TY - CHAP A1 - Staat, Manfred A1 - Duong, Minh Tuan T1 - Smoothed Finite Element Methods for Nonlinear Solid Mechanics Problems: 2D and 3D Case Studies T2 - Proceedings of the National Science and Technology Conference on Mechanical - Transportation Engineering (NSCMET 2016), 13th October 2016, Hanoi, Vietnam, Vol.2 N2 - The Smoothed Finite Element Method (SFEM) is presented as an edge-based and a facebased techniques for 2D and 3D boundary value problems, respectively. SFEMs avoid shortcomings of the standard Finite Element Method (FEM) with lower order elements such as overly stiff behavior, poor stress solution, and locking effects. Based on the idea of averaging spatially the standard strain field of the FEM over so-called smoothing domains SFEM calculates the stiffness matrix for the same number of degrees of freedom (DOFs) as those of the FEM. However, the SFEMs significantly improve accuracy and convergence even for distorted meshes and/or nearly incompressible materials. Numerical results of the SFEMs for a cardiac tissue membrane (thin plate inflation) and an artery (tension of 3D tube) show clearly their advantageous properties in improving accuracy particularly for the distorted meshes and avoiding shear locking effects. Y1 - 2016 SP - 440 EP - 445 ER - TY - JOUR A1 - Huck, Christina A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Reisert, Steffen A1 - Schubert, J. A1 - Zander, W. A1 - Begoyan, V. K. A1 - Buniatyan, V. V. A1 - Schöning, Michael Josef T1 - Chemical sensors based on a high-k perovskite oxide of barium strontium titanate JF - Procedia Engineering N2 - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor. KW - barium strontium titanate KW - high-k material KW - contactless conductivity sensor KW - multi-functional material KW - hydrogen peroxide Y1 - 2014 U6 - https://doi.org/10.1016/j.proeng.2014.11.258 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 28 EP - 31 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Bhattarai, Aroj T1 - Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants Y1 - 2018 SN - 978-3-9818074-8-6 U6 - https://doi.org/10.17185/duepublico/70340 N1 - Duisburg-Essen, Univ., Diss., 2018 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Baade, A. A1 - Emons, H. A1 - Schöning, Michael Josef T1 - Application of ISFET for pH measurements in rain droplets JF - Sensors and Actuators B. 76 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 634 EP - 638 ER - TY - JOUR A1 - Kassab, T. A1 - Han, Y. A1 - Poghossian, Arshak A1 - Ingebrandt, S. A1 - Offenhäusser, A. A1 - Schöning, Michael Josef T1 - Detection of layerby-layer adsorbed polyelectrolytes by means of field-effect based capacitive EIS structures JF - Biomedizinische Technik. 49 (2004), H. 2 Y1 - 2004 SN - 0932-4666 SP - 1034 EP - 1035 ER - TY - CHAP A1 - Platen, J. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Präparation von selbstjustierenden Nanostrukturen mittels Schichtausdehnungstechnik T2 - Sensoren und Mess-Systeme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau Y1 - 2006 SN - 3-8007-2939-3 SP - 277 EP - 280 PB - VDE Verl. CY - Berlin ER - TY - JOUR A1 - Ball, Christopher Stephen A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Kuckshinrichs, Wilhelm T1 - E-mobility from a multi-actor point of view: Uncertainties and their impacts JF - Technological Forecasting and Social Change Y1 - 2021 SN - 0040-1625 U6 - https://doi.org/10.1016/j.techfore.2021.120925 VL - 170 IS - Art. 120925 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Buniatyan, V. V. A1 - Matirosyan, N. W. A1 - Abouzar, Maryam H. A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Schubert, J. A1 - Khachatryan, V. R. A1 - Soukiassyan, G. R. T1 - (Ba,Sr)TiO3 based electrolyte-insulator-semiconductor pHsensors: comparitive study JF - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009 Y1 - 2009 SP - 71 EP - 74 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schultze, J. W. A1 - Schöning, Michael Josef T1 - Multi-parameter detection of (bio-)chemical and physical quantities using an identical transducer principle JF - Sensors and Actuators B. 91 (2003), H. 1-3 Y1 - 2003 SN - 0925-4005 SP - 83 EP - 91 ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Jessing, Max P. A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2018.11.019 SN - 0956-5663 VL - 126 SP - 510 EP - 517 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Poghossian, Arshak A1 - Malzahn, K. A1 - Abouzar, Maryam H. A1 - Mehndiratta, P. A1 - Katz, E. A1 - Schöning, Michael Josef T1 - Integration of biomolecular logic gates with field-effect transducers JF - Electrochimica Acta. 56 (2011), H. 26 Y1 - 2011 SN - 0013-4686 SP - 9661 EP - 9665 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - An electromechanical model for cardiac tissue constructs T2 - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon Y1 - 2015 SP - 1 EP - 4 PB - RWTH Aachen University CY - Aachen ER - TY - JOUR A1 - Seifarth, Volker A1 - Schehl, D. A1 - Linder, Peter A1 - Gossmann, Matthias A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Porst, Dariusz A1 - Preiß, C. A1 - Kayser, Peter A1 - Pack, O. A1 - Temiz Artmann, Aysegül T1 - Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds N2 - The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days. KW - Tissue Engineering KW - Bioreaktor KW - Organkultur KW - Harnleiter Y1 - 2011 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Biselli, Manfred A1 - Selmer, Thorsten A1 - Öhlschläger, Peter A1 - Baumann, Marcus A1 - Förster, Arnold A1 - Poghossian, Arshak T1 - Forschung „zwischen“ den Disziplinen: das Institut für Nano- und Biotechnologien JF - Analytik news : das Online-Labormagazin für Labor und Analytik N2 - "Biologie trifft Mikroelektronik", das Motto des Instituts für Nano- und Biotechnologien (INB) an der FH Aachen, unterstreicht die zunehmende Bedeutung interdisziplinär geprägter Forschungsaktivitäten. Der thematische Zusammenschluss grundständiger Disziplinen, wie die Physik, Elektrotechnik, Chemie, Biologie sowie die Materialwissenschaften, lässt neue Forschungsgebiete entstehen, ein herausragendes Beispiel hierfür ist die Nanotechnologie: Hier werden neue Werkstoffe und Materialien entwickelt, einzelne Nanopartikel oder Moleküle und deren Wechselwirkung untersucht oder Schichtstrukturen im Nanometerbereich aufgebaut, die neue und vorher nicht bekannte Eigenschaften hervorbringen. Vor diesem Hintergrund bündelt das im Jahre 2006 gegründete INB die an der FH Aachen vorhandenen Kompetenzen von derzeit insgesamt sieben Laboratorien auf den Gebieten der Halbleitertechnik und Nanoelektronik, Nanostrukturen und DNA-Sensorik, der Chemo- und Biosensorik, der Enzymtechnologie, der Mikrobiologie und Pflanzenbiotechnologie, der Zellkulturtechnik, sowie der Roten Biotechnologie synergetisch. In der Nano- und Biotechnologie steckt außergewöhnliches Potenzial! Nicht zuletzt deshalb stellen sich die Forscher der Herausforderung, in diesem Bereich gemeinsam zu forschen und Schnittstellen zu nutzen, um so bei der Gestaltung neuartiger Ideen und Produkte mitzuwirken, die zukünftig unser alltägliches Leben verändern werden. Im Folgenden werden die verschiedenen Forschungsbereiche kurz zusammenfassend vorgestellt und vorhandene Interaktionen anhand von exemplarisch ausgewählten, aktuellen Forschungsprojekten skizziert. Y1 - 2012 VL - Publ. online PB - Dr. Beyer Internet-Beratung CY - Ober-Ramstadt ER - TY - JOUR A1 - Siqueira, José R. Jr. A1 - Abouzar, Maryam H. A1 - Bäcker, Matthias A1 - Zucolotto, Valtencir A1 - Poghossian, Arshak A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors JF - physica status solidi (a) . 206 (2009), H. 3 Y1 - 2009 SN - 1862-6319 N1 - Special Issue: Engineering of Functional Interfaces (EnFI 08) SP - 462 EP - 467 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Wagner, Torsten A1 - Maris, Rob J. A1 - Ackermann, Hans-Josef A1 - Otto, Ralph A1 - Beging, Stefan A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations JF - Sensors and Actuators B: Chemical . 127 (2007), H. 1 Y1 - 2007 SN - 0925-4005 SP - 217 EP - 223 ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Ingebrandt, S. A1 - Poghossian, Arshak A1 - Zhang, Y. A1 - Vu, X. T. A1 - Moritz, W. A1 - Schöning, Michael Josef T1 - Nanoplate field-effect capacitive (bio-)chemical sensor array based on SOI structure JF - Procedia Chemistry. 1 (2009), H. 1 Y1 - 2009 SN - 1876-6196 N1 - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23 SP - 670 EP - 673 ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Krischer, M. A1 - Leinhos, Marcel A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - An application of field-effect sensors for in-situ monitoring of degradation of biopolymers JF - Sensors and actuators B: Chemical N2 - The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al–p-Si–SiO2–Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13). Y1 - 2015 U6 - https://doi.org/10.1016/j.snb.2014.10.058 SN - 1873-3077 (E-Journal); 0925-4005 (Print) VL - 207, Part B SP - 954 EP - 959 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Christiaens, P. A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Wagner, Torsten A1 - Bijnens, N. A1 - Williams, O. A. A1 - Daenen, M. A1 - Haenen, K. A1 - Schöning, Michael Josef A1 - Wagner, P. T1 - Nanocrystalline diamond-based field-effect capacitive pH sensor JF - Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.) Y1 - 2007 SN - 1-4244-0841-5 N1 - Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon SP - 1891 EP - 1894 PB - IEEE CY - Piscataway ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Ingebrandt, Sven A1 - Platen, Johannes A1 - Offenhäusser, Andreas A1 - Poghossian, Arshak ED - Comini, Elisabetta T1 - Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices JF - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. Y1 - 2006 SN - 9781558998711 IS - paper 0915-R05-04 SP - 89 EP - 94 ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Pedraza, A. M. A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Proc. Eurosensors XXIV, September 5–8, 2010, Linz, Austria SP - 918 EP - 921 ER - TY - JOUR A1 - Digel, Ilya A1 - Kurulgan Demirci, Eylem A1 - Linder, Peter A1 - Kayser, Peter T1 - Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts JF - Medical and Biological Engineering and Computing. 45 (2007), H. 1 Y1 - 2007 SN - 1741-0444 SP - 91 EP - 97 ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Characterization of biodegradable polymers with capacitive field-effect sensors JF - Sensors and actuators B: Chemical N2 - In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. KW - Impedance spectroscopy KW - C–V method KW - Real-time monitoring KW - Poly(d,l-lacticacid) KW - (Bio)degradation KW - Field-effect sensor Y1 - 2012 U6 - https://doi.org/10.1016/j.snb.2012.07.099 SN - 0925-4005 N1 - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" VL - 187 SP - 2 EP - 7 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, M. A1 - Molin, D. G. M. A1 - Akker, N. M. S. van den A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation JF - Procedia Engineering N2 - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system. Y1 - 2015 U6 - https://doi.org/10.1016/j.proeng.2015.08.815 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 948 EP - 951 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Gasparyan, F. V. A1 - Poghossian, Arshak A1 - Vitusevich, S. A. A1 - Petrychuk, M. V. A1 - Sydoruk, V. A. A1 - Surmalyan, A. V. A1 - Siqueira, J. R. A1 - Oliveira, O. N. A1 - Offenhäusser, A. A1 - Schöning, Michael Josef T1 - Low Frequency Noise In Electrolyte-Gate Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers JF - Noise and fluctuations : 20th International Conference on Noise and Fluctuations, ICNF 2009, Pisa, Italy, 14 - 19 June 2009 / ed. Massimo Macucci; Giovanni Basso Y1 - 2009 SN - 9780735406650 N1 - AIP conference proceedings ; 1129 ; International Conference on Noise and Fluctuations ; (20, 2009, Pisa) SP - 133 EP - 136 PB - American Inst. of Physics CY - Melville, NY ER - TY - JOUR A1 - Buniatyan, Vahe V. A1 - Abouzar, Maryam H. A1 - Martirosyan, Norayr W. A1 - Schubert, Jürgen A1 - Gevorgian, Spartak A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique JF - Physica Status Solidi (A). 207 (2010), H. 4 Y1 - 2010 SN - 1862-6300 N1 - Special Issue: Engineering of Functional Interfaces EnFI 2009 SP - 824 EP - 830 ER - TY - JOUR A1 - Staat, Manfred A1 - Fiorini, G. L. A1 - Lensa, W. von A1 - Burgazzi, L. T1 - Reliability Methods for Passive Safety Functions JF - Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations Y1 - 1997 CY - Pisa ER - TY - JOUR A1 - Staat, Manfred A1 - Heitzer, M. T1 - Limit and Shakedown Analysis Using a General Purpose Finite Element Code JF - Proceedings of NAFEMS World Congress '97 on Design, Simulation & Optimisation : reliability & applicability of computational methods ; Stuttgart, Germany, 9 - 11 April 1997 Y1 - 1997 SN - 1-87437-620-4 SP - 522 EP - 533 PB - NAFEMS CY - Glasgow ER - TY - JOUR A1 - Poghossian, Arshak A1 - Abouzar, Maryam H. A1 - Razavi, A. A1 - Bäcker, Matthias A1 - Bijnens, N. A1 - Williams, O. A. A1 - Haenen, K. A1 - Moritz, W. A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Nanocrystalline-diamond thin films with high pH and penicillin sensitivity prepared on a capacitive Si–SiO2 structure JF - Electrochimica Acta. 54 (2009), H. 25 Y1 - 2009 SN - 0013-4686 SP - 5981 EP - 5985 ER - TY - JOUR A1 - Jayaraman, Chandrasekaran A1 - Mummidisetty, Chaitanya Krishna A1 - Loesch, Alexandra A1 - Kaur, Sandi A1 - Hoppe-Ludwig, Shenan A1 - Staat, Manfred A1 - Jayaraman, Arun T1 - Postural and metabolic benefits of using a forearm support walker in older adults with impairments JF - Archives of Physical Medicine and Rehabilitation Y1 - 2019 U6 - https://doi.org/10.1016/j.apmr.2018.10.001 SN - 0003-9993 VL - Volume 100 IS - Issue 4 SP - 638 EP - 647 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Gun, Jenny A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Katz, Evgeny T1 - Field-Effect Nanoparticle-Based Glucose Sensor on a Chip: Amplification Effect of Coimmobilized Redox Species JF - Electroanalysis. 20 (2008), H. 16 Y1 - 2008 SN - 1521-4109 SP - 1748 EP - 1753 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Yoshinobu, T. A1 - Simonis, A. A1 - Ecken, H. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS? JF - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...] Y1 - 2000 SN - 87-89935-50-0 N1 - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen) SP - 27 EP - 30 PB - MIC, Mikroelektronik Centret CY - Lyngby, Denmark ER - TY - JOUR A1 - Staat, Manfred A1 - Heitzer, M. T1 - Direct FEM approach to design-by-analysis of pressurized components JF - Achema 2000 : Sonderausgabe / Linde. [Hrsg.: Linde AG. Red.: Volker R. Leski] Y1 - 2000 SP - 79 EP - 81 PB - Linde AG CY - Wiesbaden ER - TY - JOUR A1 - Honarvarfard, Elham A1 - Gamella, Maria A1 - Channaveerappa, Devika A1 - Darie, Costel C. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny T1 - Electrochemically Stimulated Insulin Release from a Modified Graphene–functionalized Carbon Fiber Electrode JF - Electroanalysis N2 - A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9–10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of −1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species. Y1 - 2017 U6 - https://doi.org/10.1002/elan.201700095 SN - 1521-4109 VL - 29 IS - 6 SP - 1543 EP - 1553 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Molinnus, Denise A1 - Hardt, G. A1 - Käver, L. A1 - Willenberg, H.S. A1 - Kröger, J.-C. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling JF - Sensor and Actuators B: Chemical N2 - A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician. Y1 - 2018 U6 - https://doi.org/10.1016/j.snb.2018.05.136 SN - 0925-4005 VL - 272 SP - 21 EP - 27 PB - Elsevier CY - Amsterdam ER - TY - PAT A1 - Staat, Manfred A1 - Horbach, Andreas A1 - Gatzweiler, Karl-Heinz T1 - Biaxiales Materialprüfsystem und Verfahren zu dessen Anwendung N2 - System und Verfahren zur Durchführung von Messungen biaxialer und kreuzförmiger Zugversuche, wobei ein Weg oder eine Kraft auf eine Materialprobe über mindestens zwei Nadelarme mit Nadeln geleitet wird, die in einem Gehäuse gelagert sind, wobei die Arme und/oder Nadelarme für eine ungehinderte Querkontraktion bei gleichmäßiger Lasteinleitung um eine Achse drehbar gelagert und seitlich auslenkbar sind. Y1 - 2019 N1 - Patent DE102017116067 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schultze, J. W. A1 - Schöning, Michael Josef T1 - Application of a (bio-)chemical sensor (ISFET) for the detection of physical parameters in liquids JF - Electrochimica Acta. 48 (2003), H. 20-22 Y1 - 2003 SP - 3289 EP - 3297 ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Tran, Thanh Ngoc A1 - Tolba, R. H. A1 - Staat, Manfred T1 - Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen JF - International biomechanics Y1 - 2015 U6 - https://doi.org/10.1080/23335432.2015.1049295 SN - 2333-5432 VL - Vol. 2 IS - Iss. 1 SP - 79 EP - 88 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Staat, Manfred A1 - Sponagel, Stefan A1 - Nguyen, Nhu Huynh T1 - Experiment and material model for soft tissue materials JF - Constitutive models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ... Y1 - 2010 SN - 978-0-415-56327-7 SP - 465 EP - 470 PB - CRC Press CY - Boca Raton [u.a.] ER - TY - JOUR A1 - Bäcker, Matthias A1 - Delle, L. A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Zang, Werner A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Electrochemical sensor array for bioprocess monitoring JF - Electrochimica Acta (2011) Y1 - 2011 VL - 56 IS - 26 SP - 9673 EP - 9678 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Näther, Niko A1 - Auger, V. A1 - Poghossian, Arshak A1 - Koudelka-Hep, M. T1 - Miniaturized flow-through cell with integrated capacitive EIS sensors fabricated at wafer level using Si and Su-8 technologies JF - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors Y1 - 2004 N1 - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba) SP - 554 EP - 555 PB - Japan Association of Chemical Sensors CY - Fukuoka ER - TY - JOUR A1 - Beging, Stefan A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Hataihimakul, Sudkanung A1 - Busch, H. A1 - Baldsiefen, G. A1 - Laube, N. A1 - Kleinen, L. A1 - Hosseiny, R. T1 - Feldeffektbasierender Ca2+-sensitiver Sensor für den Einsatz im Nativurin zur Bestimmung des Harnsteinbildungsrisikos JF - Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik Y1 - 2008 SN - 978-3-18-092011-5 N1 - VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008 SP - 775 EP - 782 PB - VDI-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Mourzina, Y. A1 - Mai, T. A1 - Poghossian, Arshak A1 - Ermolenko, Y. A1 - Yoshinobu, T. A1 - Vlasov, Y. A1 - Iwasaki, H. A1 - Schöning, Michael Josef T1 - K+-selective field-effect sensors as transducers for bioelectronic applications JF - Electrochimica Acta. 48 (2003), H. 20-22 Y1 - 2003 SN - 0013-4686 SP - 3333 EP - 3339 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Platen, J. A1 - Schöning, Michael Josef T1 - Towards self-aligned nanostructures by means of layerexpansion technique JF - Electrochimica Acta. 51 (2005), H. 5 Y1 - 2005 SN - 0013-4686 SP - 838 EP - 843 ER - TY - JOUR A1 - Molinnus, Denise A1 - Iken, Heiko A1 - Johnen, Anna Lynn A1 - Richstein, Benjamin A1 - Hellmich, Lena A1 - Poghossian, Arshak A1 - Knoch, Joachim A1 - Schöning, Michael Josef T1 - Miniaturized pH-Sensitive Field-Effect Capacitors with Ultrathin Ta₂O₅ Films Prepared by Atomic Layer Deposition JF - physica status solidi (a) applications and materials science N2 - Miniaturized electrolyte–insulator–semiconductor capacitors (EISCAPs) with ultrathin gate insulators have been studied in terms of their pH-sensitive sensor characteristics: three different EISCAP systems consisting of Al–p-Si–Ta2O5(5 nm), Al–p-Si–Si3N4(1 or 2 nm)–Ta2O5 (5 nm), and Al–p-Si–SiO2(3.6 nm)–Ta2O5(5 nm) layer structures are characterized in buffer solution with different pH values by means of capacitance–voltage and constant capacitance method. The SiO2 and Si3N4 gate insulators are deposited by rapid thermal oxidation and rapid thermal nitridation, respectively, whereas the Ta2O5 film is prepared by atomic layer deposition. All EISCAP systems have a clear pH response, favoring the stacked gate insulators SiO2–Ta2O5 when considering the overall sensor characteristics, while the Si3N4(1 nm)–Ta2O5 stack delivers the largest accumulation capacitance (due to the lower equivalent oxide thickness) and a higher steepness in the slope of the capacitance–voltage curve among the studied stacked gate insulator systems. KW - atomic layer deposition KW - capacitive field-effect sensors KW - pH sensors KW - ultrathin gate insulators Y1 - 2022 U6 - https://doi.org/10.1002/pssa.202100660 SN - 1862-6319 N1 - Corresponding author: Michael J. Schöning VL - 219 IS - 8 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Scheja, Sabrina A1 - Wu, Chunsheng A1 - Keusgen, Michael A1 - Mewes, Dieter A1 - Schöning, Michael Josef T1 - DNA Immobilization and Hybridization Detection by the Intrinsic Molecular Charge Using Capacitive Field-Effect Sensors Modified with a Charged Weak Polyelectrolyte Layer JF - Applied Materials & Interfaces N2 - Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte–insulator–semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance–voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event. Y1 - 2015 U6 - https://doi.org/10.1021/acsami.5b05146 VL - 36 IS - 7 SP - 20068 EP - 20075 PB - American Chemical Society CY - Washington, DC ER - TY - JOUR A1 - Bäcker, Matthias A1 - Raue, Markus A1 - Schusser, Sebastian A1 - Jeitner, C. A1 - Breuer, L. A1 - Wagner, P. A1 - Poghossian, Arshak A1 - Förster, Arnold A1 - Mang, Thomas A1 - Schöning, Michael Josef T1 - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films JF - Physica Status Solidi (a) N2 - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off. Y1 - 2012 U6 - https://doi.org/10.1002/pssa.201100763 SN - 1862-6319 VL - 209 IS - 5 SP - 839 EP - 845 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors T1 - Markierungsfreie Detektion doppelsträngiger DNA Moleküle mit Hilfe von Polyelektrolyt-modifizierten kapazitiven Feldeffekt-Sensoren JF - tm - Technisches Messen N2 - In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA. Y1 - 2017 U6 - https://doi.org/10.1515/teme-2017-0015 VL - 84 IS - 10 SP - 628 EP - 634 PB - De Gruyter CY - Oldenbourg ER - TY - JOUR A1 - Jablonski, Melanie A1 - Poghossian, Arshak A1 - Severin, Robin A1 - Keusgen, Michael A1 - Wege, Christian A1 - Schöning, Michael Josef T1 - Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles JF - Micromachines N2 - Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles. KW - capacitive field-effect sensor KW - plant virus detection KW - tobacco mosaic virus (TMV) KW - TMV adsorption KW - Ta₂O₅ gate Y1 - 2021 U6 - https://doi.org/10.3390/mi12010057 VL - 12 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kurulgan Demirci, Eylem A1 - Demirci, T. A1 - Trzewik, Jürgen A1 - Linder, Peter A1 - Karakulah, G. A1 - Artmann, Gerhard A1 - Sakizli, M. A1 - Temiz Artmann, Aysegül T1 - Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation JF - Cellular and molecular bioengineering. 4 (2011), H. 1 Y1 - 2011 SN - 1865-5025 SP - 46 EP - 55 PB - Springer CY - Berlin ER -