TY - JOUR A1 - Reisert, Steffen A1 - Geissler, H. A1 - Florke, R. A1 - Wagner, P. A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Controlling aseptic sterilization processes by means of a multi-sensor system Y1 - 2011 N1 - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France SP - 18 EP - 22 PB - IEEE CY - New York ER - TY - JOUR A1 - Schaefer, Thomas A1 - Höfken, Hans-Wilhelm A1 - Schuba, Marko T1 - Windows Phone 7 from a Digital Forensics’ Perspective Y1 - 2011 N1 - ICDF2C <3, 2011, Dublin> PB - Springer CY - Berlin ER - TY - JOUR A1 - Heiden, W. A1 - Turek, M. A1 - Schöning, Michael Josef T1 - TasteIT : Analyzing chemical sensor data using fuzzy logic Y1 - 2011 SN - 978-1-4244-9910-6 N1 - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Heiden, W. A1 - Turek, M. A1 - Schöning, Michael Josef T1 - Analysis of chemical sensor data JF - Proceedings of the 4th Russian-German Workshop "Innovation Information Technologies: Theory and practice" : Ufa, Russia, April 8-13, 2011 / eds. Yupsova, Nafisa ... Y1 - 2011 SN - 978-5-4221-0159-7 SP - 76 EP - 81 PB - State Aviation Technical Univ. CY - Ufa ER - TY - JOUR A1 - Oosterhuis, Koen A1 - Öhlschläger, Peter A1 - Berg, Joost H. van den A1 - Toebes, Mireille A1 - Gomez, Raquel A1 - Schumacher, Ton N. A1 - Haanen, John B. T1 - Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7 JF - International Journal of Cancer Y1 - 2011 SN - 1097-0215 VL - 129 IS - 2 SP - 397 EP - 406 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Öhlschläger, Peter A1 - Spies, Elmar A1 - Alvarez, Gerardo A1 - Quetting, Michael A1 - Groettrup, Marcus T1 - The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA JF - International Journal of Cancer. 128 (2011), H. 2 Y1 - 2011 SN - 1097-0215 SP - 473 EP - 481 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Immel, Timo A. A1 - Groth, Ulrich A1 - Huhn, Thomas A1 - Öhlschläger, Peter T1 - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice JF - PLoS ONE N2 - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0017869 VL - 6 IS - 3 PB - Plos CY - San Francisco, California, US ER - TY - JOUR A1 - Manea, Marilena A1 - Leurs, Ulrike A1 - Orban, Erika A1 - Baranyai, Zsuzsa A1 - Öhlschläger, Peter A1 - Marquardt, Andreas A1 - Schulcz, Akos A1 - Tejeda, Miguel T1 - Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4 JF - Bioconjugate Chemistry Y1 - 2011 SN - 1520-4812 VL - 22 IS - 7 SP - 1320 EP - 1329 PB - ACS CY - Washington, DC ER - TY - JOUR A1 - Spiess, Elmar A1 - Wilfried, Reichardt A1 - Alvarez, Gerardo A1 - Gottrup, Marcus A1 - Öhlschläger, Peter T1 - An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma JF - Molecular Therapy Y1 - 2011 SN - 1525-0016 VL - 20 IS - 3 SP - 555 EP - 564 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Arida, Hassan A. A1 - Al-haddad, Ameera A1 - Schöning, Michael Josef T1 - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode JF - International Journal of Electrochemical Science. 6 (2011), H. 9 Y1 - 2011 SN - 1452-3981 SP - 3858 EP - 3867 ER - TY - JOUR A1 - Bühler, Yves A1 - Christen, Marc A1 - Kowalski, Julia A1 - Bartelt, Perry T1 - Sensitivity of snow avalanche simulations to digital elevation model quality and resolution JF - Annals of Glaciology N2 - Digital elevation models (DEMs), represent the three-dimensional terrain and are the basic input for numerical snow avalanche dynamics simulations. DEMs can be acquired using topographic maps or remote-sensing technologies, such as photogrammetry or lidar. Depending on the acquisition technique, different spatial resolutions and qualities are achieved. However, there is a lack of studies that investigate the sensitivity of snow avalanche simulation algorithms to the quality and resolution of DEMs. Here, we perform calculations using the numerical avalance dynamics model RAMMS, varying the quality and spatial resolution of the underlying DEMs, while holding the simulation parameters constant. We study both channelized and open-terrain avalanche tracks with variable roughness. To quantify the variance of these simulations, we use well-documented large-scale avalanche events from Davos, Switzerland (winter 2007/08), and from our large-scale avalanche test site, Valĺee de la Sionne (winter 2005/06). We find that the DEM resolution and quality is critical for modeled flow paths, run-out distances, deposits, velocities and impact pressures. Although a spatial resolution of ~25 m is sufficient for large-scale avalanche modeling, the DEM datasets must be checked carefully for anomalies and artifacts before using them for dynamics calculations. KW - snow KW - avalanche Y1 - 2011 SN - 1727-5644 VL - 52 IS - 58 SP - 72 EP - 80 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Pieper, Martin A1 - Klein, Peter T1 - A simple and accurate numerical network flow model for bionic micro heat exchangers JF - Heat mass transfer Y1 - 2011 SN - 0947-7411 VL - 47 IS - 5 SP - 491 EP - 503 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pieper, Martin T1 - Multiobjective optimization with expensive objectives applied to a thermodynamic material design problem JF - Proceedings in applied mathematics and mechanics : PAMM. 11 (2011), H. 1 Y1 - 2011 SN - 1617-7061 SP - 733 EP - 734 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Schwarzer, Klemens A1 - Vieira da Silva, Maria Eugenia A1 - Schwarzer, Tarik T1 - Field results in Namibia and Brazil of the new solar desalination system for decentralised drinking water production JF - Desalination and water treatment. Vol. 31 (2011), iss. 1-3: selected papers presented at EuroMed 2010 — Desalination for Clean Water and Energy: Cooperation among Mediterranean Countries of Europe and MENA Region, 3–7 October 2010, Tel Aviv, Israel Y1 - 2011 SP - 379 EP - 386 ER - TY - JOUR A1 - Grotendorst, Johannes T1 - On calculating the rate of linear convergence of non-linear transformed sequences JF - Proceeding SNC '11 Proceedings of the 2011 International Workshop on Symbolic-Numeric Computation Y1 - 2011 SN - 978-1-4503-0515-0 SP - 24 EP - 33 PB - ACM CY - New York, NY ER - TY - JOUR A1 - Gerhards, M. A1 - Skorupa, S. A1 - Sander, Volker A1 - Belloum, A. A1 - Vesunin, D. A1 - Benabdelkader, A. T1 - HisT/PLIER : A Two-Fold Provenance Approach for Grid-Enabled Scientific Workflows Using WS-VLAM JF - 12th IEEE/ACM International Conference on Grid Computing (GRID), 2011 Y1 - 2011 U6 - https://doi.org/10.1109/Grid.2011.39 SP - 224 EP - 225 PB - IEEE CY - New York ER - TY - JOUR A1 - Kern, Alexander A1 - Schelthoff, Christof A1 - Mathieu, Moritz T1 - Calculation of interception efficiencies for airterminations using a dynamic electro-geometrical model Y1 - 2011 N1 - XI International Symposium on Lightning Protection (SIPDA), Fortaleza (Brasilien), 2011. SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Landers, Ernst Ulrich A1 - Kern, Alexander T1 - Future evolution of risk management for structures : Advancement for the future IEC 62305-2 Ed3 Y1 - 2011 N1 - XI International Symposium on Lightning Protection (SIPDA), Fortaleza (Brasilien), 2011. SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Behnam, S. A1 - Becker, A. A1 - Weber, Hans-Joachim T1 - Clinical benefit and cost-efficiency of minimized perfusion circuits for extracorporeal circulation during cardiac surgery JF - Zeitschrift für Herz-, Thorax- und Gefäßchirurgie Y1 - 2011 SN - 0930-9225 N1 - Abstracts der 40. Internationalen Jahrestagung der DGfK und 3. Fokustagung Herz Kardiotechnik – Intensivmedizin – Herzchirurgie – Rhythmustherapie 11. bis 13. November 2011 in Weimar VL - 25 IS - 5 SP - 305 EP - 306 PB - Springer CY - Berlin ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, K. A1 - Werner, Frederik A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Flexible electrochemical imaging with “zoom-in” functionality by using a new type of light-addressable potentiometric sensor Y1 - 2011 N1 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011 SP - 2133 EP - 2135 PB - IEEE CY - New York ER - TY - JOUR A1 - Miyamoto, K. A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Multi-well structure for cell culture on the chemical imaging sensor Y1 - 2011 N1 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011 SP - 2130 EP - 2132 PB - IEEE CY - New York ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Tran, L. A1 - Jockenhövel, S. A1 - Behr, M. A1 - Mottaghy, K. T1 - Numerical prediction of thrombocyte reactions for application to a vascular flow model JF - British Journal of Surgery Y1 - 2011 SN - 1365-2168 N1 - 46th Congress of the European Society for Surgical Research, Aachen, Germany, 25-28 May 2011 ; ESSR Abstracts 2011 ; Oral Sessions OP10-5 VL - 98 IS - S5 SP - S17 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Engels, Elmar A1 - Krauskopf, S. T1 - Innovation in Motion-Logic programming - a versatile interface JF - Proceedings to the 12th International Workshop on Research and Education in Mechatronics, REM 2011, Kocaeli, Turkey, 15.09.-16.09.2011 Y1 - 2011 SN - 978-975-8047-96-3 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines M. T1 - Can vascular function be assessed by the interpretation of retinal vascular diameter changes? JF - Investigative Ophthalmology & Visual Science, IOVS. 52 (2011), H. 1 Y1 - 2011 SN - 0146-0404 SP - 635 EP - 636 PB - ARVO CY - Rockville, Md. ER - TY - JOUR A1 - Lanzl, Ines M. A1 - Seidova, Seid-Fatima A1 - Maier, Mathias A1 - Schmidt-Trucksäss, Arno A1 - Halle, Martin A1 - Kotliar, Konstantin T1 - Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection JF - Acta Ophthalmologica Y1 - 2011 SN - 1755-3768 VL - 89 IS - 5 SP - 472 EP - 479 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Mikielewicz, Marek A1 - Kotliar, Konstantin A1 - Barraquer, Rafael I. A1 - Michael, Ralph T1 - Air-pulse corneal applanation signal curve parameters for the characterisation of keratoconus JF - British Journal of Ophthalmology (eBJO) Y1 - 2011 SN - 1468-2079 VL - 95 IS - 6 SP - 793 EP - 798 PB - BMJ Publ. Group CY - London ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Baumann, Marcus A1 - Vilser, Walthard A1 - Lanzl, Ines M. T1 - Pulse wave velocity in retinal arteries of healthy volunteers JF - British Journal of Ophthalmology (eBJO) Y1 - 2011 SN - 1468-2079 VL - 95 IS - 11 SP - 675 EP - 679 PB - BMJ Publ. Group CY - London ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines M. A1 - Schmidt-Trucksäss, A. A1 - Sitnikova, Diana A1 - Ali, Mohammad A1 - Blume, Katharina A1 - Halle, Martin A1 - Hansser, Henner T1 - Dynamic retinal vessel response to flicker in obesity: A methodological approach JF - Microvascular Research Y1 - 2011 SN - 0026-2862 VL - 81 IS - 1 SP - 123 EP - 128 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dashevsky, Alexey V. A1 - Lanzl, Ines M. A1 - Kotliar, Konstantin T1 - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal JF - Graefe's Archive for Clinical and Experimental Ophthalmology Y1 - 2011 SN - 0721-832x VL - 249 IS - 4 SP - 565 EP - 573 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hanssen, H. A1 - Nickel, T. A1 - Drexel, V. A1 - Hertel, G. A1 - Emslander, I. A1 - Sisic, Z. A1 - Lorang, D. A1 - Schuster, T. A1 - Kotliar, Konstantin A1 - Pressler, A. A1 - Schmidt-Trucksäss, A. A1 - Weis, M. A1 - Halle, M. T1 - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity JF - Atherosclerosis Y1 - 2011 SN - 0021-9150 VL - 216 IS - 2 SP - 433 EP - 439 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Mukherjee, Krishnendu A1 - Ramazani, Ali A1 - Yang, Li A1 - Prahl, Ulrich A1 - Bleck, Wolfgang A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Abdurakhmanov, Aydemir T1 - Characterization of gas metal arc welded hot rolled DP600 steel JF - Steel research international Y1 - 2011 SN - 1869-344X (E-Book); 1611-3683 (Print) VL - Vol. 82 IS - Iss. 12 SP - 1408 EP - 1416 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Glowania, Michael A1 - Gries, Thomas A1 - Schoene, Jens A1 - Schleser, Markus A1 - Reisgen, Uwe T1 - Innovative coating technology for textile reinforcements of concrete applications JF - 13th International Congress on Polymers in Concrete : 10 - 12 February 2010, Funchal, Madeira, Portugal.(Key engineering materials. Vol. 466) Y1 - 2011 SN - 978-3-03785-008-4 SN - 1013-9826 (E-Journal) ; 0252-1059 (Print) SP - 167 EP - 173 PB - Trans Tech Publications CY - Bäch ER - TY - JOUR A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Mokrov, Oleg A1 - Ahmed, Essam T1 - Numerical and experimental investigation of tensile behavior of laser beam welded TRIP700 steel JF - ISIJ international Y1 - 2011 SN - 1347-5460 (E-Journal); 0915-1559 (Print) VL - Vol. 51 IS - No. 3 SP - 429 EP - 434 PB - ISIJ CY - Tōkyō ER - TY - JOUR A1 - Roesner, Andreas A1 - Scheik, Sven A1 - Olowinsky, Alexander A1 - Gillner, Arnold A1 - Propawe, Reinhart A1 - Schleser, Markus A1 - Reisgen, Uwe T1 - Innovative approach of joining hybrid components JF - Journal of laser applications Y1 - 2011 SN - 1042-346X VL - Vol. 23 IS - Iss. 3 SP - 32007 PB - Laser Institute of America CY - Orlando, Fla. ER - TY - JOUR A1 - Roesner, Andreas A1 - Scheik, Sven A1 - Olowinsky, Alexander A1 - Gillner, Arnold A1 - Reisgen, Uwe A1 - Schleser, Markus T1 - Laser assisted joining of plastic metal hybrids JF - Lasers in manufacturing 2011 : proceedings of the sixth International WLT Conference on Lasers in Manufacturing, Munich, May 23 - 26 2011. (Physics procedia ; Vol. 12 (2011), Part B) Y1 - 2011 SN - 1875-3892 (E-Journal); 1875-3884 (Print) SP - 370 EP - 377 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Mokrov, Oleg A1 - Zabirov, Alexander T1 - Virtual welding equipment for simulation of GMAW processes with integration of power source regulation JF - Frontiers of materials science Y1 - 2011 SN - 2095-0268 (E-Journal); 2095-025X (Print) VL - Vol. 5 IS - Iss. 2 SP - 79 EP - 89 PB - Springer CY - Berlin ER - TY - JOUR A1 - Niehaus, F. A1 - Gabor, E. A1 - Wieland, S. A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Eck, J. T1 - Enzymes for the laundry industries: tapping the vast metagenomic pool of alkaline proteases JF - Microbial biotechnology Y1 - 2011 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 4 IS - Iss. 6 SP - 767 EP - 776 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ribitsch, D. A1 - Heumann, S. A1 - Trotscha, E. A1 - Herrero Acero, E. A1 - Greimel, K. A1 - Leber, R. A1 - Birger-Gruenberger, R. A1 - Deller, S. A1 - Eiteljoerg, I. A1 - Remler, P. A1 - Weber, Th. A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Donelli, I. A1 - Freddi, G. A1 - Schwab, H. A1 - Guebitz, G. M. T1 - Hydrolysis of polyethyleneterephthalate by p-nitrobenzylesterase from Bacillus subtilis JF - Biotechnology progress Y1 - 2011 SN - 1520-6033 (E-Journal); 8756-7938 (Print) VL - Vol. 27 IS - Iss. 4 SP - 951 EP - 960 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Mottaghy, Darius A1 - Pechnig, Renate A1 - Vogt, Christian T1 - The geothermal project Den Haag: 3D numerical models for temperature prediction and reservoir simulation JF - Geothermics N2 - The proposed Den Haag Zuidwest district heating system of the city of The Hague consists of a deep doublet in a Jurassic sandstone layer that is designed for a production temperature of 75 °C and a reinjection temperature of 40 °C at a flow rate of 150 m3 h−1. The prediction of reservoir temperature and production behavior is crucial for success of the proposed geothermal doublet. This work presents the results of a study of the important geothermal and geohydrological issues for the doublet design. In the first phase of the study, the influences of the three-dimensional (3D) structures of anticlines and synclines on the temperature field were examined. A comprehensive petrophysical investigation was performed to build a large scale 3D-model of the reservoir. Several bottomhole temperatures (BHTs), as well as petrophysical logs were used to calibrate the model using thermal conductivity measurements on 50 samples from boreholes in different lithological units in the study area. Profiles and cross sections extracted from the calculated temperature field were used to study the temperature in the surrounding areas of the planned doublet. In the second phase of the project, a detailed 3D numerical reservoir model was set up, with the aim of predicting the evolution of the producer and injector temperatures, and the extent of the cooled area around the injector. The temperature model from the first phase provided the boundary conditions for the reservoir model. Hydraulic parameters for the target horizons, such as porosity and permeability, were taken from data available from the nearby exploration wells. The simulation results are encouraging as no significant thermal breakthrough is predicted. For the originally planned location of the producer, the extracted water temperature is predicted to be around 79 °C, with an almost negligible cooling in the first 50 years of production. When the producer is located shallower parts of the reservoir, the yield water temperatures is lower, starting at ≈76 °C and decreasing to ≈74 °C after 50 years of operation. This comparatively larger decrease in temperature with time is caused by the structural feature of the reservoir, namely a higher dip causes the cooler water to easily move downward. In view of the poor reservoir data, the reservoir simulation model is constructed to allow iterative updates using data assimilation during planned drilling, testing, and production phases. Measurements during an 8 h pumping test carried out in late 2010 suggest that a flow rate of 150 m3 h−1 is achievable. Fluid temperatures of 76.5 °C were measured, which is very close to the predicted value. Y1 - 2011 U6 - https://doi.org/10.1016/j.geothermics.2011.07.001 SN - 0375-6505 VL - 40 IS - 3 SP - 199 EP - 210 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, K. A1 - Werner, Frederik A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) Y1 - 2011 U6 - https://doi.org/10.1166/sl.2011.1620 VL - 9 IS - 2 SP - 812 EP - 815 PB - American Scientific Publishers CY - Stevenson Ranch, Calif. ER - TY - JOUR A1 - Inagaki, Akiko A1 - Sleddens-Linkels, Esther A1 - Wassenaar, Evelyne A1 - Ooms, Marja A1 - Cappellen, Wiggert A. van A1 - Hoeijmakers, Jan H. J. A1 - Seibler, Jost A1 - Vogt, Thomas F. A1 - Shin, Myung K. A1 - Grootegoed, J. Anton A1 - Baarends, Willy M. T1 - Meiotic functions of RAD18 JF - Journal of Cell Science Y1 - 2011 U6 - https://doi.org/10.1242/jcs.081968 SN - 1477-9137 VL - 124 IS - 16 SP - 2837 EP - 2850 PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Raab, Monika A1 - Kappel, Sven A1 - Krämer, Andrea A1 - Sanhaji, Mourad A1 - Matthess, Yves A1 - Kurunci-Csacsko, Elisabeth A1 - Calzada-Wack, Julia A1 - Rathkolb, Birgit A1 - Rosman, Jan A1 - Adler, Thure A1 - Busch, Dirk H. A1 - Esposito, Irene A1 - Fuchs, Helmut A1 - Gailus-Durner, Valérie A1 - Klingenspor, Martin A1 - Wolf, Eckhard A1 - Sänger, Nicole A1 - Prinz, Florian A1 - Hrabe de Angelis, Martin A1 - Seibler, Jost A1 - Yuan, Juping A1 - Bergmann, Martin A1 - Knecht, Rainald A1 - Kreft, Bertolt A1 - Strebhardt, Klaus T1 - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells JF - Nature Communications Y1 - 2011 U6 - https://doi.org/10.1038/ncomms1395 SN - 2041-1723 VL - 2 IS - 395 SP - 1 EP - 11 PB - Nature CY - London ER - TY - JOUR A1 - Hasegawa, Maki A1 - Kapelyukh, Yury A1 - Tahara, Harunobu A1 - Seibler, Jost A1 - Rode, Anja A1 - Krueger, Sylvia A1 - Lee, Dongtao N. A1 - Wolf, C. Roland A1 - Scheer, Nico T1 - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line JF - Molecular Pharmacology Y1 - 2011 U6 - https://doi.org/10.1124/mol.111.071845 SN - 1521-0111 VL - 80 IS - 33 SP - 518 EP - 528 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Jordan, Sabine D. A1 - Krüger, Markus A1 - Willmes, Diana M. A1 - Redemann, Nora A1 - Wunderlich, F. Thomas A1 - Brönneke, Hella S. A1 - Merkwirth, Carsten A1 - Kashkar, Hamid A1 - Olkkonen, Vesa M. A1 - Böttger, Thomas A1 - Braun, Thomas A1 - Seibler, Jost A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism JF - Nature Cell Biology N2 - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes. Y1 - 2011 U6 - https://doi.org/10.1038/ncb2211 SN - 1465-7392 VL - 13 IS - 4 SP - 434 EP - 446 PB - Nature CY - New York ER - TY - JOUR A1 - Bongaerts, Johannes A1 - Esser, Simon A1 - Lorbach, Volker A1 - Al-Momani, Lóay A1 - Müller, Michael A. A1 - Franke, Dirk A1 - Grondal, Christoph A1 - Kurutsch, Anja A1 - Bujnicki, Robert A1 - Takors, Ralf A1 - Raeven, Leon A1 - Wubbolts, Marcel A1 - Bovenberg, Roel A1 - Nieger, Martin A1 - Schürmann, Melanie A1 - Trachtmann, Natalie A1 - Kozak, Stefan A1 - Sprenger, Georg A. A1 - Müller, Michael T1 - Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis JF - Angewandte Chemie International Edition Y1 - 2011 SN - 1521-3773 (E-Journal); 0570-0833 (Print); 1433-7851 (Print) VL - Vol. 50 IS - Iss. 34 SP - 7781 EP - 7786 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Bung, Daniel Bernhard T1 - Developing flow in skimming flow regime on embankment stepped spillways JF - Journal of hydraulic research Y1 - 2011 SN - 1814-2079 (E-Journal); 0022-1686 (Print) VL - Vol. 49 IS - Iss. 5 SP - 639 EP - 648 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Ferrein, Alexander A1 - Marais, Stephen A1 - Potgieter, Anet A1 - Steinbauer, Gerald T1 - RoboCup Junior: A vehicle for S&T education in Africa? Y1 - 2011 SN - 978-1-61284-992-8 N1 - AFRICON, 2011 SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Preiß, C. A1 - Linder, Peter A1 - Wendt, K. A1 - Krystek, M. A1 - Digel, Ilya A1 - Gossmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Porst, Dariusz A1 - Kayser, Peter A1 - Bassam, Rasha A1 - Artmann, Gerhard T1 - Engineering technology for plant physiology and plant stress research N2 - Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology. KW - Pflanzenphysiologie KW - Pflanzenstress KW - Pflanzenscanner KW - plant stress KW - plant scanner Y1 - 2011 ER - TY - JOUR A1 - Sieker, Tim A1 - Neuner, Andreas A1 - Dimitrova, Darina A1 - Tippkötter, Nils A1 - Muffler, Kai A1 - Bart, Hans-Jörg A1 - Heinzle, Elmar A1 - Ulber, Roland T1 - Ethanol production from grass silage by simultaneous pretreatment, saccharification and fermentation: First steps in the process development JF - Engineering in Life Sciences N2 - Grass silage provides a great potential as renewable feedstock. Two fractions of the grass silage, a press juice and the fiber fraction, were evaluated for their possible use for bioethanol production. Direct production of ethanol from press juice is not possible due to high concentrations of organic acids. For the fiber fraction, alkaline peroxide or enzymatic pretreatment was used, which removes the phenolic acids in the cell wall. In this study, we demonstrate the possibility to integrate the enzymatic pretreatment with a simultaneous saccharification and fermentation to achieve ethanol production from grass silage in a one-process step. Achieved yields were about 53 g ethanol per kg silage with the alkaline peroxide pretreatment and 91 g/kg with the enzymatic pretreatment at concentrations of 8.5 and 14.6 g/L, respectively. Furthermore, it was shown that additional supplementation of the fermentation medium with vitamins, trace elements and nutrient salts is not necessary when the press juice is directly used in the fermentation step. Y1 - 2011 U6 - https://doi.org/10.1002/elsc.201000160 N1 - Special Issue "Bioprocess‐oriented plant design" VL - 11 IS - 4 SP - 436 EP - 442 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Warerkar, Shashikant A1 - Schmitz, Stefan A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard A1 - Reißel, Martin A1 - Tamme, Rainer T1 - Air-Sand Heat Exchanger for High-Temperature Storage JF - Journal of Solar Energy Engineering. 133 (2011), H. 2 Y1 - 2011 SN - 0199-6231 N1 - 7 pages SP - 021010 PB - ASME CY - New York ER -