TY - JOUR A1 - Miyamoto, K. A1 - Seki, K. A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination JF - Procedia Engineering N2 - The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm. Y1 - 2014 U6 - https://doi.org/10.1016/j.proeng.2014.11.563 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 612 EP - 615 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Lustfeld, H. A1 - Hirschfeld, J. A. A1 - Reißel, Martin A1 - Steffen, B. T1 - Enhancement of precision and reduction of measuring points in tomographic reconstructions JF - Physics Letters A Y1 - 2011 SN - 0375-9601 VL - 375 IS - 8 SP - 1167 EP - 1171 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Digel, Ilya T1 - Enhancement of microbial adhesion onto solid surfaces using transition metals and water-soluble polymers : academic PhD dissertation in microbiology, Division of Applied Microbiology, Department of Microbiology, Biology Faculty, Kazakh National State University, Almaty, Kazakhstan / Ilya Digel Y1 - 1998 CY - Almaty ER - TY - JOUR A1 - Artmann, Gerhard A1 - Hovav, T. A1 - Goldfarb, A. A1 - Yedgar, S. [u.a.] T1 - Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G. JF - British Journal of Haematology. 106 (1999), H. 1 Y1 - 1999 SN - 1365-2141 SP - 178 EP - 181 ER - TY - JOUR A1 - Preiß, C. A1 - Linder, Peter A1 - Wendt, K. A1 - Krystek, M. A1 - Digel, Ilya A1 - Gossmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Porst, Dariusz A1 - Kayser, Peter A1 - Bassam, Rasha A1 - Artmann, Gerhard T1 - Engineering technology for plant physiology and plant stress research N2 - Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology. KW - Pflanzenphysiologie KW - Pflanzenstress KW - Pflanzenscanner KW - plant stress KW - plant scanner Y1 - 2011 ER - TY - JOUR A1 - Doll, Theodor A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Schöning (eds.) JF - Physica status solidi (a) Y1 - 2016 U6 - https://doi.org/10.1002/pssa.201670641 SN - 1862-6319 VL - 213 IS - 6 SP - 1393 EP - 1394 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wagner, Patrick A1 - Doll, Theodor A1 - Schöning, Michael Josef T1 - Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Schöning (eds.) JF - Physica status solidi (A) : Applications and materials science Y1 - 2014 U6 - https://doi.org/10.1002/pssa.201470241 SN - 1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print) VL - 211 IS - 6 SP - 1339 EP - 1339 PB - Wiley-VCH CY - Weinheim ER - TY - GEN A1 - Ingebrandt, Sven A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Engineering of functional interfaces / guest eds. Sven Ingebrandt ; Patrick Wagner ; Michael J. Schöning T2 - Physica Status Solidi (A) Y1 - 2013 SN - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print) VL - Vol. 210 IS - Iss. 5 SP - 845 ER - TY - GEN A1 - Staat, Manfred T1 - Engineering Mechanics. Lecture Notes. 2nd edition, translation of the 3rd corrected and extended German edition of "Technische Mechanik" N2 - English translation of the corrected lectures notes of Sebastian Krämer. Contents 0 Introduction to Mechanics 1 Statics of Rigid Bodies 2 Elastostatics (Strength of Materials) 3 Kinematics 4 Kinetics Literature KW - Technische Mechanik KW - Mechanics KW - Statics KW - Elastostatics KW - Kinematics KW - Kinetics Y1 - 2006 ER - TY - JOUR A1 - Hillen, Walter T1 - Energy scan for narrow states in e+e− annihilation at C.M. energies between 29.90 and 31.46 GeV. TASSO Collaboration JF - Physics Letters B. 88 (1979), H. 1-2 Y1 - 1979 SN - 0370-2693 SP - 199 EP - 202 ER - TY - JOUR A1 - Sander, Volker A1 - Foster, Ian T. A1 - Fidler, Markus A1 - Roy, Alain T1 - End-to-end quality of service for high-end applications / Foster, Ian T. ; Fidler, Markus ; Roy, Alain ; Sander, Volker ; Winkler, Linda JF - Computer Communications. 27 (2004), H. 14 Y1 - 2004 SN - 0140-3664 SP - 1375 EP - 1388 ER - TY - JOUR A1 - Gaigall, Daniel A1 - Gerstenberg, Julian A1 - Trinh, Thi Thu Ha T1 - Empirical process of concomitants for partly categorial data and applications in statistics JF - Bernoulli N2 - On the basis of independent and identically distributed bivariate random vectors, where the components are categorial and continuous variables, respectively, the related concomitants, also called induced order statistic, are considered. The main theoretical result is a functional central limit theorem for the empirical process of the concomitants in a triangular array setting. A natural application is hypothesis testing. An independence test and a two-sample test are investigated in detail. The fairly general setting enables limit results under local alternatives and bootstrap samples. For the comparison with existing tests from the literature simulation studies are conducted. The empirical results obtained confirm the theoretical findings. KW - bootstrap KW - Categorial variable KW - Concomitant KW - Empirical process KW - Independence test Y1 - 2022 U6 - https://doi.org/10.3150/21-BEJ1367 SN - 1573-9759 VL - 28 IS - 2 SP - 803 EP - 829 PB - International Statistical Institute CY - Den Haag, NL ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Bochev, B. A1 - Lieder, R. M. A1 - Didelez, J. P. T1 - Emission of non-equilibrium particles in the bombardment of ¹⁵⁹ Tb with 110 Mev g-particles and the validity of the pep model JF - Annual report 1981 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: F. Grümmer. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 146) Y1 - 1982 SP - 38 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Scheja, S. A1 - Wu, Chunsheng A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Electrostatic Detection of Unlabelled Single- and Double-stranded DNA Using Capacitive Field-effect Devices Functionalized with a Positively Charged Polyelectrolyte Layer JF - Procedia Engineering N2 - Capacitive field-effect electrolyte-insulator-semiconductor sensors consisting of an Al-p-Si-SiO2 structure have been used for the electrical detection of unlabelled single- and double-stranded DNA (dsDNA) molecules by their intrinsic charge. A simple functionalization protocol based on the layer-by-layer (LbL) technique was used to prepare a weak polyelectrolyte/probe-DNA bilayer, followed by the hybridization with complementary target DNA molecules. Due to the flat orientation of the LbL-adsorbed DNA molecules, a high sensor signal has been achieved. In addition, direct label-free detection of in-solution hybridized dsDNA molecules has been studied. Y1 - 2015 U6 - https://doi.org/10.1016/j.proeng.2015.08.710 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 544 EP - 547 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Weber, Hans-Joachim A1 - Mo, Xiumei A1 - Chen, Zonggang T1 - Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering / Mo Xiumei, Chen Zonggang, Hans J. Weber JF - Frontiers of materials science in China. 1 (2007), H. 1 Y1 - 2007 SN - 1673-7377 SP - 20 EP - 23 PB - - ER - TY - JOUR A1 - Weber, Hans-Joachim A1 - Mo, Xiumei T1 - Electrospinning P(LLA-CL) nanofiber: a tubular scaffold fabrication with circumferential alignment / Xiumei Mo, Hans-Joachim Weber JF - Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder Y1 - 2004 N1 - Österreichische Polymertage <6, 2003, Wien>. - (Macromolecular symposia ; 217,1) SP - 413 EP - 416 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Albanna, Walid A1 - Lueke, Jan Niklas A1 - Sjapic, Volha A1 - Kotliar, Konstantin A1 - Hescheler, Jürgen A1 - Clusmann, Hans A1 - Sjapic, Sergej A1 - Alpdogan, Serdan A1 - Schneider, Toni A1 - Schubert, Gerrit Alexander A1 - Neumaier, Felix T1 - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina JF - Current Eye Research Y1 - 2017 U6 - https://doi.org/10.1080/02713683.2017.1339807 SN - 1460-2202 IS - Article in press SP - 1 EP - 9 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Murib, M. S. A1 - Grinsven, B. van A1 - Grieten, L. A1 - Janssens, S. D. A1 - Vermeeren, V. A1 - Eersels, K. A1 - Broeders, J. A1 - Ameloot, M. A1 - Michiels, L. A1 - Ceuninck, W. De A1 - Haenen, K. A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates JF - Physica Status Solidi (A). Vol. 210 (2013), iss. 5 Y1 - 2013 SN - 0031-8965 SP - 911 EP - 917 PB - Wiley-VCH CY - Berlin ER - TY - JOUR A1 - Moreno i Codinachs, Lia A1 - Kloock, Joachim P. A1 - Schöning, Michael Josef A1 - Baldi, Antoni A1 - Ipatov, Andrey A1 - Bratov, Andrey A1 - Jimenez-Jorquera, Cecilia T1 - Electronic integrated multisensor tongue applied to grape juice and wine analysis JF - Analyst. 133 (2008) Y1 - 2008 SN - 1364-5528 SP - 1440 EP - 1448 ER - TY - THES A1 - Jung, Alexander T1 - Electromechanical modelling and simulation of hiPSC-derived cardiac cell cultures Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?https://nbn-resolving.org/urn:nbn:de:hbz:464-20210624-134942-7 SN - 978-3-9821811-1-0 N1 - Dissertation, Universität Duisburg-Essen, 2021 PB - Universität Duisburg-Essen ER - TY - CHAP A1 - Jung, Alexander A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample. Y1 - 2018 ER - TY - JOUR A1 - Honarvarfard, Elham A1 - Gamella, Maria A1 - Channaveerappa, Devika A1 - Darie, Costel C. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny T1 - Electrochemically Stimulated Insulin Release from a Modified Graphene–functionalized Carbon Fiber Electrode JF - Electroanalysis N2 - A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9–10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of −1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species. Y1 - 2017 U6 - https://doi.org/10.1002/elan.201700095 SN - 1521-4109 VL - 29 IS - 6 SP - 1543 EP - 1553 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Bäcker, Matthias A1 - Delle, L. A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Zang, Werner A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Electrochemical sensor array for bioprocess monitoring JF - Electrochimica Acta (2011) Y1 - 2011 VL - 56 IS - 26 SP - 9673 EP - 9678 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Glück, O. A1 - Thust, M. T1 - Electrochemical methods for the determination of chemical variables in aqueous media JF - The measurement, instrumentation, and sensors handbook / ed.-in-chief John G. Webster. In cooperation with IEEE Press Y1 - 1999 SN - 0-8493-8347-1 SP - 1 EP - 49 PB - CRC Press CY - Boca Raton [u.a.] ER - TY - CHAP A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Glück, Olaf A1 - Thust, Marion T1 - Electrochemical methods for the determination of chemical variables in aqueous media T2 - Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement Y1 - 2014 SN - 978-1-4398-4891-3 SP - 55-1 EP - 55-54 PB - CRC Pr. CY - Boca Raton, Fla. ER - TY - JOUR A1 - Welden, Rene A1 - Scheja, Sabrina A1 - Schöning, Michael Josef A1 - Wagner, Patrick A1 - Wagner, Torsten T1 - Electrochemical Evaluation of Light‐Addressable Electrodes Based on TiO2 for the Integration in Lab‐on‐Chip Systems JF - physica status solidi a : applications and materials sciences N2 - In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol–gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated. Y1 - 2018 U6 - https://doi.org/10.1002/pssa.201800150 SN - 1862-6319 VL - 215 IS - 15 SP - Article number 1800150 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Glück, Olaf A1 - Thust, Marion T1 - Electrochemical composition measurement T2 - Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen Y1 - 2014 SN - 978-1-4398-4891-3 SP - 55-1 EP - 55-54 PB - CRC Pr. CY - Boca Raton, Fa. ET - 2nd ed. ER - TY - JOUR A1 - Poghossian, Arshak A1 - Weil, M. A1 - Cherstvy, A. G. A1 - Schöning, Michael Josef T1 - Electrical monitoring of polyelectrolyte multilayer formation by means of capacitive field-effect devices JF - Analytical and bioanalytical chemistry N2 - The semiconductor field-effect platform represents a powerful tool for detecting the adsorption and binding of charged macromolecules with direct electrical readout. In this work, a capacitive electrolyte–insulator–semiconductor (EIS) field-effect sensor consisting of an Al-p-Si-SiO2 structure has been applied for real-time in situ electrical monitoring of the layer-by-layer formation of polyelectrolyte (PE) multilayers (PEM). The PEMs were deposited directly onto the SiO2 surface without any precursor layer or drying procedures. Anionic poly(sodium 4-styrene sulfonate) and cationic weak polyelectrolyte poly(allylamine hydrochloride) have been chosen as a model system. The effect of the ionic strength of the solution, polyelectrolyte concentration, number and polarity of the PE layers on the characteristics of the PEM-modified EIS sensors have been studied by means of capacitance–voltage and constant-capacitance methods. In addition, the thickness, surface morphology, roughness and wettabilityof the PE mono- and multilayers have been characterised by ellipsometry, atomic force microscopy and water contact-angle methods, respectively. To explain potential oscillations on the gate surface and signal behaviour of the capacitive field-effect EIS sensor modified with a PEM, a simplified electrostatic model that takes into account the reduced electrostatic screening of PE charges by mobile ions within the PEM has been proposed and discussed. Y1 - 2013 U6 - https://doi.org/10.1007/s00216-013-6951-9 SN - 1432-1130 ; 1618-2642 VL - 405 IS - 20 SP - 6425 EP - 6436 PB - Springer CY - Berlin ER - TY - CHAP A1 - Weil, M. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Cherstvy, A. T1 - Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices Y1 - 2012 SN - 978-3-9813484-2-2 U6 - https://doi.org/10.5162/IMCS2012/P2.5.2 SP - 1575 EP - 1578 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Colautti, P. A1 - Schröder, M. A1 - Tornielli, G. T1 - Electric field Gradient Effects in TEPS JF - Annual report / Istituto Nazionale di Fisica Nucleare, LNL, Laboratori Nazionali di Legnaro. 1996 (1997) Y1 - 1997 N1 - Nebent.: Annual Report LNL-INFN SP - 253 EP - 254 ER - TY - JOUR A1 - Kleefeld, Andreas A1 - Pieronek, J. T1 - Elastic transmission eigenvalues and their computation via the method of fundamental solutions JF - Applicable Analysis N2 - A stabilized version of the fundamental solution method to catch ill-conditioning effects is investigated with focus on the computation of complex-valued elastic interior transmission eigenvalues in two dimensions for homogeneous and isotropic media. Its algorithm can be implemented very shortly and adopts to many similar partial differential equation-based eigenproblems as long as the underlying fundamental solution function can be easily generated. We develop a corroborative approximation analysis which also implicates new basic results for transmission eigenfunctions and present some numerical examples which together prove successful feasibility of our eigenvalue recovery approach. KW - elastic scattering KW - method of fundamental solutions KW - Interior transmission eigenvalues Y1 - 2020 U6 - https://doi.org/10.1080/00036811.2020.1721473 SN - 1563-504X VL - 100 IS - 16 SP - 3445 EP - 3462 PB - Taylore & Francis CY - London ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Zinoviewa, N. V. A1 - Krylova, I. S. T1 - Elaboration of the conception of the biomechanical model of the aqueous intraocular outflow / Svetlova, O. V. ; Zinoviewa, N. V. ; Krylova, I. S. ; Koshitz, I. N. ; Smolnikov, B. A. ; Fedorova, E. M. ; Kotliar, K. E. JF - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 5 (2001), H. 3 Y1 - 2001 SN - 1812-5123 SP - 23 EP - 27 PB - - ER - TY - JOUR A1 - Thiebes, Anja Lena A1 - Klein, Sarah A1 - Zingsheim, Jonas A1 - Möller, Georg H. A1 - Gürzing, Stefanie A1 - Reddemann, Manuel A. A1 - Behbahani, Mehdi A1 - Cornelissen, Christian G. T1 - Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio JF - pharmaceutics N2 - Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4–33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing. KW - tri-lineage differentiation KW - survival KW - twin-fluid atomizer KW - adipose-derived stromal cells (ASCs) KW - cell atomization KW - cell aerosolization Y1 - 2022 U6 - https://doi.org/10.3390/pharmaceutics14112421 N1 - This article belongs to the Special Issue "Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells" VL - 14 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bassam, Rasha A1 - Hescheler, Jürgen A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Digel, Ilya T1 - Effects of spermine NONOate and ATP on the thermal stability of hemoglobin JF - BMC Biophysics N2 - Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell. KW - Nitric Oxide Donor KW - NONOate KW - Circular Dichroism KW - Nitric Oxide Y1 - 2012 U6 - https://doi.org/10.1186/2046-1682-5-16 SN - 2046-1682 VL - 5 PB - BioMed Central CY - London ER - TY - JOUR A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Hescheler, Jürgen A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences JF - BMC Biophysics Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?10.1186/2046-1682-6-1 SN - 2046-1682 SP - 1 EP - 14 PB - BioMed Central CY - London ER - TY - JOUR A1 - Erbayraktar, Zubeyde A1 - Yilmaz, Osman A1 - Temiz Artmann, Aysegül A1 - Cehreli, Ruksan A1 - Coker, Canan T1 - Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus JF - Biological Trace Element Research Y1 - 2007 SN - 1559-0720 VL - 118 IS - 3 SP - 217 EP - 226 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Li, Anlan A1 - Seipelt, H. A1 - Müller, C. [u.a.] T1 - Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; Müller, C.;Shi, Yong de; Artmann, Gerhard Michael JF - Pharmacology and Toxicology. 85 (1999) Y1 - 1999 SN - 0902-9938 SP - 206 EP - 211 ER - TY - CHAP A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Nojima, H. A1 - Artmann, Gerhard T1 - Effects of plasma generated ions on bacteria : [poster] N2 - Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death. KW - Clusterion KW - Bakterien KW - plasma generated ions Y1 - 2003 ER - TY - CHAP A1 - Schlemmer, Katharina A1 - Porst, Dariusz A1 - Bassam, Rasha A1 - Artmann, Gerhard A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - https://doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 100 EP - 101 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Streun, M. A1 - Christ, D. A1 - Hellendung, A. A1 - Larue, H. A1 - Ziemons, Karl A1 - Halling, H. T1 - Effects of crosstalk and gain nonuniformity using multichannel PMTs in the Clearpet® scanner JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment N2 - The ClearPET® scanners developed by the Crystal Clear Collaboration use multichannel PMTs as photodetectors with scintillator pixels coupled individually to each channel. In order to localize an event each channel anode is connected to a comparator that triggers when the anode signal exceeds a common predefined threshold. Two major difficulties here are crosstalk of light and the gain nonuniformity of the PMT channels. Crosstalk can generate false triggering in channels adjacent to the actual event. On the one hand this can be suppressed by sufficiently increasing the threshold, but on the other hand a threshold too high can already prevent valid events on the lower gain channels from being detected. Finally, both effects restrict the dynamic range of pulse heights that can be processed. The requirements to the dynamic range are not low as the ClearPET® scanners detect the depth of interaction by phoswich pixels consisting of LSO and Lu0.7Y0.3AP, two scintillators with different light yields. We will present a model to estimate the achievable dynamic range and show solutions to increase it. Y1 - 2005 SN - 0168-9002 N1 - Proceedings of the 7th International Conference on Inorganic Scintillators and their Use in Scientific and Industrial Applications VL - 537 IS - 1-2 SP - 402 EP - 405 ER - TY - CHAP A1 - Frotscher, Ralf A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Holzapfel, Gerhard A. T1 - Effectiveness of the edge-based smoothed finite element method applied to soft biological tissues T2 - ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012 Y1 - 2012 SN - 978-3-85125-223-1 PB - Verlag d. Technischen Universität Graz CY - Graz ER - TY - CHAP A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Effect of wind on flight style optimisation in ski jumping T2 - 15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK Y1 - 2016 SP - 53 EP - 54 PB - The University of Edinburgh ; Loughborough University CY - Edinburgh ER - TY - JOUR A1 - Werkhausen, Amelie A1 - Albracht, Kirsten A1 - Cronin, Neil J A1 - Paulsen, Gøran A1 - Bojsen-Møller, Jens A1 - Seynnes, Olivier R T1 - Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing JF - Frontiers in physiology N2 - During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation. KW - achilles tendon KW - energy absorption KW - energy dissipation KW - mechanical buffer KW - stiffness Y1 - 2018 U6 - https://doi.org/10.3389/fphys.2018.00794 SN - 1664-042X IS - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Baskurt, O. K. A1 - Meiselman, H. J. T1 - Effect of superoxide anions on red blood cell rheologic properties. Baskurt, O. K.; Temiz, A.; Meiselman, H. J. JF - Free Radical Biology and Medicine. 24 (1998), H. 1 Y1 - 1998 SN - 0891-5849 SP - 102 EP - 110 ER - TY - JOUR A1 - Özsoylu, Dua A1 - Kizildag, Sefa A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Effect of plasma treatment on the sensor properties of a light‐addressable potentiometric sensor (LAPS) JF - physica status solidi a : applications and materials sciences N2 - A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment. Y1 - 2019 U6 - https://doi.org/10.1002/pssa.201900259 SN - 1862-6319 N1 - Corresponding author: Torsten Wagner VL - 216 IS - 20 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Weckesser, Matthias A1 - Hufnagel, Andreas A1 - Ziemons, Karl A1 - Grießmeier, Martin A1 - Sonnenberg, Frank A1 - Hackländer, Thomas A1 - Langen, Karl-J. A1 - Holschbach, Markus A1 - Elger, Christian E. A1 - Müller-Gärtner, Hans-W. T1 - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy JF - European Journal of Nuclear Medicine N2 - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration. Y1 - 1997 SN - 1619-7089 VL - 24 IS - 9 SP - 1156 EP - 1161 ER - TY - JOUR A1 - Arreola, Julio A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Effect of O2 plasma on properties of electrolyte-insulator-semiconductor structures JF - physica status solidi a : applications and materials sciences N2 - Prior to immobilization of biomolecules or cells onto biosensor surfaces, the surface must be physically or chemically activated for further functionalization. Organosilanes are a versatile option as they facilitate the immobilization through their terminal groups and also display self-assembly. Incorporating hydroxyl groups is one of the important methods for primary immobilization. This can be done, for example, with oxygen plasma treatment. However, this treatment can affect the performance of the biosensors and this effect is not quite well understood for surface functionalization. In this work, the effect of O2 plasma treatment on EIS sensors was investigated by means of electrochemical characterizations: capacitance–voltage (C–V) and constant capacitance (ConCap) measurements. After O2 plasma treatment, the potential of the EIS sensor dramatically shifts to a more negative value. This was successfully reset by using an annealing process. KW - surface functionalization KW - O2 plasma KW - hydroxylation KW - electrolyte-insulator semiconductor sensor (EIS) KW - annealing Y1 - 2017 U6 - https://doi.org/10.1002/pssa.201700025 SN - 1862-6319 VL - 214 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Effect of nitric oxide on protein thermal stability : [abstract] N2 - As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not. KW - Stickstoffmonoxid KW - Proteine KW - Hämoglobin KW - nitric oxide gas KW - protein KW - hemoglobin Y1 - 2009 ER - TY - CHAP A1 - ElBashir, Rasha A1 - Digel, Ilya T1 - Effect of nitric oxide gas on hydrogels : [abstract] N2 - The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels. KW - Stickstoffmonoxid KW - Hydrogel KW - nitric oxide gas KW - hydrogel Y1 - 2009 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Maier, Mathias A1 - Bauer, Svetlana A1 - Feucht, Nikolaus T1 - Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model / Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines JF - Acta Ophthalmologica Scandinavica. 85 (2007), H. 7 Y1 - 2007 SN - 1755-3768 SP - 777 EP - 781 PB - - ER -