TY - CHAP A1 - Eschler, Eric A1 - Wozniak, Felix A1 - Richter, Christoph A1 - Drechsler, Klaus T1 - Materialanalyse an lokal verstärkten Triaxialgeflechten T2 - Leichtbau in Forschung und industrieller Anwendung von der Nano- bis zur Makroebene, LLC, Landshuter Leichtbau-Colloquium, 9 Y1 - 2019 SN - 978-3-9818439-2-7 SP - 120 EP - 131 PB - Leichtbau Cluster CY - Landshut ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Albracht, Kirsten A1 - Abel, Thomas A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs JF - Journal of Electromyography and Kinesiology N2 - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA. Y1 - 2020 U6 - https://doi.org/10.1016/j.jelekin.2020.102402 SN - 1050-6411 VL - 51 IS - Article 102402 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kopp, Alexander A1 - Schunck, Laura A1 - Gosau, Martin A1 - Smeets, Ralf A1 - Burg, Simon A1 - Fuest, Sandra A1 - Kröger, Nadja A1 - Zinser, Max A1 - Krohn, Sebastian A1 - Behbahani, Mehdi A1 - Köpf, Marius A1 - Lauts, Lisa A1 - Rutkowski, Rico T1 - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes JF - International Journal of Molecular Sciences N2 - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes. Y1 - 2020 U6 - https://doi.org/10.3390/ijms21186704 SN - 1422-0067 N1 - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine VL - 21 IS - 18 art. no. 6704 PB - MDPI CY - Basel ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Foitschik, Tina A1 - Rojas-Vega, Sandra A1 - Strüder, Heiko K. T1 - Kinematics and kinetics of handcycling propulsion at increasing workloads in able-bodied subjects JF - Sports Engineereing N2 - In Paralympic sports, biomechanical optimisation of movements and equipment seems to be promising for improving performance. In handcycling, information about the biomechanics of this sport is mainly provided by case studies. The aim of the current study was (1) to examine changes in handcycling propulsion kinematics and kinetics due to increasing workloads and (2) identify parameters that are associated with peak aerobic performance. Twelve non-disabled male competitive triathletes without handcycling experience voluntarily participated in the study. They performed an initial familiarisation protocol and incremental step test until exhaustion in a recumbent racing handcycle that was attached to an ergometer. During the incremental test, tangential crank kinetics, 3D joint kinematics, blood lactate and ratings of perceived exertion (local and global) were identified. As a performance criterion, the maximal power output during the step test (Pmax) was calculated and correlated with biomechanical parameters. For higher workloads, an increase in crank torque was observed that was even more pronounced in the pull phase than in the push phase. Furthermore, participants showed an increase in shoulder internal rotation and abduction and a decrease in elbow flexion and retroversion. These changes were negatively correlated with performance. At high workloads, it seems that power output is more limited by the transition from pull to push phase than at low workloads. It is suggested that successful athletes demonstrate small alterations of their kinematic profile due to increasing workloads. Future studies should replicate and expand the test spectrum (sprint and continuous loads) as well as use methods like surface electromyography (sEMG) with elite handcyclists. Y1 - 2018 U6 - https://doi.org/10.1007/s12283-018-0269-y SN - 1460-2687 VL - 21 IS - 21 SP - 283 EP - 294 PB - Springer Nature CY - Cham ER - TY - CHAP A1 - Bozakov, Zdravko A1 - Sander, Volker T1 - OpenFlow: A Perspective for Building Versatile Networks T2 - Network-Embedded Management and Applications Y1 - 2013 SN - 978-1-4419-6769-5 U6 - https://doi.org/10.1007/978-1-4419-6769-5_11 SP - 217 EP - 245 PB - Springer CY - New York, NY ER - TY - BOOK A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef ED - Yoshinobu, Tatsuo ED - Schöning, Michael Josef T1 - Light-addressing and chemical imaging technologies for electrochemical sensing Y1 - 2020 SN - 978-3-03943-029-1 U6 - https://doi.org/10.3390/books978-3-03943-029-1 N1 - This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors PB - MDPI CY - Basel ER - TY - JOUR A1 - Conzen, Catharina A1 - Albanna, Walid A1 - Weiss, Miriam A1 - Kürten, David A1 - Vilser, Walthard A1 - Kotliar, Konstantin A1 - Zäske, Charlotte A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander T1 - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes JF - Translational Stroke Research N2 - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome. Y1 - 2018 U6 - https://doi.org/10.1007/s12975-017-0585-8 SN - 1868-601X IS - 9 SP - 284 EP - 293 PB - Springer Nature CY - Cham ER - TY - RPRT A1 - Artmann, Gerhard T1 - HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten für die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "Förderung von innovativen Netzwerken" (InnoNet) des Bundesministerium für Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010 Y1 - 2011 U6 - https://doi.org/10.2314/GBV:68757076X N1 - Förderkennzeichen BMWi 16IN0536. - Verbund-Nr. 01056220 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Aachen [u.a.] ER - TY - RPRT A1 - Artmann, Gerhard T1 - FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten für die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010 Y1 - 2011 U6 - https://doi.org/10.2314/GBV:782964621 N1 - Förderkennzeichen BMBF 1760X07 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Aachen ER - TY - JOUR A1 - Hugenroth, Kristin A1 - Borchardt, Ralf A1 - Ritter, Philine A1 - Groß‑Hardt, Sascha A1 - Meyns, Bart A1 - Verbelen, Tom A1 - Steinseifer, Ulrich A1 - Kaufmann, Tim A. S. A1 - Engelmann, Ulrich M. T1 - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input JF - Scientific Reports N2 - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-96397-2 SN - 2045-2322 VL - 11 IS - Art. No. 16800 SP - 1 EP - 12 PB - Springer CY - Berlin ER - TY - JOUR A1 - Brockhaus, Moritz K. A1 - Behbahani, Mehdi A1 - Muris, Farina A1 - Jansen, Sebastian V. A1 - Schmitz- Rode, Thomas A1 - Steinseifer, Ulrich A1 - Clauser, Johanna C. T1 - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept JF - Artificial Organs N2 - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential. Y1 - 2021 U6 - https://doi.org/10.1111/aor.14046 SN - 1525-1594 VL - 45 IS - 12 SP - 1513 EP - 1521 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Olderog, M. A1 - Mohr, P. A1 - Beging, Stefan A1 - Tsoumpas, C. A1 - Ziemons, Karl T1 - Simulation study on the role of tissue-scattered events in improving sensitivity for a compact time of flight compton positron emission tomograph T2 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) N2 - In positron emission tomography improving time, energy and spatial detector resolutions and using Compton kinematics introduces the possibility to reconstruct a radioactivity distribution image from scatter coincidences, thereby enhancing image quality. The number of single scattered coincidences alone is in the same order of magnitude as true coincidences. In this work, a compact Compton camera module based on monolithic scintillation material is investigated as a detector ring module. The detector interactions are simulated with Monte Carlo package GATE. The scattering angle inside the tissue is derived from the energy of the scattered photon, which results in a set of possible scattering trajectories or broken line of response. The Compton kinematics collimation reduces the number of solutions. Additionally, the time of flight information helps localize the position of the annihilation. One of the questions of this investigation is related to how the energy, spatial and temporal resolutions help confine the possible annihilation volume. A comparison of currently technically feasible detector resolutions (under laboratory conditions) demonstrates the influence on this annihilation volume and shows that energy and coincidence time resolution have a significant impact. An enhancement of the latter from 400 ps to 100 ps leads to a smaller annihilation volume of around 50%, while a change of the energy resolution in the absorber layer from 12% to 4.5% results in a reduction of 60%. The inclusion of single tissue-scattered data has the potential to increase the sensitivity of a scanner by a factor of 2 to 3 times. The concept can be further optimized and extended for multiple scatter coincidences and subsequently validated by a reconstruction algorithm. Y1 - 2021 SN - 978-1-7281-7693-2 U6 - https://doi.org/10.1109/NSS/MIC42677.2020.9507901 N1 - 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 31 Oct.-7 Nov. 2020, Boston, MA, USA PB - IEEE CY - New York, NY ER - TY - RPRT A1 - Artmann, Gerhard T1 - Escherichia Coli Infektion und Zellschädigung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701 Y1 - 2004 U6 - https://doi.org/10.2314/GBV:482527137 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Jülich ER - TY - RPRT A1 - Artmann, Gerhard T1 - Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten. Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011 Y1 - 2011 U6 - https://doi.org/10.2314/GBV:747569150 N1 - Förderkennzeichen BMBF 1736X08 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Aachen ER - TY - RPRT A1 - Artmann, Gerhard A1 - Bäumler, H. T1 - Pharmamikrocontainer mit designgesteuerter Permeabilität als Transporter für ausgewählte Pharmaka. Ein Gemeinschaftsprojekt im Forschungsschwerpunkt "Celluar Engineering" [Laufzeit: 01.09.2000 - 28.02.2002] Y1 - 2002 PB - FH Aachen CY - Jülich ER - TY - RPRT A1 - Temiz Artmann, Aysegül T1 - Frühgeburtenrate mindern durch ein Prognoseverfahren für den vorzeitigen Blasensprung - PROMPT (Premature rupture of membranes prediction test) : Abschlussbericht ; Laufzeit des Vorhabens: 01.03.2007 - 31.12.2009 Y1 - 2010 U6 - https://doi.org/10.2314/GBV:644277858 N1 - Förderkennzeichen BMBF 1772X07 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Aachen ER - TY - JOUR A1 - Arampatzis, Adamantios A1 - Karamanidis, Kiros A1 - Albracht, Kirsten T1 - Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude JF - Journal of Experimental Biology Y1 - 2007 U6 - https://doi.org/10.1242/jeb.003814 SN - 0022-0949 VL - 210 IS - 15 SP - 2743 EP - 2753 ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy JF - Biological Cybernetics Y1 - 2006 U6 - https://doi.org/10.1007/s00422-006-0070-z SN - 1432-0770 VL - 95 IS - 1 SP - 87 EP - 96 ER - TY - CHAP A1 - Abel, Thomas A1 - Bonin, Dominik A1 - Albracht, Kirsten A1 - Zeller, Sebastian A1 - Burkett, Brendan T1 - Kinematische Untersuchung der Kurbelbewegung im Handcycling: Entwicklung einer sportartspezifischen Methode T2 - Behindertensport 1951-2011 : Historische und aktuelle Aspekte im nationalen und internationalen Dialog Y1 - 2015 SN - 9783898997249 SP - 82 EP - 91 PB - Meyer & Meyer CY - Aachen ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Albracht, Kirsten A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk T1 - Isokinematic leg extension training with an industrial robot T2 - 6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore Y1 - 2016 U6 - https://doi.org/10.1109/BIOROB.2016.7523750 SP - 950 EP - 955 ER - TY - CHAP A1 - Schreiber, Marc A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - Metrics Driven Research Collaboration: Focusing on Common Project Goals Continuously T2 - 39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina N2 - Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements. In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner’s business model. This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal. An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time. Y1 - 2017 N1 - Software Engineering in Practice (SEIP). ICSE2017 Vorabversion der Autoren ER - TY - JOUR A1 - Sousa, Marcos A. M. A1 - Siqueira, Jose R. Jr. A1 - Vercik, Andres A1 - Schöning, Michael Josef A1 - Oliveira, Osvaldo N. Jr. T1 - Determining the optimized layer-by-layer film architecture with dendrimer/carbon nanotubes for field-effect sensors JF - IEEE Sensors Journal N2 - The capacitive electrolyte–insulator–semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte–insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors. Y1 - 2017 U6 - https://doi.org/10.1109/JSEN.2017.2653238 SN - 1558-1748 VL - 17 IS - 6 SP - 1735 EP - 1740 PB - IEEE CY - New York ER - TY - JOUR A1 - Arreola, Julio A1 - Oberländer, Jan A1 - Mätzkow, M. A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Surface functionalization for spore-based biosensors with organosilanes JF - Electrochimica Acta N2 - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated. Y1 - 2017 U6 - https://doi.org/10.1016/j.electacta.2017.04.157 SN - 0013-4686 VL - 241 SP - 237 EP - 243 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Oberländer, Jan A1 - Mayer, Marlena A1 - Greeff, Anton A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Spore-based biosensor to monitor the microbicidal efficacy of gaseous hydrogen peroxide sterilization processes JF - Biosensors and Bioelectronics N2 - In this work, a spore-based biosensor is evaluated to monitor the microbicidal efficacy of sterilization processes applying gaseous hydrogen peroxide (H2O2). The sensor is based on interdigitated electrode structures (IDEs) that have been fabricated by means of thin-film technologies. Impedimetric measurements are applied to study the effect of sterilization process on spores of Bacillus atrophaeus. This resilient microorganism is commonly used in industry to proof the sterilization efficiency. The sensor measurements are accompanied by conventional microbiological challenge tests, as well as morphological characterizations with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The sensor measurements are correlated with the microbiological test routines. In both methods, namely the sensor-based and microbiological one, a tailing effect has been observed. The results are evaluated and discussed in a three-dimensional calibration plot demonstrating the sensor's suitability to enable a rapid process decision in terms of a successfully performed sterilization. Y1 - 2018 U6 - https://doi.org/10.1016/j.bios.2017.12.045 SN - 0956-5663 VL - 104 SP - 87 EP - 94 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Schmidts, Oliver A1 - Boltes, Maik A1 - Kraft, Bodo A1 - Schreiber, Marc T1 - Multi-pedestrian tracking by moving Bluetooth-LE beacons and stationary receivers T2 - 2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan Y1 - 2017 N1 - International Conference on Indoor Positioning and Indoor Navigation <8, 2017, Sapporo, Japan> SP - 1 EP - 4 ER - TY - JOUR A1 - Laura, C.O. A1 - Drechsler, Klaus A1 - Erdt, M. A1 - Wesarg, S. A1 - Bale, R. T1 - Intervention assessment tool for primary tumors in the liver JF - Current Directions in Biomedical Engineering N2 - After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm. Y1 - 2018 U6 - https://doi.org/10.1515/cdbme-2018-0081 SN - 2364-5504 VL - 4 IS - 1 SP - 337 EP - 340 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Heinke, Lars N. A1 - Knicker, Axel J. A1 - Albracht, Kirsten T1 - Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes JF - Isokinetics and Exercise Science N2 - BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results. Y1 - 2018 U6 - https://doi.org/10.3233/IES-184111 SN - 1878-5913 VL - 26 IS - 4 SP - 265 EP - 274 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Bleilevens, Christian A1 - Hill, Aileen A1 - Grzanna, Tim A1 - Fechter, Tamara A1 - Bohnen, Melanie A1 - Weber, Hans-Joachim A1 - Beckers, Christian A1 - Borosch, Sebastian A1 - Zayat, Rashad A1 - Benstoem, Carin A1 - Rossaint, Rolf A1 - Goetzenich, Andreas T1 - In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop JF - Interactive cardiovascular and thoracic surgery Y1 - 2019 U6 - https://doi.org/10.1093/icvts/ivy206 SN - 1569-9285 VL - 28 IS - 1 SP - 120 EP - 127 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines T1 - Vaskuläre Biomarker der retinalen Gefäβanalyse T1 - Vascular Biomarkers in Retinal Vessel Analysis JF - Klinische Monatsblätter fur Augenheilkunde N2 - Mit modernen nicht invasiven bildgebenden Verfahren lassen sich anhand der Fundusfotografie bzw. der optischen Verfilmung Aspekte der funktionellen und strukturellen retinalen Gefäßveränderungen objektiv untersuchen. Der Zustand und das Verhalten retinaler Gefäße beeinflussen im prä-, post- und kapillaren Bereich den Blutfluss und strömungsbedingte Stoffwechselverhältnisse passiv und aktiv über den Gefäßdurchmesser. Retinale Gefäße gleichen von Aufbau und Funktion den zerebralen Gefäßen und spiegeln den Zustand der Mikrozirkulation wider. Mithilfe von aus den Gefäßweiten berechneten Biomarkern soll eine Aussage über die Prognose von systemischen vaskulär bedingten Erkrankungen getroffen werden. Die statische retinale Gefäßanalyse befasst sich mit der Untersuchung des Zustandes der prä- und postkapillaren Gefäßdurchmesser der retinalen Mikrozirkulation anhand einer optischen Fundusaufnahme. Bei der dynamischen retinalen Gefäßanalyse wird der Längsschnitt eines retinalen Gefäßes nicht invasiv funktionell und strukturell über einen Zeitraum vor, während und nach einer spezifischen vaskulären Stimulation untersucht. Die genaue Methodologie der Auswertung und die Bezeichnung der Parameter variieren bei unterschiedlichen Ansätzen. Mittels retinaler Gefäßanalyse wurden bislang mehrere klinische Querschnitts- und Interventionsstudien in der Augenheilkunde und anderen Fachgebieten, inkl. Kardiologie, Neurologie, Neurochirurgie, Nephrologie, Gynäkologie, Sportmedizin, Diabetologie, Hypertensiologie usw. durchgeführt. Mit der statischen retinalen Gefäßanalyse steht eine kostengünstige, reproduzierbare, nicht invasive Screeningtechnik zur Verfügung, um eine prognostische Aussage über die Gefäßgesundheit eines individuellen Patienten zu treffen. Die dynamische retinale Gefäßanalyse besitzt ein weiteres diagnostisches Anwendungsspektrum als die statische, da sie das Verhalten retinaler Gefäße zeitkontinuierlich untersucht. Die Evaluation vaskulärer Erkrankungen sowie zerebro- bzw. kardiovaskulärer Morbidität und Mortalität mittels mehrerer methodologischer Modalitäten retinaler Gefäßanalyse mit ihren jeweiligen quantitativen Biomarkern bietet eine zukunftsträchtige diagnostische Perspektive. Die interdisziplinäre klinische Anwendung dieser vaskulären Biomarker gewinnt zunehmend an Bedeutung, sowohl in der Augenheilkunde als auch in anderen Fachgebieten. Y1 - 2018 U6 - https://doi.org/10.1055/a-0774-7987 SN - 0023-2165 VL - 235 IS - 12 SP - 1352 EP - 1359 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Arreola, Julio A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Toward an immobilization method for spore-based biosensors in oxidative environment JF - Electrochimica Acta Y1 - 2019 U6 - https://doi.org/10.1016/j.electacta.2019.01.148 VL - 302 SP - 394 EP - 401 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Molinnus, Denise T1 - Integration of biomolecular logic principles with electronic transducers on a chip Y1 - 2018 PB - Philipps-Universität / Fachbereich Pharmazie CY - Marburg/Lahn ER - TY - CHAP A1 - Krome, Cornelia A1 - Sander, Volker T1 - Time series analysis with apache spark and its applications to energy informatics T2 - Proceedings of the 7th DACH+ Conference on Energy Informatics N2 - In energy economy forecasts of different time series are rudimentary. In this study, a prediction for the German day-ahead spot market is created with Apache Spark and R. It is just an example for many different applications in virtual power plant environments. Other examples of use as intraday price processes, load processes of machines or electric vehicles, real time energy loads of photovoltaic systems and many more time series need to be analysed and predicted. This work gives a short introduction into the project where this study is settled. It describes the time series methods that are used in energy industry for forecasts shortly. As programming technique Apache Spark, which is a strong cluster computing technology, is utilised. Today, single time series can be predicted. The focus of this work is on developing a method to parallel forecasting, to process multiple time series simultaneously with R and Apache Spark. 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