TY - JOUR A1 - Heinke, Lars N. A1 - Knicker, Axel J. A1 - Albracht, Kirsten T1 - Test-retest reliability of the internal shoulder rotator muscles' stretch reflex in healthy men JF - Journal of Electromyography and Kinesiology N2 - Until now the reproducibility of the short latency stretch reflex of the internal rotator muscles of the glenohumeral joint has not been identified. Twenty-three healthy male participants performed three sets of external shoulder rotation stretches with various pre-activation levels on two different dates of measurement to assess test-retest reliability. All stretches were applied with a dynamometer acceleration of 104°/s2 and a velocity of 150°/s. Electromyographical response was measured via surface EMG. Reflex latencies showed a pre-activation effect (ƞ2 = 0,355). ICC ranged from 0,735 to 0,909 indicating an overall “good” relative reliability. SRD 95% lay between ±7,0 to ±12,3 ms.. The reflex gain showed overall poor test-retest reproducibility. The chosen methodological approach presented a suitable test protocol for shoulder muscles stretch reflex latency evaluation. A proof-of-concept study to validate the presented methodical approach in shoulder involvement including subjects with clinically relevant conditions is recommended. KW - stretch reflex KW - shoulder KW - test-retest reliability KW - intraclass correlation coefficient KW - standard error of measurement Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.jelekin.2021.102611 SN - 1050-6411 VL - 62 IS - Article 102611 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hillen, Walter T1 - Test of QED in e+e− annihilation at energies between 12 and 31.6 GeV. TASSO Collaboration JF - Physics Letters B. 94 (1980), H. 2 Y1 - 1980 SN - 0370-2693 SP - 259 EP - 265 ER - TY - JOUR A1 - Gaigall, Daniel T1 - Test for Changes in the Modeled Solvency Capital Requirement of an Internal Risk Model JF - ASTIN Bulletin N2 - In the context of the Solvency II directive, the operation of an internal risk model is a possible way for risk assessment and for the determination of the solvency capital requirement of an insurance company in the European Union. A Monte Carlo procedure is customary to generate a model output. To be compliant with the directive, validation of the internal risk model is conducted on the basis of the model output. For this purpose, we suggest a new test for checking whether there is a significant change in the modeled solvency capital requirement. Asymptotic properties of the test statistic are investigated and a bootstrap approximation is justified. A simulation study investigates the performance of the test in the finite sample case and confirms the theoretical results. The internal risk model and the application of the test is illustrated in a simplified example. The method has more general usage for inference of a broad class of law-invariant and coherent risk measures on the basis of a paired sample. KW - Bootstrap KW - Empirical process KW - Functional Delta Method KW - Hadamard differentiability KW - Paired sample Y1 - 2021 U6 - http://dx.doi.org/10.1017/asb.2021.20 SN - 1783-1350 VL - 51 IS - 3 SP - 813 EP - 837 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Cesari, V. A1 - Conte, V. A1 - De Nardo, L. T1 - TEPCs working at nanometre level JF - Annual report / Istituto Nazionale di Fisica Nucleare, LNL, Laboratori Nazionali di Legnaro. 1999 (2000) Y1 - 2000 N1 - LNL-INFN(REP)-160/2000 SP - 117 ER - TY - JOUR A1 - Nomdedeu, Mar Monsonis A1 - Willen, Christine A1 - Schieffer, Andre A1 - Arndt, Hartmut T1 - Temperature-dependent ranges of coexistence in a model of a two-prey-one-predator microbial food web JF - Marine Biology N2 - The objective of our study was to analyze the effects of temperature on the population dynamics of a three-species food web consisting of two prey bacteria (Pedobacter sp. and Acinetobacter johnsonii) and a protozoan predator (Tetrahymena pyriformis) as model organisms. We assessed the effects of temperature on the growth rates of all three species with the objective of developing a model with four differential equations based on the experimental data. The following hypotheses were tested at a theoretical level: Firstly, temperature changes can affect the dynamic behavior of a system by temperature-dependent parameters and interactions and secondly, food web response to temperature cannot be derived from the single species temperature response. The main outcome of the study is that temperature changes affect the parameter range where coexistence is possible within all three species. This has significant consequences on our ideas regarding the evaluation of effects of global warming. Y1 - 2012 U6 - http://dx.doi.org/10.1007/s00227-012-1966-x SN - 1432-1793 VL - 159 IS - 11 SP - 2423 EP - 2430 PB - Springer CY - Berlin ER - TY - JOUR A1 - Artmann, Gerhard A1 - Kelemen, Christina A1 - Porst, Dariusz A1 - Büldt, G. [u.a.] T1 - Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; Büldt, G.; Chien, S. JF - Biophysical Journal. 75 (1998), H. 6 Y1 - 1998 SN - 1542-0086 N1 - http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1299989&blobtype=pdf SP - 3179 EP - 3183 ER - TY - CHAP A1 - Stadler, Andreas M. A1 - Embs, Jan P. A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Zaccai, Joe A1 - Büldt, Georg T1 - Temperature transitions of hemoglobin and cytosolic water diffusion in human red blood cells : [poster] N2 - Background Hemoglobin interactions in red blood cells Hemoglobin dynamics in human red blood cells Diffusion of H2O in red blood cells KW - Erythrozyt KW - Hämoglobin KW - cytosolic water diffusion KW - hemoglobin dynamics Y1 - 2007 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Kelemen, C. A1 - Chien, S. T1 - Temperature transition of human hemoglobin at body temperature: effects of calcium. Kelemen, C.; Chien, S.; Artmann, Gerhard Michael JF - Biophysical journal. 80 (2001), H. 6 Y1 - 2001 SN - 1542-0086 SP - 2622 EP - 2630 ER - TY - JOUR A1 - Ermelenko, Y. A1 - Yoshinobu, T. A1 - Mourzina, Y. A1 - Furuichi, K. A1 - Iwasaki, H. A1 - Vlasov, Y. A1 - Schöning, Michael Josef T1 - Technology of photocurable polymeric membranes for integrated LAPS JF - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan Y1 - 2001 N1 - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki) SP - 66 EP - 68 PB - Japan Association of Chemical Sensors CY - Kasuga, Fukuoka-ken ER - TY - JOUR A1 - Mourzina, Y. A1 - Yoshinobu, T. A1 - Ermelenko, Y. A1 - Furuichi, K. A1 - Vlasov, Y. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Technology of photocurable membranes for ion sensors based on laser scanned semiconductor transducer (LSST) JF - Book of abstracts / ed. by J. Saneistr. Y1 - 2002 SN - 80-01-02576-4 N1 - Eurosensors ; (16, 2002, Praha) SP - 254 EP - 257 PB - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement CY - Prague ER - TY - JOUR A1 - Heiden, W. A1 - Turek, M. A1 - Schöning, Michael Josef T1 - TasteIT : Analyzing chemical sensor data using fuzzy logic Y1 - 2011 SN - 978-1-4244-9910-6 N1 - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Beuscher, H. A1 - Gono, Y. T1 - Systematics of 10⁺ isomers in the N=78 nuclei JF - Annual report 1977 / Institut für Kernphysik Kernforschungsanlage Jülich Y1 - 1978 N1 - Spezielle Berichte der Kernforschungsanlage Jülich ; 15 SP - 33 EP - 34 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Fischer, Felix A1 - Selver, M. Alper A1 - Gezer, Sinem A1 - Dicle, Oguz A1 - Hillen, Walter T1 - Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data JF - Journal of Medical and Biological Engineering Y1 - 2015 U6 - http://dx.doi.org/10.1007/s40846-015-0097-5 SN - 2199-4757 VL - 35 IS - 6 SP - 709 EP - 723 PB - Springer CY - Berlin ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Beuscher, H. A1 - Gono, Y. A1 - Lieder, R. M. T1 - Systematic features of isomeric states in Ce, Sm, Nd nuclei JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1977) Y1 - 1977 SP - 892 ER - TY - JOUR A1 - Turlybekuly, Amanzhol A1 - Pogrebnjak, Alexander A1 - Sukhodub, L. F. A1 - Sukhodub, Liudmyla B. A1 - Kistaubayeva, A. S. A1 - Savitskaya, Irina A1 - Shokatayeva, D. H. A1 - Bondar, Oleksandr V. A1 - Shaimardanov, Z. K. A1 - Plotnikov, Sergey V. A1 - Shaimardanova, B. H. A1 - Digel, Ilya T1 - Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix JF - Materials Science and Engineering C Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.msec.2019.109965 VL - 104 IS - Article number 109965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Muschallik, Lukas A1 - Kipp, Carina Ronja A1 - Recker, Inga A1 - Bongaerts, Johannes A1 - Pohl, Martina A1 - Gelissen, Melanie A1 - Schöning, Michael Josef A1 - Selmer, Thorsten A1 - Siegert, Petra T1 - Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase JF - Journal of Biotechnology N2 - The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled. Y1 - 2020 SN - 2590-1559 U6 - http://dx.doi.org/10.1016/j.jbiotec.2020.09.016 VL - 202 IS - Vol. 324 SP - 61 EP - 70 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Muschallik, Lukas A1 - Molinnus, Denise A1 - Jablonski, Melanie A1 - Kipp, Carina Ronja A1 - Bongaerts, Johannes A1 - Pohl, Martina A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Selmer, Thorsten A1 - Siegert, Petra T1 - Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase JF - RSC Advances N2 - α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated. Y1 - 2020 U6 - http://dx.doi.org/10.1039/D0RA02066D SN - 2046-2069 VL - 10 SP - 12206 EP - 12216 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Lehnertz, Klaus A1 - Bialonski, Stephan A1 - Horstmann, Marie-Therese A1 - Krug, Dieter A1 - Rothkegel, Alexander A1 - Staniek, Matthäus A1 - Wagner, Tobias T1 - Synchronization phenomena in human epileptic brain networks JF - Journal of neuroscience methods Y1 - 2009 U6 - http://dx.doi.org/10.1016/j.jneumeth.2009.05.015 SN - 0165-0270 VL - 183 IS - 1 SP - 42 EP - 48 ER - TY - BOOK A1 - Staat, Manfred A1 - Digel, Ilya A1 - Trzewik, Jürgen A1 - Sielemann, Stefanie A1 - Erni, Daniel A1 - Zylka, Waldemar T1 - Symposium Proceedings; 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen Y1 - 2024 SN - 978-3-940402-65-3 U6 - http://dx.doi.org/10.17185/duepublico/81475 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - BOOK A1 - Staat, Manfred A1 - Erni, Daniel T1 - Symposium Proceedings; 3rd YRA MedTech Symposium 2019: May 24 / 2019 / FH Aachen Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - BOOK A1 - Grotendorst, Johannes A1 - Dornseiffer, Jürgen A1 - Schoberth, Siegfried M. T1 - Symbolic-numeric computation techniques for problem-solving in Physical Chemistry and Biochemistry . Stand 08.06.1994 / Grotendorst, Johannes ; Dornseiffer, Jürgen ; Schoberth, Siegfried M. Y1 - 1994 N1 - zgl. Technical Report KFA-ZAM-IB-9414 ; Proceedings of the Maple Summer Workshop and Symposium (MSWS'94), Rensselaer Polytechnic Institute, 9-13 August 1994, Troy, New York PB - ZAM, KFA CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes A1 - Dornseiffer, Jürgen A1 - Schoberth, Siegfried M. T1 - Symbolic-numeric computation techniques for problem-solving in Physical Chemistry and Biochemistry . Stand 08.06.1994 / Grotendorst, Johannes ; Dornseiffer, Jürgen ; Schoberth, Siegfried M. Y1 - 1994 N1 - zgl. Technical Report KFA-ZAM-IB-9414 ; Proceedings of the Maple Summer Workshop and Symposium (MSWS'94), Rensselaer Polytechnic Institute, 9-13 August 1994, Troy, New York PB - ZAM, KFA CY - Jülich ER - TY - JOUR A1 - Kodomskoi, Leonid A1 - Kotliar, Konstantin A1 - Schröder, Andreas A1 - Weiss, Michael A1 - Hille, Konrad T1 - Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter JF - Journal of Glaucoma Y1 - 2019 U6 - http://dx.doi.org/10.1097/IJG.0000000000001321 SN - 1057-0829 IS - Epub ahead of print PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Hackl, M. A1 - Andermahr, J. A1 - Staat, Manfred A1 - Bremer, I. A1 - Borggrefe, J. A1 - Prescher, A. A1 - Müller, L. P. A1 - Wegmann, K. T1 - Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation JF - The Journal of Hand Surgery (European Volume) Y1 - 2017 U6 - http://dx.doi.org/10.1177/1753193416665943 SN - 2043-6289 (Online) SN - 1753-1934 (Print) VL - 42 IS - 4 SP - 370 EP - 376 PB - Sage CY - London ER - TY - JOUR A1 - Digel, Ilya A1 - Wehlitz, V. A1 - Kayser, Peter A1 - Figiel-Lange, A. A1 - Bassam, R. A1 - Rundstedt, F. von T1 - Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids JF - Plant Pathology N2 - Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel ‘suspension depletion’ approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10–12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach. Y1 - 2018 U6 - http://dx.doi.org/10.1111/ppa.12750 SN - 1365-3059 VL - 67 IS - 2 SP - 358 EP - 365 PB - Wiley CY - Oxford ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Jabbari, Medisa A1 - Anding, Ralf A1 - Staat, Manfred T1 - Surgical treatment of vaginal vault prolapse using different prosthetic mesh implants: a finite element analysis JF - tm - Technisches Messen N2 - Particularly multiparous elderly women may suffer from vaginal vault prolapse after hysterectomy due to weak support from lax apical ligaments. A decreased amount of estrogen and progesterone in older age is assumed to remodel the collagen thereby reducing tissue stiffness. Sacrocolpopexy is either performed as open or laparoscopic surgery using prosthetic mesh implants to substitute lax ligaments. Y-shaped mesh models (DynaMesh, Gynemesh, and Ultrapro) are implanted in a 3D female pelvic floor finite element model in the extraperitoneal space from the vaginal cuff to the first sacral (S1) bone below promontory. Numerical simulations are conducted during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues are modeled as incompressible, isotropic hyperelastic materials whereas the meshes are modeled either as orthotropic linear elastic or as isotropic hyperlastic materials. The positions of the vaginal cuff and the bladder base are calculated from the pubococcygeal line for female pelvic floor at rest, for prolapse and after repair using the three meshes. Due to mesh mechanics and mesh pore deformation along the loaded direction, the DynaMesh with regular rectangular mesh pores is found to provide better mechanical support to the organs than the Gynemesh and the Ultrapro with irregular hexagonal mesh pores. Insbesondere ältere, mehrgebährende Frauen leiden häufiger an einem Scheidenvorfall nach einer Hysterektomie aufgrund der schwachen Unterstützung durch laxe apikale Bänder. Es wird angenommen, dass eine verringerte Menge an Östrogen und Progesteron im höheren Alter das Kollagen umformt, wodurch die Gewebesteifigkeit reduziert wird. Die Sakrokolpopexie ist eine offene oder laparoskopische Operation, die mit prothetischen Netzimplantaten durchgeführt wird, um laxe Bänder zu ersetzen. Y-förmige Netzmodelle (DynaMesh, Gynemesh und Ultrapro) werden in einem 3D-Modell des weiblichen Beckenbodens im extraperitonealen Raum vom Vaginalstumpf bis zum Promontorium implantiert. Numerische Simulationen werden während des Valsalva-Manövers mit geschwächtem Gewebe durchgeführt, das durch eine reduzierte Gewebesteifigkeit modelliert wird. Die Gewebe werden als inkompressible, isotrop hyperelastische Materialien modelliert, während die Netze entweder als orthotrope linear elastische oder als isotrope hyperlastische Materialien modelliert werden. Die Positionen des Vaginalstumpfs, der Blase und der Harnröhrenachse werden anhand der Pubococcygeallinie aus der Ruhelage, für den Prolaps und nach der Reparatur unter Verwendung der drei Netze berechnet. Aufgrund der Netzmechanik und der Netzporenverformung bietet das DynaMesh mit regelmäßigen rechteckigen Netzporen eine bessere mechanische Unterstützung und eine Neupositionierung des Scheidengewölbes, der Blase und der Urethraachse als Gynemesh und Ultrapro mit unregelmäßigen hexagonalen Netzporen. Y1 - 2018 U6 - http://dx.doi.org/10.1515/teme-2017-0115 SN - 2196-7113 VL - 85 IS - 5 SP - 331 EP - 342 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Balakirski, Galina A1 - Kotliar, Konstantin A1 - Pauly, Karolin J. A1 - Krings, Laura K. A1 - Rübben, Albert A1 - Baron, Jens M. A1 - Schmitt, Laurenz T1 - Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience JF - Dermatologic Surgery N2 - BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7% (19/284) of the cases. In 95% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13% to 29% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients. Y1 - 2018 U6 - http://dx.doi.org/10.1097/DSS.0000000000001615 IS - 44 (12) SP - 1525 EP - 1536 PB - Wolters Kluwer ER - TY - JOUR A1 - Hamou, Hussam Aldin A1 - Kotliar, Konstantin A1 - Tan, Sonny Kian A1 - Weiß, Christel A1 - Blume, Christian A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander A1 - Albanna, Walid T1 - Surgical nuances and placement of subgaleal drains for supratentorial procedures—a prospective analysis of efficacy and outcome in 150 craniotomies JF - Acta Neurochirurgica N2 - Background For supratentorial craniotomy, surgical access, and closure technique, including placement of subgaleal drains, may vary considerably. The influence of surgical nuances on postoperative complications such as cerebrospinal fluid leakage or impaired wound healing overall remains largely unclear. With this study, we are reporting our experiences and the impact of our clinical routines on outcome in a prospectively collected data set. Method We prospectively observed 150 consecutive patients undergoing supratentorial craniotomy and recorded technical variables (type/length of incision, size of craniotomy, technique of dural and skin closure, type of dressing, and placement of subgaleal drains). Outcome variables (subgaleal hematoma/CSF collection, periorbital edema, impairment of wound healing, infection, and need for operative revision) were recorded at time of discharge and at late follow-up. Results Early subgaleal fluid collection was observed in 36.7% (2.8% at the late follow-up), and impaired wound healing was recorded in 3.3% of all cases, with an overall need for operative revision of 6.7%. Neither usage of dural sealants, lack of watertight dural closure, and presence of subgaleal drains, nor type of skin closure or dressing influenced outcome. Curved incisions, larger craniotomy, and tumor size, however, were associated with an increase in early CSF or hematoma collection (p < 0.0001, p = 0.001, p < 0.01 resp.), and larger craniotomy size was associated with longer persistence of subgaleal fluid collections (p < 0.05). Conclusions Based on our setting, individual surgical nuances such as the type of dural closure and the use of subgaleal drains resulted in a comparable complication rate and outcome. Subgaleal fluid collections were frequently observed after supratentorial procedures, irrespective of the closing technique employed, and resolve spontaneously in the majority of cases without significant sequelae. Our results are limited due to the observational nature in our single-center study and need to be validated by supportive prospective randomized design. Y1 - 2020 U6 - http://dx.doi.org/10.1007/s00701-019-04196-6 SN - 0942-0940 VL - 2020 IS - 162 SP - 729 EP - 736 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Jessing, Max P. A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures JF - Biosensors and Bioelectronics Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.bios.2018.11.019 SN - 0956-5663 VL - 126 SP - 510 EP - 517 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Pijanowska, Dorota G. A1 - Remiszewska, Elzbieta A1 - Pederzolli, Cecilia A1 - Lunelli, Lorenzo A1 - Vendano, Michele A1 - Canteri, Roberto A1 - Dudzinski, Konrad A1 - Kruk, Jerzy A1 - Torbicz, Wladyslaw T1 - Surface modification for microreactor fabrication N2 - In this paper, methods of surface modification of different supports, i.e. glass and polymeric beads for enzyme immobilisation are described. The developed method of enzyme immobilisation is based on Schiff’s base formation between the amino groups on the enzyme surface and the aldehyde groups on the chemically modified surface of the supports. The surface of silicon modified by APTS and GOPS with immobilised enzyme was characterised by atomic force microscopy (AFM), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and infrared spectroscopy (FTIR). The supports with immobilised enzyme (urease) were also tested in combination with microreactors fabricated in silicon and Perspex, operating in a flow-through system. For microreactors filled with urease immobilised on glass beads (Sigma) and on polymeric beads (PAN), a very high and stable signal (pH change) was obtained. The developed method of urease immobilisation can be stated to be very effective. KW - Biosensor KW - Microreactors KW - surface modification KW - enzyme immobilisation KW - lab-on-a-chip Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1480 ER - TY - JOUR A1 - Arreola, Julio A1 - Oberländer, Jan A1 - Mätzkow, M. A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Surface functionalization for spore-based biosensors with organosilanes JF - Electrochimica Acta N2 - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated. Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.electacta.2017.04.157 SN - 0013-4686 VL - 241 SP - 237 EP - 243 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Beging, Stefan A1 - Leinhos, Marcel A1 - Jablonski, Melanie A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting JF - Physica status solidi (a) Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431891 SN - 1862-6319 VL - 212 IS - 6 SP - 1353 EP - 1358 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Welden, Melanie A1 - Severins, Robin A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Siegert, Petra A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors T2 - 2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) N2 - A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy. KW - Tobacco mosaic virus KW - acetoin KW - capacitive field-effect biosensor KW - enzyme immobilization Y1 - 2022 SN - 978-1-6654-5860-3 (Online) SN - 978-1-6654-5861-0 (Print) U6 - http://dx.doi.org/10.1109/ISOEN54820.2022.9789657 N1 - IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 29 May 2022 - 01 June 2022, Aveiro, Portugal. PB - IEEE ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Bochev, B. A1 - Lieder, R. M. A1 - Didelez, J. P. T1 - Study of ²⁰⁹ Bi (a,charged parzicle Xn) reactions JF - Annual report 1979 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 72) Y1 - 1980 SP - 33 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Kutsarova, T. A1 - Bochev, B. A1 - Didelez, J. P. T1 - Study of the mechanism of the (a,dxn) and (a,txn) reactions at Ea= 45 Mev JF - Annual report 1980 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: F. Grümmer. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 99) Y1 - 1981 SP - 58 PB - Kernforschungsanlage CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Beuscher, H. A1 - Haenni, D. R. T1 - Study of the level structure in ¹³⁴ Ce JF - Nuclear physics / A. 417 (1984), H. 2 Y1 - 1984 SN - 0375-9474 SP - 189 EP - 208 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Didelez, J. P. A1 - Lieder, R. M. A1 - Beuscher, H. T1 - Study of the exitation functions of ²¹¹,²¹² Po JF - Annual report 1978 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 36) Y1 - 1979 SP - 37 PB - Kernforschungsanlage CY - Jülich ER - TY - CHAP A1 - Srivastava, Alok A1 - Singh, Virendra A1 - Dhand, Chetna A1 - Kaur, Manindar A1 - Singh, Tejvir A1 - Witte, Katrin A1 - Scherer, Ulrich W. T1 - Study of swift heavy ion modified conduction polymer composites for application as gas sensor N2 - A polyaniline-based conducting composite was prepared by oxidative polymerisation of aniline in a polyvinylchloride (PVC) matrix. The coherent free standing thin films of the composite were prepared by a solution casting method. The polyvinyl chloride-polyaniline composites exposed to 120 MeV ions of silicon with total ion fluence ranging from 1011 to 1013 ions/cm2, were observed to be more sensitive towards ammonia gas than the unirradiated composite. The response time of the irradiated composites was observed to be comparably shorter. We report for the first time the application of swift heavy ion modified insulating polymer conducting polymer (IPCP) composites for sensing of ammonia gas. KW - Biosensor KW - Conducing polymer KW - ammonia gas sensors KW - swift heavy ions KW - polymer composites Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1345 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Neskakis, A. A1 - Lieder, R. M. A1 - Sletten, G. T1 - Study of side-bands in ¹⁸⁰ Os JF - Annual report 1981 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: F. Grümmer. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 146) Y1 - 1982 SP - 61 PB - Kernforschungsanlage CY - Jülich ER - TY - CHAP A1 - Müller-Veggian, Mattea A1 - Neskakis, A. A1 - Lieder, R. M. A1 - Beuscher, H. T1 - Study of rotational aligned bands in ¹⁹⁰,¹⁹²,¹⁹⁴ Au T2 - Nuclear interactions : International Conference on Nuclear Interactions held in Canberra, 28 Aug. - 1 Sept. 1978 / ed. by Brian Albert Robson. - (Lecture notes in physics ; 92) Y1 - 1978 SN - 978-3-540-09102-8 N1 - Australian Academy of Science ; International Conference on Nuclear Interactions <1978, Canberra> SP - 428 PB - Springer CY - Berlin ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Beuscher, H. A1 - Bochev, B. A1 - Haenni, D. R. T1 - Study of reactions ²⁰⁹ Bi (a,charged particle Xn) At Ea= 45 Mev and 75 Mev JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1980) Y1 - 1980 N1 - Verhandlungen der Deutschen Physikalischen Gesellschaft ; 1980=6.R.15,8 SP - 1088 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Kutsarova, T. A1 - Bochev, B. A1 - Lieder, R. M. T1 - Study of non-equilibrium particle emission from the ¹⁵⁹ Tb (a, charged particle xn) reaction at Ea= 75 Mev JF - Annual report 1981 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: F. Grümmer. - (Spezielle Berichte der Kernforschungsanlage Jülich ; 146) Y1 - 1982 SP - 37 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Oberländer, Jan A1 - Jildeh, Zaid B. A1 - Kirchner, Patrick A1 - Wendeler, Luisa A1 - Bromm, Alexander A1 - Iken, Heiko A1 - Wagner, Patrick A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes JF - Sensors N2 - In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm2. Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings. Y1 - 2015 U6 - http://dx.doi.org/10.3390/s151026115 SN - 1424-8220 N1 - This article belongs to the Special Issue "Gas Sensors—Designs and Applications" VL - 15 IS - 10 SP - 26115 EP - 26127 PB - MDPI CY - Basel ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Gono, Y. T1 - Study of high spin states in ¹⁹⁵,¹⁹⁷ Tl JF - Annual report 1975 / Institut für Kernphysik Kernforschungsanlage Jülich / Ed. board: A. Fäßler ... Y1 - 1976 SP - 57 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Gono, Y. T1 - Study of high spin states in ¹⁹⁵,¹⁹⁷ Tl JF - Annual report / Research Institute of Physics, AFI (1975) Y1 - 1975 N1 - Forskningsinstitutet för Atomfysik SP - 112 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Gono, Y. A1 - Lieder, R. M. A1 - Mayer-Böricke, C. T1 - Study of high spin states in ¹⁹⁵,¹⁹⁷ Tl JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976) Y1 - 1976 N1 - Verhandlungen der Deutschen Physikalischen Gesellschaft ; 1976=6.R.11,8 SP - 952 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Gono, Y. A1 - Lieder, R. M. T1 - Study of high spin states and isomers in ¹³⁵,¹³⁷ Ce JF - Annual report 1975 / Institut für Kernphysik Kernforschungsanlage Jülich / Ed. board: A. Fäßler ... Y1 - 1976 SP - 51 PB - Verlag des Forschungszentrums Jülich CY - Jülich ER - TY - JOUR A1 - Hillen, Walter A1 - Unglauben, F. A1 - Murdfield, M. T1 - Study of Database Connections for a Java Medical Image Viewer. Unglauben, F.; Hillen, W.; Murdfield, M. JF - Intelligente, innovative Produktentwicklung für die industrielle Praxis. Blümel, Bernd; Stenzel, Horst [Hrsg.] Y1 - 2001 N1 - Forschungsverbund Multimedia an Fachhochschulen in Nordrhein-Westfalen SP - 29 EP - 33 PB - Forschungverbund Multimedia an Fachhochschulen CY - Köln ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Bochev, B. A1 - Kutsarova, T. T1 - Study of a-induced non-equilibrium reactions with particle-y conincidences JF - Physica scripta. 24 (1981), H. 1-2 Y1 - 1981 SN - 0031-8949 N1 - Hefttitel: Nuclei at very high spin : Sven Gösta in memoriam. Proceedings of Nobel-Symposium 50 Örenäs, Sweden, June 23. - 27., 1980 ; Nobel Symposium <50, 1980, Örenäs> SP - 123 ER - TY - THES A1 - Schieffer, Andre T1 - Studies on diversity and coexistence in an experimental microbial community N2 - Biodiversity and the coexistence of species have puzzled and fascinated biologists since decades and is a hotspot in todays’ natural sciences. Preserving this biodiversity is a great challenge as habitats and environments underlying tremendous changes like climate change and the loss of natural habitats, which are mainly due to anthropogenic influences. The coexistence of numerous species even in homogeneous environments is a stunning feature of natural communities and has been summarized under the term ‘paradox of plankton’. Up to now, there are several mechanisms discussed, which may contribute to local and global diversity of organisms. Several interspecific trade offs have been identified maintaining the coexistence of species like their abilities regarding competition and predator avoidance, their capability to disperse in space and time, and their ability to exploit variable resources. Further, micro-evolutionary dynamics supporting the coexistence of species have been added to our knowledge, and deriving from theoretical deterministic models, non-linear dynamics which describe the temporal fluctuation of abundances of organisms. Whereas competition and predation seem to be clue structural elements within interacting organisms, the intrinsic dynamic behavior – by means of temporal changes in abundance - plays an important role regarding coexistence within a community. The present work sheds light on different factors affecting the coexistence of species using experimental microbial model systems consisting of a bacterivorous ciliate as the predator and two bacteria strains as prey organism. Additionally, another experimental setup consisting of two up to five bacteria species competing for one limiting resource was investigated. Highly controllable chemostat systems were established to exclude extrinsic disturbances. According to theoretical analyses I was able to show - experimentally and theoretically - that phenotypic plasticity of one species within a microbial one-predator-two-prey food web enlarges the range of possible coexistence of all species under different dynamic conditions, compared to a food web without phenotypic plasticity. This was accompanied by non-linear (chaotic) population dynamics within all experimental systems showing phenotypic plasticity. The experiments on the interplay of competition, predation and invasion showed that all aspects have an influence on species coexistence. Under undisturbed controlled conditions all aspects were analyzed in detail and in combination. Populations showed oscillations which were shown by quasi-chaotic attractors in phase space diagrams. Competition experiments with two up to five bacteria species competing for one limiting resource showed that all organisms were able to coexist which was mediated by species oscillations entering a regime of chaos. Besides that fact it was found, that the productivity (biomass) as well as the total cell numbers – under the same nutrition supply – increased by an increasing number of species in the experimental systems. Up to now, the occurrence of non-linear dynamics in well controlled experimental studies has been recognized several times and this phenomenon seemed to be more common in natural systems than generally assumed. N2 - Biodiversität und die Koexistenz von Arten fasziniert und verblüfft Biologen seit Jahr-zehnten und stellen einen Schwerpunkt in der heutigen Umweltforschung dar. Der Schutz und die Konservierung dieser Mannigfaltigkeit stellen eine große Herausfor-derung dar, da die natürlichen Lebensräume sowie die Umwelt enormen Verände-rungen unterworfen sind, welche meist in einem anthropogenen Ursprung wurzeln. Die Koexistenz vieler Arten, auch in relativ homogenen Habitaten ist ein faszinieren-des Charakteristikum natürlicher Lebensgemeinschaften und wird als ‚Paradox des Planktons‘ bezeichnet. Gegenwärtig werden diverse Ursachen diskutiert, welche vermutlich zur lokalen und globalen Diversität von Organismen beitragen. Einige die-ser möglichen Ursachen, die zur Aufrechterhaltung der Koexistenz der Arten beitra-gen, wurden identifiziert: Das Vermögen der Konkurrenz- und Prädationsvermeidung, die Fähigkeit räumlicher sowie zeitlicher Verteilung, sowie das Vermögen variable Ressourcen zu nutzen. Des Weiteren wurden mikro-evolutionäre Phänomene und Dynamiken identifiziert, sowie, von theoretischen deterministischen Modellen ausge-hend, nichtlineare Dynamiken, welche die zeitlichen Schwankungen der Abundanzen von Organismen beschreiben. Diese Aspekte stellen die Schlüsselkomponenten zwi-schen interagierenden Organismen dar, wobei das intrinsiche, nicht lineare dynami-sche Verhalten in Form von zeitlichen Veränderungen in Abundanzen eine zusätzli-che entscheidende Rolle bezüglich der Koexistenz von Arten spielen kann. Einige dieser Aspekte wurden in der vorliegenden Arbeit untersucht. In Anlehnung an theoretische Analysen konnte experimentell sowie theoretisch gezeigt werden, dass phänotypische Plastizität in einer Bakterienart in einem mikrobiellen Ein-Räuber-zwei-Beute-Nahrungsgewebe den Bereich der möglichen Koexistenz unter sich än-dernden experimentellen Bedingungen (Änderungen der Durchflussraten der Chemostate) – im direkten Vergleich zu einem experimentellen Nahrungsgewebe ohne phänotypische Plastizität – erweitern kann. Dies wurde begleitet durch nicht lineare Abundanzschwankungen in den Populationen aller untersuchten Versuchs-ansätze. In weiteren Untersuchungen wurde das Zusammenspiel von Konkurrenz, Prädation und Invasion in einer experimentellen mikrobiellen Gemeinschaft untersucht. Unter kontrollierten Bedingungen konnten diese Aspekte detailliert untersucht werden und es konnten Aufschlüsse darüber gewonnen werden, welche Reaktionen (Interaktionen) innerhalb der untersuchten Gemeinschaften stattfinden. Im Versuchsverlauf wurden Veränderungen in den Abundanzen sowie chaotische Schwankungen der Zellzahlen festgestellt. In Konkurrenzexperimenten von zwei bis zu fünf um eine limitierende Ressource konkurrierende Bakterienarten konnte gezeigt werden, dass alle Arten – vermittelt durch chaotische Abundanzschwankungen – nebeneinander koexistieren konnten. Begleitend dazu wurde herausgefunden, dass die Produktivität (Biomasse) sowie die Gesamtzellzahl bei gleicher Nahrungsverfügbarkeit der experimentellen Systeme mit steigender Artenzahl zunehmen. Gegenwärtig ist das Auftreten von Chaos in gut kontrollierten experimentellen Studien vereinzelt beobachtet worden, wobei dieses Phänomen jedoch häufiger in der Natur aufzutreten scheint als generell vermutet. Y1 - 2012 N1 - Köln, Univ., Diss., 2012 ER -