TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Baumann, Martin A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia JF - Current Directions in Biomedical Engineering Y1 - 2017 U6 - https://doi.org/10.1515/cdbme-2017-0096 SN - 2364-5504 VL - 3 IS - 2 SP - 457 EP - 460 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Chen, Chao A1 - Jost, Peter A1 - Volker, Hanno A1 - Kaminski, Marvin A1 - Wirtssohn, Matti R. A1 - Engelmann, Ulrich M. A1 - Krüger, K. A1 - Schlich, Franziska F. A1 - Schlockermann, Carl A1 - Lobo, Ricardo P.S.M. A1 - Wuttig, Matthias T1 - Dielectric properties of amorphous phase-change materials JF - Physical Review B Y1 - 2017 U6 - https://doi.org/10.1103/PhysRevB.95.094111 SN - 2469-9950 VL - 95 IS - 9 SP - Article number 094111 ER - TY - JOUR A1 - Dantism, Shahriar A1 - Röhlen, Desiree A1 - Wagner, Torsten A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - A LAPS-based differential sensor for parallelized metabolism monitoring of various bacteria JF - Sensors N2 - Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process. Y1 - 2019 U6 - https://doi.org/10.3390/s19214692 SN - 1424-8220 VL - 19 IS - 21 PB - MDPI CY - Basel ER - TY - JOUR A1 - Karschuck, T. L. A1 - Filipov, Y. A1 - Bollella, P. A1 - Schöning, Michael Josef A1 - Katz, E. T1 - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction JF - International Journal of Unconventional Computing N2 - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions. Y1 - 2019 SN - 1548-7199 VL - 14 IS - 3-4 SP - 235 EP - 242 PB - Old City Publishing CY - Philadelphia ER - TY - THES A1 - Engelmann, Ulrich M. T1 - Assessing magnetic fluid hyperthermia : magnetic relaxation simulation, modeling of nanoparticle uptake inside pancreatic tumor cells and in vitro efficacy Y1 - 2019 SN - 978-3-945954-58-4 N1 - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2019 PB - Infinite Science Publishing CY - Lübeck ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Albracht, Kirsten A1 - Abel, Thomas A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs JF - Journal of Electromyography and Kinesiology N2 - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA. Y1 - 2020 U6 - https://doi.org/10.1016/j.jelekin.2020.102402 SN - 1050-6411 VL - 51 IS - Article 102402 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kopp, Alexander A1 - Schunck, Laura A1 - Gosau, Martin A1 - Smeets, Ralf A1 - Burg, Simon A1 - Fuest, Sandra A1 - Kröger, Nadja A1 - Zinser, Max A1 - Krohn, Sebastian A1 - Behbahani, Mehdi A1 - Köpf, Marius A1 - Lauts, Lisa A1 - Rutkowski, Rico T1 - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes JF - International Journal of Molecular Sciences N2 - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes. Y1 - 2020 U6 - https://doi.org/10.3390/ijms21186704 SN - 1422-0067 N1 - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine VL - 21 IS - 18 art. no. 6704 PB - MDPI CY - Basel ER - TY - CHAP A1 - Bozakov, Zdravko A1 - Sander, Volker T1 - OpenFlow: A Perspective for Building Versatile Networks T2 - Network-Embedded Management and Applications Y1 - 2013 SN - 978-1-4419-6769-5 U6 - https://doi.org/10.1007/978-1-4419-6769-5_11 SP - 217 EP - 245 PB - Springer CY - New York, NY ER - TY - BOOK A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef ED - Yoshinobu, Tatsuo ED - Schöning, Michael Josef T1 - Light-addressing and chemical imaging technologies for electrochemical sensing Y1 - 2020 SN - 978-3-03943-029-1 U6 - https://doi.org/10.3390/books978-3-03943-029-1 N1 - This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors PB - MDPI CY - Basel ER - TY - JOUR A1 - Conzen, Catharina A1 - Albanna, Walid A1 - Weiss, Miriam A1 - Kürten, David A1 - Vilser, Walthard A1 - Kotliar, Konstantin A1 - Zäske, Charlotte A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander T1 - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes JF - Translational Stroke Research N2 - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome. Y1 - 2018 U6 - https://doi.org/10.1007/s12975-017-0585-8 SN - 1868-601X IS - 9 SP - 284 EP - 293 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Hugenroth, Kristin A1 - Borchardt, Ralf A1 - Ritter, Philine A1 - Groß‑Hardt, Sascha A1 - Meyns, Bart A1 - Verbelen, Tom A1 - Steinseifer, Ulrich A1 - Kaufmann, Tim A. S. A1 - Engelmann, Ulrich M. T1 - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input JF - Scientific Reports N2 - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-96397-2 SN - 2045-2322 VL - 11 IS - Art. No. 16800 SP - 1 EP - 12 PB - Springer CY - Berlin ER - TY - JOUR A1 - Brockhaus, Moritz K. A1 - Behbahani, Mehdi A1 - Muris, Farina A1 - Jansen, Sebastian V. A1 - Schmitz- Rode, Thomas A1 - Steinseifer, Ulrich A1 - Clauser, Johanna C. T1 - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept JF - Artificial Organs N2 - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential. Y1 - 2021 U6 - https://doi.org/10.1111/aor.14046 SN - 1525-1594 VL - 45 IS - 12 SP - 1513 EP - 1521 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Olderog, M. A1 - Mohr, P. A1 - Beging, Stefan A1 - Tsoumpas, C. A1 - Ziemons, Karl T1 - Simulation study on the role of tissue-scattered events in improving sensitivity for a compact time of flight compton positron emission tomograph T2 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) N2 - In positron emission tomography improving time, energy and spatial detector resolutions and using Compton kinematics introduces the possibility to reconstruct a radioactivity distribution image from scatter coincidences, thereby enhancing image quality. The number of single scattered coincidences alone is in the same order of magnitude as true coincidences. In this work, a compact Compton camera module based on monolithic scintillation material is investigated as a detector ring module. The detector interactions are simulated with Monte Carlo package GATE. The scattering angle inside the tissue is derived from the energy of the scattered photon, which results in a set of possible scattering trajectories or broken line of response. The Compton kinematics collimation reduces the number of solutions. Additionally, the time of flight information helps localize the position of the annihilation. One of the questions of this investigation is related to how the energy, spatial and temporal resolutions help confine the possible annihilation volume. A comparison of currently technically feasible detector resolutions (under laboratory conditions) demonstrates the influence on this annihilation volume and shows that energy and coincidence time resolution have a significant impact. An enhancement of the latter from 400 ps to 100 ps leads to a smaller annihilation volume of around 50%, while a change of the energy resolution in the absorber layer from 12% to 4.5% results in a reduction of 60%. The inclusion of single tissue-scattered data has the potential to increase the sensitivity of a scanner by a factor of 2 to 3 times. The concept can be further optimized and extended for multiple scatter coincidences and subsequently validated by a reconstruction algorithm. Y1 - 2021 SN - 978-1-7281-7693-2 U6 - https://doi.org/10.1109/NSS/MIC42677.2020.9507901 N1 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 31 Oct.-7 Nov. 2020, Boston, MA, USA PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Arampatzis, Adamantios A1 - Karamanidis, Kiros A1 - Albracht, Kirsten T1 - Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude JF - Journal of Experimental Biology Y1 - 2007 U6 - https://doi.org/10.1242/jeb.003814 SN - 0022-0949 VL - 210 IS - 15 SP - 2743 EP - 2753 ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy JF - Biological Cybernetics Y1 - 2006 U6 - https://doi.org/10.1007/s00422-006-0070-z SN - 1432-0770 VL - 95 IS - 1 SP - 87 EP - 96 ER - TY - CHAP A1 - Schreiber, Marc A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - Metrics Driven Research Collaboration: Focusing on Common Project Goals Continuously T2 - 39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina N2 - Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements. In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner’s business model. This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal. An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time. Y1 - 2017 N1 - Software Engineering in Practice (SEIP). ICSE2017 Vorabversion der Autoren ER - TY - JOUR A1 - Sousa, Marcos A. M. A1 - Siqueira, Jose R. Jr. A1 - Vercik, Andres A1 - Schöning, Michael Josef A1 - Oliveira, Osvaldo N. Jr. T1 - Determining the optimized layer-by-layer film architecture with dendrimer/carbon nanotubes for field-effect sensors JF - IEEE Sensors Journal N2 - The capacitive electrolyte–insulator–semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte–insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors. Y1 - 2017 U6 - https://doi.org/10.1109/JSEN.2017.2653238 SN - 1558-1748 VL - 17 IS - 6 SP - 1735 EP - 1740 PB - IEEE CY - New York ER - TY - JOUR A1 - Arreola, Julio A1 - Oberländer, Jan A1 - Mätzkow, M. A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Surface functionalization for spore-based biosensors with organosilanes JF - Electrochimica Acta N2 - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated. Y1 - 2017 U6 - https://doi.org/10.1016/j.electacta.2017.04.157 SN - 0013-4686 VL - 241 SP - 237 EP - 243 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Oberländer, Jan A1 - Mayer, Marlena A1 - Greeff, Anton A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Spore-based biosensor to monitor the microbicidal efficacy of gaseous hydrogen peroxide sterilization processes JF - Biosensors and Bioelectronics N2 - In this work, a spore-based biosensor is evaluated to monitor the microbicidal efficacy of sterilization processes applying gaseous hydrogen peroxide (H2O2). The sensor is based on interdigitated electrode structures (IDEs) that have been fabricated by means of thin-film technologies. Impedimetric measurements are applied to study the effect of sterilization process on spores of Bacillus atrophaeus. This resilient microorganism is commonly used in industry to proof the sterilization efficiency. The sensor measurements are accompanied by conventional microbiological challenge tests, as well as morphological characterizations with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The sensor measurements are correlated with the microbiological test routines. In both methods, namely the sensor-based and microbiological one, a tailing effect has been observed. The results are evaluated and discussed in a three-dimensional calibration plot demonstrating the sensor's suitability to enable a rapid process decision in terms of a successfully performed sterilization. Y1 - 2018 U6 - https://doi.org/10.1016/j.bios.2017.12.045 SN - 0956-5663 VL - 104 SP - 87 EP - 94 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Schmidts, Oliver A1 - Boltes, Maik A1 - Kraft, Bodo A1 - Schreiber, Marc T1 - Multi-pedestrian tracking by moving Bluetooth-LE beacons and stationary receivers T2 - 2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan Y1 - 2017 N1 - International Conference on Indoor Positioning and Indoor Navigation <8, 2017, Sapporo, Japan> SP - 1 EP - 4 ER - TY - JOUR A1 - Laura, C.O. A1 - Drechsler, Klaus A1 - Erdt, M. A1 - Wesarg, S. A1 - Bale, R. T1 - Intervention assessment tool for primary tumors in the liver JF - Current Directions in Biomedical Engineering N2 - After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm. Y1 - 2018 U6 - https://doi.org/10.1515/cdbme-2018-0081 SN - 2364-5504 VL - 4 IS - 1 SP - 337 EP - 340 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Heinke, Lars N. A1 - Knicker, Axel J. A1 - Albracht, Kirsten T1 - Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes JF - Isokinetics and Exercise Science N2 - BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results. Y1 - 2018 U6 - https://doi.org/10.3233/IES-184111 SN - 1878-5913 VL - 26 IS - 4 SP - 265 EP - 274 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Bleilevens, Christian A1 - Hill, Aileen A1 - Grzanna, Tim A1 - Fechter, Tamara A1 - Bohnen, Melanie A1 - Weber, Hans-Joachim A1 - Beckers, Christian A1 - Borosch, Sebastian A1 - Zayat, Rashad A1 - Benstoem, Carin A1 - Rossaint, Rolf A1 - Goetzenich, Andreas T1 - In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop JF - Interactive cardiovascular and thoracic surgery Y1 - 2019 U6 - https://doi.org/10.1093/icvts/ivy206 SN - 1569-9285 VL - 28 IS - 1 SP - 120 EP - 127 ER - TY - JOUR A1 - Arreola, Julio A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Toward an immobilization method for spore-based biosensors in oxidative environment JF - Electrochimica Acta Y1 - 2019 U6 - https://doi.org/10.1016/j.electacta.2019.01.148 VL - 302 SP - 394 EP - 401 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Krome, Cornelia A1 - Sander, Volker T1 - Time series analysis with apache spark and its applications to energy informatics T2 - Proceedings of the 7th DACH+ Conference on Energy Informatics N2 - In energy economy forecasts of different time series are rudimentary. In this study, a prediction for the German day-ahead spot market is created with Apache Spark and R. It is just an example for many different applications in virtual power plant environments. Other examples of use as intraday price processes, load processes of machines or electric vehicles, real time energy loads of photovoltaic systems and many more time series need to be analysed and predicted. This work gives a short introduction into the project where this study is settled. It describes the time series methods that are used in energy industry for forecasts shortly. As programming technique Apache Spark, which is a strong cluster computing technology, is utilised. Today, single time series can be predicted. The focus of this work is on developing a method to parallel forecasting, to process multiple time series simultaneously with R and Apache Spark. Y1 - 2018 U6 - https://doi.org/10.1186/s42162-018-0043-1 N1 - Energy Informatics 2018, Volume 1 Supplement 1 ER - TY - JOUR A1 - Mennicken, Max A1 - Peter, Sophia Katharina A1 - Kaulen, Corinna A1 - Simon, Ulrich A1 - Karthäuser, Silvia T1 - Controlling the Electronic Contact at the Terpyridine/Metal Interface JF - The Journal of Physical Chemistry C Y1 - 2019 U6 - https://doi.org/10.1021/acs.jpcc.9b05865 SN - 1932-7455 VL - 123 IS - 35 SP - 21367 EP - 21375 ER - TY - JOUR A1 - Arreola, Julio A1 - Keusgen, Michael A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2019.111628 SN - 0956-5663 VL - 143 IS - 111628 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Seifarth, Volker T1 - Ureteral tissue engineering : development of a bioreactor system and subsequent characterization of the generated biohybrids Y1 - 2015 N1 - Duisburg, Essen, Universität Duisburg-Essen, Diss., 2015 PB - Universitätsbibliothek Duisburg-Essen CY - Duisburg ; Essen ER - TY - THES A1 - Oflaz, Hakan T1 - Entwicklung eines Prototypen zur Prognose von Frühgeburten : ein biomedizintechnischer Ansatz Y1 - 2012 U6 - https://doi.org/10.4126/38m-004639208 N1 - Köln, Univ., Diss., 2012 PB - Deutsche Zentralbibliothek für Medizin CY - Köln ER - TY - THES A1 - Behbahani, Mehdi T1 - Modeling and Simulation of Shear-Dependent Platelet Reactions in Blood Vessels and Blood-Contacting Medical Devices Y1 - 2011 SN - 978-3-8439-0134-5 PB - Verlag Dr. Hut CY - München ER - TY - THES A1 - Kurulgan Demirci, Eylem T1 - The effect of rhAPC on contractile tension : an in-vitro sepsis model of cardiomyocytes and endothelial cells T1 - Der Effekt von rhAPC auf die zelluläre Kontraktionskraft : ein In-vitro-Sepsismodell für Kardiomyozyten und Endothelzellen Y1 - 2012 N1 - Aachen, Techn. Hochsch., Diss., 2012 ER - TY - THES A1 - Trzewik, Jürgen T1 - Experimental analysis of biaxial mechanical tension in cell monolayers and cultured three-dimensional tissues: the celldrum technology Y1 - 2007 N1 - Zugl.: Ilmenau, Techn. Univ., Diss., 2007 PB - Univeristätsverlg Ilmenau CY - Ilmenau ER - TY - PAT A1 - Wandrey, Christian A1 - Biselli, Manfred A1 - Schröder, Bernd A1 - Schmoll, Hans-Joachim T1 - Culturing cells on macroporous glass carriers coated with gelatin, extracellular matrix protein and stromal cells Y1 - 1999 N1 - United States Patent 5,906,940 May 25, 1999 SP - 1 EP - 12 ER - TY - JOUR A1 - Krome, Cornelia A1 - Höft, Jan A1 - Sander, Volker T1 - Clustering time series applied to energy markets JF - Energy Informatics Y1 - 2019 U6 - https://doi.org/10.1186/s42162-019-0076-0 SN - 2520-8942 VL - 2 IS - Article numer 17 SP - 1 EP - 20 PB - Springer CY - Berlin ER - TY - THES A1 - Duong, Minh Tuan T1 - Hyperelastic modeling and soft-tissue growth integrated with the smoothed finite element method - SFEM Y1 - 2015 N1 - Aachen, Techn. Hochsch., Diss., 2014 PB - RWTH Aachen University ER - TY - THES A1 - Pham, Phu Tinh T1 - Upper bound limit and shakedown analysis of elastic-plastic bounded linearly kinematic hardening structures Y1 - 2011 N1 - Aachen, Techn. Hochsch., Diss., 2011 PB - RWTH Aachen University CY - Aachen ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Meskemper, Joshua A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants JF - European Journal of Applied Physiology N2 - Purpose This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise. Methods Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography. Results During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors. Conclusion Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training. Y1 - 2020 U6 - https://doi.org/10.1007/s00421-020-04373-x SN - 1439-6327 IS - 120 SP - 1403 EP - 1415 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Pohle-Fröhlich, Regina A1 - Dalitz, Christoph A1 - Richter, Charlotte A1 - Hahnen, Tobias A1 - Stäudle, Benjamin A1 - Albracht, Kirsten T1 - Estimation of muscle fascicle orientation in ultrasonic images T2 - Proceedings of the 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications - Volume 5 N2 - We compare four different algorithms for automatically estimating the muscle fascicle angle from ultrasonic images: the vesselness filter, the Radon transform, the projection profile method and the gray level cooccurence matrix (GLCM). The algorithm results are compared to ground truth data generated by three different experts on 425 image frames from two videos recorded during different types of motion. The best agreement with the ground truth data was achieved by a combination of pre-processing with a vesselness filter and measuring the angle with the projection profile method. The robustness of the estimation is increased by applying the algorithms to subregions with high gradients and performing a LOESS fit through these estimates. Y1 - 2020 SN - 978-989-758-402-2 U6 - https://doi.org/10.5220/0008933900790086 N1 - 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications VISAPP 2020, Valletta, Malta SP - 79 EP - 86 PB - SciTePress CY - Setúbal, Portugal ER - TY - JOUR A1 - Dantism, Shahriar A1 - Röhlen, Desiree A1 - Dahmen, Markus A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - LAPS-based monitoring of metabolic responses of bacterial cultures in a paper fermentation broth JF - Sensors and Actuators B: Chemical N2 - As an alternative renewable energy source, methane production in biogas plants is gaining more and more attention. Biomass in a bioreactor contains different types of microorganisms, which should be considered in terms of process-stability control. Metabolically inactive microorganisms within the fermentation process can lead to undesirable, time-consuming and cost-intensive interventions. Hence, monitoring of the cellular metabolism of bacterial populations in a fermentation broth is crucial to improve the biogas production, operation efficiency, and sustainability. In this work, the extracellular acidification of bacteria in a paper-fermentation broth is monitored after glucose uptake, utilizing a differential light-addressable potentiometric sensor (LAPS) system. The LAPS system is loaded with three different model microorganisms (Escherichia coli, Corynebacterium glutamicum, and Lactobacillus brevis) and the effect of the fermentation broth at different process stages on the metabolism of these bacteria is studied. In this way, different signal patterns related to the metabolic response of microorganisms can be identified. By means of calibration curves after glucose uptake, the overall extracellular acidification of bacterial populations within the fermentation process can be evaluated. Y1 - 2020 U6 - https://doi.org/10.1016/j.snb.2020.128232 SN - 0925-4005 VL - 320 IS - Art. 128232 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Roeth, A.A. A1 - Slabu, I. A1 - Kessler, A. A1 - Engelmann, Ulrich M. T1 - Local treatment of pancreatic cancer with magnetic nanoparticles JF - HPB Y1 - 2019 U6 - https://doi.org/10.1016/j.hpb.2019.10.959 SN - 1365-182X VL - 21 IS - Supplement 3 SP - S868 EP - S869 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Welden, Rene A1 - Schöning, Michael Josef A1 - Wagner, Patrick H. A1 - Wagner, Torsten T1 - Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions JF - Sensors N2 - In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor–electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types. Y1 - 2020 U6 - https://doi.org/10.3390/s20061680 SN - 1424-8220 VL - 20 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Jildeh, Zaid B. A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Vahidpour, Farnoosh A1 - Wagner, Patrick H. A1 - Schöning, Michael Josef T1 - Development of a package-sterilization process for aseptic filling machines: A numerical approach and validation for surface treatment with hydrogen peroxide JF - Sensor and Actuators A: Physical N2 - Within the present work a sterilization process by a heated gas mixture that contains hydrogen peroxide (H₂O₂) is validated by experiments and numerical modeling techniques. The operational parameters that affect the sterilization efficacy are described alongside the two modes of sterilization: gaseous and condensed H₂O₂. Measurements with a previously developed H₂O₂ gas sensor are carried out to validate the applied H₂O₂ gas concentration during sterilization. We performed microbiological tests at different H₂O₂ gas concentrations by applying an end-point method to carrier strips, which contain different inoculation loads of Geobacillus stearothermophilus spores. The analysis of the sterilization process of a pharmaceutical glass vial is performed by numerical modeling. The numerical model combines heat- and advection-diffusion mass transfer with vapor–pressure equations to predict the location of condensate formation and the concentration of H₂O₂ at the packaging surfaces by changing the gas temperature. For a sterilization process of 0.7 s, a H₂O₂ gas concentration above 4% v/v is required to reach a log-count reduction above six. The numerical results showed the location of H₂O₂ condensate formation, which decreases with increasing sterilant-gas temperature. The model can be transferred to different gas nozzle- and packaging geometries to assure the absence of H₂O₂ residues. Y1 - 2020 U6 - https://doi.org/10.1016/j.sna.2019.111691 SN - 0924-4247 VL - 303 IS - 111691 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Hingley, Peter A1 - Dikta, Gerhard T1 - Finding a well performing box-jenkins forecasting model for annualised patent filings counts T2 - International Symposium on Forecasting, Thessaloniki, Greece, June 2019 Y1 - 2019 ER - TY - JOUR A1 - Attar, Mandana Hossein Zadeh A1 - Merk, Hans F. A1 - Kotliar, Konstantin A1 - Wurpts, Gerda A1 - Röseler, Stefani A1 - Moll-Slodowy, Silke A1 - Plange, Johann A1 - Baron, Jens Malte A1 - Balakirski, Galina T1 - The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria JF - European Journal of Dermatology Y1 - 2019 U6 - https://doi.org/10.1684/ejd.2019.3680 VL - 29 IS - 6 SP - 614 EP - 618 ER - TY - JOUR A1 - Mennicken, Max A1 - Peter, Sophia K. A1 - Kaulen, Corinna A1 - Simon, Ulrich A1 - Karthäuser, Silvia T1 - Transport through Redox-Active Ru-Terpyridine Complexes Integrated in Single Nanoparticle Devices JF - The Journal of Physical Chemistry C N2 - Transition metal complexes are electrofunctional molecules due to their high conductivity and their intrinsic switching ability involving a metal-to-ligand charge transfer. Here, a method is presented to contact reliably a few to single redox-active Ru-terpyridine complexes in a CMOS compatible nanodevice and preserve their electrical functionality. Using hybrid materials from 14 nm gold nanoparticles (AuNP) and bis-{4′-[4-(mercaptophenyl)-2,2′:6′,2″-terpyridine]}-ruthenium(II) complexes a device size of 30² nm² inclusive nanoelectrodes is achieved. Moreover, this method bears the opportunity for further downscaling. The Ru-complex AuNP devices show symmetric and asymmetric current versus voltage curves with a hysteretic characteristic in two well separated conductance ranges. By theoretical approximations based on the single-channel Landauer model, the charge transport through the formed double-barrier tunnel junction is thoroughly analyzed and its sensibility to the molecule/metal contact is revealed. It can be verified that tunneling transport through the HOMO is the main transport mechanism while decoherent hopping transport is present to a minor extent. Y1 - 2020 U6 - https://doi.org/10.1021/acs.jpcc.9b11716 SN - 1932-7455 VL - 124 IS - 8 SP - 4881 EP - 4889 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Pilas, Johanna A1 - Selmer, Thorsten A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Screen-printed carbon electrodes modified with graphene oxide for the design of a reagent-free NAD+-dependent biosensor array JF - Analytical Chemistry Y1 - 2019 U6 - https://doi.org/10.1021/acs.analchem.9b04481 VL - 91 IS - 23 SP - 15293 EP - 15299 PB - ACS Publications CY - Washington ER - TY - JOUR A1 - Grundlach, Michael A1 - Baumann, Martin A1 - Engelmann, Ulrich M. ED - Dössel, Olaf T1 - How Multimodal Examinations Can Increase Sustainable Student Gain by Aligning Teaching and Assessment JF - Current Directions in Biomedical Engineering N2 - Modern industry and multi-discipline projects require highly trained individuals with resilient science and engineering back-grounds. Graduates must be able to agilely apply excellent theoretical knowledge in their subject matter as well as essential practical “hands-on” knowledge of diverse working processes to solve complex problems. To meet these demands, university education follows the concept of Constructive Alignment and thus increasingly adopts the teaching of necessary practical skills to the actual industry requirements and assessment routines. However, a systematic approach to coherently align these three central teaching demands is strangely absent from current university curricula. We demonstrate the feasibility of implementing practical assessments in a regular theory-based examination, thus defining the term “blended assessment”. We assessed a course for natural science and engineering students pursuing a career in biomedical engineering, and evaluated the benefit of blended assessment exams for students and lecturers. Our controlled study assessed the physiological background of electrocardiograms (ECGs), the practical measurement of ECG curves, and their interpretation of basic pathologic alterations. To study on long time effects, students have been assessed on the topic twice with a time lag of 6 months. Our findings suggest a significant improvement in student gain with respect to practical skills and theoretical knowledge. The results of the reassessments support these outcomes. From the lecturers ́ point of view, blended assessment complements practical training courses while keeping organizational effort manageable. We consider blended assessment a viable tool for providing an improved student gain, industry-ready education format that should be evaluated and established further to prepare university graduates optimally for their future careers. KW - constructive alignment KW - examination KW - long-term retention KW - multimodal KW - practical learning Y1 - 2021 SN - 2364-5504 U6 - https://doi.org/10.1515/cdbme-2021-2019 VL - 7 IS - 7/2 SP - 73 EP - 76 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Pöttgen, Philipp A1 - Ederer, Thorsten A1 - Altherr, Lena A1 - Pelz, Peter F. T1 - Developing a control strategy for booster stations under uncertain load JF - Applied Mechanics and Materials N2 - Booster stations can fulfill a varying pressure demand with high energy-efficiency, because individual pumps can be deactivated at smaller loads. Although this is a seemingly simple approach, it is not easy to decide precisely when to activate or deactivate pumps. Contemporary activation controls derive the switching points from the current volume flow through the system. However, it is not measured directly for various reasons. Instead, the controller estimates the flow based on other system properties. This causes further uncertainty for the switching decision. In this paper, we present a method to find a robust, yet energy-efficient activation strategy. KW - Technical Operations Research (TOR) KW - Booster Station KW - Pump System KW - Discrete Optimization Y1 - 2015 SN - 1662-7482 U6 - https://doi.org/10.4028/www.scientific.net/AMM.807.241 N1 - Ebenfalls weltweit einsehbar unter: http://wl.fst.tu-darmstadt.de/wl/publications/paper_151123_SFB805_ ICUME_Developing_a_Control_Strategy_for_Booster_Stations_under_Uncertain_Load_poettgen_ederer_pelz_altherr.pdf VL - 807 IS - 807 SP - 241 EP - 246 PB - Trans Tech Publications CY - Bäch ER - TY - CHAP A1 - Büsgen, André A1 - Klöser, Lars A1 - Kohl, Philipp A1 - Schmidts, Oliver A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - Exploratory analysis of chat-based black market profiles with natural language processing T2 - Proceedings of the 11th International Conference on Data Science, Technology and Applications N2 - Messenger apps like WhatsApp or Telegram are an integral part of daily communication. Besides the various positive effects, those services extend the operating range of criminals. Open trading groups with many thousand participants emerged on Telegram. Law enforcement agencies monitor suspicious users in such chat rooms. This research shows that text analysis, based on natural language processing, facilitates this through a meaningful domain overview and detailed investigations. We crawled a corpus from such self-proclaimed black markets and annotated five attribute types products, money, payment methods, user names, and locations. Based on each message a user sends, we extract and group these attributes to build profiles. Then, we build features to cluster the profiles. Pretrained word vectors yield better unsupervised clustering results than current state-of-the-art transformer models. The result is a semantically meaningful high-level overview of the user landscape of black market chatrooms. Additionally, the extracted structured information serves as a foundation for further data exploration, for example, the most active users or preferred payment methods. KW - Clustering KW - Natural Language Processing KW - Information Extraction KW - Profile Extraction KW - Text Mining Y1 - 2022 SN - 978-989-758-583-8 U6 - https://doi.org/10.5220/0011271400003269 SN - 2184-285X N1 - 11th International Conference on Data Science, Technology and Applications DATA - Volume 1, 83-94, 2022, Lisbon, Portugal SP - 83 EP - 94 ER - TY - JOUR A1 - Mandekar, Swati A1 - Holland, Abigail A1 - Thielen, Moritz A1 - Behbahani, Mehdi A1 - Melnykowycz, Mark T1 - Advancing towards Ubiquitous EEG, Correlation of In-Ear EEG with Forehead EEG JF - Sensors N2 - Wearable EEG has gained popularity in recent years driven by promising uses outside of clinics and research. The ubiquitous application of continuous EEG requires unobtrusive form-factors that are easily acceptable by the end-users. In this progression, wearable EEG systems have been moving from full scalp to forehead and recently to the ear. The aim of this study is to demonstrate that emerging ear-EEG provides similar impedance and signal properties as established forehead EEG. EEG data using eyes-open and closed alpha paradigm were acquired from ten healthy subjects using generic earpieces fitted with three custom-made electrodes and a forehead electrode (at Fpx) after impedance analysis. Inter-subject variability in in-ear electrode impedance ranged from 20 kΩ to 25 kΩ at 10 Hz. Signal quality was comparable with an SNR of 6 for in-ear and 8 for forehead electrodes. Alpha attenuation was significant during the eyes-open condition in all in-ear electrodes, and it followed the structure of power spectral density plots of forehead electrodes, with the Pearson correlation coefficient of 0.92 between in-ear locations ELE (Left Ear Superior) and ERE (Right Ear Superior) and forehead locations, Fp1 and Fp2, respectively. The results indicate that in-ear EEG is an unobtrusive alternative in terms of impedance, signal properties and information content to established forehead EEG. KW - in-ear EEG KW - correlation KW - forehead EEG KW - impedance spectroscopy KW - biopotential electrodes Y1 - 2022 U6 - https://doi.org/10.3390/s22041568 SN - 1424-8220 VL - 22 IS - 4 SP - 1 EP - 19 PB - MDPI CY - Basel ER -