reflecting the importance of diverse perspectives, research institutions have a special responsibility to actively deal with diversity, as they are publicly funded institutions that drive socially relevant development and educate future generations of developers, leaders and decision-makers. Nevertheless, only a few studies have so far dealt with the influence of the special framework conditions of the science system on diversity management. Focusing on the interdependency of the organizational culture and diversity management especially in a university research environment, this chapter aims in a first step to provide a theoretical perspective on the framework conditions of a complex research organization in Germany in order to understand the system-specific factors influencing diversity management. In a second step, an exploratory cluster analysis is presented, investigating the perception of diversity and possible influencing factors moderating this perception in a scientific organization. Combining both steps, the results show specific mechanisms and structures of the university research environment that have an impact on diversity management and rigidify structural barriers preventing an increase of diversity. The quantitative study also points out that the management level takes on a special role model function in the scientific system and thus has an influence on the perception of diversity. Consequently, when developing diversity management approaches in research organizations, it is necessary to consider the top-down direction of action, the special nature of organizational structures in the university research environment as well as the special role of the professorial level as role model for the scientific staff. KW - Diversity management KW - Organizational culture KW - Change management KW - Psychological concepts KW - Perception Y1 - 2022 SN - 978-1-80117-959-1 (Print) SN - 978-1-80117-956-0 (Online) U6 - http://dx.doi.org/10.1108/978-1-80117-956-020221010 SP - 365 EP - 392 PB - Emerald Publishing Limited CY - Bingley ER - TY - JOUR A1 - von Häfen, Hajo A1 - Krautwald, Clemens A1 - Stolle, Jacob A1 - Bung, Daniel Bernhard A1 - Goseberg, Nils T1 - Overland flow of broken solitary waves over a two-dimensional coastal plane JF - Coastal Engineering N2 - Landslides, rock falls or related subaerial and subaqueous mass slides can generate devastating impulse waves in adjacent waterbodies. Such waves can occur in lakes and fjords, or due to glacier calving in bays or at steep ocean coastlines. Infrastructure and residential houses along coastlines of those waterbodies are often situated on low elevation terrain, and are potentially at risk from inundation. Impulse waves, running up a uniform slope and generating an overland flow over an initially dry adjacent horizontal plane, represent a frequently found scenario, which needs to be better understood for disaster planning and mitigation. This study presents a novel set of large-scale flume test focusing on solitary waves propagating over a 1:14.5 slope and breaking onto a horizontal section. Examining the characteristics of overland flow, this study gives, for the first time, insight into the fundamental process of overland flow of a broken solitary wave: its shape and celerity, as well as its momentum when wave breaking has taken place beforehand. KW - Landslide tsunamis KW - Hazard assessment KW - Large scale tests KW - Overland flow KW - Solitary waves Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.coastaleng.2022.104125 SN - 1872-7379 VL - 175 IS - August PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Brauner, Philipp A1 - Vervier, Luisa A1 - Brillowski, Florian A1 - Dammers, Hannah A1 - Steuer-Dankert, Linda A1 - Schneider, Sebastian A1 - Baier, Ralph A1 - Ziefle, Martina A1 - Gries, Thomas A1 - Leicht-Scholten, Carmen A1 - Mertens, Alexander A1 - Nagel, Saskia K. T1 - Organization Routines in Next Generation Manufacturing T2 - Forecasting Next Generation Manufacturing N2 - Next Generation Manufacturing promises significant improvements in performance, productivity, and value creation. In addition to the desired and projected improvements regarding the planning, production, and usage cycles of products, this digital transformation will have a huge impact on work, workers, and workplace design. Given the high uncertainty in the likelihood of occurrence and the technical, economic, and societal impacts of these changes, we conducted a technology foresight study, in the form of a real-time Delphi analysis, to derive reliable future scenarios featuring the next generation of manufacturing systems. This chapter presents the organization dimension and describes each projection in detail, offering current case study examples and discussing related research, as well as implications for policy makers and firms. Specifically, we highlight seven areas in which the digital transformation of production will change how we work, how we organize the work within a company, how we evaluate these changes, and how employment and labor rights will be affected across company boundaries. The experts are unsure whether the use of collaborative robots in factories will replace traditional robots by 2030. They believe that the use of hybrid intelligence will supplement human decision-making processes in production environments. Furthermore, they predict that artificial intelligence will lead to changes in management processes, leadership, and the elimination of hierarchies. However, to ensure that social and normative aspects are incorporated into the AI algorithms, restricting measurement of individual performance will be necessary. Additionally, AI-based decision support can significantly contribute toward new, socially accepted modes of leadership. Finally, the experts believe that there will be a reduction in the workforce by the year 2030. Y1 - 2022 SN - 978-3-031-07734-0 U6 - http://dx.doi.org/10.1007/978-3-031-07734-0_5 SP - 75 EP - 94 PB - Springer CY - Cham ER - TY - JOUR A1 - Penner, Crystal A1 - Usherovich, Samuel A1 - Niedermeier, Jana A1 - Bélanger-Champagne, Camille A1 - Trinczek, Michael A1 - Paulßen, Elisabeth A1 - Hoehr, Cornelia T1 - Organic Scintillator-Fibre Sensors for Proton Therapy Dosimetry: SCSF-3HF and EJ-260 JF - electronics N2 - In proton therapy, the dose from secondary neutrons to the patient can contribute to side effects and the creation of secondary cancer. A simple and fast detection system to distinguish between dose from protons and neutrons both in pretreatment verification as well as potentially in vivo monitoring is needed to minimize dose from secondary neutrons. Two 3 mm long, 1 mm diameter organic scintillators were tested for candidacy to be used in a proton–neutron discrimination detector. The SCSF-3HF (1500) scintillating fibre (Kuraray Co. Chiyoda-ku, Tokyo, Japan) and EJ-260 plastic scintillator (Eljen Technology, Sweetwater, TX, USA) were irradiated at the TRIUMF Neutron Facility and the Proton Therapy Research Centre. In the proton beam, we compared the raw Bragg peak and spread-out Bragg peak response to the industry standard Markus chamber detector. Both scintillator sensors exhibited quenching at high LET in the Bragg peak, presenting a peak-to-entrance ratio of 2.59 for the EJ-260 and 2.63 for the SCSF-3HF fibre, compared to 3.70 for the Markus chamber. The SCSF-3HF sensor demonstrated 1.3 times the sensitivity to protons and 3 times the sensitivity to neutrons as compared to the EJ-260 sensor. Combined with our equations relating neutron and proton contributions to dose during proton irradiations, and the application of Birks’ quenching correction, these fibres provide valid candidates for inexpensive and replicable proton-neutron discrimination detectors Y1 - 2022 U6 - http://dx.doi.org/10.3390/electronics12010011 SN - 2079-9292 N1 - This article belongs to the Special Issue "Applications of Optical Fiber Sensors" VL - 12 IS - 1 PB - MDPI CY - Basel ER - TY - CHAP A1 - Gaigall, Daniel T1 - On Consistent Hypothesis Testing In General Hilbert Spaces N2 - Inference on the basis of high-dimensional and functional data are two topics which are discussed frequently in the current statistical literature. A possibility to include both topics in a single approach is working on a very general space for the underlying observations, such as a separable Hilbert space. We propose a general method for consistently hypothesis testing on the basis of random variables with values in separable Hilbert spaces. We avoid concerns with the curse of dimensionality due to a projection idea. We apply well-known test statistics from nonparametric inference to the projected data and integrate over all projections from a specific set and with respect to suitable probability measures. In contrast to classical methods, which are applicable for real-valued random variables or random vectors of dimensions lower than the sample size, the tests can be applied to random vectors of dimensions larger than the sample size or even to functional and high-dimensional data. In general, resampling procedures such as bootstrap or permutation are suitable to determine critical values. The idea can be extended to the case of incomplete observations. Moreover, we develop an efficient algorithm for implementing the method. Examples are given for testing goodness-of-fit in a one-sample situation in [1] or for testing marginal homogeneity on the basis of a paired sample in [2]. Here, the test statistics in use can be seen as generalizations of the well-known Cramérvon-Mises test statistics in the one-sample and two-samples case. The treatment of other testing problems is possible as well. By using the theory of U-statistics, for instance, asymptotic null distributions of the test statistics are obtained as the sample size tends to infinity. Standard continuity assumptions ensure the asymptotic exactness of the tests under the null hypothesis and that the tests detect any alternative in the limit. Simulation studies demonstrate size and power of the tests in the finite sample case, confirm the theoretical findings, and are used for the comparison with concurring procedures. A possible application of the general approach is inference for stock market returns, also in high data frequencies. In the field of empirical finance, statistical inference of stock market prices usually takes place on the basis of related log-returns as data. In the classical models for stock prices, i.e., the exponential Lévy model, Black-Scholes model, and Merton model, properties such as independence and stationarity of the increments ensure an independent and identically structure of the data. Specific trends during certain periods of the stock price processes can cause complications in this regard. In fact, our approach can compensate those effects by the treatment of the log-returns as random vectors or even as functional data. Y1 - 2022 U6 - http://dx.doi.org/10.11159/icsta22.157 N1 - Proceedings of the 4th International Conference on Statistics: Theory and Applications (ICSTA’22) Prague, Czech Republic – July 28- 30 SP - Paper No. 157 PB - Avestia Publishing CY - Orléans, Kanada ER - TY - JOUR A1 - Marinkovic, Marko A1 - Butenweg, Christoph T1 - Numerical analysis of the in-plane behaviour of decoupled masonry infilled RC frames JF - Engineering Structures N2 - Damage of reinforced concrete (RC) frames with masonry infill walls has been observed after many earthquakes. Brittle behaviour of the masonry infills in combination with the ductile behaviour of the RC frames makes infill walls prone to damage during earthquakes. Interstory deformations lead to an interaction between the infill and the RC frame, which affects the structural response. The result of this interaction is significant damage to the infill wall and sometimes to the surrounding structural system too. In most design codes, infill walls are considered as non-structural elements and neglected in the design process, because taking into account the infills and considering the interaction between frame and infill in software packages can be complicated and impractical. A good way to avoid negative aspects arising from this behavior is to ensure no or low-interaction of the frame and infill wall, for instance by decoupling the infill from the frame. This paper presents the numerical study performed to investigate new connection system called INODIS (Innovative Decoupled Infill System) for decoupling infill walls from surrounding frame with the aim to postpone infill activation to high interstory drifts thus reducing infill/frame interaction and minimizing damage to both infills and frames. The experimental results are first used for calibration and validation of the numerical model, which is then employed for investigating the influence of the material parameters as well as infill’s and frame’s geometry on the in-plane behaviour of the infilled frames with the INODIS system. For all the investigated situations, simulation results show significant improvements in behaviour for decoupled infilled RC frames in comparison to the traditionally infilled frames. KW - Seismic loading KW - Earthquake KW - In-plane performance, isolation KW - Infill wall design KW - Numerical modelling Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.engstruct.2022.114959 SN - 0141-0296 VL - 272 IS - 1 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W.K. T1 - Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material JF - Journal of Pharmaceutical and Biomedical Analysis N2 - Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed. For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard. The method was successfully validated for its accuracy, reproducibility, and precision. The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %. The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride. A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available. A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs. NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity). KW - NMR spectroscopy KW - Heparin KW - Crude heparin KW - USP KW - Ions Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.jpba.2022.114915 SN - 0731-7085 VL - 219 IS - Article number: 114915 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W.K. T1 - Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent JF - Journal of Pharmaceutical and Biomedical Analysis N2 - NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products. KW - NMR spectroscopy KW - Inorganic ions KW - Heparin KW - Standardization Y1 - 2022 SN - 0731-7085 U6 - http://dx.doi.org/10.1016/j.jpba.2021.114530 VL - 209 IS - Article number: 114530 PB - Elsevier ER - TY - JOUR A1 - Herssens, Nolan A1 - Cowburn, James A1 - Albracht, Kirsten A1 - Braunstein, Bjoern A1 - Cazzola, Dario A1 - Colyer, Steffi A1 - Minetti, Alberto E. A1 - Pavei, Gaspare A1 - Rittweger, Jörn A1 - Weber, Tobias A1 - Green, David A. ED - Cattaneo, Luigi T1 - Movement in low gravity environments (MoLo) programme – the MoLo-L.O.O.P. study protocol JF - PLOS ONE / Public Library of Science N2 - Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity. Y1 - 2022 U6 - http://dx.doi.org/10.1371/journal.pone.0278051 SN - 1932-6203 VL - 17 IS - 11 PB - Plos CY - San Francisco ER - TY - JOUR A1 - Rossi, Leonardo A1 - Winands, Mark H. M. A1 - Butenweg, Christoph ED - Zhang, Jessica T1 - Monte Carlo Tree Search as an intelligent search tool in structural design problems JF - Engineering with Computers : An International Journal for Simulation-Based Engineering N2 - Monte Carlo Tree Search (MCTS) is a search technique that in the last decade emerged as a major breakthrough for Artificial Intelligence applications regarding board- and video-games. In 2016, AlphaGo, an MCTS-based software agent, outperformed the human world champion of the board game Go. This game was for long considered almost infeasible for machines, due to its immense search space and the need for a long-term strategy. Since this historical success, MCTS is considered as an effective new approach for many other scientific and technical problems. Interestingly, civil structural engineering, as a discipline, offers many tasks whose solution may benefit from intelligent search and in particular from adopting MCTS as a search tool. In this work, we show how MCTS can be adapted to search for suitable solutions of a structural engineering design problem. The problem consists of choosing the load-bearing elements in a reference reinforced concrete structure, so to achieve a set of specific dynamic characteristics. In the paper, we report the results obtained by applying both a plain and a hybrid version of single-agent MCTS. The hybrid approach consists of an integration of both MCTS and classic Genetic Algorithm (GA), the latter also serving as a term of comparison for the results. The study’s outcomes may open new perspectives for the adoption of MCTS as a design tool for civil engineers. KW - Monte Carlo Tree Search KW - Structural design KW - Artificial intelligence KW - Civil engineering KW - Genetic algorithm Y1 - 2022 U6 - http://dx.doi.org/10.1007/s00366-021-01338-2 SN - 1435-5663 SN - 0177-0667 VL - 38 IS - 4 SP - 3219 EP - 3236 PB - Springer Nature CY - Cham ER - TY - CHAP A1 - Mertens, Alexander A1 - Brauner, Philipp A1 - Baier, Ralph A1 - Brillowski, Florian A1 - Dammers, Hannah A1 - van Dyck, Marc A1 - Kong, Iris A1 - Königs, Peter A1 - Kordtomeikel, Frauke A1 - Liehner, Gian Luca A1 - Pütz, Sebastian A1 - Rodermann, Niklas A1 - Schaar, Anne Kathrin A1 - Steuer-Dankert, Linda A1 - Vervier, Luisa A1 - Wlecke, Shari A1 - Gries, Thomas A1 - Leicht-Scholten, Carmen A1 - Nagel, Saskia K. A1 - Piller, Frank T. A1 - Schuh, Günther A1 - Ziefle, Martina A1 - Nitsch, Verena ED - Michael, Judith ED - Pfeiffer, Jérôme ED - Wortmann, Andreas T1 - Modelling Human Factors in Cyber Physical Production Systems by the Integration of Human Digital Shadows T2 - Modellierung 2022 Satellite Events N2 - The future of industrial manufacturing and production will increasingly manifest in the form of cyber-physical production systems. Here, Digital Shadows will act as mediators between the physical and digital world to model and operationalize the interactions and relationships between different entities in production systems. Until now, the associated concepts have been primarily pursued and implemented from a technocentric perspective, in which human actors play a subordinate role, if they are considered at all. This paper outlines an anthropocentric approach that explicitly considers the characteristics, behavior, and traits and states of human actors in socio-technical production systems. For this purpose, we discuss the potentials and the expected challenges and threats of creating and using Human Digital Shadows in production. KW - human digital shadow KW - cyber physical production system KW - human factors Y1 - 2022 U6 - http://dx.doi.org/10.18420/modellierung2022ws-018 SP - 147 EP - 149 PB - GI Gesellschaft für Informatik CY - Bonn ER - TY - CHAP A1 - Zahra, Mahdi A1 - Phani Srujan, Merige A1 - Caminos, Ricardo Alexander Chico A1 - Schmitz, Pascal A1 - Herrmann, Ulf A1 - Teixeira Boura, Cristiano José A1 - Schmitz, Mark A1 - Gielen, Hans A1 - Gedle, Yibekal A1 - Dersch, Jürgen T1 - Modeling the thermal behavior of solar salt in electrical resistance heaters for the application in PV-CSP hybrid power plants T2 - SOLARPACES 2020 N2 - Concentrated Solar Power (CSP) systems are able to store energy cost-effectively in their integrated thermal energy storage (TES). By intelligently combining Photovoltaics (PV) systems with CSP, a further cost reduction of solar power plants is expected, as well as an increase in dispatchability and flexibility of power generation. PV-powered Resistance Heaters (RH) can be deployed to raise the temperature of the molten salt hot storage from 385 °C up to 565 °C in a Parabolic Trough Collector (PTC) plant. To avoid freezing and decomposition of molten salt, the temperature distribution in the electrical resistance heater is investigated in the present study. For this purpose, a RH has been modeled and CFD simulations have been performed. The simulation results show that the hottest regions occur on the electric rod surface behind the last baffle. A technical optimization was performed by adjusting three parameters: Shell-baffle clearance, electric rod-baffle clearance and number of baffles. After the technical optimization was carried out, the temperature difference between the maximum temperature and the average outlet temperature of the salt is within the acceptable limits, thus critical salt decomposition has been avoided. Additionally, the CFD simulations results were analyzed and compared with results obtained with a one-dimensional model in Modelica. KW - Solar thermal technologies KW - Hybrid energy system KW - Concentrated solar power KW - Energy storage KW - Photovoltaics Y1 - 2022 SN - 978-0-7354-4195-8 U6 - http://dx.doi.org/10.1063/5.0086268 SN - 1551-7616 (online) SN - 0094-243X (print) N1 - 26th International Conference on Concentrating Solar Power and Chemical Energy Systems 28 September–2 October 2020 Freiburg, Germany IS - 2445 / 1 PB - AIP conference proceedings / American Institute of Physics CY - Melville, NY ER - TY - JOUR A1 - Heuermann, Holger A1 - Emmrich, Thomas A1 - Bongartz, Simon T1 - Microwave spark plug to support ignitions with high compression ratios JF - IEEE Transactions on Plasma Science N2 - Upcoming gasoline engines should run with a larger number of fuels beginning from petrol over methanol up to gas by a wide range of compression ratios and a homogeneous charge. In this article, the microwave (MW) spark plug, based on a high-speed frequency hopping system, is introduced as a solution, which can support a nitrogen compression ratio up to 1:39 in a chamber and more. First, an overview of the high-speed frequency hopping MW ignition and operation system as well as the large number of applications are presented. Both gives an understanding of this new base technology for MW plasma generation. Focus of the theoretical part is the explanation of the internal construction of the spark plug, on the achievable of the high voltage generation as well as the high efficiency to hold the plasma. In detail, the development process starting with circuit simulations and ending with the numerical multiphysics field simulations is described. The concept is evaluated with a reference prototype covering the frequency range between 2.40 and 2.48 GHz and working over a large power range from 20 to 200 W. A larger number of different measurements starting by vector hot-S11 measurements and ending by combined working scenarios out of hot temperature, high pressure and charge motion are winding up the article. The limits for the successful pressure tests were given by the pressure chamber. Pressures ranged from 1 to 39 bar and charge motion up to 25 m/s as well as temperatures from 30◦ to 125◦. KW - Automotive application KW - ignition KW - microplasma KW - microwave (MW) plasma KW - plasma jet Y1 - 2022 U6 - http://dx.doi.org/10.1109/TPS.2022.3183690 SN - 1939-9375 IS - Early Access SP - 1 EP - 6 PB - IEEE ER - TY - CHAP A1 - Dannen, Tammo A1 - Schindele, Benedikt A1 - Prümmer, Marcel A1 - Arntz, Kristian A1 - Bergs, Thomas T1 - Methodology for the self-optimizing determination of additive manufacturing process eligibility and optimization potentials in toolmaking T2 - Procedia CIRP N2 - Additive Manufacturing (AM) of metallic workpieces faces a continuously rising technological relevance and market size. Producing complex or highly strained unique workpieces is a significant field of application, making AM highly relevant for tool components. Its successful economic application requires systematic workpiece based decisions and optimizations. Considering geometric and technological requirements as well as the necessary post-processing makes deciding effortful and requires in-depth knowledge. As design is usually adjusted to established manufacturing, associated technological and strategic potentials are often neglected. To embed AM in a future proof industrial environment, software-based self-learning tools are necessary. Integrated into production planning, they enable companies to unlock the potentials of AM efficiently. This paper presents an appropriate methodology for the analysis of process-specific AM-eligibility and optimization potential, added up by concrete optimization proposals. For an integrated workpiece characterization, proven methods are enlarged by tooling-specific figures. The first stage of the approach specifies the model’s initialization. A learning set of tooling components is described using the developed key figure system. Based on this, a set of applicable rules for workpiece-specific result determination is generated through clustering and expert evaluation. Within the following application stage, strategic orientation is quantified and workpieces of interest are described using the developed key figures. Subsequently, the retrieved information is used for automatically generating specific recommendations relying on the generated ruleset of stage one. Finally, actual experiences regarding the recommendations are gathered within stage three. Statistic learning transfers those to the generated ruleset leading to a continuously deepening knowledge base. This process enables a steady improvement in output quality. KW - Additive manufacturing KW - Laser-Powder Bed Fusion KW - L-PBF KW - Binder Jetting KW - Directed Energy Deposition Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.procir.2022.05.188 SN - 2212-8271 N1 - 55th CIRP Conference on Manufacturing Systems VL - 107 SP - 1539 EP - 1544 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Chloé, Radermacher A1 - Malyaran, Hanna A1 - Craveiro, Rogerio Bastos A1 - Peglow, Sarah A1 - Behbahani, Mehdi A1 - Pufe, Thomas A1 - Wolf, Michael A1 - Neuss, Sabine T1 - Mechanical loading on cementoblasts: a mini review JF - Osteologie N2 - Orthodontic treatments are concomitant with mechanical forces and thereby cause teeth movements. The applied forces are transmitted to the tooth root and the periodontal ligaments which is compressed on one side and tensed up on the other side. Indeed, strong forces can lead to tooth root resorption and the crown-to-tooth ratio is reduced with the potential for significant clinical impact. The cementum, which covers the tooth root, is a thin mineralized tissue of the periodontium that connects the periodontal ligament with the tooth and is build up by cementoblasts. The impact of tension and compression on these cells is investigated in several in vivo and in vitro studies demonstrating differences in protein expression and signaling pathways. In summary, osteogenic marker changes indicate that cyclic tensile forces support whereas static tension inhibits cementogenesis. Furthermore, cementogenesis experiences the same protein expression changes in static conditions as static tension, but cyclic compression leads to the exact opposite of cyclic tension. Consistent with marker expression changes, the singaling pathways of Wnt/ß-catenin and RANKL/OPG show that tissue compression leads to cementum degradation and tension forces to cementogenesis. However, the cementum, and in particular its cementoblasts, remain a research area which should be explored in more detail to understand the underlying mechanism of bone resorption and remodeling after orthodontic treatments. KW - Cementoblast KW - Compression KW - Tension KW - Mechanotransduction KW - Forces Y1 - 2022 U6 - http://dx.doi.org/10.1055/a-1826-0777 SN - 1019-1291 VL - 31 IS - 2 SP - 111 EP - 118 PB - Thieme CY - Stuttgart ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Trinh, Tu Luc A1 - Dao, Ngoc Tien A1 - Giap, Van Tan A1 - Truong, Manh Khuyen A1 - Dinh, Thuy Ha A1 - Staat, Manfred T1 - Limit and shakedown analysis of structures under random strength T2 - Proceedings of (NACOME2022) The 11th National Conference on Mechanics, Vol. 1. Solid Mechanics, Rock Mechanics, Artificial Intelligence, Teaching and Training, Hanoi, December 2-3, 2022 N2 - Direct methods comprising limit and shakedown analysis is a branch of computational mechanics. It plays a significant role in mechanical and civil engineering design. The concept of direct method aims to determinate the ultimate load bearing capacity of structures beyond the elastic range. For practical problems, the direct methods lead to nonlinear convex optimization problems with a large number of variables and onstraints. If strength and loading are random quantities, the problem of shakedown analysis is considered as stochastic programming. This paper presents a method so called chance constrained programming, an effective method of stochastic programming, to solve shakedown analysis problem under random condition of strength. In this our investigation, the loading is deterministic, the strength is distributed as normal or lognormal variables. KW - Reliability of structures KW - Stochastic programming KW - Chance constrained programming KW - Shakedown analysis KW - Limit analysis Y1 - 2022 SN - 978-604-357-084-7 SP - 510 EP - 518 PB - Nha xuat ban Khoa hoc tu nhien va Cong nghe (Verlag Naturwissenschaft und Technik) CY - Hanoi ER - TY - JOUR A1 - Bhattarai, Aroj A1 - May, Charlotte Anabell A1 - Staat, Manfred A1 - Kowalczyk, Wojciech A1 - Tran, Thanh Ngoc T1 - Layer-specific damage modeling of porcine large intestine under biaxial tension JF - Bioengineering N2 - The mechanical behavior of the large intestine beyond the ultimate stress has never been investigated. Stretching beyond the ultimate stress may drastically impair the tissue microstructure, which consequently weakens its healthy state functions of absorption, temporary storage, and transportation for defecation. Due to closely similar microstructure and function with humans, biaxial tensile experiments on the porcine large intestine have been performed in this study. In this paper, we report hyperelastic characterization of the large intestine based on experiments in 102 specimens. We also report the theoretical analysis of the experimental results, including an exponential damage evolution function. The fracture energies and the threshold stresses are set as damage material parameters for the longitudinal muscular, the circumferential muscular and the submucosal collagenous layers. A biaxial tensile simulation of a linear brick element has been performed to validate the applicability of the estimated material parameters. The model successfully simulates the biomechanical response of the large intestine under physiological and non-physiological loads. KW - biaxial tensile experiment KW - anisotropy KW - hyperelastic KW - constitutive modeling KW - damage Y1 - 2022 U6 - http://dx.doi.org/10.3390/bioengineering9100528 SN - 2306-5354 N1 - Der Artikel gehört zum Sonderheft "Computational Biomechanics" VL - 9 IS - 10, Early Access SP - 1 EP - 17 PB - MDPI CY - Basel ER - TY - JOUR A1 - Morandi, Paolo A1 - Butenweg, Christoph A1 - Breis, Khaled A1 - Beyer, Katrin A1 - Magenes, Guido ED - Ansal, Atilla T1 - Latest findings on the behaviour factor q for the seismic design of URM buildings JF - Bulletin of Earthquake Engineering N2 - Recent earthquakes as the 2012 Emilia earthquake sequence showed that recently built unreinforced masonry (URM) buildings behaved much better than expected and sustained, despite the maximum PGA values ranged between 0.20–0.30 g, either minor damage or structural damage that is deemed repairable. Especially low-rise residential and commercial masonry buildings with a code-conforming seismic design and detailing behaved in general very well without substantial damages. The low damage grades of modern masonry buildings that was observed during this earthquake series highlighted again that codified design procedures based on linear analysis can be rather conservative. Although advances in simulation tools make nonlinear calculation methods more readily accessible to designers, linear analyses will still be the standard design method for years to come. The present paper aims to improve the linear seismic design method by providing a proper definition of the q-factor of URM buildings. These q-factors are derived for low-rise URM buildings with rigid diaphragms which represent recent construction practise in low to moderate seismic areas of Italy and Germany. The behaviour factor components for deformation and energy dissipation capacity and for overstrength due to the redistribution of forces are derived by means of pushover analyses. Furthermore, considerations on the behaviour factor component due to other sources of overstrength in masonry buildings are presented. As a result of the investigations, rationally based values of the behaviour factor q to be used in linear analyses in the range of 2.0–3.0 are proposed. KW - Unreinforced masonry buildings KW - Modern constructions KW - Seismic design KW - Linear elastic analysis KW - Behaviour factor q Y1 - 2022 U6 - http://dx.doi.org/10.1007/s10518-022-01419-7 SN - 1573-1456 SN - 1570-761X VL - 20 IS - 11 SP - 5797 EP - 5848 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Kempt, Hendrik A1 - Freyer, Nils A1 - Nagel, Saskia K. T1 - Justice and the normative standards of explainability in healthcare JF - Philosophy & Technology N2 - Providing healthcare services frequently involves cognitively demanding tasks, including diagnoses and analyses as well as complex decisions about treatments and therapy. From a global perspective, ethically significant inequalities exist between regions where the expert knowledge required for these tasks is scarce or abundant. One possible strategy to diminish such inequalities and increase healthcare opportunities in expert-scarce settings is to provide healthcare solutions involving digital technologies that do not necessarily require the presence of a human expert, e.g., in the form of artificial intelligent decision-support systems (AI-DSS). Such algorithmic decision-making, however, is mostly developed in resource- and expert-abundant settings to support healthcare experts in their work. As a practical consequence, the normative standards and requirements for such algorithmic decision-making in healthcare require the technology to be at least as explainable as the decisions made by the experts themselves. The goal of providing healthcare in settings where resources and expertise are scarce might come with a normative pull to lower the normative standards of using digital technologies in order to provide at least some healthcare in the first place. We scrutinize this tendency to lower standards in particular settings from a normative perspective, distinguish between different types of absolute and relative, local and global standards of explainability, and conclude by defending an ambitious and practicable standard of local relative explainability. KW - Clinical decision support systems KW - Justice KW - Medical AI KW - Explainability KW - Normative standards Y1 - 2022 U6 - http://dx.doi.org/10.1007/s13347-022-00598-0 VL - 35 IS - Article number: 100 SP - 1 EP - 19 PB - Springer Nature CY - Berlin ER - TY - JOUR A1 - Lindner, Simon A1 - Burger, René A1 - Rutledge, Douglas N. A1 - Do, Xuan Tung A1 - Rumpf, Jessica A1 - Diehl, Bernd W. K. A1 - Schulze, Margit A1 - Monakhova, Yulia T1 - Is the calibration transfer of multivariate calibration models between high- and low-field NMR instruments possible? A case study of lignin molecular weight JF - Analytical chemistry N2 - Although several successful applications of benchtop nuclear magnetic resonance (NMR) spectroscopy in quantitative mixture analysis exist, the possibility of calibration transfer remains mostly unexplored, especially between high- and low-field NMR. This study investigates for the first time the calibration transfer of partial least squares regressions [weight average molecular weight (Mw) of lignin] between high-field (600 MHz) NMR and benchtop NMR devices (43 and 60 MHz). For the transfer, piecewise direct standardization, calibration transfer based on canonical correlation analysis, and transfer via the extreme learning machine auto-encoder method are employed. Despite the immense resolution difference between high-field and low-field NMR instruments, the results demonstrate that the calibration transfer from high- to low-field is feasible in the case of a physical property, namely, the molecular weight, achieving validation errors close to the original calibration (down to only 1.2 times higher root mean square errors). These results introduce new perspectives for applications of benchtop NMR, in which existing calibrations from expensive high-field instruments can be transferred to cheaper benchtop instruments to economize. Y1 - 2022 SN - 1520-6882 U6 - http://dx.doi.org/10.1021/acs.analchem.1c05125 VL - 94 IS - 9 SP - 3997 EP - 4004 PB - ACS Publications CY - Washington, DC ER - TY - CHAP A1 - Weiss, Christian A1 - Heslenfeld, Jonas A1 - Saewe, Jasmin Kathrin A1 - Bremen, Sebastian A1 - Häfner, Constantin Leon T1 - Investigation on the influence of powder humidity in Laser Powder Bed Fusion (LPBF) T2 - Procedia CIRP N2 - In the Laser Powder Bed Fusion (LPBF) process, parts are built out of metal powder material by exposure of a laser beam. During handling operations of the powder material, several influencing factors can affect the properties of the powder material and therefore directly influence the processability during manufacturing. Contamination by moisture due to handling operations is one of the most critical aspects of powder quality. In order to investigate the influences of powder humidity on LPBF processing, four materials (AlSi10Mg, Ti6Al4V, 316L and IN718) are chosen for this study. The powder material is artificially humidified, subsequently characterized, manufactured into cubic samples in a miniaturized process chamber and analyzed for their relative density. The results indicate that the processability and reproducibility of parts made of AlSi10Mg and Ti6Al4V are susceptible to humidity, while IN718 and 316L are barely influenced. KW - LPBF KW - Additive Manufacturing KW - Powder Material KW - Humidity Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.procir.2022.08.102 SN - 2212-8271 N1 - Teil der Sonderausgabe: 12th CIRP Conference on Photonic Technologies [LANE 2022] VL - 111 SP - 115 EP - 120 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Riga, Evi A1 - Pitilakis, Kyriazis A1 - Butenweg, Christoph A1 - Apostolaki, Stefania A1 - Karatzetzou, Anna ED - Arion, Cristian ED - Scupin, Alexandra ED - Ţigănescu, Alexandru T1 - Investigating the impact of the new European Seismic Hazard Model ESHM20 on the seismic design and safety control of industrial facilities T2 - The Third European Conference on Earthquake Engineering and Seismology September 4 – September 9, 2022, Bucharest N2 - The seismic performance and safety of major European industrial facilities has a global interest for Europe, its citizens and economy. A potential major disaster at an industrial site could affect several countries, probably far beyond the country where it is located. However, the seismic design and safety assessment of these facilities is practically based on national, often outdated seismic hazard assessment studies, due to many reasons, including the absence of a reliable, commonly developed seismic hazard model for whole Europe. This important gap is no more existing, as the 2020 European Seismic Hazard Model ESHM20 was released in December 2021. In this paper we investigate the expected impact of the adoption of ESHM20 on the seismic demand for industrial facilities, through the comparison of the ESHM20 probabilistic hazard at the sites where industrial facilities are located with the respective national and European regulations. The goal of this preliminary work in the framework of Working Group 13 of the European Association for Earthquake Engineering (EAEE), is to identify potential inadequacies in the design and safety control of existing industrial facilities and to highlight the expected impact of the adoption of the new European Seismic Hazard Model on the design of new industrial facilities and the safety assessment of existing ones. KW - ESHM20, industrial facilities KW - seismic hazard KW - seismic design KW - safety control Y1 - 2022 SN - 978-973-100-533-1 SP - 3261 EP - 3270 ER - TY - CHAP A1 - Niederwestberg, Stefan A1 - Schneider, Falko A1 - Teixeira Boura, Cristiano José A1 - Herrmann, Ulf T1 - Introduction to a direct irradiated transparent tube particle receiver T2 - SOLARPACES 2020 N2 - New materials often lead to innovations and advantages in technical applications. This also applies to the particle receiver proposed in this work that deploys high-temperature and scratch resistant transparent ceramics. With this receiver design, particles are heated through direct-contact concentrated solar irradiance while flowing downwards through tubular transparent ceramics from top to bottom. In this paper, the developed particle receiver as well as advantages and disadvantages are described. Investigations on the particle heat-up characteristics from solar irradiance were carried out with DEM simulations which indicate that particle temperatures can reach up to 1200 K. Additionally, a simulation model was set up for investigating the dynamic behavior. A test receiver at laboratory scale has been designed and is currently being built. In upcoming tests, the receiver test rig will be used to validate the simulation results. The design and the measurement equipment is described in this work. KW - Solar irradiance KW - Ceramics Y1 - 2022 SN - 978-0-7354-4195-8 U6 - http://dx.doi.org/10.1063/5.0086735 SN - 1551-7616 (online) SN - 0094-243X (print) N1 - 26th International Conference on Concentrating Solar Power and Chemical Energy Systems 28 September–2 October 2020 Freiburg, Germany IS - 2445 / 1 PB - AIP conference proceedings / American Institute of Physics CY - Melville, NY ER - TY - JOUR A1 - Hein, Andreas M. A1 - Eubanks, T. Marshall A1 - Lingam, Manasvi A1 - Hibberd, Adam A1 - Fries, Dan A1 - Schneider, Jean A1 - Kervella, Pierre A1 - Kennedy, Robert A1 - Perakis, Nikolaos A1 - Dachwald, Bernd T1 - Interstellar now! Missions to explore nearby interstellar objects JF - Advances in Space Research N2 - The recently discovered first hyperbolic objects passing through the Solar System, 1I/’Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system. KW - Interstellar objects KW - Trajectories KW - Missions Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.asr.2021.06.052 SN - 0273-1177 VL - 69 IS - 1 SP - 402 EP - 414 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Lenz, Maximilian A1 - Kahmann, Stephanie Lucina A1 - Behbahani, Mehdi A1 - Pennig, Lenhard A1 - Hackl, Michael A1 - Leschinger, Tim A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation JF - Archives of Orthopaedic and Trauma Surgery N2 - Introduction In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration. Materials and methods Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer’s classification was used to analyse the fractures. Results In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities. Conclusion A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education. KW - Proximal humerus fracture KW - Biomechanical simulation KW - Fracture configuration KW - Fracture simulation KW - Rotator cuff Y1 - 2022 U6 - http://dx.doi.org/10.1007/s00402-022-04471-9 SN - 1434-3916 PB - Springer CY - Berlin, Heidelberg ER - TY - CHAP A1 - Schwager, Christian A1 - Angele, Florian A1 - Nouri, Bijan A1 - Schwarzbözl, Peter A1 - Teixeira Boura, Cristiano José A1 - Herrmann, Ulf T1 - Impact of DNI forecast quality on performance prediction for a commercial scale solar tower: Application of nowcasting DNI maps to dynamic solar tower simulation T2 - SolarPACES conference proceedings N2 - Concerning current efforts to improve operational efficiency and to lower overall costs of concentrating solar power (CSP) plants with prediction-based algorithms, this study investigates the quality and uncertainty of nowcasting data regarding the implications for process predictions. DNI (direct normal irradiation) maps from an all-sky imager-based nowcasting system are applied to a dynamic prediction model coupled with ray tracing. The results underline the need for high-resolution DNI maps in order to predict net yield and receiver outlet temperature realistically. Furthermore, based on a statistical uncertainty analysis, a correlation is developed, which allows for predicting the uncertainty of the net power prediction based on the corresponding DNI forecast uncertainty. However, the study reveals significant prediction errors and the demand for further improvement in the accuracy at which local shadings are forecasted. KW - Process prediction KW - DNI forecasting KW - Nowcasting KW - Uncertainty analysis KW - Molten salt receiver system, Y1 - 2024 U6 - http://dx.doi.org/10.52825/solarpaces.v1i.675 SN - 2751-9899 (online) N1 - 28th International Conference on Concentrating Solar Power and Chemical Energy Systems, 27-30 September, Albuquerque, NM, USA IS - Vol. 1 PB - TIB Open Publishing CY - Hannover ER - TY - JOUR A1 - Philipp, Mohr A1 - Efthimiou, Nikos A1 - Pagano, Fiammetta A1 - Kratochwil, Nicolaus A1 - Pizzichemi, Marco A1 - Tsoumpas, Charalampos A1 - Auffray, Etiennette A1 - Ziemons, Karl T1 - Image reconstruction analysis for positron emission tomography with heterostructured scintillators JF - IEEE Transactions on Radiation and Plasma Medical Sciences N2 - The concept of structure engineering has been proposed for exploring the next generation of radiation detectors with improved performance. A TOF-PET geometry with heterostructured scintillators with a pixel size of 3.0×3.1×15 mm3 was simulated using Monte Carlo. The heterostructures consisted of alternating layers of BGO as a dense material with high stopping power and plastic (EJ232) as a fast light emitter. The detector time resolution was calculated as a function of the deposited and shared energy in both materials on an event-by-event basis. While sensitivity was reduced to 32% for 100 μm thick plastic layers and 52% for 50 μm, the CTR distribution improved to 204±49 ps and 220±41 ps respectively, compared to 276 ps that we considered for bulk BGO. The complex distribution of timing resolutions was accounted for in the reconstruction. We divided the events into three groups based on their CTR and modeled them with different Gaussian TOF kernels. On a NEMA IQ phantom, the heterostructures had better contrast recovery in early iterations. On the other hand, BGO achieved a better contrast to noise ratio (CNR) after the 15th iteration due to the higher sensitivity. The developed simulation and reconstruction methods constitute new tools for evaluating different detector designs with complex time responses. KW - TOF PET KW - Heterostructure KW - Metascintillator KW - Multiple TOF kernels KW - Image Reconstruction Y1 - 2022 U6 - http://dx.doi.org/10.1109/TRPMS.2022.3208615 SN - 2469-7311 SN - 2469-7303 VL - 7 IS - 1 SP - 41 EP - 51 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Werfel, Stanislas A1 - Günthner, Roman A1 - Hapfelmeier, Alexander A1 - Hanssen, Henner A1 - Kotliar, Konstantin A1 - Heemann, Uwe A1 - Schmaderer, Christoph ED - Guzik, Tomasz J. T1 - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning JF - Cardiovascular Research N2 - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations. KW - Machine learning KW - Retinal vessels KW - Microcirculation KW - Haemodialysis KW - Myocardial infarction and cardiac death Y1 - 2022 U6 - http://dx.doi.org/10.1093/cvr/cvab040 SN - 0008-6363 VL - 118 IS - 2 SP - 612 EP - 621 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Rübbelke, Dirk A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Zobel, Luzy T1 - Hydrogen-based steel production and global climate protection: An empirical analysis of the potential role of a European cross border adjustment mechanism JF - Journal of Cleaner Production N2 - The European Union's aim to become climate neutral by 2050 necessitates ambitious efforts to reduce carbon emissions. Large reductions can be attained particularly in energy intensive sectors like iron and steel. In order to prevent the relocation of such industries outside the EU in the course of tightening environmental regulations, the establishment of a climate club jointly with other large emitters and alternatively the unilateral implementation of an international cross-border carbon tax mechanism are proposed. This article focuses on the latter option choosing the steel sector as an example. In particular, we investigate the financial conditions under which a European cross border mechanism is capable to protect hydrogen-based steel production routes employed in Europe against more polluting competition from abroad. By using a floor price model, we assess the competitiveness of different steel production routes in selected countries. We evaluate the climate friendliness of steel production on the basis of specific GHG emissions. In addition, we utilize an input-output price model. It enables us to assess impacts of rising cost of steel production on commodities using steel as intermediates. Our results raise concerns that a cross-border tax mechanism will not suffice to bring about competitiveness of hydrogen-based steel production in Europe because the cost tends to remain higher than the cost of steel production in e.g. China. Steel is a classic example for a good used mainly as intermediate for other products. Therefore, a cross-border tax mechanism for steel will increase the price of products produced in the EU that require steel as an input. This can in turn adversely affect competitiveness of these sectors. Hence, the effects of higher steel costs on European exports should be borne in mind and could require the cross-border adjustment mechanism to also subsidize exports. Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.jclepro.2022.135040 SN - 0959-6526 VL - 380 IS - Part 2, Art. Nr.:135040 PB - Elsevier ER -