TY - JOUR A1 - Schoenrock, Britt A1 - Muckelt, Paul E. A1 - Hastermann, Maria A1 - Albracht, Kirsten A1 - MacGregor, Robert A1 - Martin, David A1 - Gunga, Hans-Christian A1 - Salanova, Michele A1 - Stokes, Maria J. A1 - Warner, Martin B. A1 - Blottner, Dieter T1 - Muscle stiffness indicating mission crew health in space JF - Scientific Reports N2 - Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes. KW - Ageing KW - Anatomy KW - Muscle KW - Musculoskeletal system KW - Physiology Y1 - 2024 U6 - http://dx.doi.org/10.1038/s41598-024-54759-6 SN - 2045-2322 N1 - Corresponding author: Dieter Blottner VL - 14 IS - Article number: 4196 PB - Springer Nature CY - London ER - TY - JOUR A1 - Hafidi, Youssef A1 - El Hatka, Hicham A1 - Schmitz, Dominik A1 - Krauss, Manuel A1 - Pettrak, Jürgen A1 - Biel, Markus A1 - Ittobane, Najim T1 - Sustainable soil additives for water and micronutrient supply: swelling and chelating properties of polyaspartic acid hydrogels utilizing newly developed crosslinkers JF - Gels N2 - Drought and water shortage are serious problems in many arid and semi-arid regions. This problem is getting worse and even continues in temperate climatic regions due to climate change. To address this problem, the use of biodegradable hydrogels is increasingly important for the application as water-retaining additives in soil. Furthermore, efficient (micro-)nutrient supply can be provided by the use of tailored hydrogels. Biodegradable polyaspartic acid (PASP) hydrogels with different available (1,6-hexamethylene diamine (HMD) and L-lysine (LYS)) and newly developed crosslinkers based on diesters of glycine (GLY) and (di-)ethylene glycol (DEG and EG, respectively) were synthesized and characterized using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) and regarding their swelling properties (kinetic, absorbency under load (AUL)) as well as biodegradability of PASP hydrogel. Copper (II) and zinc (II), respectively, were loaded as micronutrients in two different approaches: in situ with crosslinking and subsequent loading of prepared hydrogels. The results showed successful syntheses of di-glycine-ester-based crosslinkers. Hydrogels with good water-absorbing properties were formed. Moreover, the developed crosslinking agents in combination with the specific reaction conditions resulted in higher water absorbency with increased crosslinker content used in synthesis (10% vs. 20%). The prepared hydrogels are candidates for water-storing soil additives due to the biodegradability of PASP, which is shown in an exemple. The incorporation of Cu(II) and Zn(II) ions can provide these micronutrients for plant growth. KW - micronutrients KW - swelling properties KW - biodegradable polymers KW - hydrogels KW - superabsorbent polymers KW - glycine KW - polyaspartic acid Y1 - 2024 U6 - http://dx.doi.org/10.3390/gels10030170 SN - 2310-2861 VL - 10 IS - 3 SP - Artikel 170 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bertz, Morten A1 - Schöning, Michael Josef A1 - Molinnus, Denise A1 - Homma, Takayuki T1 - Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping JF - Physica status solidi (a) applications and materials science N2 - To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem. KW - hydrogen peroxide KW - optical spore trapping KW - Raman spectroscopy KW - sterilization conditions KW - temperature Y1 - 2024 U6 - http://dx.doi.org/10.1002/pssa.202300866 SN - 1862-6319 (Online) SN - 1862-6300 (Print) IS - Early View PB - Wiley-VCH CY - Berlin ER - TY - JOUR A1 - Pogorelova, Natalia A1 - Rogachev, Evgeniy A1 - Akimbekov, Nuraly A1 - Digel, Ilya T1 - Effect of dehydration method on the micro- and nanomorphological properties of bacterial cellulose produced by Medusomyces gisevii on different substrates JF - Journal of materials science N2 - Many important properties of bacterial cellulose (BC), such as moisture absorption capacity, elasticity and tensile strength, largely depend on its structure. This paper presents a study on the effect of the drying method on BC films produced by Medusomyces gisevii using two different procedures: room temperature drying (RT, (24 ± 2 °C, humidity 65 ± 1%, dried until a constant weight was reached) and freeze-drying (FD, treated at − 75 °C for 48 h). BC was synthesized using one of two different carbon sources—either glucose or sucrose. Structural differences in the obtained BC films were evaluated using atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray diffraction. Macroscopically, the RT samples appeared semi-transparent and smooth, whereas the FD group exhibited an opaque white color and sponge-like structure. SEM examination showed denser packing of fibrils in FD samples while RT-samples displayed smaller average fiber diameter, lower surface roughness and less porosity. AFM confirmed the SEM observations and showed that the FD material exhibited a more branched structure and a higher surface roughness. The samples cultivated in a glucose-containing nutrient medium, generally displayed a straight and ordered shape of fibrils compared to the sucrose-derived BC, characterized by a rougher and wavier structure. The BC films dried under different conditions showed distinctly different crystallinity degrees, whereas the carbon source in the culture medium was found to have a relatively small effect on the BC crystallinity. Y1 - 2024 U6 - http://dx.doi.org/10.1007/s10853-024-09596-3 SN - 1573-4803 (Online) SN - 0022-2461 (Print) N1 - Corresponding author: Ilya Digel VL - 2024 PB - Springer Science + Business Media CY - Dordrecht ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Simsek, Beril A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study JF - Sensors N2 - Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled Néel–Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays. KW - key performance indicators KW - magnetic biosensing KW - coupled Néel–Brownian relaxation dynamics KW - frequency mixing magnetic detection KW - magnetic relaxation KW - micromagnetic simulation KW - magnetic nanoparticles Y1 - 2024 U6 - http://dx.doi.org/10.3390/s24061945 SN - 1424-8220 N1 - This article belongs to the Special Issue "Advances in Magnetic Sensors and Their Applications" VL - 24 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Zhen, Manghao A1 - Liang, Yunpei A1 - Staat, Manfred A1 - Li, Quanqui A1 - Li, Jianbo T1 - Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression JF - Theoretical and Applied Fracture Mechanics N2 - The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress–strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress–strain curves of the fissured sandstone specimens. KW - Constitutive model KW - Damage mechanics theory KW - Discontinuous fractures KW - Uniaxial compression test KW - Non-parallel fissures Y1 - 2024 U6 - http://dx.doi.org/10.1016/j.tafmec.2024.104373 SN - 0167-8442 VL - 131 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Yoshinobu, Tatsuo A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Field-effect sensors combined with the scanned light pulse technique: from artificial olfactory images to chemical imaging technologies JF - Chemosensors N2 - The artificial olfactory image was proposed by Lundström et al. in 1991 as a new strategy for an electronic nose system which generated a two-dimensional mapping to be interpreted as a fingerprint of the detected gas species. The potential distribution generated by the catalytic metals integrated into a semiconductor field-effect structure was read as a photocurrent signal generated by scanning light pulses. The impact of the proposed technology spread beyond gas sensing, inspiring the development of various imaging modalities based on the light addressing of field-effect structures to obtain spatial maps of pH distribution, ions, molecules, and impedance, and these modalities have been applied in both biological and non-biological systems. These light-addressing technologies have been further developed to realize the position control of a faradaic current on the electrode surface for localized electrochemical reactions and amperometric measurements, as well as the actuation of liquids in microfluidic devices. KW - visualization KW - light-addressing technologies KW - scanned light pulse technique KW - field-effect structure KW - MOS KW - metal-oxide-semiconductor structure KW - catalytic metal KW - electronic nose KW - gas sensor KW - artificial olfactory image Y1 - 2024 U6 - http://dx.doi.org/10.3390/chemosensors12020020 SN - 2227-9040 N1 - This article belongs to the Special Issue "An Exciting Journey of Chemical Sensors and Biosensors: A Theme Issue in Honor of Professor Ingemar Lundström" Corresponding author: Tatsuo Yoshinobu, Michael J. Schöning VL - 12 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Koch, Christopher A1 - Böhnisch, Nils A1 - Verdonck, Hendrik A1 - Hach, Oliver A1 - Braun, Carsten T1 - Comparison of unsteady low- and mid-fidelity propeller aerodynamic methods for whirl flutter applications JF - Applied Sciences N2 - Aircraft configurations with propellers have been drawing more attention in recent times, partly due to new propulsion concepts based on hydrogen fuel cells and electric motors. These configurations are prone to whirl flutter, which is an aeroelastic instability affecting airframes with elastically supported propellers. It commonly needs to be mitigated already during the design phase of such configurations, requiring, among other things, unsteady aerodynamic transfer functions for the propeller. However, no comprehensive assessment of unsteady propeller aerodynamics for aeroelastic analysis is available in the literature. This paper provides a detailed comparison of nine different low- to mid-fidelity aerodynamic methods, demonstrating their impact on linear, unsteady aerodynamics, as well as whirl flutter stability prediction. Quasi-steady and unsteady methods for blade lift with or without coupling to blade element momentum theory are evaluated and compared to mid-fidelity potential flow solvers (UPM and DUST) and classical, derivative-based methods. Time-domain identification of frequency-domain transfer functions for the unsteady propeller hub loads is used to compare the different methods. Predictions of the minimum required pylon stiffness for stability show good agreement among the mid-fidelity methods. The differences in the stability predictions for the low-fidelity methods are higher. Most methods studied yield a more unstable system than classical, derivative-based whirl flutter analysis, indicating that the use of more sophisticated aerodynamic modeling techniques might be required for accurate whirl flutter prediction. KW - Aeroelasticity KW - Flutter KW - Propeller whirl flutter KW - Unsteady aerodynamics KW - 1P hub loads Y1 - 2024 U6 - http://dx.doi.org/10.3390/app14020850 SN - 2076-3417 VL - 14 IS - 2 SP - 1 EP - 28 PB - MDPI CY - Basel ER - TY - JOUR A1 - Hoffstadt, Kevin A1 - Nikolausz, Marcell A1 - Krafft, Simone A1 - Bonatelli, Maria A1 - Kumar, Vivekanantha A1 - Harms, Hauke A1 - Kuperjans, Isabel T1 - Optimization of the ex situ biomethanation of hydrogen and carbon dioxide in a novel meandering plug flow reactor: start-up phase and flexible operation JF - Bioengineering KW - methanation KW - plug flow reactor KW - bubble column KW - biomethane KW - P2G Y1 - 2024 U6 - http://dx.doi.org/10.3390/bioengineering11020165 SN - 2306-5354 VL - 11 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Schopp, Christoph A1 - Rohrbach, Felix A1 - Langer, Luc A1 - Heuermann, Holger T1 - Detection of welding wire length by active S11 measurement JF - IEEE Transactions on Plasma Science N2 - A novel method to determine the extruded length of a metallic wire for a directed energy deposition (DED) process using a microwave (MW) plasma jet with a straight-through wire feed is presented. The method is based on the relative comparison of the measured frequency response obtained by the large-signal scattering parameter (Hot-S) technique. In the practical working range, repeatability of less than 6% for a nonactive plasma and 9% for the active plasma state is found. Measurements are conducted with a focus on a simple solution to decrease the processing time and reduce the integration time of the process into the existing hardware. It is shown that monitoring a single frequency for magnitude and phase changes is sufficient to achieve good accuracy. A combination of different measurement values to determine the length is possible. The applicability to different diameter of the same material is shown as well as a contact detection of the wire and metallic substrate. KW - Circuit simulation KW - Hot S-parameter KW - Modeling KW - Plasma KW - Plasma diagnostics Y1 - 2024 U6 - http://dx.doi.org/10.1109/TPS.2024.3356659 SN - 0093-3813 (Print) SN - 1939-9375 (Online) IS - Early Access SP - 1 EP - 6 PB - IEEE ER - TY - JOUR A1 - Turdumamatov, Samat A1 - Belda, Aljoscha A1 - Heuermann, Holger T1 - Shaping a decoupled atmospheric pressure microwave plasma with antenna structures, Maxwell’s equations, and boundary conditions JF - IEEE Transactions on Plasma Science N2 - This article addresses the need for an innovative technique in plasma shaping, utilizing antenna structures, Maxwell’s laws, and boundary conditions within a shielded environment. The motivation lies in exploring a novel approach to efficiently generate high-energy density plasma with potential applications across various fields. Implemented in an E01 circular cavity resonator, the proposed method involves the use of an impedance and field matching device with a coaxial connector and a specially optimized monopole antenna. This setup feeds a low-loss cavity resonator, resulting in a high-energy density air plasma with a surface temperature exceeding 3500 o C, achieved with a minimal power input of 80 W. The argon plasma, resembling the shape of a simple monopole antenna with modeled complex dielectric values, offers a more energy-efficient alternative compared to traditional, power-intensive plasma shaping methods. Simulations using a commercial electromagnetic (EM) solver validate the design’s effectiveness, while experimental validation underscores the method’s feasibility and practical implementation. Analyzing various parameters in an argon atmosphere, including hot S -parameters and plasma beam images, the results demonstrate the successful application of this technique, suggesting its potential in coating, furnace technology, fusion, and spectroscopy applications. KW - 3-D printing KW - Furnace KW - Fusion KW - Hot S-parameter KW - Mode converter Y1 - 2024 U6 - http://dx.doi.org/10.1109/TPS.2024.3383589 SN - 0093-3813 (Print) SN - 1939-9375 (Online) IS - Early Access SP - 1 EP - 9 PB - IEEE ER - TY - JOUR A1 - Karschuck, Tobias A1 - Poghossian, Arshak A1 - Ser, Joey A1 - Tsokolakyan, Astghik A1 - Achtsnicht, Stefan A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage JF - Sensors and Actuators B: Chemical N2 - Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed. KW - Field-effect biosensor KW - Capacitive model KW - Enzyme coverage KW - Multianalyte detection KW - Penicillin Y1 - 2024 U6 - http://dx.doi.org/10.1016/j.snb.2024.135530 SN - 0925-4005 (Print) SN - 1873-3077 (Online) N1 - Corresponding Author: Michael J. Schöning VL - 408 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Böhnisch, Nils A1 - Braun, Carsten A1 - Muscarello, Vincenzo A1 - Marzocca, Pier T1 - About the wing and whirl flutter of a slender wing–propeller system JF - Journal of Aircraft N2 - Next-generation aircraft designs often incorporate multiple large propellers attached along the wingspan (distributed electric propulsion), leading to highly flexible dynamic systems that can exhibit aeroelastic instabilities. This paper introduces a validated methodology to investigate the aeroelastic instabilities of wing–propeller systems and to understand the dynamic mechanism leading to wing and whirl flutter and transition from one to the other. Factors such as nacelle positions along the wing span and chord and its propulsion system mounting stiffness are considered. Additionally, preliminary design guidelines are proposed for flutter-free wing–propeller systems applicable to novel aircraft designs. The study demonstrates how the critical speed of the wing–propeller systems is influenced by the mounting stiffness and propeller position. Weak mounting stiffnesses result in whirl flutter, while hard mounting stiffnesses lead to wing flutter. For the latter, the position of the propeller along the wing span may change the wing mode shapes and thus the flutter mechanism. Propeller positions closer to the wing tip enhance stability, but pusher configurations are more critical due to the mass distribution behind the elastic axis. Y1 - 2024 U6 - http://dx.doi.org/10.2514/1.C037542 SN - 1533-3868 SP - 1 EP - 14 PB - American Institute of Aeronautics and Astronautics ER - TY - JOUR A1 - Pieronek, Lukas A1 - Kleefeld, Andreas T1 - On trajectories of complex-valued interior transmission eigenvalues JF - Inverse problems and imaging : IPI N2 - This paper investigates the interior transmission problem for homogeneous media via eigenvalue trajectories parameterized by the magnitude of the refractive index. In the case that the scatterer is the unit disk, we prove that there is a one-to-one correspondence between complex-valued interior transmission eigenvalue trajectories and Dirichlet eigenvalues of the Laplacian which turn out to be exactly the trajectorial limit points as the refractive index tends to infinity. For general simply-connected scatterers in two or three dimensions, a corresponding relation is still open, but further theoretical results and numerical studies indicate a similar connection. KW - Interior transmission problem KW - Eigenvalue trajectories KW - Complex-valued eigenvalues Y1 - 2024 U6 - http://dx.doi.org/10.3934/ipi.2023041 SN - 1930-8337 (Print) SN - 1930-8345 (Online) VL - 18 IS - 2 SP - 480 EP - 516 PB - AIMS CY - Springfield, Mo ER - TY - JOUR A1 - Ringers, Christa A1 - Bialonski, Stephan A1 - Ege, Mert A1 - Solovev, Anton A1 - Hansen, Jan Niklas A1 - Jeong, Inyoung A1 - Friedrich, Benjamin M. A1 - Jurisch-Yaksi, Nathalie T1 - Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia JF - eLife N2 - Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to exhibit a remarkable coordination of their beat in the form of traveling metachronal waves, a phenomenon which supposedly enhances fluid transport. Yet, how cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine experiments, novel analysis tools, and theory to address this knowledge gap. To investigate collective dynamics of cilia, we studied zebrafish multiciliated epithelia in the nose and the brain. We focused mainly on the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Even though synchronization is local only, we observed global patterns of traveling metachronal waves across the zebrafish multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right noses, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions, i.e., cilia colliding with each other, and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment coincide and generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping. Y1 - 2023 U6 - http://dx.doi.org/10.7554/eLife.77701 SN - 2050-084X VL - 12 PB - eLife Sciences Publications ER - TY - JOUR A1 - Bergmann, Ole A1 - Möhren, Felix A1 - Braun, Carsten A1 - Janser, Frank T1 - On the influence of elasticity on swept propeller noise JF - AIAA SCITECH 2023 Forum N2 - High aerodynamic efficiency requires propellers with high aspect ratios, while propeller sweep potentially reduces noise. Propeller sweep and high aspect ratios increase elasticity and coupling of structural mechanics and aerodynamics, affecting the propeller performance and noise. Therefore, this paper analyzes the influence of elasticity on forward-swept, backward-swept, and unswept propellers in hover conditions. A reduced-order blade element momentum approach is coupled with a one-dimensional Timoshenko beam theory and Farassat's formulation 1A. The results of the aeroelastic simulation are used as input for the aeroacoustic calculation. The analysis shows that elasticity influences noise radiation because thickness and loading noise respond differently to deformations. In the case of the backward-swept propeller, the location of the maximum sound pressure level shifts forward by 0.5 °, while in the case of the forward-swept propeller, it shifts backward by 0.5 °. Therefore, aeroacoustic optimization requires the consideration of propeller deformation. Y1 - 2023 U6 - http://dx.doi.org/10.2514/6.2023-0210 N1 - Session: Propeller, Open Rotor, and Rotorcraft Noise II AIAA SCITECH 2023 Forum, 23-27 January 2023, National Harbor, MD & Online PB - AIAA ER - TY - JOUR A1 - Ayala, Rafael Ceja A1 - Harris, Isaac A1 - Kleefeld, Andreas A1 - Pallikarakis, Nikolaos T1 - Analysis of the transmission eigenvalue problem with two conductivity parameters JF - Applicable Analysis N2 - In this paper, we provide an analytical study of the transmission eigenvalue problem with two conductivity parameters. We will assume that the underlying physical model is given by the scattering of a plane wave for an isotropic scatterer. In previous studies, this eigenvalue problem was analyzed with one conductive boundary parameter whereas we will consider the case of two parameters. We prove the existence and discreteness of the transmission eigenvalues as well as study the dependence on the physical parameters. We are able to prove monotonicity of the first transmission eigenvalue with respect to the parameters and consider the limiting procedure as the second boundary parameter vanishes. Lastly, we provide extensive numerical experiments to validate the theoretical work. KW - Transmission Eigenvalues KW - Conductive Boundary Condition KW - Inverse Scattering Y1 - 2023 U6 - http://dx.doi.org/10.1080/00036811.2023.2181167 SN - 0003-6811 PB - Taylor & Francis ER - TY - JOUR A1 - Gaigall, Daniel A1 - Gerstenberg, Julian T1 - Cramér-von-Mises tests for the distribution of the excess over a confidence level JF - Journal of Nonparametric Statistics N2 - The Cramér-von-Mises distance is applied to the distribution of the excess over a confidence level. Asymptotics of related statistics are investigated, and it is seen that the obtained limit distributions differ from the classical ones. For that reason, quantiles of the new limit distributions are given and new bootstrap techniques for approximation purposes are introduced and justified. The results motivate new one-sample goodness-of-fit tests for the distribution of the excess over a confidence level and a new confidence interval for the related fitting error. Simulation studies investigate size and power of the tests as well as coverage probabilities of the confidence interval in the finite sample case. A practice-oriented application of the Cramér-von-Mises tests is the determination of an appropriate confidence level for the fitting approach. The adoption of the idea to the well-known problem of threshold detection in the context of peaks over threshold modelling is sketched and illustrated by data examples. KW - Cramér-von-Mises test KW - conditional excess distribution KW - confidence interval KW - goodness-of-fit test Y1 - 2023 U6 - http://dx.doi.org/10.1080/10485252.2023.2173958 SN - 1048-5252 (Print) SN - 1029-0311 (Online) PB - Taylor & Francis ER - TY - JOUR A1 - Liphardt, Anna-Maria A1 - Fernandez-Gonzalo, Rodrigo A1 - Albracht, Kirsten A1 - Rittweger, Jörn A1 - Vico, Laurence T1 - Musculoskeletal research in human space flight – unmet needs for the success of crewed deep space exploration JF - npj Microgravity N2 - Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper “Human Physiology – Musculoskeletal system”, this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback. Y1 - 2023 U6 - http://dx.doi.org/10.1038/s41526-023-00258-3 SN - 2373-8065 VL - 9 IS - Article number: 9 SP - 1 EP - 9 PB - Springer Nature ER - TY - JOUR A1 - Gaigall, Daniel ED - AitSahlia, Farid T1 - Allocating and forecasting changes in risk JF - Journal of risk N2 - We consider time-dependent portfolios and discuss the allocation of changes in the risk of a portfolio to changes in the portfolio’s components. For this purpose we adopt established allocation principles. We also use our approach to obtain forecasts for changes in the risk of the portfolio’s components. To put the approach into practice we present an implementation based on the output of a simulation. Allocation is illustrated with an example portfolio in the context of Solvency II. The quality of the forecasts is investigated with an empirical study. KW - portfolio risk KW - allocation KW - forecast KW - covariance principle KW - conditional expectation principle Y1 - 2023 U6 - http://dx.doi.org/10.21314/JOR.2022.048 SN - 1755-2842 SN - 1465-1211 VL - 25 IS - 3 SP - 1 EP - 24 PB - Infopro Digital Risk CY - London ER - TY - JOUR A1 - Gaigall, Daniel T1 - On the applicability of several tests to models with not identically distributed random effects JF - Statistics : A Journal of Theoretical and Applied Statistics N2 - We consider Kolmogorov–Smirnov and Cramér–von-Mises type tests for testing central symmetry, exchangeability, and independence. In the standard case, the tests are intended for the application to independent and identically distributed data with unknown distribution. The tests are available for multivariate data and bootstrap procedures are suitable to obtain critical values. We discuss the applicability of the tests to random effects models, where the random effects are independent but not necessarily identically distributed and with possibly unknown distributions. Theoretical results show the adequacy of the tests in this situation. The quality of the tests in models with random effects is investigated by simulations. Empirical results obtained confirm the theoretical findings. A real data example illustrates the application. KW - central symmetry test KW - exchangeability test KW - independence test KW - random effects KW - not identically distributed Y1 - 2023 SN - 0323-3944 U6 - http://dx.doi.org/10.1080/02331888.2023.2193748 SN - 1029-4910 VL - 57 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Bialonski, Stephan A1 - Grieger, Niklas T1 - Der KI-Chatbot ChatGPT: Eine Herausforderung für die Hochschulen JF - Die neue Hochschule N2 - Essays, Gedichte, Programmcode: ChatGPT generiert automatisch Texte auf bisher unerreicht hohem Niveau. Dieses und nachfolgende Systeme werden nicht nur die akademische Welt nachhaltig verändern. Y1 - 2023 U6 - http://dx.doi.org/10.5281/zenodo.7533758 SN - 0340-448X VL - 2023 IS - 1 SP - 24 EP - 27 PB - HLB CY - Bonn ER - TY - JOUR A1 - Šakić, Bogdan A1 - Marinković, Marko A1 - Butenweg, Christoph A1 - Klinkel, Sven ED - Yang, J. T1 - Influence of slab deflection on the out-of-plane capacity of unreinforced masonry partition walls JF - Engineering Structures N2 - Severe damage of non-structural elements is noticed in previous earthquakes, causing high economic losses and posing a life threat for the people. Masonry partition walls are one of the most commonly used non-structural elements. Therefore, their behaviour under earthquake loading in out-of-plane (OOP) direction is investigated by several researches in the past years. However, none of the existing experimental campaigns or analytical approaches consider the influence of prior slab deflection on OOP response of partition walls. Moreover, none of the existing construction techniques for the connection of partition walls with surrounding reinforced concrete (RC) is investigated for the combined slab deflection and OOP loading. However, the inevitable time-dependent behaviour of RC slabs leads to high values of final slab deflections which can further influence boundary conditions of partition walls. Therefore, a comprehensive study on the influence of slab deflection on the OOP capacity of masonry partitions is conducted. In the first step, experimental tests are carried out. Results of experimental tests are further used for the calibration of the numerical model employed for a parametric study. Based on the results, behaviour under combined loading for different construction techniques is explained. The results show that slab deflection leads either to severe damage or to a high reduction of OOP capacity. Existing practical solutions do not account for these effects. In this contribution, recommendations to overcome the problems of combined slab deflection and OOP loading on masonry partition walls are given. Possible interaction of in-plane (IP) loading, with the combined slab deflection and OOP loading on partition walls, is not investigated in this study. KW - Masonry partition walls KW - Earthquake KW - Out-of-plane capacity KW - Slab deflection Y1 - 2023 U6 - http://dx.doi.org/10.1016/j.engstruct.2022.115342 SN - 0141-0296 VL - 276 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Niedermeier, Jana A1 - Penner, Crystal A1 - Usherovich, Samuel A1 - Bélanger-Champagne, Camille A1 - Paulßen, Elisabeth A1 - Cornelia, Hoehr T1 - Optical Fibers as Dosimeter Detectors for Mixed Proton/Neutron Fields - A Biological Dosimeter JF - electronics N2 - In recent years, proton therapy has gained importance as a cancer treatment modality due to its conformality with the tumor and the sparing of healthy tissue. However, in the interaction of the protons with the beam line elements and patient tissues, potentially harmful secondary neutrons are always generated. To ensure that this neutron dose is as low as possible, treatment plans could be created to also account for and minimize the neutron dose. To monitor such a treatment plan, a compact, easy to use, and inexpensive dosimeter must be developed that not only measures the physical dose, but which can also distinguish between proton and neutron contributions. To that end, plastic optical fibers with scintillation materials (Gd₂O₂S:Tb, Gd₂O₂S:Eu, and YVO₄:Eu) were irradiated with protons and neutrons. It was confirmed that sensors with different scintillation materials have different sensitivities to protons and neutrons. A combination of these three scintillators can be used to build a detector array to create a biological dosimeter. KW - biological dosimeter KW - Bragg peak KW - relative dosimetry KW - optical fibers KW - proton therapy KW - protons KW - neutrons Y1 - 2023 U6 - http://dx.doi.org/10.3390/electronics12020324 SN - 2079-9292 N1 - This article belongs to the Special Issue "Applications of Optical Fiber Sensors" VL - 12 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Rübbelke, Dirk A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Zobel, Luzy T1 - Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production JF - Data in Brief N2 - Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (Rübbelke, 2022). KW - Energy-intensive industry KW - Steel industry KW - Competitiveness KW - Floor prices KW - Cross border adjustment mechanism Y1 - 2023 U6 - http://dx.doi.org/10.1016/j.dib.2023.108907 SN - 2352-3409 VL - 47 IS - Article 108907 SP - 1 EP - 5 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Haeger, Gerrit A1 - Grankin, Alina A1 - Wagner, Michaela T1 - Construction of an Aspergillus oryzae triple amylase deletion mutant as a chassis to evaluate industrially relevant amylases using multiplex CRISPR/Cas9 editing technology JF - Applied Research N2 - Aspergillus oryzae is an industrially relevant organism for the secretory production of heterologous enzymes, especially amylases. The activities of potential heterologous amylases, however, cannot be quantified directly from the supernatant due to the high background activity of native α-amylase. This activity is caused by the gene products of amyA, amyB, and amyC. In this study, an in vitro CRISPR/Cas9 system was established in A. oryzae to delete these genes simultaneously. First, pyrG of A. oryzae NSAR1 was mutated by exploiting NHEJ to generate a counter-selection marker. Next, all amylase genes were deleted simultaneously by co-transforming a repair template carrying pyrG of Aspergillus nidulans and flanking sequences of amylase gene loci. The rate of obtained triple knock-outs was 47%. We showed that triple knockouts do not retain any amylase activity in the supernatant. The established in vitro CRISPR/Cas9 system was used to achieve sequence-specific knock-in of target genes. The system was intended to incorporate a single copy of the gene of interest into the desired host for the development of screening methods. Therefore, an integration cassette for the heterologous Fpi amylase was designed to specifically target the amyB locus. The site-specific integration rate of the plasmid was 78%, with exceptional additional integrations. Integration frequency was assessed via qPCR and directly correlated with heterologous amylase activity. Hence, we could compare the efficiency between two different signal peptides. In summary, we present a strategy to exploit CRISPR/Cas9 for gene mutation, multiplex knock-out, and the targeted knock-in of an expression cassette in A. oryzae. Our system provides straightforward strain engineering and paves the way for development of fungal screening systems. KW - aspergillus KW - CRISPR/Cas9 KW - filamentous fungi KW - genome engineering Y1 - 2023 U6 - http://dx.doi.org/10.1002/appl.202200106 SN - 2702-4288 IS - Early View SP - 1 EP - 15 PB - Wiley-VCH ER - TY - JOUR A1 - Bruksle, Ieva A1 - Chwallek, Constanze A1 - Krastina, Anzelika T1 - Strengthening sustainability in entrepreneurship education - implications for shifting entrepreneurial thinking towards sustainability at universities JF - ACTA PROSPERITATIS N2 - By developing innovative solutions to social and environmental problems, sustainable ventures carry greatpotential. Entrepreneurship which focuses especially on new venture creation can be developed through education anduniversities, in particular, are called upon to provide an impetus for social change. But social innovations are associatedwith certain hurdles, which are related to the multi-dimensionality, i.e. the tension between creating social,environmental and economic value and dealing with a multiplicity of stakeholders. The already complex field ofentrepreneurship education has to face these challenges. This paper, therefore, aims to identify starting points for theintegration of sustainability into entrepreneurship education. To pursue this goal experiences from three differentproject initiatives between the partner universities: Lapland University of Applied Sciences, FH Aachen University ofApplied Sciences and Turiba University are reflected and findings are systematically condensed into recommendationsfor education on sustainable entrepreneurship. KW - climate change KW - entrepreneurship education KW - Finland KW - Germany KW - Latvia Y1 - 2023 U6 - http://dx.doi.org/10.37804/1691-6077-2023-14-37-48 SN - 1691-6077 VL - 14 IS - 1 SP - 37 EP - 48 PB - Sciendo ER - TY - JOUR A1 - Savitskaya, Irina A1 - Zhantlessova, Sirina A1 - Kistaubayeva, Aida A1 - Ignatova, Ludmila A1 - Shokatayeva, Dina A1 - Sinyavsky, Yuriy A1 - Kushugulova, Almagul A1 - Digel, Ilya T1 - Prebiotic cellulose–pullulan matrix as a “vehicle” for probiotic biofilm delivery to the host large intestine JF - Polymers N2 - This study describes the development of a new combined polysaccharide-matrix-based technology for the immobilization of Lactobacillus rhamnosus GG (LGG) bacteria in biofilm form. The new composition allows for delivering the bacteria to the digestive tract in a manner that improves their robustness compared with planktonic cells and released biofilm cells. Granules consisting of a polysaccharide matrix with probiotic biofilms (PMPB) with high cell density (>9 log CFU/g) were obtained by immobilization in the optimized nutrient medium. Successful probiotic loading was confirmed by fluorescence microscopy and scanning electron microscopy. The developed prebiotic polysaccharide matrix significantly enhanced LGG viability under acidic (pH 2.0) and bile salt (0.3%) stress conditions. Enzymatic extract of feces, mimicking colon fluid in terms of cellulase activity, was used to evaluate the intestinal release of probiotics. PMPB granules showed the ability to gradually release a large number of viable LGG cells in the model colon fluid. In vivo, the oral administration of PMPB granules in rats resulted in the successful release of probiotics in the colon environment. The biofilm-forming incubation method of immobilization on a complex polysaccharide matrix tested in this study has shown high efficacy and promising potential for the development of innovative biotechnologies. KW - immobilization KW - prebiotic KW - bacterial cellulose KW - biofilms KW - Lactobacillus rhamnosus GG Y1 - 2023 U6 - http://dx.doi.org/10.3390/polym16010030 N1 - This article belongs to the Section "Polymer Composites and Nanocomposites" IS - 16(1) PB - MDPI CY - Basel ER - TY - JOUR A1 - Timme, Michael T1 - Die Erbringung einer Leistung in der irrigen Vorstellung einer Bestellung (Zu BGH, MDR 2023, 1439) JF - Monatsschrift für Deutsches Recht Y1 - 2023 U6 - http://dx.doi.org/10.9785/mdtr-2023-772402 SN - 2194-4202 (online) SN - 0340-1812 (print) VL - 77 IS - 24 SP - R293 EP - R296 PB - Verlag Dr. Otto Schmidt CY - Köln ER - TY - JOUR A1 - Vögele, Stefan A1 - Josyabhatla, Vishnu Teja A1 - Ball, Christopher A1 - Rhoden, Imke A1 - Grajewski, Matthias A1 - Rübbelke, Dirk A1 - Kuckshinrichs, Wilhelm T1 - Robust assessment of energy scenarios from stakeholders' perspectives JF - Energy N2 - Using scenarios is vital in identifying and specifying measures for successfully transforming the energy system. Such transformations can be particularly challenging and require the support of a broader set of stakeholders. Otherwise, there will be opposition in the form of reluctance to adopt the necessary technologies. Usually, processes for considering stakeholders' perspectives are very time-consuming and costly. In particular, there are uncertainties about how to deal with modifications in the scenarios. In principle, new consulting processes will be required. In our study, we show how multi-criteria decision analysis can be used to analyze stakeholders' attitudes toward transition paths. Since stakeholders differ regarding their preferences and time horizons, we employ a multi-criteria decision analysis approach to identify which stakeholders will support or oppose a transition path. We provide a flexible template for analyzing stakeholder preferences toward transition paths. This flexibility comes from the fact that our multi-criteria decision aid-based approach does not involve intensive empirical work with stakeholders. Instead, it involves subjecting assumptions to robustness analysis, which can help identify options to influence stakeholders' attitudes toward transitions. Y1 - 2023 U6 - http://dx.doi.org/10.1016/j.energy.2023.128326 SN - 1873-6785 (Online) SN - 0360-5442 (Print) IS - In Press, Article 128326 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schulze, Sven A1 - Feyerl, Günter A1 - Pischinger, Stefan T1 - Advanced ECMS for hybrid electric heavy-duty trucks with predictive battery discharge and adaptive operating strategy under real driving conditions JF - Energies N2 - To fulfil the CO2 emission reduction targets of the European Union (EU), heavy-duty (HD) trucks need to operate 15% more efficiently by 2025 and 30% by 2030. Their electrification is necessary as conventional HD trucks are already optimized for the long-haul application. The resulting hybrid electric vehicle (HEV) truck gains most of the fuel saving potential by the recuperation of potential energy and its consecutive utilization. The key to utilizing the full potential of HEV-HD trucks is to maximize the amount of recuperated energy and ensure its intelligent usage while keeping the operating point of the internal combustion engine as efficient as possible. To achieve this goal, an intelligent energy management strategy (EMS) based on ECMS is developed for a parallel HEV-HD truck which uses predictive discharge of the battery and adaptive operating strategy regarding the height profile and the vehicle mass. The presented EMS can reproduce the global optimal operating strategy over long phases and lead to a fuel saving potential of up to 2% compared with a heuristic strategy. Furthermore, the fuel saving potential is correlated with the investigated boundary conditions to deepen the understanding of the impact of intelligent EMS for HEV-HD trucks. KW - Energy management strategies KW - ECMS KW - CO2 emission reduction targets KW - Driving cycle recognition KW - Predictive battery discharge Y1 - 2023 U6 - http://dx.doi.org/10.3390/en16135171 SN - 1996-1073 N1 - The article belongs to the Special Issue "Energy Management Strategies of Electrified Vehicles toward the Real-World Driving". VL - 16 IS - 13 PB - MDPI CY - Basel ER - TY - JOUR A1 - Heieis, Jule A1 - Böcker, Jonas A1 - D'Angelo, Olfa A1 - Mittag, Uwe A1 - Albracht, Kirsten A1 - Schönau, Eckhard A1 - Meyer, Andreas A1 - Voigtmann, Thomas A1 - Rittweger, Jörn T1 - Curvature of gastrocnemius muscle fascicles as function of muscle–tendon complex length and contraction in humans JF - Physiological Reports N2 - It has been shown that muscle fascicle curvature increases with increasing contraction level and decreasing muscle–tendon complex length. The analyses were done with limited examination windows concerning contraction level, muscle–tendon complex length, and/or intramuscular position of ultrasound imaging. With this study we aimed to investigate the correlation between fascicle arching and contraction, muscle–tendon complex length and their associated architectural parameters in gastrocnemius muscles to develop hypotheses concerning the fundamental mechanism of fascicle curving. Twelve participants were tested in five different positions (90°/105°*, 90°/90°*, 135°/90°*, 170°/90°*, and 170°/75°*; *knee/ankle angle). They performed isometric contractions at four different contraction levels (5%, 25%, 50%, and 75% of maximum voluntary contraction) in each position. Panoramic ultrasound images of gastrocnemius muscles were collected at rest and during constant contraction. Aponeuroses and fascicles were tracked in all ultrasound images and the parameters fascicle curvature, muscle–tendon complex strain, contraction level, pennation angle, fascicle length, fascicle strain, intramuscular position, sex and age group were analyzed by linear mixed effect models. Mean fascicle curvature of the medial gastrocnemius increased with contraction level (+5 m−1 from 0% to 100%; p = 0.006). Muscle–tendon complex length had no significant impact on mean fascicle curvature. Mean pennation angle (2.2 m−1 per 10°; p < 0.001), inverse mean fascicle length (20 m−1 per cm−1; p = 0.003), and mean fascicle strain (−0.07 m−1 per +10%; p = 0.004) correlated with mean fascicle curvature. Evidence has also been found for intermuscular, intramuscular, and sex-specific intramuscular differences of fascicle curving. Pennation angle and the inverse fascicle length show the highest predictive capacities for fascicle curving. Due to the strong correlations between pennation angle and fascicle curvature and the intramuscular pattern of curving we suggest for future studies to examine correlations between fascicle curvature and intramuscular fluid pressure. KW - biomechanics KW - connective tissue KW - physiology KW - ultrasound Y1 - 2023 U6 - http://dx.doi.org/10.14814/phy2.15739 SN - 2051-817X VL - 11 IS - 11 SP - e15739, Seite 1-11 PB - Wiley ER - TY - JOUR A1 - Kuchler, Timon A1 - Günthner, Roman A1 - Ribeiro, Andrea A1 - Hausinger, Renate A1 - Streese, Lukas A1 - Wöhnl, Anna A1 - Kesseler, Veronika A1 - Negele, Johanna A1 - Assali, Tarek A1 - Carbajo-Lozoya, Javier A1 - Lech, Maciej A1 - Adorjan, Kristina A1 - Stubbe, Hans Christian A1 - Hanssen, Henner A1 - Kotliar, Konstantin A1 - Haller, Berhard A1 - Heemann, Uwe A1 - Schmaderer, Christoph T1 - Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation N2 - Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5–190.2] vs. 189.1 [179.4–197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8–0.9] vs. 0.88 [0.8–0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = − 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management. KW - Endothelial dysfunction KW - Long COVID KW - Post-COVID-19 syndrome KW - retinal microvasculature Y1 - 2023 U6 - http://dx.doi.org/10.1007/s10456-023-09885-6 N1 - Corresponding author: Christoph Schmaderer VL - 26 SP - 547 EP - 563 PB - Springer Nature CY - Dordrecht ER - TY - JOUR A1 - Trapp, Svenja A1 - Lammers, Tom A1 - Engudar, Gokce A1 - Hoehr, Cornelia A1 - Denkova, Antonia G. A1 - Paulßen, Elisabeth A1 - de Kruijff, Robin M. T1 - Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop JF - EJNMMI Radiopharmacy and Chemistry KW - Microfluidic solvent extraction KW - Ga-68 KW - Cyclotron production KW - Medical radionuclide production KW - Metal contaminants Y1 - 2023 U6 - http://dx.doi.org/10.1186/s41181-023-00195-2 SN - 2365-421X VL - 2023 IS - 8, Article number: 9 SP - 1 EP - 14 PB - Springer Nature ER - TY - JOUR A1 - Cheenakula, Dheeraja A1 - Griebel, Kai A1 - Montag, David A1 - Grömping, Markus ED - Huang, Xiaowu T1 - Concept development of a mainstream deammonification and comparison with conventional process in terms of energy, performance and economical construction perspectives JF - Frontiers in Microbiology N2 - Deammonification for nitrogen removal in municipal wastewater in temperate and cold climate zones is currently limited to the side stream of municipal wastewater treatment plants (MWWTP). This study developed a conceptual model of a mainstream deammonification plant, designed for 30,000 P.E., considering possible solutions corresponding to the challenging mainstream conditions in Germany. In addition, the energy-saving potential, nitrogen elimination performance and construction-related costs of mainstream deammonification were compared to a conventional plant model, having a single-stage activated sludge process with upstream denitrification. The results revealed that an additional treatment step by combining chemical precipitation and ultra-fine screening is advantageous prior the mainstream deammonification. Hereby chemical oxygen demand (COD) can be reduced by 80% so that the COD:N ratio can be reduced from 12 to 2.5. Laboratory experiments testing mainstream conditions of temperature (8–20°C), pH (6–9) and COD:N ratio (1–6) showed an achievable volumetric nitrogen removal rate (VNRR) of at least 50 gN/(m3∙d) for various deammonifying sludges from side stream deammonification systems in the state of North Rhine-Westphalia, Germany, where m3 denotes reactor volume. Assuming a retained Norganic content of 0.0035 kgNorg./(P.E.∙d) from the daily loads of N at carbon removal stage and a VNRR of 50 gN/(m3∙d) under mainstream conditions, a resident-specific reactor volume of 0.115 m3/(P.E.) is required for mainstream deammonification. This is in the same order of magnitude as the conventional activated sludge process, i.e., 0.173 m3/(P.E.) for an MWWTP of size class of 4. The conventional plant model yielded a total specific electricity demand of 35 kWh/(P.E.∙a) for the operation of the whole MWWTP and an energy recovery potential of 15.8 kWh/(P.E.∙a) through anaerobic digestion. In contrast, the developed mainstream deammonification model plant would require only a 21.5 kWh/(P.E.∙a) energy demand and result in 24 kWh/(P.E.∙a) energy recovery potential, enabling the mainstream deammonification model plant to be self-sufficient. The retrofitting costs for the implementation of mainstream deammonification in existing conventional MWWTPs are nearly negligible as the existing units like activated sludge reactors, aerators and monitoring technology are reusable. However, the mainstream deammonification must meet the performance requirement of VNRR of about 50 gN/(m3∙d) in this case. KW - anammox KW - energy efficiency KW - mainstream deammonification KW - nitrogen elimination KW - wastewater Y1 - 2023 U6 - http://dx.doi.org/10.3389/fmicb.2023.1155235 SN - 1664-302X VL - 14 IS - 11155235 SP - 1 EP - 15 PB - Frontiers ER - TY - JOUR A1 - Golland, Alexander T1 - Immaterieller Schadensersatz bei Datenschutzverstößen – EuGH tariert aus JF - NWB - Steuer- und Wirtschaftsrecht N2 - Umsatzbasierte Bußgelder – wie sonst nur aus dem Kartellrecht bekannt – waren einer der Gründe, warum die Datenschutz-Grundverordnung (DSGVO) vor ihrem Inkrafttreten für erhebliches Aufsehen sorgte. Die vielfach relevanteren Schadensersatzansprüche, die, wie bei „Dieselgate“, aufgrund der Vielzahl von betroffenen Personen und der aus Sicht von Rechtsdienstleistern bestehenden Skalierbarkeit mit weitaus höheren Einbußen für Unternehmen einhergehen können, blieben zunächst unbeachtet. Inzwischen ist der Schadensersatzanspruch gem. Art. 82 DSGVO die Vorschrift, die die meisten Vorlagen zum Europäischen Gerichtshof (EuGH) der letzten Jahre hervorgerufen hat. Am 4.5.2023 hat nun der EuGH (Urteil v. 4.5.2023 - Rs. C-300/21, NWB GAAAJ-41389) in einem Grundsatzurteil über zentrale Fragen rund um den Ersatz immaterieller Schäden als Folge von Datenschutzverstößen entschieden. KW - Datenschutzgrundverordnung KW - Schadensersatz Y1 - 2023 SN - 0028-3460 VL - 2023 IS - 26 SP - 1845 EP - 1845 PB - NWB Verlag CY - Herne ER - TY - JOUR A1 - Ohrtmann, Jan-Peter A1 - Golland, Alexander T1 - Datenschutz & Datenrecht – ein Ausblick auf 2023: Nationale Entwicklungen, EuGH-Vorlagen & Aufsicht JF - Datenschutz-Berater (DSB) N2 - Die Verfasser vermitteln einen Überblick über die nationalen Gesetzgebungsverfahren und wesentliche EuGH-Vorlagefragen betreffend den Datenschutz und das Datenrecht für das Jahr 2023. Zunächst folgen u.a. Hinweise in Bezug auf den Hinweisgeberschutz, die Verabschiedung der Einwilligungsverwaltungs-Verordnung zur Konkretisierung des § 26 TTDSG und das Mobilitätsdatengesetz. Anschließend werden Vorlagefragen deutscher Gerichte, die dem EuGH vorgelegt und bereits am 12.01.2023 beantwortet wurden, wie etwa C-154/21 und C-132/21 und die EuGH-Entscheidung vom 9.2.2023 (C-453/21), thematisiert. Überdies führen die Autoren wesentliche Entscheidungen des EuGH an, die im Jahr 2023 aus dem Bereich Datenrecht und Datenschutz zu erwarten seien. Auch Aktivitäten der Datenschutzaufsicht auf nationaler und europäischer Ebene finden Erwähnung. Die Verfasser machen abschließend auf besonders interessante Entscheidungen, die 2023 erwartet werden, wie etwa das EuGH-Urteil zum Auskunftsanspruch, sowie auf das Verhältnis des der Whistleblowing-RL umzusetzende Hinweisgeberschutzgesetz einerseits und Vorgaben des Datenschutzes andererseits, aufmerksam. Sie empfehlen, die künftige Rechtsprechung des EuGH im Blick zu behalten. Y1 - 2023 VL - 2023 IS - 3 SP - 73 EP - 75 PB - Fachmedien Recht und Wirtschaft CY - Frankfurt am Main ER - TY - JOUR A1 - Ohrtmann, Jan-Peter A1 - Golland, Alexander T1 - Datenschutz & Datenrecht – ein Ausblick auf 2023: Gesetzgebungsverfahren auf EU-Ebene JF - Datenschutz-Berater (DSB) N2 - Die Verfasser stellen in ihrem Beitrag die künftig in Kraft tretenden oder schon in Kraft getretenen Gesetzesvorhaben der europäischen Union vor. Vorab werde auf die abgelaufene Frist zur Anpassung von Standardvertragsklausel hingewiesen. Die Anpassung könne ggf. durch den Data Privacy Act der Kommission bewirkt werden, da dieser eine Angemessenheit suggeriere. Neben dem Digital Markets Act, der die Wahrung der Diskriminierungsfreiheit den Gatekeeper-Plattformen bezüglich der Bewerbung von Waren Dritter vorschreibt, sind ebenfalls der Digital Service Act und der Data Governance Act in Kraft getreten und werden künftig wirksam. Letzteres bezweckt den Datenaustausch von nicht-personenbezogenen Daten öffentlich-rechtlicher Datensätze, wobei anders als bei DSA, der die Verbraucherrechte durchsetzen möchte, mangels Verpflichtung die praktische Umsetzung ausbleiben werde. In der Entwurfsphase stecken der Artificial Intelligence Act, der Data Act, sowie der Cyber Resilience Act. Allen drei sei wegen dem weiten Anwendungsspielraum, der Bußgeldandrohung oder der Cyber-Bedrohungslage besondere praktische Relevanz beizumessen. Die Kommission weite durch diese Gesetzesvorhaben ihre Regelungsabsicht auch auf nicht-personenbezogene Daten und dem Datentransfer aus. Im Ergebnis werden die Unternehmen mit mehr Verpflichtungen konfrontiert, zu dessen Umsetzung ein funktionierendes Compliance-Management-System unabdingbar sei. Y1 - 2023 VL - 2023 IS - 2 SP - 43 EP - 46 PB - Fachmedien Recht und Wirtschaft CY - Frankfurt am Main ER - TY - JOUR A1 - Waldvogel, Janice A1 - Freyler, Kathrin A1 - Helm, Michael A1 - Monti, Elena A1 - Stäudle, Benjamin A1 - Gollhofer, Albert A1 - Narici, Marco V. A1 - Ritzmann, Ramona A1 - Albracht, Kirsten T1 - Changes in gravity affect neuromuscular control, biomechanics, and muscle-tendon mechanics in energy storage and dissipation tasks JF - Journal of Applied Physiology N2 - This study evaluates neuromechanical control and muscle-tendon interaction during energy storage and dissipation tasks in hypergravity. During parabolic flights, while 17 subjects performed drop jumps (DJs) and drop landings (DLs), electromyography (EMG) of the lower limb muscles was combined with in vivo fascicle dynamics of the gastrocnemius medialis, two-dimensional (2D) kinematics, and kinetics to measure and analyze changes in energy management. Comparisons were made between movement modalities executed in hypergravity (1.8 G) and gravity on ground (1 G). In 1.8 G, ankle dorsiflexion, knee joint flexion, and vertical center of mass (COM) displacement are lower in DJs than in DLs; within each movement modality, joint flexion amplitudes and COM displacement demonstrate higher values in 1.8 G than in 1 G. Concomitantly, negative peak ankle joint power, vertical ground reaction forces, and leg stiffness are similar between both movement modalities (1.8 G). In DJs, EMG activity in 1.8 G is lower during the COM deceleration phase than in 1 G, thus impairing quasi-isometric fascicle behavior. In DLs, EMG activity before and during the COM deceleration phase is higher, and fascicles are stretched less in 1.8 G than in 1 G. Compared with the situation in 1 G, highly task-specific neuromuscular activity is diminished in 1.8 G, resulting in fascicle lengthening in both movement modalities. Specifically, in DJs, a high magnitude of neuromuscular activity is impaired, resulting in altered energy storage. In contrast, in DLs, linear stiffening of the system due to higher neuromuscular activity combined with lower fascicle stretch enhances the buffering function of the tendon, and thus the capacity to safely dissipate energy. KW - electromyography KW - locomotion KW - overload KW - stretch-shortening cycle KW - ultrasound Y1 - 2023 U6 - http://dx.doi.org/10.1152/japplphysiol.00279.2022 SN - 1522-1601 (Onlineausgabe) SN - 8750-7587 (Druckausgabe) VL - 134 IS - 1 SP - 190 EP - 202 PB - American Physiological Society CY - Bethesda, Md. ER - TY - JOUR A1 - Rhoden, Imke A1 - Ball, Christopher Stephen A1 - Grajewski, Matthias A1 - Kuckshinrich, Wilhelm T1 - Reverse engineering of stakeholder preferences – A multi-criteria assessment of the German passenger car sector JF - Renewable and Sustainable Energy Reviews N2 - Germany is a frontrunner in setting frameworks for the transition to a low-carbon system. The mobility sector plays a significant role in this shift, affecting different people and groups on multiple levels. Without acceptance from these stakeholders, emission targets are out of reach. This research analyzes how the heterogeneous preferences of various stakeholders align with the transformation of the mobility sector, looking at the extent to which the German transformation paths are supported and where stakeholders are located. Under the research objective of comparing stakeholders' preferences to identify which car segments require additional support for a successful climate transition, a status quo of stakeholders and car performance criteria is the foundation for the analysis. Stakeholders' hidden preferences hinder the derivation of criteria weightings from stakeholders; therefore, a ranking from observed preferences is used. This study's inverse multi-criteria decision analysis means that weightings can be predicted and used together with a recalibrated performance matrix to explore future preferences toward car segments. Results show that stakeholders prefer medium-sized cars, with the trend pointing towards the increased potential for alternative propulsion technologies and electrified vehicles. These insights can guide the improved targeting of policy supporting the energy and mobility transformation. Additionally, the method proposed in this work can fully handle subjective approaches while incorporating a priori information. A software implementation of the proposed method completes this work and is made publicly available. KW - Regionalization KW - Multi-criteria decision analysis KW - Preference assessment KW - E-Mobility KW - Mobility transition Y1 - 2023 U6 - http://dx.doi.org/10.1016/j.rser.2023.113352 SN - 1364-0321 VL - 181 IS - July 2023 SP - Article number: 113352 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Fayyazi, Mojgan A1 - Sardar, Paramjotsingh A1 - Thomas, Sumit Infent A1 - Daghigh, Roonak A1 - Jamali, Ali A1 - Esch, Thomas A1 - Kemper, Hans A1 - Langari, Reza A1 - Khayyam, Hamid T1 - Artificial intelligence/machine learning in energy management systems, control, and optimization of hydrogen fuel cell vehicles N2 - Environmental emissions, global warming, and energy-related concerns have accelerated the advancements in conventional vehicles that primarily use internal combustion engines. Among the existing technologies, hydrogen fuel cell electric vehicles and fuel cell hybrid electric vehicles may have minimal contributions to greenhouse gas emissions and thus are the prime choices for environmental concerns. However, energy management in fuel cell electric vehicles and fuel cell hybrid electric vehicles is a major challenge. Appropriate control strategies should be used for effective energy management in these vehicles. On the other hand, there has been significant progress in artificial intelligence, machine learning, and designing data-driven intelligent controllers. These techniques have found much attention within the community, and state-of-the-art energy management technologies have been developed based on them. This manuscript reviews the application of machine learning and intelligent controllers for prediction, control, energy management, and vehicle to everything (V2X) in hydrogen fuel cell vehicles. The effectiveness of data-driven control and optimization systems are investigated to evolve, classify, and compare, and future trends and directions for sustainability are discussed. KW - optimization system KW - intelligent control KW - fuel cell vehicle KW - machine learning KW - artificial intelligence KW - intelligent energy management Y1 - 2023 U6 - http://dx.doi.org/10.3390/su15065249 N1 - This article belongs to the Special Issue "Circular Economy and Artificial Intelligence" VL - 15 IS - 6 SP - 38 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bertz, Morten A1 - Molinnus, Denise A1 - Schöning, Michael Josef A1 - Homma, Takayuki T1 - Real-time monitoring of H₂O₂ sterilization on individual bacillus atrophaeus spores by optical sensing with trapping Raman spectroscopy JF - Chemosensors N2 - Hydrogen peroxide (H₂O₂), a strong oxidizer, is a commonly used sterilization agent employed during aseptic food processing and medical applications. To assess the sterilization efficiency with H₂O₂, bacterial spores are common microbial systems due to their remarkable robustness against a wide variety of decontamination strategies. Despite their widespread use, there is, however, only little information about the detailed time-resolved mechanism underlying the oxidative spore death by H₂O₂. In this work, we investigate chemical and morphological changes of individual Bacillus atrophaeus spores undergoing oxidative damage using optical sensing with trapping Raman microscopy in real-time. The time-resolved experiments reveal that spore death involves two distinct phases: (i) an initial phase dominated by the fast release of dipicolinic acid (DPA), a major spore biomarker, which indicates the rupture of the spore’s core; and (ii) the oxidation of the remaining spore material resulting in the subsequent fragmentation of the spores’ coat. Simultaneous observation of the spore morphology by optical microscopy corroborates these mechanisms. The dependence of the onset of DPA release and the time constant of spore fragmentation on H₂O₂ shows that the formation of reactive oxygen species from H₂O₂ is the rate-limiting factor of oxidative spore death. KW - DPA (dipicolinic acid) KW - sterilization KW - Bacillus atrophaeus spores KW - optical trapping KW - Raman spectroscopy KW - optical sensor setup Y1 - 2023 U6 - http://dx.doi.org/10.3390/chemosensors11080445 SN - 2227-9040 N1 - This article belongs to the Special Issue "Biosensors and Chemical Sensors for Food and Healthcare Monitoring—Celebrating the 10th Anniversary" VL - 8 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wendlandt, Tim A1 - Koch, Claudia A1 - Britz, Beate A1 - Liedek, Anke A1 - Schmidt, Nora A1 - Werner, Stefan A1 - Gleba, Yuri A1 - Vahidpour, Farnoosh A1 - Welden, Melanie A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System JF - Viruses N2 - Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes. KW - biosensor KW - horseradish peroxidase (HRP) KW - glucose oxidase (GOx) KW - enzyme cascade KW - turnip vein clearing virus (TVCV) KW - tobacco mosaic virus (TMV) Y1 - 2023 U6 - http://dx.doi.org/doi.org/10.3390/v15091951 SN - 1999-4915 N1 - This article belongs to the Special Issue "Tobamoviruses 2023" VL - 9 IS - 15 PB - MDPI CY - Basel ER - TY - JOUR A1 - Dellmann, Sophia Florence A1 - Glorius, J. A1 - Litvinov, Yu A. A1 - Reifarth, R. A1 - Al-Khasawneh, Kafa A1 - Aliotta, M. A1 - Bott, L. A1 - Brückner, Benjamin A1 - Bruno, C. G. A1 - Chen, Ruijiu A1 - Davinson, T. A1 - Dickel, T. A1 - Dillmann, Iris A1 - Dmytriev, D. A1 - Erbacher, P. A1 - Freire-Fernández, D. A1 - Forstner, Oliver A1 - Geissel, H. A1 - Göbel, K. A1 - Griffin, Christopher J. A1 - Grisenti, R. A1 - Gumberidze, Alexandre A1 - Haettner, Emma A1 - Hagmann, Siegbert A1 - Heil, M. A1 - Heß, R. A1 - Hillenbrand, P.-M. A1 - Joseph, R. A1 - Jurado, B. A1 - Kozhuharov, Christophor A1 - Kulikov, I. A1 - Löher, Bastian A1 - Langer, Christoph A1 - Leckenby, Guy A1 - Lederer-Woods, C. A1 - Lestinsky, M. A1 - Litvinov, S. A. A1 - Lorenz, B. A. A1 - Lorenz, E. A1 - Marsh, J. A1 - Menz, Esther Babette A1 - Morgenroth, T. A1 - Petridis, N. A1 - Pibernat, Jerome A1 - Popp, U. A1 - Psaltis, Athanasios A1 - Sanjari, Shahab A1 - Scheidenberger, C. A1 - Sguazzin, M. A1 - Sidhu, Ragandeep Singh A1 - Spillmann, Uwe A1 - Steck, M. A1 - Stöhlker, T. A1 - Surzhykov, A. A1 - Swartz, J. A. A1 - Törnqvist, H. A1 - Varga, L. A1 - Vescovi, Diego A1 - Weick, H. A1 - Weigand, M. A1 - Woods, P. A1 - Xing, Y. A1 - Yamaguchi, Taiyo T1 - Proton capture on stored radioactive ¹¹⁸Te ions JF - EPJ Web of Conferences N2 - Experimental determination of the cross sections of proton capture on radioactive nuclei is extremely difficult. Therefore, it is of substantial interest for the understanding of the production of the p-nuclei. For the first time, a direct measurement of proton-capture cross sections on stored, radioactive ions became possible in an energy range of interest for nuclear astrophysics. The experiment was performed at the Experimental Storage Ring (ESR) at GSI by making use of a sensitive method to measure (p,γ) and (p,n) reactions in inverse kinematics. These reaction channels are of high relevance for the nucleosyn-thesis processes in supernovae, which are among the most violent explosions in the universe and are not yet well understood. The cross section of the ¹¹⁸Te(p,γ) reaction has been measured at energies of 6 MeV/u and 7 MeV/u. The heavy ions interacted with a hydrogen gas jet target. The radiative recombination process of the fully stripped ¹¹⁸Te ions and electrons from the hydrogen target was used as a luminosity monitor. An overview of the experimental method and preliminary results from the ongoing analysis will be presented. Y1 - 2023 U6 - http://dx.doi.org/10.1051/epjconf/202327911018 SN - 2100-014X N1 - Volume 279, 2023. Nuclear Physics in Astrophysics – X (NPA-X 2022). VL - 279 IS - Article Number: 11018 SP - 1 EP - 5 PB - EDP Sciences ER - TY - JOUR A1 - Morais, Paulo V. A1 - Suman, Pedro H. A1 - Schöning, Michael Josef A1 - Siqueira Junior, José R. A1 - Orlandi, Marcelo O. T1 - Layer-by-layer film based on Sn₃O₄ nanobelts as sensing units to detect heavy metals using a capacitive field-effect sensor platform JF - Chemosensors N2 - Lead and nickel, as heavy metals, are still used in industrial processes, and are classified as “environmental health hazards” due to their toxicity and polluting potential. The detection of heavy metals can prevent environmental pollution at toxic levels that are critical to human health. In this sense, the electrolyte–insulator–semiconductor (EIS) field-effect sensor is an attractive sensing platform concerning the fabrication of reusable and robust sensors to detect such substances. This study is aimed to fabricate a sensing unit on an EIS device based on Sn₃O₄ nanobelts embedded in a polyelectrolyte matrix of polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) using the layer-by-layer (LbL) technique. The EIS-Sn₃O₄ sensor exhibited enhanced electrochemical performance for detecting Pb²⁺ and Ni²⁺ ions, revealing a higher affinity for Pb²⁺ ions, with sensitivities of ca. 25.8 mV/decade and 2.4 mV/decade, respectively. Such results indicate that Sn₃O₄ nanobelts can contemplate a feasible proof-of-concept capacitive field-effect sensor for heavy metal detection, envisaging other future studies focusing on environmental monitoring. KW - Sn₃O₄ KW - nanobelts KW - field-effect sensor KW - LbL films KW - heavy metals Y1 - 2023 U6 - http://dx.doi.org/10.3390/chemosensors11080436 SN - 2227-9040 N1 - This article belongs to the Special Issue The Application of Electrochemical Sensors or Biosensors Based on Nanomaterials VL - 11 IS - 8 PB - MDPI CY - Basel ER - TY - JOUR A1 - Thoma, Andreas A1 - Thomessen, Karolin A1 - Gardi, Alessandro A1 - Fisher, A. A1 - Braun, Carsten T1 - Prioritising paths: An improved cost function for local path planning for UAV in medical applications JF - The Aeronautical Journal N2 - Even the shortest flight through unknown, cluttered environments requires reliable local path planning algorithms to avoid unforeseen obstacles. The algorithm must evaluate alternative flight paths and identify the best path if an obstacle blocks its way. Commonly, weighted sums are used here. This work shows that weighted Chebyshev distances and factorial achievement scalarising functions are suitable alternatives to weighted sums if combined with the 3DVFH* local path planning algorithm. Both methods considerably reduce the failure probability of simulated flights in various environments. The standard 3DVFH* uses a weighted sum and has a failure probability of 50% in the test environments. A factorial achievement scalarising function, which minimises the worst combination of two out of four objective functions, reaches a failure probability of 26%; A weighted Chebyshev distance, which optimises the worst objective, has a failure probability of 30%. These results show promise for further enhancements and to support broader applicability. KW - Path planning KW - Cost function KW - Multi-objective optimization Y1 - 2023 U6 - http://dx.doi.org/10.1017/aer.2023.68 SN - 0001-9240 (Print) SN - 2059-6464 (Online) IS - First View SP - 1 EP - 18 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Fissabre, Anke A1 - Rottke, Evelin ED - Bergdoll, Barry ED - Schwarting, Andreas ED - Tragbar, Klaus T1 - Das Quelle-Fertighaus : Einklang von Maß, Konstruktion und Entwurf JF - architectura N2 - The steel prefabricated family house ›Quelle-Fertighaus‹ designed and constructed by the German company Quelle, is an innovative modular system commercialised in 1962. All aspects of the Quelle-Fertighaus are planned on the principle of minimal effort for maximal flexibility. The clever design of the ground plan based on a 4 m × 7 m module offers the flexibility for either one to three additional modules. The steel construction is innovative and unique, consisting of load-bearing portal frames acting as braces. The house design is furthermore characterised by a simple metrical grid layout and the practical placement of the foundation and basement, which allowed the very cost-effective production and the lowest price for a prefabricated family house in Germany during the postwar era. Nowadays its portal-frame-construction offers an interesting approach for its renovation and transformation according to present building demands. KW - Quelle-Fertighaus KW - Stahlkonstruktion KW - Portalrahmen KW - Modulbau KW - 60er Jahre Y1 - 2023 U6 - http://dx.doi.org/10.1515/atc-2021-1005 SN - 2569-1554 VL - 51 IS - 1 SP - 57 EP - 78 PB - Deutscher Kunstverlag (DKV) CY - Berlin ER - TY - JOUR A1 - Pfaff, Raphael T1 - Braking distance prediction for vehicle consist in low-speed on-sight operation: a Monte Carlo approach JF - Railway Engineering Science N2 - The first and last mile of a railway journey, in both freight and transit applications, constitutes a high effort and is either non-productive (e.g. in the case of depot operations) or highly inefficient (e.g. in industrial railways). These parts are typically managed on-sight, i.e. with no signalling and train protection systems ensuring the freedom of movement. This is possible due to the rather short braking distances of individual vehicles and shunting consists. The present article analyses the braking behaviour of such shunting units. For this purpose, a dedicated model is developed. It is calibrated on published results of brake tests and validated against a high-definition model for low-speed applications. Based on this model, multiple simulations are executed to obtain a Monte Carlo simulation of the resulting braking distances. Based on the distribution properties and established safety levels, the risk of exceeding certain braking distances is evaluated and maximum braking distances are derived. Together with certain parameters of the system, these can serve in the design and safety assessment of driver assistance systems and automation of these processes. KW - Freight rail KW - Shunting KW - Braking curves KW - Brake set-up KW - Driver assistance system Y1 - 2023 U6 - http://dx.doi.org/10.1007/s40534-023-00303-7 SN - 2662-4753 (eISSN) SN - 2662-4745 (Print) VL - 31 IS - 2 SP - 135 EP - 144 PB - SpringerOpen ER - TY - JOUR A1 - Kowalewski, Paul A1 - Bragard, Michael A1 - Hüning, Felix A1 - De Doncker, Rik W. T1 - An inexpensive Wiegand-sensor-based rotary encoder without rotating magnets for use in electrical drives JF - IEEE Transactions on Instrumentation and Measurement N2 - This paper introduces an inexpensive Wiegand-sensor-based rotary encoder that avoids rotating magnets and is suitable for electrical-drive applications. So far, Wiegand-sensor-based encoders usually include a magnetic pole wheel with rotating permanent magnets. These encoders combine the disadvantages of an increased magnet demand and a limited maximal speed due to the centripetal force acting on the rotating magnets. The proposed approach reduces the total demand of permanent magnets drastically. Moreover, the rotating part is manufacturable from a single piece of steel, which makes it very robust and cheap. This work presents the theoretical operating principle of the proposed approach and validates its benefits on a hardware prototype. The presented proof-of-concept prototype achieves a mechanical resolution of 4.5 ° by using only 4 permanent magnets, 2Wiegand sensors and a rotating steel gear wheel with 20 teeth. KW - Rotary encoder KW - Wiegand sensor Y1 - 2023 U6 - http://dx.doi.org/10.1109/TIM.2023.3326166 SN - 0018-9456 (Print) SN - 1557-9662 (Online) N1 - Early Access SP - 10 Seiten PB - IEEE ER - TY - JOUR A1 - Timme, Michael T1 - Bauliche Veränderungen durch Wohnungseigentümer und die Zustimmung der Gemeinschaft : Zugleich eine Besprechung des BGH, Urt. v. 17.3.2023 – V ZR 140/22, MDR 2023, 619 JF - Monatsschrift für Deutsches Recht N2 - Durch das WEMoG (Gesetz v. 16.10.2020, BGBl. I 2187) hat der Gesetzgeber die Regelung des § 20 WEG eingeführt. Demnach ist auch für bauliche Veränderungen an Räumen und Flächen, die einem Sondernutzungsrecht unterliegen, die Zustimmung der Gemeinschaft notwendig. Der BGH hat nun mit Urt. v. 17.3.2023 –V ZR 140/22, MDR 2023, 619 deutlich gemacht, dass bei Fehlen eines entsprechenden Beschlusses, die bauliche Veränderung durch einen einzelnen Wohnungseigentümer nicht vorgenommen werden darf, sondern eine rechtswidrige Eigentumsbeeinträchtigung darstellt. Der folgende Beitrag nimmt die Entscheidung zum Anlass, um die neue Rechtslage durch § 20 WEG eingehend zu erläutern. Gleichzeitig werden die Folgen der aktuellen Entscheidung näher dargestellt. Y1 - 2023 SN - 2194-4202 (online) SN - 0340-1812 (print) VL - 77 IS - 13 SP - 815 EP - 818 PB - Verlag Dr. Otto Schmidt CY - Köln ER -