TY - JOUR A1 - Stadler, Andreas M. A1 - Garvey, G. J. A1 - Bocahut, A. A1 - Sacquin-Mora, S. A1 - Digel, Ilya A1 - Schneider, G. J. A1 - Natali, F. A1 - Artmann, Gerhard A1 - Zaccai, G. T1 - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics JF - Journal of the Royal Society Interface N2 - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits. Y1 - 2012 U6 - https://doi.org/10.1098/rsif.2012.0364 SN - 1742-5689 VL - 9 IS - 76 SP - 2845 EP - 2855 PB - The Royal Society CY - London ER - TY - JOUR A1 - Savitskaya, I. S. A1 - Kistaubayeva, A. S. A1 - Digel, Ilya A1 - Shokatayeva, D. H. T1 - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials JF - Eurasian Chemico-Technological Journal Y1 - 2017 U6 - https://doi.org/10.18321/ectj670 SN - 2522-4867 VL - 19 IS - 3 SP - 255 EP - 264 ER - TY - CHAP A1 - Dachwald, Bernd A1 - Xu, Changsheng A1 - Feldmann, Marco A1 - Plescher, Engelbert A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Development and testing of a subsurface probe for detection of life in deep ice : [abstract] N2 - We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named “IceMole”, is currently developed, built, and tested at the FH Aachen University of Applied Sciences’ Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth). KW - Eisschicht KW - Sonde KW - subsurface probe KW - subsurface ice research Y1 - 2011 ER - TY - JOUR A1 - Molinnus, Denise A1 - Muschallik, Lukas A1 - Gonzalez, Laura Osorio A1 - Bongaerts, Johannes A1 - Wagner, Torsten A1 - Selmer, Thorsten A1 - Siegert, Petra A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Development and characterization of a field-effect biosensor for the detection of acetoin JF - Biosensors and Bioelectronics N2 - A capacitive electrolyte-insulator-semiconductor (EIS) field-effect biosensor for acetoin detection has been presented for the first time. The EIS sensor consists of a layer structure of Al/p-Si/SiO₂/Ta₂O₅/enzyme acetoin reductase. The enzyme, also referred to as butane-2,3-diol dehydrogenase from B. clausii DSM 8716T, has been recently characterized. The enzyme catalyzes the (R)-specific reduction of racemic acetoin to (R,R)- and meso-butane-2,3-diol, respectively. Two different enzyme immobilization strategies (cross-linking by using glutaraldehyde and adsorption) have been studied. Typical biosensor parameters such as optimal pH working range, sensitivity, hysteresis, linear concentration range and long-term stability have been examined by means of constant-capacitance (ConCap) mode measurements. Furthermore, preliminary experiments have been successfully carried out for the detection of acetoin in diluted white wine samples. Y1 - 2018 U6 - https://doi.org/10.1016/j.bios.2018.05.023 VL - 115 SP - 1 EP - 6 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Mansurov, Zulkhair A1 - Zhubanova, Azhar A. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Savitskaja, Irina S. A1 - Kozhalakova, A. A. A1 - Kistaubaeva, Aida S. T1 - The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials N2 - Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it’s microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties – ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS. KW - Kohlenstofffaser KW - Lipopolysaccharide KW - nanostrukturierte carbonisierte Pflanzenteile KW - lipopolysaccharides KW - nanostructured carbonized plant parts Y1 - 2008 ER - TY - CHAP A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Nojima, H. A1 - Artmann, Gerhard T1 - Effects of plasma generated ions on bacteria : [poster] N2 - Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death. KW - Clusterion KW - Bakterien KW - plasma generated ions Y1 - 2003 ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Zhubanova, A. A. T1 - Investigation the Influence of Carbonized Material Based On Rice Husk on Viability and Migration of Fibroblasts in T3B3 Cell Culture JF - KazNU Bulletin. Biology series Y1 - 2013 SN - 1563-0218 N1 - Original in russischer Sprache VL - 59 IS - 3/1 SP - 20 EP - 23 ER - TY - CHAP A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Nojima, H. A1 - Artmann, Gerhard T1 - Plasma-generated cluster ions' effects on indoor microflora : [abstract] N2 - Recently, SHARP corporation has developed the world’s first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered. KW - Clusterion KW - Raumluft KW - Luftreiniger KW - Plasmacluster ion technology KW - Air purification Y1 - 2003 ER - TY - CHAP A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Razzaque, Mohammed S. T1 - Vitamin D and Phosphate Interactions in Health and Disease T2 - Phosphate Metabolism N2 - Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease. KW - Vitamin D KW - PTH KW - Phosphate KW - FGF23 KW - Klotho Y1 - 2022 SN - 978-3-030-91621-3 U6 - https://doi.org/10.1007/978-3-030-91623-7_5 SP - 37 EP - 46 PB - Springer CY - Cham ER - TY - JOUR A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Stadler, Andreas M. A1 - Büldt, Georg A1 - Zaccai, Guiseppe A1 - Artmann, Gerhard T1 - Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions JF - Regenerative medicine. 2 (2007), H. 5 Y1 - 2007 SN - 1746-0751 N1 - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany SP - 573 EP - 573 ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Lutfor, Afzalunnessa B. A1 - Razzaque, Mohammed S. T1 - Vitamin D and the Host-Gut Microbiome: A Brief Overview JF - Acta Histochemica et Cytochemica N2 - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression. Y1 - 2020 U6 - https://doi.org/10.1267/ahc.20011 SN - 1347-5800 VL - 53 IS - 3 SP - 33 EP - 42 PB - Japan Society of Histochemistry and Cytochemistry CY - Osaka ER - TY - CHAP A1 - Digel, Ilya A1 - Mansurov, Zulkhair A1 - Biisenbaev, Makhmut A1 - Savitskaya, Irina A1 - Kistaubaeva, Aida A1 - Akimbekov, Nuraly S. A1 - Zhubanova, Azhar ED - Hu, Ning T1 - Heterogeneous Composites on the Basis of Microbial Cells and Nanostructured Carbonized Sorbents T2 - Composites and Their Applications N2 - The fact that microorganisms prefer to grow on liquid/solid phase surfaces rather than in the surrounding aqueous phase was noticed long time ago [1]. Virtually any surface – animal, mineral, or vegetable – is a subject for microbial colonization and subsequent biofilm formation. It would be adequate to name just a few notorious examples on microbial colonization of contact lenses, ship hulls, petroleum pipelines, rocks in streams and all kinds of biomedical implants. The propensity of microorganisms to become surface-bound is so profound and ubiquitous that it vindicates the advantages for attached forms over their free-ranging counterparts [2]. Indeed, from ecological and evolutionary standpoints, for many microorganisms the surface-bound state means dwelling in nutritionally favorable, non-hostile environments [3]. Therefore, in most of natural and artificial ecosystems surface-associated microorganisms vastly outnumber organisms in suspension and often organize into complex communities with features that differ dramatically from those of free cells [4]. Y1 - 2012 SN - 978-953-51-0706-4 U6 - https://doi.org/10.5772/47796 SP - 249 EP - 272 PB - Intech CY - London ER - TY - CHAP A1 - Digel, Ilya A1 - Sadykov, R. A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations T2 - Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies Y1 - 2015 SN - 9781634826990 SP - 75 EP - 99 PB - Nova Science Publ. ER - TY - JOUR A1 - Pogorelova, Natalia A1 - Rogachev, Evgeniy A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya T1 - Effect of dehydration method on the micro- and nanomorphological properties of bacterial cellulose produced by Medusomyces gisevii on different substrates JF - Journal of materials science N2 - Many important properties of bacterial cellulose (BC), such as moisture absorption capacity, elasticity and tensile strength, largely depend on its structure. This paper presents a study on the effect of the drying method on BC films produced by Medusomyces gisevii using two different procedures: room temperature drying (RT, (24 ± 2 °C, humidity 65 ± 1%, dried until a constant weight was reached) and freeze-drying (FD, treated at − 75 °C for 48 h). BC was synthesized using one of two different carbon sources—either glucose or sucrose. Structural differences in the obtained BC films were evaluated using atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray diffraction. Macroscopically, the RT samples appeared semi-transparent and smooth, whereas the FD group exhibited an opaque white color and sponge-like structure. SEM examination showed denser packing of fibrils in FD samples while RT-samples displayed smaller average fiber diameter, lower surface roughness and less porosity. AFM confirmed the SEM observations and showed that the FD material exhibited a more branched structure and a higher surface roughness. The samples cultivated in a glucose-containing nutrient medium, generally displayed a straight and ordered shape of fibrils compared to the sucrose-derived BC, characterized by a rougher and wavier structure. The BC films dried under different conditions showed distinctly different crystallinity degrees, whereas the carbon source in the culture medium was found to have a relatively small effect on the BC crystallinity. Y1 - 2024 U6 - https://doi.org/10.1007/s10853-024-09596-3 SN - 1573-4803 (Online) SN - 0022-2461 (Print) N1 - Corresponding author: Ilya Digel VL - 2024 PB - Springer Science + Business Media CY - Dordrecht ER - TY - CHAP A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Nojima, H. T1 - Plasma cluster ions (PCI) influence on microbial cells viability : [abstract] N2 - Recently, SHARP corporation has developed the world’s first “Plasma Cluster Ions (PCI)” air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp. KW - Clusterion KW - Raumluft KW - Luftreiniger KW - Plasmacluster ion technology KW - Air purification Y1 - 2003 ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Zhubanova, A. A. A1 - Mansurov, Z. A. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Use of Carbonized Rise Shell for the local treatment of wounds JF - Eurasian ChemTech Journal N2 - On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis. Y1 - 2010 U6 - https://doi.org/10.18321/ectj35 SN - 2522-4867 VL - 12 IS - 2 SP - 133 EP - 138 PB - Institute of Combustion Problems CY - Almaty ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - O’Heras, C. A1 - Tastambek, K.T. A1 - Savitskaya, I.S. A1 - Ualyeva, P.S. A1 - Mansurov, Z.A. A1 - Zhubanova, A.A. T1 - Adsorption of bacterial lipopol ysaccharides on carbonized ri ce husks obtained in the batch experiments JF - KazNU Bulletin. Biology series Y1 - 2015 SN - 1563-0218 VL - 60 IS - No 1/2 SP - 144 EP - 148 ER - TY - CHAP A1 - Mansurov, Zulkhair A. A1 - Jandosov, Jakpar A1 - Chenchik, D. A1 - Azat, Seitkhan A1 - Savitskaya, Irina S. A1 - Kistaubaeva, Aida A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Zhubanova, Azhar Achmet T1 - Biocomposite Materials Based on Carbonized Rice Husk in Biomedicine and Environmental Applications T2 - Carbon Nanomaterials in Biomedicine and the Environment N2 - This chapter describes the prospects for biomedical and environmental engineering applications of heterogeneous materials based on nanostructured carbonized rice husk. Efforts in engineering enzymology are focused on the following directions: development and optimization of immobilization methods leading to novel biotechnological and biomedical applications; construction of biocomposite materials based on individual enzymes, multi-enzyme complexes and whole cells, targeted on realization of specific industrial processes. Molecular biological and biochemical studies on cell adhesion focus predominantly on identification, isolation and structural analysis of attachment-responsible biological molecules and their genetic determinants. The chapter provides a short overview of applications of the biocomposite materials based of nanostructured carbonized adsorbents. It emphasizes that further studies and better understanding of the interactions between CNS and microbial cells are necessary. The future use of living cells as biocatalysts, especially in the environmental field, needs more systematic investigations of the microbial adsorption phenomenon. Y1 - 2020 SN - 978-981-4800-27-3 U6 - https://doi.org/10.1201/9780429428647-2 SP - 3 EP - 32 PB - Jenny Stanford Publishing Pte. Ltd. CY - Singapore ER - TY - THES A1 - Bronder, Thomas T1 - Label-free detection of tuberculosis DNA with capacitive field-effect biosensors Y1 - 2020 U6 - https://doi.org/10.17192/z2021.0056 N1 - Dissertation, Universität, Marburg 2020 PB - Philipps-Universität Marburg CY - Marburg ER - TY - JOUR A1 - Digel, Ilya A1 - Zhubanova, Azhar A. A1 - Nojima, H. A1 - Artmann, Gerhard T1 - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology JF - Biotechnologija : teorija i praktika (2004) Y1 - 2004 SN - 1028-9399 SP - 46 EP - 52 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Stadler, Andreas M. T1 - Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA JF - Tissue Engineering. 13 (2007), H. 7 Y1 - 2007 SN - 1076-3279 N1 - TERMIS-EU Meeting Abstracts London, UK September 4–7, 2007 SP - 1778 EP - 1778 ER - TY - JOUR A1 - Turlybekuly, Amanzhol A1 - Pogrebnjak, Alexander A1 - Sukhodub, L. F. A1 - Sukhodub, Liudmyla B. A1 - Kistaubayeva, A. S. A1 - Savitskaya, Irina A1 - Shokatayeva, D. H. A1 - Bondar, Oleksandr V. A1 - Shaimardanov, Z. K. A1 - Plotnikov, Sergey V. A1 - Shaimardanova, B. H. A1 - Digel, Ilya T1 - Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix JF - Materials Science and Engineering C Y1 - 2019 U6 - https://doi.org/10.1016/j.msec.2019.109965 VL - 104 IS - Article number 109965 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - O\'Heras, Carlos A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - Nanostructured carbon-based column for LPS/protein adsorption : [abstract] N2 - The absence of a general method for endotoxin removal from liquid interfaces gives an opportunity to find new methods and materials to overcome this gap. Activated nanostructured carbon is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study is to find the adsorption rates for a carboneous material produced at different temperatures, as well as to reveal possible differences between the performance of the material for each of the adsorbates used during the study (hemoglobin, serum albumin and lipopolysaccharide, LPS). KW - Kohlenstofffaser KW - Adsorption KW - Lipopolysaccharide KW - aktivierte nanostrukturierte Kohlenstofffaser KW - lipopolysaccharides KW - activated nanostructured carbon Y1 - 2009 ER - TY - CHAP A1 - ElBashir, Rasha A1 - Digel, Ilya T1 - Effect of nitric oxide gas on hydrogels : [abstract] N2 - The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels. KW - Stickstoffmonoxid KW - Hydrogel KW - nitric oxide gas KW - hydrogel Y1 - 2009 ER - TY - JOUR A1 - Karnatak, Rajat A1 - Kantz, Holger A1 - Bialonski, Stephan T1 - Early warning signal for interior crises in excitable systems JF - Physical Review E Y1 - 2017 U6 - https://doi.org/10.1103/PhysRevE.96.042211 SN - 2470-0053 VL - 96 IS - 4 SP - 042211 ER - TY - CHAP A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Effect of nitric oxide on protein thermal stability : [abstract] N2 - As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not. KW - Stickstoffmonoxid KW - Proteine KW - Hämoglobin KW - nitric oxide gas KW - protein KW - hemoglobin Y1 - 2009 ER - TY - JOUR A1 - Leimena, W. A1 - Artmann, Gerhard A1 - Dachwald, Bernd A1 - Temiz Artmann, Aysegül A1 - Gossmann, Matthias A1 - Digel, Ilya T1 - Feasibility of an in-situ microbial decontamination of an ice-melting probe JF - Eurasian Chemico-Technological Journal. 12 (2010), H. 2 Y1 - 2010 SN - 1562-3920 SP - 145 EP - 150 ER - TY - JOUR A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Hescheler, Jürgen A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences JF - BMC Biophysics Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?10.1186/2046-1682-6-1 SN - 2046-1682 SP - 1 EP - 14 PB - BioMed Central CY - London ER - TY - JOUR A1 - Turaliyeva, M. A1 - Yeshibaev, A. A1 - Saparbekova, A. A1 - Akynova, L. A1 - Abildayeva, R. A1 - Sadenova, M. A1 - Sartayeva, K. A1 - Schieffer, Andre A1 - Digel, Ilya T1 - Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia JF - Asian journal of microbiology, biotechnology & environmental sciences : AJMBES N2 - At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and Ñetonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested. Y1 - 2016 SN - 0972-3005 VL - 18 IS - 2 SP - 359 EP - 366 PB - EM International ER - TY - CHAP A1 - Pham, Phu Tinh A1 - Staat, Manfred T1 - A simplification for shakedown analysis of hardening structures T2 - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon Y1 - 2015 SP - 1 EP - 4 PB - RWTH Aachen University CY - Aachen ER - TY - JOUR A1 - Vu, Duc-Khoi A1 - Staat, Manfred T1 - An algorithm for shakedown analysis of structure with temperature dependent yield stress N2 - This work is an attempt to answer the question: How to use convex programming in shakedown analysis of structures made of materials with temperature-dependent properties. Based on recently established shakedown theorems and formulations, a dual relationship between upper and lower bounds of the shakedown limit load is found, an algorithmfor shakedown analysis is proposed. While the original problem is neither convex nor concave, the algorithm presented here has the advantage of employing convex programming tools. KW - Einspielen KW - Temperaturabhängigkeit KW - Fließgrenze KW - Shakedown KW - shakedown analysis KW - yield stress Y1 - 2004 ER - TY - JOUR A1 - Ciritsis, Alexander A1 - Horbach, Andreas A1 - Staat, Manfred A1 - Kuhl, Christiane K. A1 - Kraemer, Nils Andreas T1 - Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo JF - Journal of Biomedical Materials Research: Part B: Applied Biomaterials N2 - Purpose In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. Material and Methods Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio). Results In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4% for TPU and of 1.2% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF. Conclusion The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827–833, 2018. Y1 - 2018 U6 - https://doi.org/10.1002/jbm.b.33877 SN - 1552-4981 VL - 106 IS - 2 SP - 827 EP - 833 PB - Wiley CY - New York, NY ER - TY - GEN A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Kahmann, Stephanie Lucina A1 - Heinze, Nicolai A1 - Staat, Manfred A1 - Neiss, Wolfram F. A1 - Scaal, Martin A1 - Müller, Lars P. T1 - Reply to the letter to the editor: shortening osteotomy of the proximal radius T2 - Knee Surgery, Sports Traumatology, Arthroscopy Y1 - 2017 U6 - https://doi.org/10.1007/s00167-017-4666-8 VL - 25 IS - 10 SP - 3328 EP - 3329 ER - TY - JOUR A1 - Staat, Manfred A1 - Ballmann, J. T1 - Computation of impacts on elastic solids by methods of bicharacteristics JF - Computational Mechanics '88 : theory and applications ; proceedings of the International Conference on Computational Engineering Science April 10-14, 1988, Atlanta, GA, USA ; vol. 2 N2 - Shock waves, explosions, impacts or cavitation bubble collapses may generate stress waves in solids causing cracks or unexpected dammage due to focussing, physical nonlinearity or interaction with existing cracks. There is a growing interest in wave propagation, which poses many novel problems to experimentalists and theorists. KW - Bicharakteristikenverfahren KW - Elastizität KW - elastic solids KW - bicharacteristics Y1 - 1988 SP - 1719 EP - 1722 ER - TY - JOUR A1 - Staat, Manfred T1 - Basis Reduction for the Shakedown Problem for Bounded Kinematic Hardening Material N2 - Limit and shakedown analysis are effective methods for assessing the load carrying capacity of a given structure. The elasto–plastic behavior of the structure subjected to loads varying in a given load domain is characterized by the shakedown load factor, defined as the maximum factor which satisfies the sufficient conditions stated in the corresponding static shakedown theorem. The finite element dicretization of the problem may lead to very large convex optimization. For the effective solution a basis reduction method has been developed that makes use of the special problem structure for perfectly plastic material. The paper proposes a modified basis reduction method for direct application to the two-surface plasticity model of bounded kinematic hardening material. The considered numerical examples show an enlargement of the load carrying capacity due to bounded hardening. KW - Finite-Elemente-Methode KW - Einspielen KW - Basis Reduktion KW - konvexe Optimierung KW - FEM KW - Druckgeräte KW - Basis reduction KW - Convex optimization KW - FEM KW - Shakedown analysis Y1 - 2000 ER - TY - CHAP A1 - Staat, Manfred A1 - Ballmann, J. T1 - Fundamental aspects of numerical methods for the propagation of multi-dimensional nonlinear waves in solids T2 - Nonlinear hyperbolic equations : theory, computations methods, and applications ; proceedings of the 2nd International Conference on Nonlinear Hyperbolic Problems, Aachen N2 - The nonlinear scalar constitutive equations of gases lead to a change in sound speed from point to point as would be found in linear inhomogeneous (and time dependent) media. The nonlinear tensor constitutive equations of solids introduce the additional local effect of solution dependent anisotropy. The speed of a wave passing through a point changes with propagation direction and its rays are inclined to the front. It is an open question whether the widely used operator splitting techniques achieve a dimensional splitting with physically reasonable results for these multi-dimensional problems. May be this is the main reason why the theoretical and numerical investigations of multi-dimensional wave propagation in nonlinear solids are so far behind gas dynamics. We hope to promote the subject a little by a discussion of some fundamental aspects of the solution of the equations of nonlinear elastodynamics. We use methods of characteristics because they only integrate mathematically exact equations which have a direct physical interpretation. KW - Nichtlineare Welle KW - Nichtlineare Gleichung KW - Festkörper KW - Elastodynamik KW - Multi-dimensional wave propagation KW - nonlinear solids KW - nonlinear tensor constitutive equation Y1 - 1989 SP - 574 EP - 588 ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Matthies, Hermann G. A1 - Stavroulakis, Georgios Eleftherios A1 - Staat, Manfred T1 - Direct plastic structural design by chance constrained programming T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - We propose a stochastic programming method to analyse limit and shakedown of structures under random strength with lognormal distribution. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit or the shakedown limit. The edge-based smoothed finite element method (ES-FEM) using three-node linear triangular elements is used. Y1 - 2018 ER - TY - JOUR A1 - Staat, Manfred A1 - Heitzer, M. A1 - Lang, H. A1 - Wirtz, K. T1 - Direct Finite Element Route for Design-by-Analysis of Pressure Components JF - International Journal of Pressure Vessels and Piping. 82 (2005), H. 1 Y1 - 2005 SN - 0308-0161 SP - 61 EP - 67 ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred ED - Eberhardsteiner, J. T1 - Numerical stability enhancement of modeling hyperelastic materials T2 - Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Y1 - 2012 N1 - 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012 ER - TY - JOUR A1 - Pogorelova, Natalia A1 - Rogachev, Evgeniy A1 - Digel, Ilya A1 - Chernigova, Svetlana A1 - Nardin, Dmitry T1 - Bacterial Cellulose Nanocomposites: Morphology and Mechanical Properties JF - Materials N2 - Bacterial cellulose (BC) is a promising material for biomedical applications due to its unique properties such as high mechanical strength and biocompatibility. This article describes the microbiological synthesis, modification, and characterization of the obtained BC-nanocomposites originating from symbiotic consortium Medusomyces gisevii. Two BC-modifications have been obtained: BC-Ag and BC-calcium phosphate (BC-Ca3(PO4)2). Structure and physicochemical properties of the BC and its modifications were investigated by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and infrared Fourier spectroscopy as well as by measurements of mechanical and water holding/absorbing capacities. Topographic analysis of the surface revealed multicomponent thick fibrils (150–160 nm in diameter and about 15 µm in length) constituted by 50–60 nm nanofibrils weaved into a left-hand helix. Distinctive features of Ca-phosphate-modified BC samples were (a) the presence of 500–700 nm entanglements and (b) inclusions of Ca3(PO4)2 crystals. The samples impregnated with Ag nanoparticles exhibited numerous roundish inclusions, about 110 nm in diameter. The boundaries between the organic and inorganic phases were very distinct in both cases. The Ag-modified samples also showed a prominent waving pattern in the packing of nanofibrils. The obtained BC gel films possessed water-holding capacity of about 62.35 g/g. However, the dried (to a constant mass) BC-films later exhibited a low water absorption capacity (3.82 g/g). It was found that decellularized BC samples had 2.4 times larger Young’s modulus and 2.2 times greater tensile strength as compared to dehydrated native BC films. We presume that this was caused by molecular compaction of the BC structure. Y1 - 2020 SN - 1996-1944 U6 - https://doi.org/10.3390/ma13122849 VL - 13 IS - 12 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - JOUR A1 - Hackl, M. A1 - Andermahr, J. A1 - Staat, Manfred A1 - Bremer, I. A1 - Borggrefe, J. A1 - Prescher, A. A1 - Müller, L. P. A1 - Wegmann, K. T1 - Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation JF - The Journal of Hand Surgery (European Volume) Y1 - 2017 U6 - https://doi.org/10.1177/1753193416665943 SN - 2043-6289 (Online) SN - 1753-1934 (Print) VL - 42 IS - 4 SP - 370 EP - 376 PB - Sage CY - London ER - TY - JOUR A1 - Göddeke, Dominik A1 - Strzodka, Robert A1 - Mohd-Yusof, Jamaludin A1 - McCormick, Patrick A1 - Buijssen, Sven H.M. A1 - Grajewski, Matthias A1 - Turek, Stefan T1 - Exploring weak scalability for FEM calculations on a GPU-enhanced cluster JF - Parallel Computing Y1 - 2007 U6 - https://doi.org/10.1016/j.parco.2007.09.002 SN - 0167-8191 VL - 33 IS - 10-11 SP - 685 EP - 699 ER - TY - JOUR A1 - Stulpe, Werner A1 - Hellwig, K.-E. T1 - A Classical Reformulation of Finite-Dimensional Quantum Mechanics. Hellwig, K.-E.; Stulpe, W. JF - Quantum measurement, irreversibility and the physics of information / Symposium on the Foundations of Modern Physics 1993, Cologne, Germany 1 - 5 June 1993. Ed. Paul Busch Y1 - 1993 SN - 981021507X N1 - Symposium on the Foundations of Modern Physics ; <1993, Köln> SP - 209 EP - 214 PB - World Scientific CY - Singapore [u.a.] ER - TY - JOUR A1 - Staat, Manfred T1 - LISA - a European project for FEM-based limit and shakedown analysis N2 - The load-carrying capacity or the safety against plastic limit states are the central questions in the design of structures and passive components in the apparatus engineering. A precise answer is most simply given by limit and shakedown analysis. These methods can be based on static and kinematic theorems for lower and upper bound analysis. Both may be formulated as optimization problems for finite element discretizations of structures. The problems of large-scale analysis and the extension towards realistic material modelling will be solved in a European research project. Limit and shakedown analyses are briefly demonstrated with illustrative examples. KW - Einspielen KW - Traglast KW - Finite-Elemente-Methode KW - Traglastanalyse KW - Einspielanalyse KW - FEM KW - limit analysis KW - shakedown analysis Y1 - 2001 ER - TY - JOUR A1 - Topçu, Murat A1 - Madabhushi, Gopal S.P. A1 - Staat, Manfred T1 - A generalized shear-lag theory for elastic stress transfer between matrix and fibres having a variable radius JF - International Journal of Solids and Structures N2 - A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP. KW - Natural fibres KW - Polymer-matrix composites KW - Biocomposites KW - Stress concentrations KW - Finite element analysis Y1 - 2022 U6 - https://doi.org/10.1016/j.ijsolstr.2022.111464 SN - 0020-7683 VL - 239–240 IS - Art. No. 111464 PB - Elsevier CY - New York, NY ER - TY - BOOK A1 - Stulpe, Werner T1 - Classical Representations of Quantum Mechanics Related to Statistically Complete Observables Y1 - 1997 SN - 3-89685-438-0 N1 - Zugl. Berlin, Techn. Univ., Habil.-Schr. 1997 PB - Wissenschaft und Technik Verl. CY - Berlin ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Horbach, Andreas A1 - Staat, Manfred A1 - Kowalczyk, Wojciech A1 - Tran, Thanh Ngoc T1 - Virgin passive colon biomechanics and a literature review of active contraction constitutive models JF - Biomechanics N2 - The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel–Gasser–Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill’s three-element model, Murphy’s four-state cross-bridge chemical kinetic model and Huxley’s sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine. KW - virgin passive KW - strain energy function KW - smooth muscle contraction KW - viscoelasticity KW - damage Y1 - 2022 U6 - https://doi.org/10.3390/biomechanics2020013 SN - 2673-7078 VL - 2 IS - 2 SP - 138 EP - 157 PB - MDPI CY - Basel ER - TY - JOUR A1 - Abel, Alexander A1 - Kahmann, Stephanie Lucina A1 - Mellon, Stephen A1 - Staat, Manfred A1 - Jung, Alexander T1 - An open-source tool for the validation of finite element models using three-dimensional full-field measurements JF - Medical Engineering & Physics N2 - Three-dimensional (3D) full-field measurements provide a comprehensive and accurate validation of finite element (FE) models. For the validation, the result of the model and measurements are compared based on two respective point-sets and this requires the point-sets to be registered in one coordinate system. Point-set registration is a non-convex optimization problem that has widely been solved by the ordinary iterative closest point algorithm. However, this approach necessitates a good initialization without which it easily returns a local optimum, i.e. an erroneous registration. The globally optimal iterative closest point (Go-ICP) algorithm has overcome this drawback and forms the basis for the presented open-source tool that can be used for the validation of FE models using 3D full-field measurements. The capability of the tool is demonstrated using an application example from the field of biomechanics. Methodological problems that arise in real-world data and the respective implemented solution approaches are discussed. Y1 - 2020 U6 - https://doi.org/10.1016/j.medengphy.2019.10.015 SN - 1350-4533 VL - 77 SP - 125 EP - 129 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Jung, Alexander A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample. Y1 - 2018 ER - TY - JOUR A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Govorukha, Kristina A1 - Rübbelke, Dirk T1 - Challenges for the European steel industry: Analysis, possible consequences and impacts on sustainable development JF - Applied Energy N2 - The steel industry in the European Union (EU), important for the economy as a whole, faces various challenges. These are inter alia volatile prices for relevant input factors, uncertainties concerning the regulation of CO₂-emissions and market shocks caused by the recently introduced additional import duties in the US, which is an important sales market. We examine primary and secondary effects of these challenges on the steel industry in the EU and their impacts on European and global level. Developing and using a suitable meta-model, we analyze the competitiveness of key steel producing countries with respect to floor prices depending on selected cost factors and draw conclusions on the impacts in the trade of steel on emissions, energy demand, on the involvement of developing countries in the value chain as well on the need for innovations to avoid relocations of production. Hence, our study contributes to the assessment of sustainable industrial development, which is aimed by the Sustainability Development Goal “Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation countries”. By applying information on country-specific Human Development Indexes (reflecting aspects of life expectancy, education, and per capita income), we show that relocating energy-intensive industries from the EU may not only increase global energy demand and CO₂-emissions, but may also be to the disadvantage of developing countries. Y1 - 2020 U6 - https://doi.org/10.1016/j.apenergy.2020.114633 SN - 0306-2619 VL - 264 IS - Article number: 114633 PB - Elsevier CY - Amsterdam ER -