TY - CHAP A1 - Milijaš, Aleksa A1 - Šakić, Bogdan A1 - Marinković, Marko A1 - Butenweg, Christoph A1 - Gams, Matija A1 - Klinkel, Sven ED - Arion, Cristian ED - Scupin, Alexandra ED - Ţigănescu, Alexandru T1 - Effects of prior in-plane damage on out-of-plane response of masonry infills with openings T2 - The Third European Conference on Earthquake Engineering and Seismology N2 - Masonry infill walls are the most traditional enclosure system that is still widely used in RC frame buildings all over the world, particularly in seismic active regions. Although infill walls are usually neglected in seismic design, during an earthquake event they are subjected to in-plane and out-of-plane forces that can act separately or simultaneously. Since observations of damage to buildings after recent earthquakes showed detrimental effects of in-plane and out-of-plane load interaction on infill walls, the number of studies that focus on influence of in-plane damage on out-of-plane response has significantly increased. However, most of the xperimental campaigns have considered only solid infills and there is a lack of combined in-plane and out-of-plane experimental tests on masonry infills with openings, although windows and doors strongly affect seismic performance. In this paper, two types of experimental tests on infills with window openings are presented. The first is a pure out-of-plane test and the second one is a sequential in-plane and out-of-plane test aimed at investigating the effects of existing in-plane damage on outof-plane response. Additionally, findings from two tests with similar load procedure that were carried out on fully infilled RC frames in the scope of the same project are used for comparison. Test results clearly show that window opening increased vulnerability of infills to combined seismic actions and that prevention of damage in infills with openings is of the utmost importance for seismic safety. KW - Seismic loading KW - In-plane load KW - Out-of-plane load KW - Interaction KW - Window opening Y1 - 2022 SN - 978-973-100-533-1 N1 - 3ECEES - Third European Conference on Earthquake Engineering and Seismology, September 4 – September 9, 2022, Bucharest SP - 2747 EP - 2756 ER - TY - CHAP A1 - Riga, Evi A1 - Pitilakis, Kyriazis A1 - Butenweg, Christoph A1 - Apostolaki, Stefania A1 - Karatzetzou, Anna ED - Arion, Cristian ED - Scupin, Alexandra ED - Ţigănescu, Alexandru T1 - Investigating the impact of the new European Seismic Hazard Model ESHM20 on the seismic design and safety control of industrial facilities T2 - The Third European Conference on Earthquake Engineering and Seismology N2 - The seismic performance and safety of major European industrial facilities has a global interest for Europe, its citizens and economy. A potential major disaster at an industrial site could affect several countries, probably far beyond the country where it is located. However, the seismic design and safety assessment of these facilities is practically based on national, often outdated seismic hazard assessment studies, due to many reasons, including the absence of a reliable, commonly developed seismic hazard model for whole Europe. This important gap is no more existing, as the 2020 European Seismic Hazard Model ESHM20 was released in December 2021. In this paper we investigate the expected impact of the adoption of ESHM20 on the seismic demand for industrial facilities, through the comparison of the ESHM20 probabilistic hazard at the sites where industrial facilities are located with the respective national and European regulations. The goal of this preliminary work in the framework of Working Group 13 of the European Association for Earthquake Engineering (EAEE), is to identify potential inadequacies in the design and safety control of existing industrial facilities and to highlight the expected impact of the adoption of the new European Seismic Hazard Model on the design of new industrial facilities and the safety assessment of existing ones. KW - ESHM20, industrial facilities KW - seismic hazard KW - seismic design KW - safety control Y1 - 2022 SN - 978-973-100-533-1 N1 - 3ECEES - Third European Conference on Earthquake Engineering and Seismology, September 4 – September 9, 2022, Bucharest SP - 3261 EP - 3270 ER - TY - CHAP A1 - Pütz, Sebastian A1 - Baier, Ralph A1 - Brauner, Philipp A1 - Brillowski, Florian A1 - Dammers, Hannah A1 - Liehner, Luca A1 - Mertens, Alexander A1 - Rodemann, Niklas A1 - Schneider, Sebastian A1 - Schollemann, Alexander A1 - Steuer-Dankert, Linda A1 - Vervier, Luisa A1 - Gries, Thomas A1 - Leicht-Scholten, Carmen A1 - Nagel, Saskia K. A1 - Piller, Frank T. A1 - Schuh, Günther A1 - Ziefle, Martina A1 - Nitsch, Verena T1 - An interdisciplinary view on humane interfaces for digital shadows in the internet of production T2 - 2022 15th International Conference on Human System Interaction (HSI) N2 - Digital shadows play a central role for the next generation industrial internet, also known as Internet of Production (IoP). However, prior research has not considered systematically how human actors interact with digital shadows, shaping their potential for success. To address this research gap, we assembled an interdisciplinary team of authors from diverse areas of human-centered research to propose and discuss design and research recommendations for the implementation of industrial user interfaces for digital shadows, as they are currently conceptualized for the IoP. Based on the four use cases of decision support systems, knowledge sharing in global production networks, human-robot collaboration, and monitoring employee workload, we derive recommendations for interface design and enhancing workers’ capabilities. This analysis is extended by introducing requirements from the higher-level perspectives of governance and organization. KW - digital twin KW - digital shadow KW - cyber-physical production system KW - human-machine interface Y1 - 2022 SN - 978-1-6654-6823-7 (Print) SN - 978-1-6654-6822-0 (Online) U6 - https://doi.org/10.1109/HSI55341.2022.9869467 SN - 2158-2246 (Print) SN - 2158-2254 (Online) N1 - 15th International Conference on Human System Interaction (HSI), 28-31 July 2022, Melbourne, Australia. PB - IEEE ER - TY - CHAP A1 - Marinković, Marko A1 - Butenweg, Christoph ED - Papadrakakis, Manolis ED - Fragiadakis, Michalis T1 - Experimental and numerical analysis of RC frames with decoupled masonry infills T2 - 7th ECCOMAS Thematic Conference on Computational Methods in Structural Dynamics and Earthquake Engineering N2 - Masonry infill walls are commonly used in reinforced concrete (RC) frame structures, also in seismically active areas, although they often experience serious damage during earthquakes. One of the main reasons for their poor behaviour is the connection to the frame, which is usually constructed using mortar. This paper describes the novel solution for infill/frame connection based on application of elastomeric material between them. The system called INODIS (Innovative Decoupled Infill System) has the aim to postpone the activation of infill in in-plane direction and at the same time to provide sufficient out-of-plane support. First, experimental tests on infilled frame specimens are presented and the comparison of the results between traditionally infilled frames and infilled frames with the INODIS system are given. The results are then used for calibration and validation of numerical model, which can be further employed for investigating the influence of some material parameters on the behaviour of infilled frames with the INODIS system. KW - Earthquake KW - In-plane KW - Out-of-plane KW - Isolation KW - Seismic Y1 - 2019 SN - 978-618-82844-5-6 U6 - https://doi.org/10.7712/120119.7088.18845 SN - 2623-3347 N1 - COMPDYN 2019, 24-26 June 2019, Crete, Greece. SP - 2464 EP - 2479 PB - National Technical University of Athens CY - Athen ER - TY - CHAP A1 - Marinković, Marko A1 - Butenweg, Christoph T1 - Out-of-plane behavior of decoupled masonry infills under seismic loading T2 - Proceedings of the 17th World Conference on Earthquake Engineering N2 - Masonry is used in many buildings not only for load-bearing walls, but also for non-load-bearing enclosure elements in the form of infill walls. Many studies confirmed that infill walls interact with the surrounding reinforced concrete frame, thus changing dynamic characteristics of the structure. Consequently, masonry infills cannot be neglected in the design process. However, although the relevant standards contain requirements for infill walls, they do not describe how these requirements are to be met concretely. This leads in practice to the fact that the infill walls are neither dimensioned nor constructed correctly. The evidence of this fact is confirmed by the recent earthquakes, which have led to enormous damages, sometimes followed by the total collapse of buildings and loss of human lives. Recently, the increasing effort has been dedicated to the approach of decoupling of masonry infills from the frame elements by introducing the gap in between. This helps in removing the interaction between infills and frame, but raises the question of out-of-plane stability of the panel. This paper presents the results of the experimental campaign showing the out-of-plane behavior of masonry infills decoupled with the system called INODIS (Innovative decoupled infill system), developed within the European project INSYSME (Innovative Systems for Earthquake Resistant Masonry Enclosures in Reinforced Concrete Buildings). Full scale specimens were subjected to the different loading conditions and combinations of in-plane and out-of-plane loading. Out-of-plane capacity of the masonry infills with the INODIS system is compared with traditionally constructed infills, showing that INODIS system provides reliable out-of-plane connection under various loading conditions. In contrast, traditional infills performed very poor in the case of combined and simultaneously applied in-plane and out-of-plane loading, experiencing brittle behavior under small in-plane drifts followed by high out-of-plane displacements. Decoupled infills with the INODIS system have remained stable under out-of-plane loads, even after reaching high in-plane drifts and being damaged. KW - in-plane KW - out-of-plane KW - INODIS KW - earthquake KW - connection detail Y1 - 2020 N1 - 17th World Conference on Earthquake Engineering, Sendai, Japan, September 27 to October 2, 2021 N1 - (Die Konferenz war ursprünglich für den 13-18 September 2020 angesetzt) ER - TY - CHAP A1 - Milkova, Kristina A1 - Butenweg, Christoph A1 - Dumova-Jovanoska, Elena T1 - Methodology for development of seismic vulnerability curve for existing unreinforced Masonry buildings T2 - Proceedings of the 17th World Conference on Earthquake Engineering N2 - Seismic behavior of an existing unreinforced masonry building built pre-modern code, located in the City of Ohrid, Republic of North Macedonia has been investigated in this paper. The analyzed school building is selected as an archetype in an ongoing project named “Seismic vulnerability assessment of existing masonry structures in Republic of North Macedonia (SeismoWall)”. Two independent segments were included in this research: Seismic hazard assessment by creating a cite specific response spectra and Seismic vulnerability definition by creating a region - specific series of vulnerability curves for the chosen building topology. A reliable Seismic Hazard Assessment for a selected region is a crucial point for performing a seismic risk analysis of a characteristic building class. In that manner, a scenario – based method that incorporates together the knowledge of tectonic style of the considered region, the active fault characterization, the earth crust model and the historical seismicity named Neo Deterministic approach is used for calculation of the response spectra for the location of the building. Variations of the rupturing process are taken into account in the nucleation point of the rupture, in the rupture velocity pattern and in the istribution of the slip on the fault. The results obtained from the multiple scenarios are obtained as an envelope of the response spectra computed for the cite using the procedure Maximum Credible Seismic Input (MCSI). Capacity of the selected building has been determined by using nonlinear static analysis. MINEA software (SDA Engineering) was used for verification of the structural safety of the chosen unreinforced masonry structure. In the process of optimization of the number of samples, computational cost required in a Monte Carlo simulation is significantly reduced since the simulation is performed on a polynomial response surface function for prediction of the structural response. Performance point, found as the intersection of the capacity of the building and the spectra used, is chosen as a response parameter. Five levels of damage limit states based on the capacity curve of the building are defined in dependency on the yield displacement and the maximum displacement. Maximum likelihood estimation procedure is utilized in the process of vulnerability curves determination. As a result, region specific series of vulnerability curves for the chosen type of masonry structures are defined. The obtained probabilities of exceedance a specific damage states as a result from vulnerability curves are compared with the observed damages happened after the earthquake in July 2017 in the City of Ohrid, North Macedonia. KW - Masonry structures KW - Vulnerability Curves KW - Capacity Curve KW - Neo-Deterministic KW - Seismic Hazard Y1 - 2020 N1 - 17th World Conference on Earthquake Engineering, Sendai, Japan, September 27 to October 2, 2021 N1 - (Die Konferenz war ursprünglich für den 13-18 September 2020 angesetzt) ER - TY - CHAP A1 - Butenweg, Christoph A1 - Bursi, Oreste S. A1 - Nardin, Chiara A1 - Lanese, Igor A1 - Pavese, Alberto A1 - Marinković, Marko A1 - Paolacci, Fabrizio A1 - Quinci, Gianluca T1 - Experimental investigation on the seismic performance of a multi-component system for major-hazard industrial facilities T2 - Conference Proceedings: Pressure Vessels & Piping Conference Vol.5 N2 - Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi-Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behaviour of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behaviour of the test structure and of its relative several installations is investigated. Furthermore, both process components and primary structure interactions are considered and analyzed. Several PGA-scaled artificial ground motions are applied to study the seismic response at different levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the experimental setup of the investigated structure and installations, selected measurement data and describes the obtained damage. Furthermore, important findings for the definition of performance limits, the effectiveness of floor response spectra in industrial facilities will be presented and discussed. KW - industrial facilities KW - piping KW - installations KW - seismic loading KW - earthquakes Y1 - 2021 SN - 9780791885352 U6 - https://doi.org/10.1115/PVP2021-61696 N1 - ASME 2021 Pressure Vessels & Piping Conference, July 13–15, 2021, Virtual, Online PB - American Society of Mechanical Engineers (ASME) CY - New York ER - TY - CHAP A1 - Balaskas, Georgios A1 - Hoffmeister, Benno A1 - Butenweg, Christoph A1 - Pilz, Marco A1 - Bauer, Anna ED - Papadrakakis, Manolis ED - Fragiadakis, Michalis T1 - Earthquake early warning and response system based on intelligent seismic and monitoring sensors embedded in a communication platform and coupled with BIM models T2 - Proceedings of COMPDYN 2021 N2 - This paper describes the concept of an innovative, interdisciplinary, user-oriented earthquake warning and rapid response system coupled with a structural health monitoring system (SHM), capable to detect structural damages in real time. The novel system is based on interconnected decentralized seismic and structural health monitoring sensors. It is developed and will be exemplarily applied on critical infrastructures in Lower Rhine Region, in particular on a road bridge and within a chemical industrial facility. A communication network is responsible to exchange information between sensors and forward warnings and status reports about infrastructures’health condition to the concerned recipients (e.g., facility operators, local authorities). Safety measures such as emergency shutdowns are activated to mitigate structural damages and damage propagation. Local monitoring systems of the infrastructures are integrated in BIM models. The visualization of sensor data and the graphic representation of the detected damages provide spatial content to sensors data and serve as a useful and effective tool for the decision-making processes after an earthquake in the region under consideration. KW - early warning and response system KW - interconnected sensor systems KW - seismic structural damage detection via SHM KW - integration SHM in BIM Y1 - 2021 SN - 978-618-85072-5-8 U6 - https://doi.org/10.7712/120121.8539.18855 SN - 2623-3347 N1 - COMPDYN 2021, 28-30 June 2021, Streamed from Athens, Greece, 8th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering SP - 987 EP - 998 PB - National Technical University of Athens CY - Athen ER - TY - CHAP A1 - Milkova, Kristina A1 - Butenweg, Christoph A1 - Dumova-Jovanoska, Elena T1 - Region-sensitive comprehensive procedure for determination of seismic fragility curves T2 - 1st Croatian Conference on Earthquake Engineering 1CroCEE N2 - Seismic vulnerability estimation of existing structures is unquestionably interesting topic of high priority, particularly after earthquake events. Having in mind the vast number of old masonry buildings in North Macedonia serving as public institutions, it is evident that the structural assessment of these buildings is an issue of great importance. In this paper, a comprehensive methodology for the development of seismic fragility curves of existing masonry buildings is presented. A scenario – based method that incorporates the knowledge of the tectonic style of the considered region, the active fault characterization, the earth crust model and the historical seismicity (determined via the Neo Deterministic approach) is used for calculation of the necessary response spectra. The capacity of the investigated masonry buildings has been determined by using nonlinear static analysis. MINEA software (SDA Engineering) is used for verification of the structural safety of the structures Performance point, obtained from the intersection of the capacity of the building and the spectra used, is selected as a response parameter. The thresholds of the spectral displacement are obtained by splitting the capacity curve into five parts, utilizing empirical formulas which are represented as a function of yield displacement and ultimate displacement. As a result, four levels of damage limit states are determined. A maximum likelihood estimation procedure for the process of fragility curves determination is noted as a final step in the proposed procedure. As a result, region specific series of vulnerability curves for structures are defined. KW - seismic risk KW - seismic vulnerability KW - fragility curves KW - masonry structures Y1 - 2021 U6 - https://doi.org/10.5592/CO/1CroCEE.2021.158 N1 - 1st Croatian Conference on Earthquake Engineering 1CroCEE 2021, 22.–24. März 2021, University of Zagreb Faculty of Civil Engineering, Zagreb, Croatia SP - 121 EP - 128 PB - University of Zagreb CY - Zagreb ER - TY - CHAP A1 - Butenweg, Christoph ED - Kuzmanović, Vladan ED - Ignjatović, Ivan T1 - Integrated approach for monitoring and management of buildings with digital building models and modern sensor technologies T2 - Proceedings of the International Conference Civil Engineering 2021 - Achievements and Visions N2 - Nowadays modern high-performance buildings and facilities are equipped with monitoring systems and sensors to control building characteristics like energy consumption, temperature pattern and structural safety. The visualization and interpretation of sensor data is typically based on simple spreadsheets and non-standardized user-oriented solutions, which makes it difficult for building owners, facility managers and decision-makers to evaluate and understand the data. The solution of this problem in the future are integrated BIM-Sensor approaches which allow the generation of BIM models incorporating all relevant information of monitoring systems. These approaches support both the dynamic visualization of key structural performance parameters, the effective long-term management of sensor data based on BIM and provide a user-friendly interface to communicate with various stakeholders. A major benefit for the end user is the use of the BIM software architecture, which is the future standard anyway. In the following, the application of the integrated BIM-Sensor approach is illustrated for a typical industrial facility as a part of an early warning and rapid response system for earthquake events currently developed in the research project “ROBUST” with financial support by the German Federal Ministry for Economic Affairs and Energy (BMWI). Y1 - 2021 N1 - Civil Engineering 2021 – Achievements and Visions, University of Belgrade, October 25 – 26, 2021 Belgrade, Serbia SP - 67 EP - 75 PB - University of Belgrade CY - Belgrade ER - TY - JOUR A1 - Falkenberg, Fabian A1 - Bott, Michael A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae JF - Frontiers in Microbiology N2 - The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions. Subtilases are divided in several groups and especially subtilisins are of interest as they are used in various industrial sectors. Therefore, we searched for new subtilisin sequences of the family Bacillaceae using a data mining approach. The obtained 1,400 sequences were phylogenetically classified in the context of the subtilase family. This required an updated comprehensive overview of the different groups within this family. To fill this gap, we conducted a phylogenetic survey of the S8 family with characterised holotypes derived from the MEROPS database. The analysis revealed the presence of eight previously uncharacterised groups and 13 subgroups within the S8 family. The sequences that emerged from the data mining with the set filter parameters were mainly assigned to the subtilisin subgroups of true subtilisins, high-alkaline subtilisins, and phylogenetically intermediate subtilisins and represent an excellent source for new subtilisin candidates. Y1 - 2022 U6 - https://doi.org/10.3389/fmicb.2022.1017978 SN - 1664-302X VL - 2022 IS - 13 PB - Frontiers CY - Lausanne ER - TY - JOUR A1 - Haeger, Gerrit A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - A convenient ninhydrin assay in 96-well format for amino acid-releasing enzymes using an air-stable reagent JF - Analytical Biochemistry N2 - An improved and convenient ninhydrin assay for aminoacylase activity measurements was developed using the commercial EZ Nin™ reagent. Alternative reagents from literature were also evaluated and compared. The addition of DMSO to the reagent enhanced the solubility of Ruhemann's purple (RP). Furthermore, we found that the use of a basic, aqueous buffer enhances stability of RP. An acidic protocol for the quantification of lysine was developed by addition of glacial acetic acid. The assay allows for parallel processing in a 96-well format with measurements microtiter plates. Y1 - 2022 U6 - https://doi.org/10.1016/j.ab.2022.114819 SN - 1096-0309 IS - 624 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Welden, Melanie A1 - Severins, Robin A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Bongaerts, Johannes A1 - Siegert, Petra A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor JF - Chemosensors N2 - Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte–insulator–semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin–streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage–current, capacitance–voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution. Y1 - 2022 U6 - https://doi.org/10.3390/chemosensors10060218 SN - 2227-9040 N1 - This article belongs to the Special Issue "Nanostructured Devices for Biochemical Sensing" VL - 10 IS - 6 PB - MDPI CY - Basel ER - TY - CHAP A1 - Welden, Melanie A1 - Severins, Robin A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Siegert, Petra A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors T2 - 2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) N2 - A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy. KW - Tobacco mosaic virus KW - acetoin KW - capacitive field-effect biosensor KW - enzyme immobilization Y1 - 2022 SN - 978-1-6654-5860-3 (Online) SN - 978-1-6654-5861-0 (Print) U6 - https://doi.org/10.1109/ISOEN54820.2022.9789657 N1 - IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 29 May 2022 - 01 June 2022, Aveiro, Portugal. PB - IEEE ER - TY - JOUR A1 - Ojovan, Michael I. A1 - Steinmetz, Hans-Jürgen T1 - Approaches to Disposal of Nuclear Waste JF - Energies N2 - We present a concise mini overview on the approaches to the disposal of nuclear waste currently used or deployed. The disposal of nuclear waste is the end point of nuclear waste management (NWM) activities and is the emplacement of waste in an appropriate facility without the intention to retrieve it. The IAEA has developed an internationally accepted classification scheme based on the end points of NWM, which is used as guidance. Retention times needed for safe isolation of waste radionuclides are estimated based on the radiotoxicity of nuclear waste. Disposal facilities usually rely on a multi-barrier defence system to isolate the waste from the biosphere, which comprises the natural geological barrier and the engineered barrier system. Disposal facilities could be of a trench type, vaults, tunnels, shafts, boreholes, or mined repositories. A graded approach relates the depth of the disposal facilities’ location with the level of hazard. Disposal practices demonstrate the reliability of nuclear waste disposal with minimal expected impacts on the environment and humans. KW - borehole disposal KW - geological disposal KW - disposal facility KW - retention time KW - nuclear waste Y1 - 2022 U6 - https://doi.org/10.3390/en15207804 SN - 1996-1073 N1 - This article belongs to the Special Issue "Treatment of Radioactive Waste and Sustainability Energy" VL - 15 IS - 20 PB - MDPI CY - Basel ER - TY - JOUR A1 - Zhantlessova, Sirina A1 - Savitskaya, Irina A1 - Kistaubayeva, Aida A1 - Ignatova, Ludmila A1 - Talipova, Aizhan A1 - Pogrebnjak, Alexander A1 - Digel, Ilya T1 - Advanced “Green” prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy JF - Polymers N2 - Bacterial cellulose (BC) is a biopolymer produced by different microorganisms, but in biotechnological practice, Komagataeibacter xylinus is used. The micro- and nanofibrillar structure of BC, which forms many different-sized pores, creates prerequisites for the introduction of other polymers into it, including those synthesized by other microorganisms. The study aims to develop a cocultivation system of BC and prebiotic producers to obtain BC-based composite material with prebiotic activity. In this study, pullulan (PUL) was found to stimulate the growth of the probiotic strain Lactobacillus rhamnosus GG better than the other microbial polysaccharides gellan and xanthan. BC/PUL biocomposite with prebiotic properties was obtained by cocultivation of Komagataeibacter xylinus and Aureobasidium pullulans, BC and PUL producers respectively, on molasses medium. The inclusion of PUL in BC is proved gravimetrically by scanning electron microscopy and by Fourier transformed infrared spectroscopy. Cocultivation demonstrated a composite effect on the aggregation and binding of BC fibers, which led to a significant improvement in mechanical properties. The developed approach for “grafting” of prebiotic activity on BC allows preparation of environmentally friendly composites of better quality. KW - coculture KW - pullulan KW - exopolysaccharides KW - prebiotic KW - bacterial cellulose Y1 - 2022 U6 - https://doi.org/10.3390/polym14153224 SN - 2073-4360 N1 - This article belongs to the Special Issue "Cellulose Based Composites" VL - 14 IS - 15 PB - MDPI CY - Basel ER - TY - JOUR A1 - Welden, Melanie A1 - Poghossian, Arshak A1 - Vahidpour, Farnoosh A1 - Wendlandt, Tim A1 - Keusgen, Michael A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers JF - Biosensors N2 - Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1–3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate. KW - urease KW - enzyme-logic gate KW - bi-enzyme biosensor KW - capacitive field-effect sensor KW - tobacco mosaic virus (TMV) KW - penicillinase Y1 - 2022 U6 - https://doi.org/10.3390/bios12010043 SN - 2079-6374 N1 - This article belongs to the Special Issue "Biosensors: 10th Anniversary Feature Papers" VL - 12 IS - 1 PB - MDPI CY - Basel ER - TY - CHAP A1 - Gaigall, Daniel T1 - On Consistent Hypothesis Testing In General Hilbert Spaces T2 - Proceedings of the 4th International Conference on Statistics: Theory and Applications (ICSTA’22) N2 - Inference on the basis of high-dimensional and functional data are two topics which are discussed frequently in the current statistical literature. A possibility to include both topics in a single approach is working on a very general space for the underlying observations, such as a separable Hilbert space. We propose a general method for consistently hypothesis testing on the basis of random variables with values in separable Hilbert spaces. We avoid concerns with the curse of dimensionality due to a projection idea. We apply well-known test statistics from nonparametric inference to the projected data and integrate over all projections from a specific set and with respect to suitable probability measures. In contrast to classical methods, which are applicable for real-valued random variables or random vectors of dimensions lower than the sample size, the tests can be applied to random vectors of dimensions larger than the sample size or even to functional and high-dimensional data. In general, resampling procedures such as bootstrap or permutation are suitable to determine critical values. The idea can be extended to the case of incomplete observations. Moreover, we develop an efficient algorithm for implementing the method. Examples are given for testing goodness-of-fit in a one-sample situation in [1] or for testing marginal homogeneity on the basis of a paired sample in [2]. Here, the test statistics in use can be seen as generalizations of the well-known Cramérvon-Mises test statistics in the one-sample and two-samples case. The treatment of other testing problems is possible as well. By using the theory of U-statistics, for instance, asymptotic null distributions of the test statistics are obtained as the sample size tends to infinity. Standard continuity assumptions ensure the asymptotic exactness of the tests under the null hypothesis and that the tests detect any alternative in the limit. Simulation studies demonstrate size and power of the tests in the finite sample case, confirm the theoretical findings, and are used for the comparison with concurring procedures. A possible application of the general approach is inference for stock market returns, also in high data frequencies. In the field of empirical finance, statistical inference of stock market prices usually takes place on the basis of related log-returns as data. In the classical models for stock prices, i.e., the exponential Lévy model, Black-Scholes model, and Merton model, properties such as independence and stationarity of the increments ensure an independent and identically structure of the data. Specific trends during certain periods of the stock price processes can cause complications in this regard. In fact, our approach can compensate those effects by the treatment of the log-returns as random vectors or even as functional data. Y1 - 2022 U6 - https://doi.org/10.11159/icsta22.157 N1 - 4th International Conference on Statistics: Theory and Applications (ICSTA’22), Prague, Czech Republic – July 28- 30 SP - Paper No. 157 PB - Avestia Publishing CY - Orléans, Kanada ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - Testing marginal homogeneity in Hilbert spaces with applications to stock market returns JF - Test N2 - This paper considers a paired data framework and discusses the question of marginal homogeneity of bivariate high-dimensional or functional data. The related testing problem can be endowed into a more general setting for paired random variables taking values in a general Hilbert space. To address this problem, a Cramér–von-Mises type test statistic is applied and a bootstrap procedure is suggested to obtain critical values and finally a consistent test. The desired properties of a bootstrap test can be derived that are asymptotic exactness under the null hypothesis and consistency under alternatives. Simulations show the quality of the test in the finite sample case. A possible application is the comparison of two possibly dependent stock market returns based on functional data. The approach is demonstrated based on historical data for different stock market indices. Y1 - 2022 U6 - https://doi.org/10.1007/s11749-022-00802-5 SN - 1863-8260 VL - 2022 IS - 31 SP - 749 EP - 770 PB - Springer ER - TY - JOUR A1 - Gaigall, Daniel A1 - Gerstenberg, Julian A1 - Trinh, Thi Thu Ha T1 - Empirical process of concomitants for partly categorial data and applications in statistics JF - Bernoulli N2 - On the basis of independent and identically distributed bivariate random vectors, where the components are categorial and continuous variables, respectively, the related concomitants, also called induced order statistic, are considered. The main theoretical result is a functional central limit theorem for the empirical process of the concomitants in a triangular array setting. A natural application is hypothesis testing. An independence test and a two-sample test are investigated in detail. The fairly general setting enables limit results under local alternatives and bootstrap samples. For the comparison with existing tests from the literature simulation studies are conducted. The empirical results obtained confirm the theoretical findings. KW - bootstrap KW - Categorial variable KW - Concomitant KW - Empirical process KW - Independence test Y1 - 2022 U6 - https://doi.org/10.3150/21-BEJ1367 SN - 1573-9759 VL - 28 IS - 2 SP - 803 EP - 829 PB - International Statistical Institute CY - Den Haag, NL ER - TY - JOUR A1 - Gaigall, Daniel T1 - Test for Changes in the Modeled Solvency Capital Requirement of an Internal Risk Model JF - ASTIN Bulletin N2 - In the context of the Solvency II directive, the operation of an internal risk model is a possible way for risk assessment and for the determination of the solvency capital requirement of an insurance company in the European Union. A Monte Carlo procedure is customary to generate a model output. To be compliant with the directive, validation of the internal risk model is conducted on the basis of the model output. For this purpose, we suggest a new test for checking whether there is a significant change in the modeled solvency capital requirement. Asymptotic properties of the test statistic are investigated and a bootstrap approximation is justified. A simulation study investigates the performance of the test in the finite sample case and confirms the theoretical results. The internal risk model and the application of the test is illustrated in a simplified example. The method has more general usage for inference of a broad class of law-invariant and coherent risk measures on the basis of a paired sample. KW - Bootstrap KW - Empirical process KW - Functional Delta Method KW - Hadamard differentiability KW - Paired sample Y1 - 2021 U6 - https://doi.org/10.1017/asb.2021.20 SN - 1783-1350 VL - 51 IS - 3 SP - 813 EP - 837 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Gaigall, Daniel T1 - Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic on partly not identically distributed data JF - Communications in Statistics - Theory and Methods N2 - The established Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic is investigated for partly not identically distributed data. Surprisingly, it turns out that the statistic has the well-known distribution-free limiting null distribution of the classical criterion under standard regularity conditions. An application is testing goodness-of-fit for the regression function in a non parametric random effects meta-regression model, where the consistency is obtained as well. Simulations investigate size and power of the approach for small and moderate sample sizes. A real data example based on clinical trials illustrates how the test can be used in applications. KW - Brownian Pillow KW - Hoeffding-Blum-Kiefer-Rosenblatt independence test KW - not identically distributed KW - random effects meta-regression model Y1 - 2020 U6 - https://doi.org/10.1080/03610926.2020.1805767 SN - 1532-415X VL - 51 IS - 12 SP - 4006 EP - 4028 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Morandi, Paolo A1 - Butenweg, Christoph A1 - Breis, Khaled A1 - Beyer, Katrin A1 - Magenes, Guido ED - Ansal, Atilla T1 - Latest findings on the behaviour factor q for the seismic design of URM buildings JF - Bulletin of Earthquake Engineering N2 - Recent earthquakes as the 2012 Emilia earthquake sequence showed that recently built unreinforced masonry (URM) buildings behaved much better than expected and sustained, despite the maximum PGA values ranged between 0.20–0.30 g, either minor damage or structural damage that is deemed repairable. Especially low-rise residential and commercial masonry buildings with a code-conforming seismic design and detailing behaved in general very well without substantial damages. The low damage grades of modern masonry buildings that was observed during this earthquake series highlighted again that codified design procedures based on linear analysis can be rather conservative. Although advances in simulation tools make nonlinear calculation methods more readily accessible to designers, linear analyses will still be the standard design method for years to come. The present paper aims to improve the linear seismic design method by providing a proper definition of the q-factor of URM buildings. These q-factors are derived for low-rise URM buildings with rigid diaphragms which represent recent construction practise in low to moderate seismic areas of Italy and Germany. The behaviour factor components for deformation and energy dissipation capacity and for overstrength due to the redistribution of forces are derived by means of pushover analyses. Furthermore, considerations on the behaviour factor component due to other sources of overstrength in masonry buildings are presented. As a result of the investigations, rationally based values of the behaviour factor q to be used in linear analyses in the range of 2.0–3.0 are proposed. KW - Unreinforced masonry buildings KW - Modern constructions KW - Seismic design KW - Linear elastic analysis KW - Behaviour factor q Y1 - 2022 U6 - https://doi.org/10.1007/s10518-022-01419-7 SN - 1573-1456 SN - 1570-761X VL - 20 IS - 11 SP - 5797 EP - 5848 PB - Springer Nature CY - Cham ER - TY - GEN A1 - Topcu, Murat A1 - Madabhushi, Gopal Santana Phani A1 - Staat, Manfred T1 - Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster N2 - Datasets from FEM Simulations done with COMSOL Multiphysics and Code_Aster for an elastic stress transfer between matrix and fibres having a variable radius. KW - Natural fibres KW - Polymer-matrix composites KW - Biocomposites KW - Stress concentrations KW - Finite element analysis (FEA) Y1 - 2022 U6 - https://doi.org/10.6084/m9.figshare.19333295.v2 ER - TY - JOUR A1 - Šakić, Bogdan A1 - Marinković, Marko A1 - Butenweg, Christoph A1 - Klinkel, Sven ED - Yang, J. T1 - Influence of slab deflection on the out-of-plane capacity of unreinforced masonry partition walls JF - Engineering Structures N2 - Severe damage of non-structural elements is noticed in previous earthquakes, causing high economic losses and posing a life threat for the people. Masonry partition walls are one of the most commonly used non-structural elements. Therefore, their behaviour under earthquake loading in out-of-plane (OOP) direction is investigated by several researches in the past years. However, none of the existing experimental campaigns or analytical approaches consider the influence of prior slab deflection on OOP response of partition walls. Moreover, none of the existing construction techniques for the connection of partition walls with surrounding reinforced concrete (RC) is investigated for the combined slab deflection and OOP loading. However, the inevitable time-dependent behaviour of RC slabs leads to high values of final slab deflections which can further influence boundary conditions of partition walls. Therefore, a comprehensive study on the influence of slab deflection on the OOP capacity of masonry partitions is conducted. In the first step, experimental tests are carried out. Results of experimental tests are further used for the calibration of the numerical model employed for a parametric study. Based on the results, behaviour under combined loading for different construction techniques is explained. The results show that slab deflection leads either to severe damage or to a high reduction of OOP capacity. Existing practical solutions do not account for these effects. In this contribution, recommendations to overcome the problems of combined slab deflection and OOP loading on masonry partition walls are given. Possible interaction of in-plane (IP) loading, with the combined slab deflection and OOP loading on partition walls, is not investigated in this study. KW - Masonry partition walls KW - Earthquake KW - Out-of-plane capacity KW - Slab deflection Y1 - 2023 U6 - https://doi.org/10.1016/j.engstruct.2022.115342 SN - 0141-0296 VL - 276 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Welden, Rene A1 - Jablonski, Melanie A1 - Wege, Christina A1 - Keusgen, Michael A1 - Wagner, Patrick Hermann A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase JF - Biosensors N2 - The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte’s pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS. KW - microfluidics KW - enzyme kinetics KW - actuator-sensor system KW - light-addressable electrode KW - light-addressable potentiometric sensor Y1 - 2021 U6 - https://doi.org/10.3390/bios11060171 SN - 2079-6374 N1 - This article belongs to the Special Issue "Selected Papers from the 1st International Electronic Conference on Biosensors (IECB 2020)" VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - CHAP A1 - Taddei, Francesca A1 - Lozana, Lara A1 - Michel, Philipp A1 - Butenweg, Christoph A1 - Klinkel, Sven ED - Papadrakakis, Manolis ED - Papadrakakis, M. ED - Papadopoulos, V. ED - Plevris, V. T1 - Practical recommendations for the foundation design of onshore wind turbines including soil-structure interaction T2 - 5th International Conference on Computational Methods in Structural , Hersonissos, Greece Dynamics and Earthquake Engineering, COMPDYN 2015, 25.05.2015-27.05.2015, Hersonissos, Greece. Y1 - 2015 ER - TY - CHAP A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Pavese, Alberto A1 - Lanese, Igor A1 - Hoffmeister, Benno A1 - Pinkawa, Marius A1 - Vulcu, Mihai-Cristian A1 - Bursi, Oreste A1 - Nardin, Chiara A1 - Paolacci, Fabrizio A1 - Quinci, Gianluca A1 - Fragiadakis, Michalis A1 - Weber, Felix A1 - Huber, Peter A1 - Renault, Philippe A1 - Gündel, Max A1 - Dyke, Shirley A1 - Ciucci, M. A1 - Marino, A. T1 - Seismic performance of multi-component systems in special risk industrial facilities T2 - Proceedings of the seventeenth world conference on earthquake engineering N2 - Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi- Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behavior of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behavior of the test structure and installations is investigated with and without base isolation. Furthermore, both firmly anchored and isolated components are taken into account to compare their dynamic behavior and interactions with each other. Artificial and synthetic ground motions are applied to study the seismic response at different PGA levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the numerical simulations to calibrate the tests on the prototype, the experimental setup of the investigated structure and installations, selected measurement data and finally describes preliminary experimental results. KW - industrial facilities KW - piping KW - installations KW - seismic loading KW - earthquakes Y1 - 2021 N1 - 17. World Conference on Earthquake Engineering, 17WCEE, Sendai, Japan, 2021-09-27 - 2021-10-02 ER - TY - BOOK A1 - Laack, Walter van T1 - Greater Than the Entire Universe Y1 - 2022 SN - 978-3-936624-52-6 PB - van Laack GmbH CY - Aachen ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Bronder, Thomas A1 - Wu, Chunsheng A1 - Scheja, Sabrina A1 - Jessing, Max A1 - Metzger-Boddien, Christoph A1 - Keusgen, Michael A1 - Poghossian, Arshak T1 - Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities JF - Proceedings N2 - Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed. Y1 - 2017 U6 - https://doi.org/10.3390/proceedings1080719 SN - 2504-3900 N1 - This article belongs to the Proceedings of "Proceedings of the 5th International Symposium on Sensor Science (I3S 2017)" VL - 1 IS - 8 SP - Artikel 719 PB - MDPI CY - Basel ER - TY - JOUR A1 - Gaigall, Daniel T1 - Testing marginal homogeneity of a continuous bivariate distribution with possibly incomplete paired data JF - Metrika N2 - We discuss the testing problem of homogeneity of the marginal distributions of a continuous bivariate distribution based on a paired sample with possibly missing components (missing completely at random). Applying the well-known two-sample Crámer–von-Mises distance to the remaining data, we determine the limiting null distribution of our test statistic in this situation. It is seen that a new resampling approach is appropriate for the approximation of the unknown null distribution. We prove that the resulting test asymptotically reaches the significance level and is consistent. Properties of the test under local alternatives are pointed out as well. Simulations investigate the quality of the approximation and the power of the new approach in the finite sample case. As an illustration we apply the test to real data sets. KW - Marginal homogeneity test KW - Crámer–von-Mises distance KW - Paired sample KW - Incomplete data KW - Resampling test Y1 - 2019 U6 - https://doi.org/10.1007/s00184-019-00742-5 SN - 1435-926X VL - 2020 IS - 83 SP - 437 EP - 465 PB - Springer ER - TY - JOUR A1 - Gaigall, Daniel T1 - Rothman–Woodroofe symmetry test statistic revisited JF - Computational Statistics & Data Analysis N2 - The Rothman–Woodroofe symmetry test statistic is revisited on the basis of independent but not necessarily identically distributed random variables. The distribution-freeness if the underlying distributions are all symmetric and continuous is obtained. The results are applied for testing symmetry in a meta-analysis random effects model. The consistency of the procedure is discussed in this situation as well. A comparison with an alternative proposal from the literature is conducted via simulations. Real data are analyzed to demonstrate how the new approach works in practice. Y1 - 2020 U6 - https://doi.org/10.1016/j.csda.2019.106837 SN - 0167-9473 VL - 2020 IS - 142 SP - Artikel 106837 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - On an asymptotic relative efficiency concept based on expected volumes of confidence regions JF - Statistics - A Journal of Theoretical and Applied Statistic N2 - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting. KW - Volume of confidence regions KW - asymptotic relative efficiency KW - likelihood ratio test KW - multivariate normal distribution KW - multinomial distribution Y1 - 2019 U6 - https://doi.org/10.1080/02331888.2019.1683560 SN - 1029-4910 VL - 53 IS - 6 SP - 1396 EP - 1436 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Gaigall, Daniel T1 - On a new approach to the multi-sample goodness-of-fit problem JF - Communications in Statistics - Simulation and Computation N2 - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions. KW - Goodness-of-fit test KW - Multi-sample problem KW - Parametric bootstrap Y1 - 2019 U6 - https://doi.org/10.1080/03610918.2019.1618472 SN - 1532-4141 VL - 53 IS - 10 SP - 2971 EP - 2989 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - A consistent goodness-of-fit test for huge dimensional and functional data JF - Journal of Nonparametric Statistics N2 - A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cramér-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals. KW - Cramér-von-Mises statistic KW - separable Hilbert space KW - huge dimensional data KW - functional data Y1 - 2018 U6 - https://doi.org/10.1080/10485252.2018.1486402 SN - 1029-0311 VL - 30 IS - 4 SP - 834 EP - 859 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel A1 - Thiele, Jan Philipp T1 - Statistical inference for L²-distances to uniformity JF - Computational Statistics N2 - The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study. KW - Integrated empirical distribution (survival) function KW - Goodness-of-fit tests for uniformity KW - Numerical inversion of Laplace transforms KW - Coverage probability KW - Equivalence test Y1 - 2018 U6 - https://doi.org/10.1007/s00180-018-0820-0 SN - 1613-9658 VL - 2018 IS - 33 SP - 1863 EP - 1896 PB - Springer CY - Berlin ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - On Hotelling’s T² test in a special paired sample case JF - Communications in Statistics - Theory and Methods N2 - In a special paired sample case, Hotelling’s T² test based on the differences of the paired random vectors is the likelihood ratio test for testing the hypothesis that the paired random vectors have the same mean; with respect to a special group of affine linear transformations it is the uniformly most powerful invariant test for the general alternative of a difference in mean. We present an elementary straightforward proof of this result. The likelihood ratio test for testing the hypothesis that the covariance structure is of the assumed special form is derived and discussed. Applications to real data are given. KW - complete block symmetry KW - Hotelling’s T² test KW - likelihood ratio test KW - uniformly most powerful invariant test Y1 - 2017 U6 - https://doi.org/10.1080/03610926.2017.1408828 SN - 1532-415X VL - 48 IS - 2 SP - 257 EP - 267 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - Hotelling’s T² tests in paired and independent survey samples: An efficiency comparison JF - Journal of Multivariate Analysis N2 - Hotelling’s T² tests in paired and independent survey samples are compared using the traditional asymptotic efficiency concepts of Hodges–Lehmann, Bahadur and Pitman, as well as through criteria based on the volumes of corresponding confidence regions. Conditions characterizing the superiority of a procedure are given in terms of population canonical correlation type coefficients. Statistical tests for checking these conditions are developed. Test statistics based on the eigenvalues of a symmetrized sample cross-covariance matrix are suggested, as well as test statistics based on sample canonical correlation type coefficients. Y1 - 2017 U6 - https://doi.org/10.1016/j.jmva.2016.11.004 SN - 0047-259X VL - 2017 IS - 154 SP - 177 EP - 198 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dickhoff, Jens A1 - Horikawa, Atsushi A1 - Funke, Harald T1 - Hydrogen Combustion - new DLE Combustor Addresses NOx Emissions and Flashback JF - Turbomachinery international : the global journal of energy equipment Y1 - 2021 SN - 2767-2328 SN - 0149-4147 VL - 62 IS - 4 SP - 26 EP - 27 PB - MJH Life Sciences CY - Cranbury ER - TY - CHAP A1 - Thoma, Andreas A1 - Stiemer, Luc A1 - Braun, Carsten A1 - Fisher, Alex A1 - Gardi, Alessandro G. T1 - Potential of hybrid neural network local path planner for small UAV in urban environments T2 - AIAA SCITECH 2023 Forum N2 - This work proposes a hybrid algorithm combining an Artificial Neural Network (ANN) with a conventional local path planner to navigate UAVs efficiently in various unknown urban environments. The proposed method of a Hybrid Artificial Neural Network Avoidance System is called HANNAS. The ANN analyses a video stream and classifies the current environment. This information about the current Environment is used to set several control parameters of a conventional local path planner, the 3DVFH*. The local path planner then plans the path toward a specific goal point based on distance data from a depth camera. We trained and tested a state-of-the-art image segmentation algorithm, PP-LiteSeg. The proposed HANNAS method reaches a failure probability of 17%, which is less than half the failure probability of the baseline and around half the failure probability of an improved, bio-inspired version of the 3DVFH*. The proposed HANNAS method does not show any disadvantages regarding flight time or flight distance. Y1 - 2023 U6 - https://doi.org/10.2514/6.2023-2359 N1 - AIAA SCITECH 2023 Forum, 23-27 January 2023, National Harbor, Md & Online PB - AIAA CY - Reston, Va. ER - TY - CHAP A1 - Chircu, Alina A1 - Czarnecki, Christian A1 - Friedmann, Daniel A1 - Pomaskow, Johanna A1 - Sultanow, Eldar T1 - Towards a Digital Twin of Society T2 - Proceedings of the 56th Hawaii International Conference on System Sciences 2023 N2 - This paper describes the potential for developing a digital twin of society- a dynamic model that can be used to observe, analyze, and predict the evolution of various societal aspects. Such a digital twin can help governmental agencies and policy makers in interpreting trends, understanding challenges, and making decisions regarding investments or policies necessary to support societal development and ensure future prosperity. The paper reviews related work regarding the digital twin paradigm and its applications. The paper presents a motivating case study- an analysis of opportunities and challenges faced by the German federal employment agency, Bundesagentur f¨ur Arbeit (BA), proposes solutions using digital twins, and describes initial proofs of concept for such solutions. KW - Digital twin KW - Digital transformation KW - Prototype KW - Society KW - Stress testing Y1 - 2023 SN - 978-0-9981331-6-4 N1 - 56th Hawaii International Conference on System Sciences, HICSS 2023, Maui, Hawaii, USA, January 3-6, 2023 SP - 6748 EP - 6757 PB - University of Hawai'i CY - Honolulu ER - TY - JOUR A1 - Gorzalka, Philip A1 - Schmiedt, Jacob Estevam A1 - Schorn, Christian T1 - Automated Generation of an Energy Simulation Model for an Existing Building from UAV Imagery JF - Buildings N2 - An approach to automatically generate a dynamic energy simulation model in Modelica for a single existing building is presented. It aims at collecting data about the status quo in the preparation of energy retrofits with low effort and costs. The proposed method starts from a polygon model of the outer building envelope obtained from photogrammetrically generated point clouds. The open-source tools TEASER and AixLib are used for data enrichment and model generation. A case study was conducted on a single-family house. The resulting model can accurately reproduce the internal air temperatures during synthetical heating up and cooling down. Modelled and measured whole building heat transfer coefficients (HTC) agree within a 12% range. A sensitivity analysis emphasises the importance of accurate window characterisations and justifies the use of a very simplified interior geometry. Uncertainties arising from the use of archetype U-values are estimated by comparing different typologies, with best- and worst-case estimates showing differences in pre-retrofit heat demand of about ±20% to the average; however, as the assumptions made are permitted by some national standards, the method is already close to practical applicability and opens up a path to quickly estimate possible financial and energy savings after refurbishment. KW - Modelica KW - heat transfer coefficient KW - heat demand KW - building energy modelling KW - building energy simulation Y1 - 2021 U6 - https://doi.org/10.3390/buildings11090380 SN - 2075-5309 N1 - This article belongs to the Special Issue "Application of Computer Technology in Buildings" VL - 11 IS - 9 PB - MDPI CY - Basel ER - TY - JOUR A1 - Gaigall, Daniel ED - AitSahlia, Farid T1 - Allocating and forecasting changes in risk JF - Journal of risk N2 - We consider time-dependent portfolios and discuss the allocation of changes in the risk of a portfolio to changes in the portfolio’s components. For this purpose we adopt established allocation principles. We also use our approach to obtain forecasts for changes in the risk of the portfolio’s components. To put the approach into practice we present an implementation based on the output of a simulation. Allocation is illustrated with an example portfolio in the context of Solvency II. The quality of the forecasts is investigated with an empirical study. KW - portfolio risk KW - allocation KW - forecast KW - covariance principle KW - conditional expectation principle Y1 - 2023 U6 - https://doi.org/10.21314/JOR.2022.048 SN - 1755-2842 SN - 1465-1211 VL - 25 IS - 3 SP - 1 EP - 24 PB - Infopro Digital Risk CY - London ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Trinh, Tu Luc A1 - Dao, Ngoc Tien A1 - Giap, Van Tan A1 - Truong, Manh Khuyen A1 - Dinh, Thuy Ha A1 - Staat, Manfred T1 - Limit and shakedown analysis of structures under random strength T2 - Proceedings of (NACOME2022) The 11th National Conference on Mechanics, Vol. 1. Solid Mechanics, Rock Mechanics, Artificial Intelligence, Teaching and Training N2 - Direct methods comprising limit and shakedown analysis is a branch of computational mechanics. It plays a significant role in mechanical and civil engineering design. The concept of direct method aims to determinate the ultimate load bearing capacity of structures beyond the elastic range. For practical problems, the direct methods lead to nonlinear convex optimization problems with a large number of variables and onstraints. If strength and loading are random quantities, the problem of shakedown analysis is considered as stochastic programming. This paper presents a method so called chance constrained programming, an effective method of stochastic programming, to solve shakedown analysis problem under random condition of strength. In this our investigation, the loading is deterministic, the strength is distributed as normal or lognormal variables. KW - Reliability of structures KW - Stochastic programming KW - Chance constrained programming KW - Shakedown analysis KW - Limit analysis Y1 - 2022 SN - 978-604-357-084-7 N1 - 11th National Conference on Mechanics (NACOME 2022), December 2-3, 2022, VNU University of Engineering and Technology, Hanoi, Vietnam SP - 510 EP - 518 PB - Nha xuat ban Khoa hoc tu nhien va Cong nghe (Verlag Naturwissenschaft und Technik) CY - Hanoi ER - TY - JOUR A1 - Gaigall, Daniel T1 - On the applicability of several tests to models with not identically distributed random effects JF - Statistics : A Journal of Theoretical and Applied Statistics N2 - We consider Kolmogorov–Smirnov and Cramér–von-Mises type tests for testing central symmetry, exchangeability, and independence. In the standard case, the tests are intended for the application to independent and identically distributed data with unknown distribution. The tests are available for multivariate data and bootstrap procedures are suitable to obtain critical values. We discuss the applicability of the tests to random effects models, where the random effects are independent but not necessarily identically distributed and with possibly unknown distributions. Theoretical results show the adequacy of the tests in this situation. The quality of the tests in models with random effects is investigated by simulations. Empirical results obtained confirm the theoretical findings. A real data example illustrates the application. KW - central symmetry test KW - exchangeability test KW - independence test KW - random effects KW - not identically distributed Y1 - 2023 SN - 0323-3944 U6 - https://doi.org/10.1080/02331888.2023.2193748 SN - 1029-4910 VL - 57 PB - Taylor & Francis CY - London ER - TY - GEN A1 - Wiegner, J. A1 - Volker, H. A1 - Mainz, F. A1 - Backes, A. A1 - Löken, M. A1 - Hüning, Felix T1 - Wiegand-Effect-Powered Wireless IT Sensor Node N2 - With the growing interest in small distributed sensors for the “Internet of Things”, more attention is being paid to energy harvesting techologies. Reducing or eliminating the need for external power sources or batteries make devices more self-sufficient, more reliable, and reduces maintenance requirements. The Wiegand effect is a proven technology for harvesting small amounts of electrical power from mechanical motion. Y1 - 2022 N1 - PSMA International Energy Harvesting Workshop ~ 5-7 April 2022, Raleigh, NC, USA ER - TY - JOUR A1 - Falkenberg, Fabian A1 - Voß, Leonie A1 - Bott, Michael A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - New robust subtilisins from halotolerant and halophilic Bacillaceae JF - Applied Microbiology and Biotechnology N2 - The aim of the present study was the characterisation of three true subtilisins and one phylogenetically intermediate subtilisin from halotolerant and halophilic microorganisms. Considering the currently growing enzyme market for efficient and novel biocatalysts, data mining is a promising source for novel, as yet uncharacterised enzymes, especially from halophilic or halotolerant Bacillaceae, which offer great potential to meet industrial needs. Both halophilic bacteria Pontibacillus marinus DSM 16465ᵀ and Alkalibacillus haloalkaliphilus DSM 5271ᵀ and both halotolerant bacteria Metabacillus indicus DSM 16189 and Litchfieldia alkalitelluris DSM 16976ᵀ served as a source for the four new subtilisins SPPM, SPAH, SPMI and SPLA. The protease genes were cloned and expressed in Bacillus subtilis DB104. Purification to apparent homogeneity was achieved by ethanol precipitation, desalting and ion-exchange chromatography. Enzyme activity could be observed between pH 5.0–12.0 with an optimum for SPPM, SPMI and SPLA around pH 9.0 and for SPAH at pH 10.0. The optimal temperature for SPMI and SPLA was 70 °C and for SPPM and SPAH 55 °C and 50 °C, respectively. All proteases showed high stability towards 5% (w/v) SDS and were active even at NaCl concentrations of 5 M. The four proteases demonstrate potential for future biotechnological applications. KW - Biotechnological application KW - Bacillaceae KW - Subtilisin KW - Subtilases KW - Halotolerant protease Y1 - 2023 U6 - https://doi.org/10.1007/s00253-023-12553-w SN - 1432-0614 N1 - Corresponding author: Petra Siegert VL - 107 SP - 3939 EP - 3954 PB - Springer Nature CY - Berlin ER - TY - CHAP A1 - Kreyer, Jörg A1 - Esch, Thomas T1 - Simulation Tool for Predictive Control Strategies for an ORCSystem in Heavy Duty Vehicles T2 - European GT Conference 2017 N2 - Scientific questions - How can a non-stationary heat offering in the commercial vehicle be used to reduce fuel consumption? - Which potentials offer route and environmental information among with predicted speed and load trajectories to increase the efficiency of a ORC-System? Methods - Desktop bound holistic simulation model for a heavy duty truck incl. an ORC System - Prediction of massflows, temperatures and mixture quality (AFR) of exhaust gas Y1 - 2017 N1 - European GT Conference 2017, 9.-10. Oktober 2017, Frankfurt a.M. ER - TY - RPRT A1 - Esch, Thomas A1 - Funke, Harald A1 - Roosen, Petra T1 - SIoBiA – Safety Implications of Biofuels in Aviation N2 - Biofuels potentially interesting also for aviation purposes are predominantly liquid fuels produced from biomass. The most common biofuels today are biodiesel and bioethanol. Since diesel engines are rather rare in aviation this survey is focusing on ethanol admixed to gasoline products. The Directive 2003/30/EC of the European Parliament and the Council of May 8th 2003 on the promotion of the use of biofuels or other renewable fuels for transport encourage a growing admixture of biogenic fuel components to fossil automotive gasoline. Some aircraft models equipped with spark ignited piston engines are approved for operation with automotive gasoline, frequently called “MOGAS” (motor gasoline). The majority of those approvals is limited to MOGAS compositions that do not contain methanol or ethanol beyond negligible amounts. In the past years (bio-)MTBE or (bio-)ETBE have been widely used as blending component of automotive gasoline whilst the usage of low-molecular alcohols like methanol or ethanol has been avoided due to the handling problems especially with regard to the strong affinity for water. With rising mandatory bio-admixtures the conversion of the basic biogenic ethanol to ETBE, causing a reduction of energetic payoff, becomes more and more unattractive. Therefore the direct ethanol admixture is accordingly favoured. Due to the national enforcements of the directive 2003/30/EC more oxygenates produced from organic materials like bioethanol have started to appear in automotive gasolines already. The current fuel specification EN 228 already allows up to 3 % volume per volume (v/v) (bio-)methanol or up to 5 % v/v (bio-)ethanol as fuel components. This is also roughly the amount of biogenic components to comply with the legal requirements to avoid monetary penalties for producers and distributors of fuels. Since automotive fuel is cheaper than the common aviation gasoline (AVGAS), creates less problems with lead deposits in the engine, and in general produces less pollutants it is strongly favoured by pilots. But being designed for a different set of usage scenarios the use of automotive fuel with low molecular alcohols for aircraft operation may have adverse effects in aviation operation. Increasing amounts of ethanol admixtures impose various changes in the gasoline’s chemical and physical properties, some of them rather unexpected and not within the range of flight experiences even of long-term pilots. Y1 - 2010 N1 - Analysis of the safety implications of the use of biofuels (ethanol admixture) for piston engines and general aviation aircraft and assessment of potential environmental benefits. PB - EASA CY - Köln ER - TY - JOUR A1 - Esch, Thomas T1 - Trends in commercial vehicle powertrains JF - ATZautotechnology N2 - Low emission zones and truck bans, the rising price of diesel and increases in road tolls: all of these factors are putting serious pressure on the transport industry. Commercial vehicle manufacturers and their suppliers are in the process of identifying new solutions to these challenges as part of their efforts to meet the EEV (enhanced environmentally friendly vehicle) limits, which are currently the most robust European exhaust and emissions standards for trucks and buses. KW - European Transient Cycle KW - Common Rail Injection System KW - Commercial Vehicle KW - Selective Catalytic Reduction KW - Diesel Engine Y1 - 2010 U6 - https://doi.org/10.1007/BF03247185 SN - 2192-886X VL - 2010 IS - 10 SP - 26 EP - 31 PB - Vieweg & Sohn CY - Wiesbaden ER -