TY - JOUR A1 - Molinnus, Denise A1 - Hardt, Gabriel A1 - Siegert, Petra A1 - Willenberg, Holger S. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling JF - Electroanalysis N2 - An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5–1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma. Y1 - 2018 U6 - https://doi.org/10.1002/elan.201800026 SN - 1521-4109 VL - 30 IS - 5 SP - 937 EP - 942 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Molinnus, Denise A1 - Bäcker, Matthias A1 - Siegert, Petra A1 - Willenberg, H. A1 - Poghossian, Arshak A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Detection of Adrenaline Based on Substrate Recycling Amplification JF - Procedia Engineering N2 - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied. Y1 - 2015 U6 - https://doi.org/10.1016/j.proeng.2015.08.708 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 540 EP - 543 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Molinnus, Denise A1 - Hardt, Gabriel A1 - Käver, Larissa A1 - Willenberg, Holger S. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology T2 - MDPI Proceedings Y1 - 2017 U6 - https://doi.org/10.3390/proceedings1040506 ER - TY - JOUR A1 - Allefeld, Carsten A1 - Bialonski, Stephan T1 - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains JF - Physical Review E Y1 - 2007 U6 - https://doi.org/10.1103/PhysRevE.76.066207 SN - 2470-0053 VL - 76 IS - 6 SP - 066207 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Detecting Both Physical and (Bio-)Chemical Parameters by Means of ISFET Devices JF - Electroanalysis. 16 (2004), H. 22 Y1 - 2004 SN - 1040-0397 SP - 1863 EP - 1872 ER - TY - JOUR A1 - Grajewski, Matthias A1 - Kleefeld, Andreas T1 - Detecting and approximating decision boundaries in low-dimensional spaces JF - Numerical Algorithms N2 - A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch’s factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms. KW - MCDA KW - Inverse scattering problem KW - Fault approximation KW - Fault detection Y1 - 2023 SN - 1572-9265 N1 - Corresponding author: Matthias Grajewski VL - 93 IS - 4 PB - Springer Science+Business Media CY - Dordrecht ER - TY - JOUR A1 - Choi, Chang-Hoon A1 - Felder, Tim A1 - Felder, Jörg A1 - Tellmann, Lutz A1 - Hong, Suk-Min A1 - Wegener, Hans-Peter A1 - Shah, N Jon A1 - Ziemons, Karl T1 - Design, evaluation and comparison of endorectal coils for hybrid MR-PET imaging of the prostate JF - Physics in Medicine & Biology N2 - Prostate cancer is one of the most common cancers among men and its early detection is critical for its successful treatment. The use of multimodal imaging, such as MR-PET, is most advantageous as it is able to provide detailed information about the prostate. However, as the human prostate is flexible and can move into different positions under external conditions, it is important to localise the focused region-of-interest using both MRI and PET under identical circumstances. In this work, we designed five commonly used linear and quadrature radiofrequency surface coils suitable for hybrid MR-PET use in endorectal applications. Due to the endorectal design and the shielded PET insert, the outer face of the coils investigated was curved and the region to be imaged was outside the volume of the coil. The tilting angles of the coils were varied with respect to the main magnetic field direction. This was done to approximate the various positions from which the prostate could be imaged. The transmit efficiencies and safety excitation efficiencies from simulations, together with the signal-to-noise ratios from the MR images were calculated and analysed. Overall, it was found that the overlapped loops driven in quadrature were superior to the other types of coils we tested. In order to determine the effect of the different coil designs on PET, transmission scans were carried out, and it was observed that the differences between attenuation maps with and without the coils were negligible. The findings of this work can provide useful guidance for the integration of such coil designs into MR-PET hybrid systems in the future. Y1 - 2020 U6 - https://doi.org/10.1088/1361-6560/ab87f8 SN - 0031-9155 VL - 65 IS - 11 PB - IOP CY - Bristol ER - TY - JOUR A1 - Heinrichs, U. A1 - Pietrzyk, Uwe A1 - Ziemons, Karl T1 - Design optimization of the PMT-ClearPET prototypes based on simulation studies with GEANT3 JF - IEEE Transactions on Nuclear Science N2 - Within the Crystal Clear Collaboration (CCC), four centers are developing second generation high performance small animal positron emission tomography (PET) scanners for different kinds of animals and medical applications. The first prototypes are photomultiplier tube (PMT)-based systems including depth of interaction (DOI) detection by using a phoswich layer of lutetium oxyorthosilicate (LSO) and lutetium yttrium aluminum perovskite (LuYAP). The aim of these simulation studies is to optimize sensitivity and spatial resolution of given designs, which vary in fields of view (FOVs) caused by different detector configurations (ring/octagon) and sizes. For this purpose the simulation tool GEANT3 (CERN, Geneva, Switzerland) was used. Y1 - 2003 SN - 0018-9499 VL - 50 IS - 5 SP - 1428 EP - 1432 ER - TY - CHAP A1 - Staat, Manfred T1 - Design by Analysis of Pressure Components by non-linear Optimization N2 - This paper presents the direct route to Design by Analysis (DBA) of the new European pressure vessel standard in the language of limit and shakedown analysis (LISA). This approach leads to an optimization problem. Its solution with Finite Element Analysis is demonstrated for some examples from the DBA-Manual. One observation from the examples is, that the optimisation approach gives reliable and close lower bound solutions leading to simple and optimised design decision. KW - Analytischer Zulaessigkeitsnachweis KW - FEM KW - Einspiel-Analyse KW - design-by-analysis KW - finite element analysis KW - limit and shakedown analysis Y1 - 2003 ER - TY - JOUR A1 - Staat, Manfred A1 - Schwartz, M. A1 - Lang, H. A1 - Wirtz, K. A1 - Heitzer, M. T1 - Design by Analysis of Pressure Components by non-linear Optimization JF - The 10th International Conference on Pressure Vessel Technology, July 7-10, 2003, Vienna, Austria, Proceedings ICPVT-10 / Zeman, J. L. [ed] Y1 - 2003 SN - 3950152814 SP - 59 EP - 65 PB - ÖGS, Österreichische Gesellschaft für Schweißtechnik CY - Wien ER - TY - JOUR A1 - Beer, S. A1 - Streun, M. A1 - Hombach, T. A1 - Buehler, J. A1 - Jahnke, S. A1 - Khodaverdi, M. A1 - Larue, H. A1 - Minwuyelet, S. A1 - Parl, C. A1 - Roeb, G. A1 - Schurr, U. A1 - Ziemons, Karl T1 - Design and initial performance of PlanTIS: a high-resolution positron emission tomograph for plants JF - Physics in Medicine and Biology N2 - Positron emitters such as 11C, 13N and 18F and their labelled compounds are widely used in clinical diagnosis and animal studies, but can also be used to study metabolic and physiological functions in plants dynamically and in vivo. A very particular tracer molecule is 11CO2 since it can be applied to a leaf as a gas. We have developed a Plant Tomographic Imaging System (PlanTIS), a high-resolution PET scanner for plant studies. Detectors, front-end electronics and data acquisition architecture of the scanner are based on the ClearPET™ system. The detectors consist of LSO and LuYAP crystals in phoswich configuration which are coupled to position-sensitive photomultiplier tubes. Signals are continuously sampled by free running ADCs, and data are stored in a list mode format. The detectors are arranged in a horizontal plane to allow the plants to be measured in the natural upright position. Two groups of four detector modules stand face-to-face and rotate around the field-of-view. This special system geometry requires dedicated image reconstruction and normalization procedures. We present the initial performance of the detector system and first phantom and plant measurements. Y1 - 2010 U6 - https://doi.org/10.1088/0031-9155/55/3/006 SN - 1361-6560 VL - 55 IS - 3 SP - 635 EP - 646 PB - IOP CY - Bristol ER - TY - CHAP A1 - Terstegge, Andreas A1 - Weber, S. A1 - Herzog, H. A1 - Müller-Gärtner, H. W. A1 - Halling, H. T1 - Design and implementation aspects of a 3D reconstruction algorithm for the Jülich TierPET system T2 - 1997 International Meeting on Fully ThreeDimensional Image Reconstruction in Radiology and Nuclear Medicine : 3D97 Y1 - 1997 SP - 170 EP - 173 ER - TY - BOOK A1 - Sander, Volker T1 - Design and evaluation of a bandwidth broker that provides network quality of service for grid applications Y1 - 2003 SN - 3-00-010002-4 N1 - NIC series ; 16 ; Zugl. Aachen, Techn. Hochsch., Diss., 2002 PB - John von Neumann Institute for Computing (NIC) CY - Jülich ER - TY - JOUR A1 - Defosse, Jerome A1 - Kleinschmidt, Joris A1 - Schmutz, Axel A1 - Loop, Torsten A1 - Staat, Manfred A1 - Gatzweiler, Karl-Heinz A1 - Wappler, Frank A1 - Schieren, Mark T1 - Dental strain on maxillary incisors during tracheal intubation with double-lumen tubes and different laryngoscopy techniques - a blinded manikin study JF - Journal of Cardiothoracic and Vascular Anesthesia KW - anaesthetic complications KW - dental trauma KW - difficult airway KW - double-lumen tube intubation KW - videolaryngoscopy Y1 - 2022 U6 - https://doi.org/10.1053/j.jvca.2022.02.017 SN - 1053-0770 VL - 36 IS - 8, Part B SP - 3021 EP - 3027 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Digel, Ilya A1 - Kern, Inna A1 - Geenen, Eva-Maria A1 - Akimbekov, Nuraly S. T1 - Dental plaque removal by ultrasonic toothbrushes JF - dentistry journal N2 - With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness. Y1 - 2020 U6 - https://doi.org/10.3390/dj8010028 SN - 2304-6767 VL - 8 IS - 28 SP - 1 EP - 13 PB - MDPI CY - Basel ER - TY - JOUR A1 - Stulpe, Werner T1 - Density Operator JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 166 EP - 169 PB - Springer CY - Berlin ER - TY - JOUR A1 - Malan, Leone A1 - Hamer, Mark A1 - Känel, Roland von A1 - Kotliar, Konstantin A1 - Wyk, Roelof D. van A1 - Lambert, Gavin W. A1 - Vilser, Walthard A1 - Ziemssen, Tjalf A1 - Schlaich, Markus P. A1 - Smith, Wayne A1 - Magnusson, Martin A1 - Wentzel, Annemarie A1 - Myburgh, Carlien E. A1 - Steyn, Hendrik S. A1 - Malan, Nico T. T1 - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study JF - Cardiovascular Journal of Africa Y1 - 2020 U6 - https://doi.org/10.5830/CVJA-2020-031 SN - 1680-0745 VL - 26 IS - 31 SP - 1 EP - 12 PB - Clinics Cardive Publishing CY - Durbanville ER - TY - JOUR A1 - Schusser, Sebastian A1 - Menzel, S. A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Degradation of thin poly(lactic acid) films: characterization by capacitance-voltage, atomic force microscopy, scanning electron microscopy and contact-angle measurements JF - Electrochimica Acta Y1 - 2013 SN - 1873-3859 (E-Journal); 0013-4686 (Print) VL - Vol. 113 SP - 779 EP - 784 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Heiduschka, P. A1 - Romann, I. A1 - Ecken, H. A1 - Schöning, Michael Josef A1 - Schuhmann, W. A1 - Thanos, S. T1 - Defined adhesion and growth of neurones on artificial structured substrates JF - Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz Y1 - 2001 SN - 0-08-044014-2 SP - 299 EP - 307 PB - Elsevier [u.a.] CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Ortner, Marion A1 - Hauser, Christine A1 - Schmaderer, Christoph A1 - Muggenthaler, Claudia A1 - Hapfelmeier, Alexander A1 - Sorg, Christian A1 - Diehl-Schmid, Janine A1 - Kurz, Alexander A1 - Förstl, Hans A1 - Ikenberg, Benno A1 - Kotliar, Konstantin A1 - Holger, Poppert A1 - Grimmer, Timo T1 - Decreased vascular pulsatility in Alzheimer’s disease dementia measured by transcranial color-coded duplex sonography JF - Neuropsychiatric disease and treatment N2 - Purpose: Impaired paravascular drainage of β-Amyloid (Aβ) has been proposed as a contributing cause for sporadic Alzheimer’s disease (AD), as decreased cerebral blood vessel pulsatility and subsequently reduced propulsion in this pathway could lead to the accumulation and deposition of Aβ in the brain. Therefore, we hypothesized that there is an increased impairment in pulsatility across AD spectrum. Patients and Methods: Using transcranial color-coded duplex sonography (TCCS) the resistance and pulsatility index (RI; PI) of the middle cerebral artery (MCA) in healthy controls (HC, n=14) and patients with AD dementia (ADD, n=12) were measured. In a second step, we extended the sample by adding patients with mild cognitive impairment (MCI) stratified by the presence (MCI-AD, n=8) or absence of biomarkers (MCI-nonAD, n=8) indicative for underlying AD pathology, and compared RI and PI across the groups. To control for atherosclerosis as a confounder, we measured the arteriolar-venular-ratio of retinal vessels. Results: Left and right RI (p=0.020; p=0.027) and left PI (p=0.034) differed between HC and ADD controlled for atherosclerosis with AUCs of 0.776, 0.763, and 0.718, respectively. The RI and PI of MCI-AD tended towards ADD, of MCI-nonAD towards HC, respectively. RIs and PIs were associated with disease severity (p=0.010, p=0.023). Conclusion: Our results strengthen the hypothesis that impaired pulsatility could cause impaired amyloid clearance from the brain and thereby might contribute to the development of AD. However, further studies considering other factors possibly influencing amyloid clearance as well as larger sample sizes are needed. Y1 - 2019 U6 - https://doi.org/10.2147/NDT.S225754 SN - 1178-2021 IS - 15 SP - 3487 EP - 3499 PB - Dove Medical Press CY - Albany, Auckland ER - TY - JOUR A1 - Digel, Ilya A1 - Kurulgan Demirci, Eylem A1 - Linder, Peter A1 - Kayser, Peter T1 - Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts JF - Medical and Biological Engineering and Computing. 45 (2007), H. 1 Y1 - 2007 SN - 1741-0444 SP - 91 EP - 97 ER - TY - CHAP A1 - Maurer, Florian A1 - Sejdija, Jonathan A1 - Sander, Volker T1 - Decentralized energy data storages through an Open Energy Database Server N2 - In the research domain of energy informatics, the importance of open datais rising rapidly. This can be seen as various new public datasets are created andpublished. Unfortunately, in many cases, the data is not available under a permissivelicense corresponding to the FAIR principles, often lacking accessibility or reusability.Furthermore, the source format often differs from the desired data format or does notmeet the demands to be queried in an efficient way. To solve this on a small scale atoolbox for ETL-processes is provided to create a local energy data server with openaccess data from different valuable sources in a structured format. So while the sourcesitself do not fully comply with the FAIR principles, the provided unique toolbox allows foran efficient processing of the data as if the FAIR principles would be met. The energydata server currently includes information of power systems, weather data, networkfrequency data, European energy and gas data for demand and generation and more.However, a solution to the core problem - missing alignment to the FAIR principles - isstill needed for the National Research Data Infrastructure. KW - Open Data KW - Database KW - Time-series Y1 - 2024 U6 - https://doi.org/10.5281/zenodo.10607895 N1 - 1st NFDI4Energy Conference (NFDI4Energy) , Hanover, Germany, 20-21 February 2024 ER - TY - GEN A1 - Topcu, Murat A1 - Madabhushi, Gopal Santana Phani A1 - Staat, Manfred T1 - Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster N2 - Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster for an elastic stress transfer between matrix and fibres having a variable radius. KW - Natural fibres KW - Polymer-matrix composites KW - Biocomposites KW - Stress concentrations KW - Finite element analysis (FEA) Y1 - 2022 U6 - https://doi.org/10.6084/m9.figshare.19333295.v2 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Ansmann, Gerrit A1 - Kantz, Holger T1 - Data-driven prediction and prevention of extreme events in a spatially extended excitable system JF - Physical Review E Y1 - 2015 U6 - https://doi.org/10.1103/PhysRevE.92.042910 SN - 2470-0053 VL - 92 IS - 4 SP - 042910 ER - TY - JOUR A1 - Grotendorst, Johannes A1 - Kless, A. A1 - Eitrich, T. T1 - Data Mining in F & E / Kless, A. ; Eitrich, T. ; Meyer, W. ; Grotendorst, J. JF - BioWorld: Magazin für Molekularbiologische und Biotechnologische Applikationen. 9 (2004), H. 2 Y1 - 2004 SN - 1424-8514 SP - 22 EP - 23 ER - TY - JOUR A1 - Grotendorst, Johannes A1 - Kless, A. A1 - Dickhaus, T. A1 - Meyer, W. T1 - Data Mining in der pharmazeutischen Forschung und Entwicklung / Kless, A. ; Dickhaus, T. ; Meyer, W. ; Grotendorst, J. JF - LITUS - Laboratory IT User Service. 1 (2004) Y1 - 2004 SP - 20 EP - 21 ER - TY - JOUR A1 - Bandlitz, Stefan A1 - Nakhoul, Makram A1 - Kotliar, Konstantin T1 - Daily variations of corneal white-to-white diameter measured with different methods JF - Clinical and experimental optometry N2 - Purpose: A precise determination of the corneal diameter is essential for the diagnosis of various ocular diseases, cataract and refractive surgery as well as for the selection and fitting of contact lenses. The aim of this study was to investigate the agreement between two automatic and one manual method for corneal diameter determination and to evaluate possible diurnal variations in corneal diameter. Patients and Methods: Horizontal white-to-white corneal diameter of 20 volunteers was measured at three different fixed times of a day with three methods: Scheimpflug method (Pentacam HR, Oculus), placido based topography (Keratograph 5M, Oculus) and manual method using an image analysis software at a slitlamp (BQ900, Haag-Streit). Results: The two-factorial analysis of variance could not show a significant effect of the different instruments (p = 0.117), the different time points (p = 0.506) and the interaction between instrument and time point (p = 0.182). Very good repeatability (intraclass correlation coefficient ICC, quartile coefficient of dispersion QCD) was found for all three devices. However, manual slitlamp measurements showed a higher QCD than the automatic measurements with the Keratograph 5M and the Pentacam HR at all measurement times. Conclusion: The manual and automated methods used in the study to determine corneal diameter showed good agreement and repeatability. No significant diurnal variations of corneal diameter were observed during the period of time studied. Y1 - 2022 U6 - https://doi.org/10.2147/OPTO.S360651 SN - 0816-4622 IS - 14 SP - 173 EP - 181 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Embs, Jan P. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Unruh, Tobias A1 - Büldt, Georg A1 - Zaccai, Guiseppe T1 - Cytoplasmic water and hydration layer dynamics in human red blood cells JF - Journal of the American Chemical Society. 50 (2008), H. 130 Y1 - 2008 SN - 1520-5126 SP - 16852 EP - 16853 ER - TY - JOUR A1 - Ge, B. A1 - Meyer, T. A1 - Schöning, Michael Josef A1 - Wollenberger, U. A1 - Lisdat, F., T1 - Cytochrome c‘ from Chromatium vinosum on gold electrodes JF - Electrochemistry Communications. 2 (2000), H. 8 Y1 - 2000 SN - 1388-2481 SP - 557 EP - 561 ER - TY - JOUR A1 - Staat, Manfred T1 - Cyclic plastic deformation tests to verify FEM-based shakedown analyses N2 - Fatigue analyses are conducted with the aim of verifying that thermal ratcheting is limited. To this end it is important to make a clear distintion between the shakedown range and the ratcheting range (continuing deformation). As part of an EU-supported research project, experiments were carried out using a 4-bar model. The experiment comprised a water-cooled internal tube, and three insulated heatable outer test bars. The system was subjected to alternating axial forces, superimposed with alternating temperatures at the outer bars. The test parameters were partly selected on the basis of previous shakedown analyses. During the test, temperatures and strains were measured as a function of time. The loads and the resulting stresses were confirmed on an ongoing basis during performance of the test, and after it. Different material models were applied for this incremental elasto-plastic analysis using the ANSYS program. The results of the simulation are used to verify the FEM-based shakedown analysis. KW - Materialermüdung KW - Einspielen KW - Materialermüdung KW - shakedown analyses KW - thermal ratcheting KW - fatigue analyses Y1 - 2001 ER - TY - JOUR A1 - Heieis, Jule A1 - Böcker, Jonas A1 - D'Angelo, Olfa A1 - Mittag, Uwe A1 - Albracht, Kirsten A1 - Schönau, Eckhard A1 - Meyer, Andreas A1 - Voigtmann, Thomas A1 - Rittweger, Jörn T1 - Curvature of gastrocnemius muscle fascicles as function of muscle–tendon complex length and contraction in humans JF - Physiological Reports N2 - It has been shown that muscle fascicle curvature increases with increasing contraction level and decreasing muscle–tendon complex length. The analyses were done with limited examination windows concerning contraction level, muscle–tendon complex length, and/or intramuscular position of ultrasound imaging. With this study we aimed to investigate the correlation between fascicle arching and contraction, muscle–tendon complex length and their associated architectural parameters in gastrocnemius muscles to develop hypotheses concerning the fundamental mechanism of fascicle curving. Twelve participants were tested in five different positions (90°/105°*, 90°/90°*, 135°/90°*, 170°/90°*, and 170°/75°*; *knee/ankle angle). They performed isometric contractions at four different contraction levels (5%, 25%, 50%, and 75% of maximum voluntary contraction) in each position. Panoramic ultrasound images of gastrocnemius muscles were collected at rest and during constant contraction. Aponeuroses and fascicles were tracked in all ultrasound images and the parameters fascicle curvature, muscle–tendon complex strain, contraction level, pennation angle, fascicle length, fascicle strain, intramuscular position, sex and age group were analyzed by linear mixed effect models. Mean fascicle curvature of the medial gastrocnemius increased with contraction level (+5 m−1 from 0% to 100%; p = 0.006). Muscle–tendon complex length had no significant impact on mean fascicle curvature. Mean pennation angle (2.2 m−1 per 10°; p < 0.001), inverse mean fascicle length (20 m−1 per cm−1; p = 0.003), and mean fascicle strain (−0.07 m−1 per +10%; p = 0.004) correlated with mean fascicle curvature. Evidence has also been found for intermuscular, intramuscular, and sex-specific intramuscular differences of fascicle curving. Pennation angle and the inverse fascicle length show the highest predictive capacities for fascicle curving. Due to the strong correlations between pennation angle and fascicle curvature and the intramuscular pattern of curving we suggest for future studies to examine correlations between fascicle curvature and intramuscular fluid pressure. KW - biomechanics KW - connective tissue KW - physiology KW - ultrasound Y1 - 2023 U6 - https://doi.org/10.14814/phy2.15739 SN - 2051-817X VL - 11 IS - 11 SP - e15739, Seite 1-11 PB - Wiley ER - TY - PAT A1 - Wandrey, Christian A1 - Biselli, Manfred A1 - Schröder, Bernd A1 - Schmoll, Hans-Joachim T1 - Culturing cells on macroporous glass carriers coated with gelatin, extracellular matrix protein and stromal cells Y1 - 1999 N1 - United States Patent 5,906,940 May 25, 1999 SP - 1 EP - 12 ER - TY - JOUR A1 - Thust, M. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Naser, S. A1 - Müller-Veggian, Mattea A1 - Kordos, P. A1 - Lüth, H. T1 - Crosssensitivity of a capacitive penicillin sensor combined with a diffusion barrier JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague) SP - 573 EP - 576 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Didelez, J. P. T1 - Crosssections and isomers ratios for ²¹¹,²¹² Po JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1978) Y1 - 1978 SP - 949 PB - Physik-Verlag CY - Weinheim ER - TY - JOUR A1 - Thust, M. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Naser, S. A1 - Müller-Veggian, Mattea A1 - Kordos, P. A1 - Lüth, H. T1 - Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors <13, 1999, 's-Gravenhage> ; Eurosensors <13, 1999, The Hague> ; European Conference on Solid-State Transducers <13, 1999, The Hague> SP - 573 EP - 576 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Poghossian, Arshak A1 - Thust, M. A1 - Schöning, Michael Josef A1 - Müller-Veggian, Mattea A1 - Kordos, P. A1 - Lüth, H. T1 - Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier JF - Sensors and Actuators B. 68 (2000), H. 1-3 Y1 - 2000 SN - 0925-4005 SP - 260 EP - 265 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Didelez, J. P. T1 - Cross sections and isomer ratios for ²¹¹,²¹² Po JF - Annual report 1977 / Institut für Kernphysik Kernforschungsanlage Jülich Y1 - 1978 N1 - Spezielle Berichte der Kernforschungsanlage Jülich ; 15 SP - 49 EP - 50 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Rübbelke, Dirk A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Zobel, Luzy T1 - Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production JF - Data in Brief N2 - Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (Rübbelke, 2022). KW - Energy-intensive industry KW - Steel industry KW - Competitiveness KW - Floor prices KW - Cross border adjustment mechanism Y1 - 2023 U6 - https://doi.org/10.1016/j.dib.2023.108907 SN - 2352-3409 VL - 47 IS - Article 108907 SP - 1 EP - 5 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Gaigall, Daniel A1 - Gerstenberg, Julian T1 - Cramér-von-Mises tests for the distribution of the excess over a confidence level JF - Journal of Nonparametric Statistics N2 - The Cramér-von-Mises distance is applied to the distribution of the excess over a confidence level. Asymptotics of related statistics are investigated, and it is seen that the obtained limit distributions differ from the classical ones. For that reason, quantiles of the new limit distributions are given and new bootstrap techniques for approximation purposes are introduced and justified. The results motivate new one-sample goodness-of-fit tests for the distribution of the excess over a confidence level and a new confidence interval for the related fitting error. Simulation studies investigate size and power of the tests as well as coverage probabilities of the confidence interval in the finite sample case. A practice-oriented application of the Cramér-von-Mises tests is the determination of an appropriate confidence level for the fitting approach. The adoption of the idea to the well-known problem of threshold detection in the context of peaks over threshold modelling is sketched and illustrated by data examples. KW - Cramér-von-Mises test KW - conditional excess distribution KW - confidence interval KW - goodness-of-fit test Y1 - 2023 U6 - https://doi.org/10.1080/10485252.2023.2173958 SN - 1048-5252 (Print) SN - 1029-0311 (Online) PB - Taylor & Francis ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Malkoc, Ü. A1 - Steffen, A. A1 - Marso, M. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Coupling of insect antennae to field-effect transistors for biochemical sensing JF - Electrochimica Acta. 44 (1999), H. 21-22 Y1 - 1999 SN - 0013-4686 SP - 3821 EP - 3826 ER - TY - JOUR A1 - Molinnus, Denise A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Katz, Evgeny A1 - Schöning, Michael Josef T1 - Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips JF - Electroanalysis N2 - The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor. Y1 - 2017 U6 - https://doi.org/10.1002/elan.201700208 SN - 1521-4109 VL - 29 IS - 8 SP - 1840 EP - 1849 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Krämer, Melina A1 - Pita, Marcos A1 - Zhou, Jian A1 - Ornatska, Maryna A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny T1 - Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information JF - Journal of Physical Chemistry C: Nanomaterials and Interfaces. 113 (2009), H. 6 Y1 - 2009 SN - 1932-7455 SP - 2573 EP - 2579 PB - American Cemical Society CY - Washington, DC ER - TY - CHAP A1 - Schreiber, Marc A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - Cost-efficient quality assurance of natural language processing tools through continuous monitoring with continuous integration T2 - 3rd International Workshop on Software Engineering Research and Industrial Practice Y1 - 2016 U6 - https://doi.org/10.1145/2897022.2897029 N1 - SER&IP’16, May 17 2016, Austin, TX, USA SP - 46 EP - 52 ER - TY - JOUR A1 - Alnemer, Momin Sami Mohammad A1 - Kotliar, Konstantin A1 - Neuhaus, Valentin A1 - Pape, Hans-Christoph A1 - Ciritsis, Bernhard D. T1 - Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model JF - Cost Effectiveness and Resource Allocation N2 - Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks. KW - Hip fractures KW - Prevention KW - Geriatric KW - Cost-effectiveness KW - Prophylaxis Y1 - 2023 U6 - https://doi.org/10.1186/s12962-023-00482-4 SN - 1478-7547 N1 - Corresponding author: Momin S. Alnemer IS - 21, Article number: 77 PB - Springer Nature ER - TY - GEN A1 - Jung, Alexander A1 - Müller, Wolfram A1 - Staat, Manfred T1 - Corrigendum to “Wind and fairness in ski jumping: A computer modelling analysis” [J. Biomech. 75 (2018) 147–153] T2 - Journal of Biomechanics Y1 - 2021 U6 - https://doi.org/10.1016/j.jbiomech.2021.110690 SN - 0021-9290 N1 - Refers to: Alexander Jung, Wolfram Müller, Manfred Staat: Wind and fairness in ski jumping: A computer modelling analysis. Journal of Biomechanics, Volume 75. 25 June 2018. Pages 147-153. https://doi.org/10.1016/j.jbiomech.2018.05.001 VL - 128 IS - Article number: 110690 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716–722] JF - Journals of Biomechanics Y1 - 2018 U6 - https://doi.org/10.1016/j.jbiomech.2018.02.001 SN - 0021-9290 N1 - refers to Journal of Biomechanics Vol 47, Issue 3, Pages 716-722: https://doi.org/10.1016/j.jbiomech.2013.11.021 SP - 313 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, Gamal A1 - Falk, R. A1 - Crookshank, M. T1 - Corrigendum to “Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration”. Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T. JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 1802 ER - TY - JOUR A1 - Zhantlessova, Sirina A1 - Savitskaya, Irina A1 - Kistaubayeva, Aida A1 - Ignatova, Ludmila A1 - Talipova, Aizhan A1 - Pogrebnjak, Alexander A1 - Digel, Ilya T1 - Correction: Zhantlessova et al. advanced “Green” prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy. Polymers 2022, 14, 3224 JF - Polymers Y1 - 2024 U6 - https://doi.org/10.3390/polym16131802 SN - 2073-4360 N1 - This article belongs to the Special Issue Cellulose Based Composites VL - 16 IS - 13 PB - MDPI CY - Basel ER - TY - JOUR A1 - Mourzina, Y. G. A1 - Schöning, Michael Josef A1 - Schubert, J. A1 - Zander, W. A1 - Legin, A. V. A1 - Vlasov, Y. G. A1 - Lüth, H. T1 - Copper, cadmium and thallium thin film sensors based on chalcogenide glasses JF - Analytica Chimica Acta. 433 (2001) Y1 - 2001 SN - 0378-4304 SP - 103 EP - 110 ER - TY - JOUR A1 - Hennemann, Jörg A1 - Kohl, Claus-Dieter A1 - Reisert, Steffen A1 - Kirchner, Patrick A1 - Schöning, Michael Josef T1 - Copper oxide nanofibres for detection of hydrogen peroxide vapour at high concentrations JF - physica status solidi (a) N2 - We present a sensor concept based on copper(II)oxide (CuO) nanofibres for the detection of hydrogen peroxide (H2O2) vapour in the percent per volume (% v/v) range. The fibres were produced by using the electrospinning technique. To avoid water condensation in the pores, the fibres were initially modified by an exposure to H2S to get an enclosed surface. By a thermal treatment at 350 °C the fibres were oxidised back to CuO. Thereby, the visible pores disappear which was verified by SEM analysis. The fibres show a decrease of resistance with increasing H2O2 concentration which is due to the fact that hydrogen peroxide is an oxidising gas and CuO a p-type semiconductor. The sensor shows a change of resistance within the minute range to the exposure until the maximum concentration of 6.9% v/v H2O2. At operating temperatures below 450 °C the corresponding sensor response to a concentration of 4.1% v/v increases. The sensor shows a good reproducibility of the signal at different measurements. CuO seems to be a suitable candidate for the detection of H2O2 vapour at high concentrations. Resistance behaviour of the sensor under exposure to H2O2 vapours between 2.3 and 6.9% v/v at an operating temperature of 450 °C. Y1 - 2013 U6 - https://doi.org/10.1002/pssa.201200775 SN - 1862-6319 VL - 210 IS - 5 SP - 859 EP - 863 PB - Wiley CY - Weinheim ER -