TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Jünger, M.
A1  - Keusgen, M.
T1  - Knoblauchgehaltsbestimmungen mit einem feldeffektbasierten Halbleiterbiosensor
JF  - Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. März 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik
Y1  - 2004
SN  - 3-18-091829-2
N1  - Auch erschienen als: VDI-Berichte ; 1829
SP  - 707
EP  - 714
PB  - VDI
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Simsek, Beril
A1  - Shalaby, Ahmed
A1  - Krause, Hans-Joachim
T1  - Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study
JF  - Sensors
N2  - Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled Néel–Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays.
KW  - key performance indicators
KW  - magnetic biosensing
KW  - coupled Néel–Brownian relaxation dynamics
KW  - frequency mixing magnetic detection
KW  - magnetic relaxation
KW  - micromagnetic simulation
KW  - magnetic nanoparticles
Y1  - 2024
U6  - http://dx.doi.org/10.3390/s24061945
SN  - 1424-8220
N1  - This article belongs to the Special Issue "Advances in Magnetic Sensors and Their Applications"
VL  - 24
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Oberländer, Jan
A1  - Reisert, Steffen
A1  - Kirchner, Patrick
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Kalorimetrische Gassensoren zur H2O2-Detektion in aseptischen Sterilisationsprozessen
T2  - 11. Dresdner Sensor-Symposium : 9.-11.12.2013
Y1  - 2013
SN  - 978-3-9813484-5-3
SP  - 234
EP  - 238
ER  - 
TY  - JOUR
A1  - Mourzina, Y.
A1  - Mai, T.
A1  - Poghossian, Arshak
A1  - Ermolenko, Y.
A1  - Yoshinobu, T.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - K+-selective field-effect sensors as transducers for bioelectronic applications
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3333
EP  - 3339
ER  - 
TY  - CHAP
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Mlynek, D.
A1  - Hataihimakul, S.
A1  - Pedraza, A.
A1  - Dhawan, S.
A1  - Laube, N.
A1  - Kleinen, L.
A1  - Baldsiefen, G.
A1  - Busch, H.
A1  - Schöning, Michael Josef
T1  - Ion-selective sensors for the determination of the risk of urinary stone formation
T2  - Micro- and Nanosystems in biochemical diagnosis : Principles and applications
Y1  - 2010
SP  - 74
EP  - 80
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Mourzina, Y. G.
A1  - Yoshinobu, T.
A1  - Schubert, J.
A1  - Lüth, H.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - Ion-selective lightaddressable potentiometric sensor (LAPS) with chalcogenide thin film by pulsed laser deposition
JF  - Sensors and Actuators B. 80 (2001), H. 2
Y1  - 2001
SN  - 0925-4005
SP  - 136
EP  - 140
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Investigation of the spatial resolution of a laser-based stimulation process for light-addressable hydrogels with incorporated graphene oxide by means of IR thermography
JF  - Sensors and Actuators A: Physical
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.sna.2017.11.031
SN  - 0924-4247
VL  - 268
SP  - 126
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ismail, A.B.M.
A1  - Harada, T.
A1  - Yoshinobu, T.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
T1  - Investigation of pulsed laser-deposited Al2O3 as a high pH-sensitive layer for LAPS-based biosensing applications
JF  - Sensors and Actuators B. 71 (2000), H. 3
Y1  - 2000
SN  - 0925-4005
SP  - 169
EP  - 172
ER  - 
TY  - JOUR
A1  - Näther, Niko
A1  - Henkel, Hartmut
A1  - Schneider, Andreas
A1  - Schöning, Michael Josef
T1  - Investigation of different catalytically active and passive materials for realising a hydrogen peroxide gas sensor
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 449
EP  - 454
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Sabitova, A.
A1  - Ebert, Ph.
A1  - Lenz, A.
A1  - Schaafhausen, S.
A1  - Ivanova, L.
A1  - Dähne, M.
A1  - Hoffmann, A.
A1  - Dunin-Borkowski, R. E.
A1  - Förster, Arnold
A1  - Grandidier, B.
A1  - Eisele, H.
T1  - Intrinsic bandgap of cleaved ZnO(112¯0) surfaces
JF  - Applied physics letters
Y1  - 2013
SN  - 1077-3118 (E-Journal); 0003-6951 (Print)
VL  - Vol. 102
SP  - 021608
ER  - 
TY  - BOOK
A1  - Molinnus, Denise
T1  - Integration of biomolecular logic principles with electronic transducers on a chip
Y1  - 2018
PB  - Philipps-Universität / Fachbereich Pharmazie
CY  - Marburg/Lahn
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Malzahn, K.
A1  - Abouzar, Maryam H.
A1  - Mehndiratta, P.
A1  - Katz, E.
A1  - Schöning, Michael Josef
T1  - Integration of biomolecular logic gates with field-effect transducers
JF  - Electrochimica Acta. 56 (2011), H. 26
Y1  - 2011
SN  - 0013-4686
SP  - 9661
EP  - 9665
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Rolka, David
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Integration of a capacitive EIS sensor into a FIA system for pH and penicillin determination
JF  - Sensors. 4 (2004)
Y1  - 2004
SN  - 1424-8220
SP  - 84
EP  - 94
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schroth, Peter
A1  - Lüth, Hans
A1  - Hummel, Hans E.
A1  - Schütz, Stefan
T1  - Insect chemoreceptors coupled to silicon transistors as innovative biosensors
JF  - Proceedings of SPIE. 4205 (2001)
Y1  - 2001
SP  - 152
EP  - 162
ER  - 
TY  - JOUR
A1  - Kloock, Joachim P.
A1  - Mourzina, Y.G.
A1  - Ermolenko, Y.
A1  - Doll, T.
A1  - Schubert, J.
A1  - Schöning, Michael Josef
T1  - Inorganic thin-film sensor membranes with PLD-prepared chalcogenide glasses: Challenges and implementation
JF  - Sensors. 4 (2004), H. 10
Y1  - 2004
SN  - 1424-8220
SP  - 156
EP  - 162
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schubert, J
A1  - Kloock, Joachim P.
A1  - Zander, W.
A1  - Mourzina, Y. G.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
T1  - Innovative thin film techniques for microfabricating electrochemical sensors
JF  - Lecture Notes of the ICB Seminars
Y1  - 2002
SP  - 55
EP  - 66
PB  - MCB
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schubert, Joachim P.
A1  - Kloock, Joachim P.
A1  - Zander, W.
A1  - Mourzina, Y. G.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
T1  - Innovative thin film techniques for microfabricating electrochemical sensors
JF  - Biocybernetics and Biomedical Engineering. 21 (2001), H. 4
Y1  - 2001
SN  - 0208-5216
SP  - 107
EP  - 119
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
A1  - Schubert, J.
A1  - Steffen, A.
A1  - Lüth, H.
T1  - Innovative Schichttechniken und Messprinzipien für kapazitive Feldeffektsensoren
JF  - Sensoren und Mess-Systeme : Vorträge der 11. ITG/GMA-Fachtagung vom 11. bis 12. März 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl ....
Y1  - 2002
SN  - 3-8007-2675-0
N1  - Sensoren und Mess-Systeme 2002
SP  - 151
EP  - 154
PB  - VDE-Verl.
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Hamad, E. M.
A1  - Bilatto, S. E. R.
A1  - Adly, N. Y.
A1  - Correa, D. S.
A1  - Wolfrum, B.
A1  - Schöning, Michael Josef
A1  - Offenhäusser, A.
A1  - Yakushenko, A.
T1  - Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices
JF  - Lab on a Chip
N2  - Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.
Y1  - 2016
U6  - http://dx.doi.org/10.1039/C5LC01195G
SN  - 1473-0189
VL  - 16
IS  - 1
SP  - 70
EP  - 74
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Bertz, Morten
A1  - Schöning, Michael Josef
A1  - Molinnus, Denise
A1  - Homma, Takayuki
T1  - Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping
JF  - Physica status solidi (a) applications and materials science
N2  - To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem.
KW  - hydrogen peroxide
KW  - optical spore trapping
KW  - Raman spectroscopy
KW  - sterilization conditions
KW  - temperature
Y1  - 2024
U6  - http://dx.doi.org/10.1002/pssa.202300866
SN  - 1862-6319 (Online)
SN  - 1862-6300 (Print)
IS  - Early View
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Janus, Kevin Alexander
A1  - Achtsnicht, Stefan
A1  - Tempel, Laura
A1  - Drinic, Aleksaner
A1  - Kopp, Alexander
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon
JF  - Physica status solidi : pss. A, Applications and materials science
N2  - Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5–10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.
KW  - amperometric biosensors
KW  - biocompatible
KW  - biodegradabl
KW  - encapsulation materials
KW  - fibroin
Y1  - 2023
U6  - http://dx.doi.org/10.1002/pssa.202300081
SN  - 1862-6300 (Print)
SN  - 1862-6319 (Online)
N1  - Corresponding author: Michael J. Schöning
VL  - 220
IS  - 22
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Martinez, Ronny
A1  - Jakob, Felix
A1  - Tu, Ran
A1  - Siegert, Petra
A1  - Maurer, Karl-Heinz
A1  - Schwaneberg, Ulrich
T1  - Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution
JF  - Biotechnology and bioengineering
Y1  - 2013
SN  - 1097-0290 (E-Journal); 0006-3592 (Print); 0368-1467 (Print)
VL  - Vol. 110
IS  - Iss. 3
SP  - 711
EP  - 720
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Molinnus, Denise
A1  - Beging, Stefan
A1  - Schöning, Michael Josef
T1  - Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection
JF  - Analytical chemistry
N2  - The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor’s surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance–voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.
Y1  - 2014
U6  - http://dx.doi.org/10.1021/ac500458s
SN  - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)
VL  - 86
IS  - 11
SP  - 5370
EP  - 5375
PB  - ACS Publications
CY  - Columbus
ER  - 
TY  - JOUR
A1  - Miyamoto, Koichiro
A1  - Seki, Kosuke
A1  - Suto, Takeyuki
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers
JF  - Sensor and Actuators B: Chemical
N2  - The chemical imaging sensor is a semiconductor-based chemical sensor capable of visualizing pH and ion distributions. The spatial resolution depends on the lateral diffusion of photocarriers generated by illumination of the semiconductor substrate. In this study, two types of optical setups, one based on a bundle of optical fibers and the other based on a binocular tube head, were developed to project a hybrid illumination of a modulated light beam and a ring-shaped constant illumination onto the sensor plate. An improved spatial resolution was realized by the ring-shaped constant illumination, which suppressed lateral diffusion of photocarriers by enhanced recombination due to the increased carrier concentration.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.snb.2018.07.016
SN  - 0925-4005
VL  - 273
SP  - 1328
EP  - 1333
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Delle, Lotta E.
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Müller, Frank
A1  - Grandthyll, Samuel
A1  - Jacobs, Karin
A1  - Lilischkis, Rainer
A1  - Vu, Xuan T.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Thoelen, Roland
A1  - Weil, Maryam
A1  - Ingebrandt, Sven
T1  - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431863
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1327
EP  - 1334
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Oberländer, Jan
A1  - Arreola, Julio
A1  - Hansen, Christina
A1  - Greeff, Anton
A1  - Mayer, Marlena
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Impedimetric Biosensor to Enable Fast Evaluation of Gaseous Sterilization Processes
T2  - MDPI Proceedings
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040435
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers
JF  - Physica Status Solidi (A)
N2  - Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/pssa.201200941
SN  - 1521-396X ; 0031-8965
VL  - 210
IS  - 5
SP  - 905
EP  - 910
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Mai, D.-T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
T1  - Impedance effect of an ion-sensitive membrane: characterisation of an EMIS sensor by impedance spectroscopy, capacitance-voltage and constant-capacitance method
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 423
EP  - 428
ER  - 
TY  - JOUR
A1  - Mourzina, Ioulia G.
A1  - Yoshinobu, Tatsuo
A1  - Ermolenko, Yuri E.
A1  - Vlasov, Yuri G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors
JF  - Microchimica Acta. 144 (2004), H. 1-3
Y1  - 2004
SN  - 0026-3672
SP  - 41
EP  - 50
ER  - 
TY  - JOUR
A1  - Mourzina, I.G.
A1  - Yoshinobu, T.
A1  - Ermolenko, Y.E.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors
JF  - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors
Y1  - 2004
N1  - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba)
SP  - 788
EP  - 789
PB  - Japan Association of Chemical Sensors
CY  - Fukuoka
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Sugawara, Yuri
A1  - Kanoh, Shin´ichiro
A1  - Yoshinobu, Tatsuo
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Image correction method for the chemical imaging sensor
JF  - Sensors and Actuators B: Chemical. 144 (2010), H. 2
Y1  - 2010
N1  - 22nd International Conference on Eurosensors - Dresden, Germany, 7-10 September 2008 ; Eurosensors ; (22, 2008, Dresden)
SP  - 344
EP  - 348
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Strobel, M.
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, R.
A1  - Wagner, Torsten
T1  - Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems
JF  - Physica status solidi (a)
N2  - Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201533056
SN  - 1862-6300
VL  - 213
IS  - 6
SP  - 1520
EP  - 1525
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Silva, Anielle C. A.
A1  - Dantas, Noelio O.
A1  - Schöning, Michael Josef
A1  - Siqueira, José R., Jr.
T1  - Hybrid Layer‐by‐Layer Film of Polyelectrolytes‐Embedded Catalytic CoFe2O4 Nanocrystals as Sensing Units in Capacitive Electrolyte‐Insulator‐Semiconductor Devices
JF  - physica status solidi a : applications and materials sciences
Y1  - 2019
U6  - http://dx.doi.org/10.1002/pssa.201900044
VL  - 216
IS  - 1900044
SP  - 1
EP  - 9
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Whitehead, Mark
A1  - Öhlschläger, Peter
A1  - Almajhdi, Fahad N.
A1  - Alloza, Leonor
A1  - Marzábal, Pablo
A1  - Meyers, Ann E.
A1  - Hitzeroth, Inga I.
A1  - Rybicki, Edward P.
T1  - Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
JF  - BMC cancer
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1471-2407-14-367
SN  - 1471-2407
IS  - 14:367
SP  - 1
EP  - 15
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Förster, Arnold
A1  - Lepsa, M. I.
A1  - Freundt, D.
T1  - Hot electron injector Gunn diode for advanced driver assistance systems
JF  - Applied physics A: materials science and processing. 87 (2007), H. 3
Y1  - 2007
SN  - 0947-8396
N1  - ISSN der E-Ausg.: 1432-0630 ; Special issue
SP  - 545
EP  - 558
ER  - 
TY  - JOUR
A1  - Hoskens, R.C.P.
A1  - Roer, T.G. van de
A1  - Tolstikhin, V.I.
A1  - Förster, Arnold
T1  - Hot electron injection laser: vertically integrated transistor-laser structure for high-speed, low-chirp direct modulation
JF  - LEOS 2000 : 2000 IEEE annual meeting conference proceedings; 13th annual meeting; IEEE Lasers and Electro-Optics Society 2000 annual meeting; 13-16 November 2000, The Westin Rio Mar Beach, Rio Grande, Puerto Rico. Vol. 2
Y1  - 2000
SN  - 0-7803-5947-X
N1  - 2000 IEEE LEOS annual meeting
SP  - 444
EP  - 445
PB  - IEEE Service Center
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Itabashi, Akinori
A1  - Kosaka, Naoki
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - High-speed chemical imaging system based on front-side-illuminated LAPS
JF  - Sensors and actuators B: Chemical
N2  - The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the spatial distribution of specific ions on the sensing surface. The conventional chemical imaging system based on the light-addressable potentiometric sensor (LAPS), however, required a long time to obtain a chemical image, due to the slow mechanical scan of a single light beam. For high-speed imaging, a plurality of light beams modulated at different frequencies can be employed to measure the ion concentrations simultaneously at different locations on the sensor plate by frequency division multiplex (FDM). However, the conventional measurement geometry of back-side illumination limited the bandwidth of the modulation frequency required for FDM measurement, because of the low-pass filtering characteristics of carrier diffusion in the Si substrate. In this study, a high-speed chemical imaging system based on front-side-illuminated LAPS was developed, which achieved high-speed spatiotemporal recording of pH change at a rate of 70 frames per second.
Y1  - 2013
U6  - http://dx.doi.org/10.1016/j.snb.2013.03.016
SN  - 1873-3077
VL  - 182
SP  - 315
EP  - 321
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Itabashi, Akinori
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - High-speed chemical imaging inside a microfluidic channel
JF  - Sensors and actuators. B: Chemical
N2  - In this study, a high-speed chemical imaging system was developed for visualization of the interior of a microfluidic channel. A microfluidic channel was constructed on the sensor surface of the light-addressable potentiometric sensor (LAPS), on which the ion concentrations could be measured in parallel at up to 64 points illuminated by optical fibers. The temporal change of pH distribution inside the microfluidic channel was recorded at a maximum rate of 100 frames per second (fps). The high frame rate allowed visualization of moving interfaces and plugs in the channel even at a flow velocity of 111 mm/s, which suggests the feasibility of plug-based microfluidic devices for flow-injection analysis (FIA).
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.snb.2013.12.090
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
VL  - 194
SP  - 521
EP  - 527
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Voigt, Birgit
A1  - Albrecht, Dirk
A1  - Sievers, Susanne
A1  - Becher, Dörte
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Schweder, Thomas
A1  - Maurer, Karl-Heinz
A1  - Hecker, Michael
T1  - High-resolution proteome maps of Bacillus licheniformis cells growing in minimal medium
JF  - Proteomics
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pmic.201400504
SN  - 1615-9861
VL  - 15
IS  - 15
SP  - 2629
EP  - 2633
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Sensors and Actuators B: Chemical
N2  - Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2011.12.102
SN  - 0925-4005
N1  - Part of special issue "Selected Papers presented at Eurosensors XXV"
VL  - 175
SP  - 118
EP  - 122
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 346
EP  - 349
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Moritz, W.
A1  - Yoshinobu, T.
A1  - Finger, F.
A1  - Krause, S.
A1  - Martin-Fernandez, M.
A1  - Schöning, Michael Josef
T1  - High resolution LAPS using amorphous silicon as the semiconductor material
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 436
EP  - 444
ER  - 
TY  - JOUR
A1  - Bressel, A.
A1  - Schultze, J.W.
A1  - Khan, W.
A1  - Wolfaardt, G. M.
A1  - Rohns, H.-P.
A1  - Irmscher, R.
A1  - Schöning, Michael Josef
T1  - High resolution gravimetric, optical and electrochemical investigations of microbial biofilm formation in aqueous systems
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3363
EP  - 3372
ER  - 
TY  - JOUR
A1  - Heine, A.
A1  - Herrmann, G.
A1  - Selmer, Thorsten
A1  - Terwesten, F.
A1  - Buckel, W.
A1  - Reuter, K.
T1  - High resolution crystal structure of clostridium propionicum β-Alanyl-CoA:Ammonia Lyase, a new member of the "Hot Dog Fold" protein superfamily
JF  - Proteins
N2  - Clostridium propionicum is the only organism known to ferment β-alanine, a constituent of coenzyme A (CoA) and the phosphopantetheinyl prosthetic group of holo-acyl carrier protein. The first step in the fermentation is a CoA-transfer to β-alanine. Subsequently, the resulting β-alanyl-CoA is deaminated by the enzyme β-alanyl-CoA:ammonia lyase (Acl) to reversibly form ammonia and acrylyl-CoA. We have determined the crystal structure of Acl in its apo-form at a resolution of 0.97 Å as well as in complex with CoA at a resolution of 1.59 Å. The structures reveal that the enyzme belongs to a superfamily of proteins exhibiting a so called “hot dog fold” which is characterized by a five-stranded antiparallel β-sheet with a long α-helix packed against it. The functional unit of all “hot dog fold” proteins is a homodimer containing two equivalent substrate binding sites which are established by the dimer interface. In the case of Acl, three functional dimers combine to a homohexamer strongly resembling the homohexamer formed by YciA-like acyl-CoA thioesterases. Here, we propose an enzymatic mechanism based on the crystal structure of the Acl·CoA complex and molecular docking. Proteins 2014; 82:2041–2053. © 2014 Wiley Periodicals, Inc.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/prot.24557
SN  - 1097-0134 (E-Journal); 0887-3585 (Print)
VL  - 82
IS  - 9
SP  - 2041
EP  - 2053
PB  - Wiley-Liss
CY  - New York
ER  - 
TY  - JOUR
A1  - Turek, Monika
A1  - Schöning, Michael Josef
A1  - Kloock, Joachim P.
A1  - Schubert, Jürgen
A1  - Zander, Willi
A1  - Krüger, Peter
A1  - Keusgen, Michael
T1  - Herstellung und Charakterisierung eines hybriden Sensorarrays auf Halbleiterbasis für die Umweltanalytik
JF  - Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik
Y1  - 2008
SN  - 978-3-18-092011-5
N1  - VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008
SP  - 803
EP  - 810
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - CHAP
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Heavy metal detection with semiconductor devices based on PLD-prepared chalcogenide glass thin films
T2  - Armenian Journal of Physics
Y1  - 2007
SN  - 1829-1171
SP  - 95
EP  - 98
ER  - 
TY  - JOUR
A1  - Grinsven, Bart van
A1  - Bon, Natalie vanden
A1  - Strauven, Hannelore
A1  - Grieten, Lars
A1  - Murib, Mohammed
A1  - Jiménez Monroy, Kathia L.
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Schöning, Michael Josef
A1  - Vermeeren, Veronique
A1  - Ameloot, Marcel
A1  - Michiels, Luc
A1  - Thoelen, Ronald
A1  - Ceuninck, Ward de
A1  - Wagner, Patrick
T1  - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.
JF  - ACS Nano
N2  - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.
Y1  - 2012
U6  - http://dx.doi.org/10.1021/nn300147e
SN  - 1936-086X
VL  - 6
IS  - 3
SP  - 2712
EP  - 2721
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Eurlings, Y.
A1  - Grinsven, B. van
A1  - Boyen, H.-G.
A1  - Conings, B.
A1  - Michiels, L.
A1  - Ameloot, M.
A1  - Carleer, R.
A1  - Warmer, J.
A1  - Kaul, P.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Heat-transfer based characterization of DNA on synthetic sapphire chips
JF  - Sensors and Actuators B: Chemical
N2  - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.snb.2016.02.027
SN  - 0925-4005
VL  - 230
IS  - 230
SP  - 260
EP  - 271
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Molina, Roberto
A1  - Yoshinobu, Tatsuo
A1  - Kloock, Joachim P.
A1  - Biselli, Manfred
A1  - Canzoneri, Michele
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
T1  - Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications
JF  - Electrochimica Acta. 53 (2007), H. 2
Y1  - 2007
SN  - 0013-4686
SP  - 305
EP  - 311
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Maris, Rob J.
A1  - Ackermann, Hans-Josef
A1  - Otto, Ralph
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations
JF  - Sensors and Actuators B: Chemical  . 127 (2007), H. 1
Y1  - 2007
SN  - 0925-4005
SP  - 217
EP  - 223
ER  -