TY - JOUR A1 - Dashevsky, Alexey V. A1 - Lanzl, Ines M. A1 - Kotliar, Konstantin T1 - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal JF - Graefe's Archive for Clinical and Experimental Ophthalmology Y1 - 2011 SN - 0721-832x VL - 249 IS - 4 SP - 565 EP - 573 PB - Springer CY - Berlin ER - TY - JOUR A1 - Baumann, Marcus A1 - Schwarz, Sonja A1 - Kotliar, Konstantin A1 - Eynatten, Maximilian von A1 - Trucksaess, Arno A1 - Burckhardt, Klaus A1 - Lutz, Jens A1 - Heemann, Uwe A1 - Lanzl, Ines T1 - Non-diabetic chronic kidney disease influences retinal microvasculature JF - Kidney and Blood Pressure Research Y1 - 2009 SN - 1423-0143 VL - 32 IS - 6 SP - 428 EP - 433 PB - - ER - TY - JOUR A1 - Hanssen, H. A1 - Nickel, T. A1 - Drexel, V. A1 - Hertel, G. A1 - Emslander, I. A1 - Sisic, Z. A1 - Lorang, D. A1 - Schuster, T. A1 - Kotliar, Konstantin A1 - Pressler, A. A1 - Schmidt-Trucksäss, A. A1 - Weis, M. A1 - Halle, M. T1 - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity JF - Atherosclerosis Y1 - 2011 SN - 0021-9150 VL - 216 IS - 2 SP - 433 EP - 439 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Burkhardt, Klaus A1 - Schwarz, Sonja A1 - Pan, Chengrui A1 - Stelter, Felix A1 - Kotliar, Konstantin A1 - Eynatten, Maxilian von A1 - Sollinger, Daniel A1 - Lanzl, Ines A1 - Heemann, Uwe A1 - Baumann, Marcus T1 - Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy JF - Cardiovascular Diabetology Y1 - 2009 SN - 1475-2840 VL - 8 IS - 10 SP - 1 EP - 8 PB - - ER - TY - JOUR A1 - Garhofer, Gerhard A1 - Bek, Toke A1 - Boehm, Andreas G. A1 - Gherghel, Doina A1 - Grundwald, Juan A1 - Jeppesen, Peter A1 - Kergoat, Hélène A1 - Kotliar, Konstantin A1 - Lanzl, Ines A1 - Lovasik, John V. A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Orgul, Selim A1 - Schmetterer, Leopold T1 - Use of the retinal vessel analyzer in ocular blood flow research JF - Acta Ophthalmol N2 - The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, the commercially available retinal vessel analyzer. This report is intended to provide informed guidelines for measuring ocular blood flow with this system. The report describes the principles underlying the method and the instruments currently available, and discusses clinical protocol and the specific parameters measured by the system. Unresolved questions and the possible limitations of the technique are also discussed. Y1 - 2010 U6 - https://doi.org/10.1111/j.1755-3768.2009.01587.x SN - 1755-3768 VL - 88 IS - 7 SP - 717 EP - 722 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Kozlova, Tatiana V. A1 - Lanzl, Ines M. T1 - Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations JF - Biomedizinische Technik = Biomedical Engineering Y1 - 2009 SN - 1862-278X VL - 54 IS - 1 SP - 14 EP - 22 PB - - ER - TY - JOUR A1 - Seidova, Seid-Fatima A1 - Kotliar, Konstantin A1 - Foerger, Frauke A1 - Klopfer, Matthias A1 - Lanzl, Ines T1 - Functional retinal changes in Gaucher disease JF - Documenta Ophthalmologica Y1 - 2009 SN - 1573-2622 VL - 118 IS - 2 SP - 151 EP - 154 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines M. A1 - Maier, Mathias A1 - Feucht, Nikolaus T1 - Intraocular pressure effects of pegaptanib (macugen) injections in patients with and without glaucoma / Lanzl, Ines M. ; Maier, Mathias ; Feucht, Nikolaus ; Lohmann, Chris P. ; Kotliar, Konstantin E. JF - American Journal of Ophthalmology . 145 (2008), H. 1 Y1 - 2008 SN - 1879-1891 SP - 185 EP - 185 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, Walthatd A1 - Nagel, Edgar A1 - Lanzl, Ines M. T1 - Retinal vessel reaction in response to chromatic flickering light / Kotliar, Konstantin E. ; Vilser, Walthard ; Nagel, Edgar ; Lanzl, Ines M. JF - Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5 Y1 - 2004 SN - 1435-702X SP - 377 EP - 392 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Bauer, S. M. A1 - Zamuraev, L. A. T1 - Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E. JF - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2 Y1 - 2006 SN - 1812-5123 SP - 41 EP - 47 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Koshitz, I. N. A1 - Svetlova, O. V. A1 - Zaseeva, M. V. T1 - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli JF - Glaukoma (2006) Y1 - 2006 N1 - Original in Russisch SP - 35 EP - 53 PB - - ER - TY - JOUR A1 - Maggakis-Kelemen, C. A1 - Bork, M. A1 - Kayser, Peter A1 - Biselli, Manfred A1 - Artmann, Gerhard T1 - Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells JF - Medical and biological engineering and computing. 41 (2003), H. 3 Y1 - 2003 SN - 0140-0118 SP - 350 EP - 356 ER - TY - JOUR A1 - Tran, Thanh Ngoc A1 - Pham, Phu Tinh A1 - Vu, D. K. A1 - Staat, Manfred T1 - Reliability Analysis of Inelastic Shell Structures Under Variable Loads JF - Limit States of Materials and Structures : Direct Methods / Hrsg. Dieter Weichert; Hrsg. Alan Ponter Y1 - 2009 SN - 978-1-4020-9633-4 SP - 135 EP - 156 PB - Springer Netherland CY - Berlin ER - TY - JOUR A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Zerlin, Kay A1 - Maggakis-Kelemen, Christina A1 - Linder, Peter A1 - Porst, Dariusz A1 - Kayser, Peter A1 - Stadler, David A1 - Dikta, Gerhard A1 - Temiz Artmann, Aysegül T1 - Hemoglobin senses body temperature JF - European Biophysics Journal Y1 - 2009 SN - 0175-7571 VL - 38 IS - 5 SP - 589 EP - 600 ER - TY - JOUR A1 - Kaul, D. K. A1 - Koshkaryev, A. A1 - Artmann, Gerhard A1 - Barshtein, G. A1 - Yedgar, S. T1 - Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance JF - American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4 Y1 - 2008 SN - 1522-1539 VL - 295 IS - 4 SP - H1788 EP - H1793 ER - TY - JOUR A1 - Stadler, A. M. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Embs, Jan P. A1 - Zaccai, Joe A1 - Büldt, Georg T1 - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature JF - Biophysical Journal. 95 (2008), H. 11 Y1 - 2008 SN - 1542-0086 SP - 5449 EP - 5461 ER - TY - JOUR A1 - Eschweiler, J. A1 - Laack, Walter van A1 - Staat, Manfred T1 - Elektromyographische Untersuchungen zur Kräftigung der Oberschenkelmuskulatur mit einem myoelektrischen Stimulator nach arthroskopischen Eingriffen am Kniegelenk JF - Orthopädische Praxis. 43 (2007), H. 10 Y1 - 2007 SN - 0030-588x SP - 539 EP - 542 ER - TY - JOUR A1 - Scholz, A. A1 - Ley, Wilfried A1 - Dachwald, Bernd A1 - Miau, J. J. A1 - Juang, J. C. T1 - Flight results of the COMPASS-1 picosatellite mission JF - Acta Astronautica. 67 (2010), H. 9-10 Y1 - 2010 SN - 0094-5765 SP - 1289 EP - 1298 ER - TY - JOUR A1 - Dachwald, Bernd A1 - Seboldt, Wolfgang T1 - Solar sailcraft of the first generation mission applications to near-earth asteroids Y1 - 2003 N1 - 54th International Astronautical Congress of the International Astronautical Federation, the International Academy of Astronautics, and the International Institute of Space Law 29 September - 3 October 2003, Bremen, Germany IAC-03-Q.5.06 ER - TY - JOUR A1 - Dachwald, Bernd A1 - Seboldt, Wolfgang T1 - Solar sailcraft of the first generation technology development / Seboldt, Wolfgang ; Dachwald, Bernd Y1 - 2003 N1 - 54th International Astronautical Congress of the International Astronautical Federation, the International Academy of Astronautics, and the International Institute of Space Law 29 September - 3 October 2003, Bremen, Germany IAC-03-S.03 ER - TY - JOUR A1 - Linden, A. A1 - Fischöder, M. A1 - Laack, Walter van A1 - Staat, Manfred T1 - Einschränkung von Taluskippung und -vorschub durch Sprunggelenkorthesen nach fibularer Bandruptur JF - OUP Zeitschrift für die orthopädische und unfallchirurgische Praxis N2 - Die fibulare Bandruptur zählt zu einer der am häufigsten auftretenden Verletzungen des Bewegungsapparats. In den meisten Fällen wird heute die konservativ frühfunktionelle Therapie mit Sprunggelenkorthesen allgemein bevorzugt. Im Rahmen der vorliegenden Studie wurden 14 verschiedene Sprunggelenkorthesen im Hinblick auf ihre Einschränkung von Taluskippung und Talusvorschub untersucht. Zur Simulation einer fibularen Bandruptur wurde ein Unterschenkelmodell aus Holz mit Fußteil, mit angelegten Orthesen in einen Scheuba-Halteapparat eingespannt und mit 150 N seitlich sowie anterior-posterior belastet. Anhand der erstellten "gehaltenen" Röntgenaufnahmen konnten Taluskippung und Talusvorschub jeder einzelnen Orthese eindeutig bestimmt werden. Die meisten Orthesen erreichten zufriedenstellende Ergebnisse. Es stellte sich heraus, dass vor allem eine eng anliegende, im Gelenkbereich anatomisch angepasste Form vorteilhaft zu sein scheint. N2 - The ankle sprain is actually one of the most common injuries. Nowadays the conservative pre-functional therapy with ankle braces is generally preferred. In the present study 14 different ankle braces were tested with regard to their ability to constrict the talar tilt and anterior drawer displacement. As part of the tests a wooden model of a foot was used in order to simulate an ankle sprain. This model was clamped in a Scheuba-device with different ankle braces and a force of 150 N was applied to it. The stress radiographs showed different talar tilts and anterior drawers of each brace. Most ankle braces achieved a satisfying result. It has become obvious that a tight fitting and an anatomically designed shape seem to be favourable. T2 - Constraint of talar tilt and anterior drawer by different ankle braces after the rupture of fibular ligaments KW - Sprunggelenkorthesen KW - fibulare Bandruptur KW - Distorsion des oberen Sprunggelenks KW - ankle sprain KW - rupture of the fibular ligament KW - ankle braces Y1 - 2013 SN - 2193-5785 U6 - https://doi.org/10.3238/oup.2013.0306-0309 VL - 2 IS - 6 SP - 306 EP - 309 PB - Deutscher Ärzte-Verl. CY - Köln ER - TY - JOUR A1 - Staat, Manfred T1 - Limit and shakedown analysis under uncertainty JF - International journal of computational methods : IJCM Y1 - 2013 SN - 0219-8762 SP - Publ. online PB - World Scientific Publishing CY - Singapore ER - TY - CHAP A1 - Frotscher, Ralf A1 - Goßmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM T2 - 1st International Conference "Shell and Membrane Theories in Mechanics and Biology: From Macro- to Nanoscale Structures", Minsk, Belarus, Sept. 16-20, 2013 Y1 - 2013 SN - 978-985-553-135-8 SP - 165 EP - 167 PB - Verl. d. Weißruss. Staatl. Univ. CY - Minsk ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - Shakedown analysis of Reissner-Mindlin plates using the edge-based smoothed finite element method T2 - Direct methods for limit states in structures and materials / Dieter Weichert ; Alan Ponter, ed. N2 - This paper concerns the development of a primal-dual algorithm for limit and shakedown analysis of Reissner-Mindlin plates made of von Mises material. At each optimization iteration, the lower bound of the shakedown load multiplier is calculated simultaneously with the upper bound using the duality theory. An edge-based smoothed finite element method (ES-FEM) combined with the discrete shear gap (DSG) technique is used to improve the accuracy of the solutions and to avoid the transverse shear locking behaviour. The method not only possesses all inherent features of convergence and accuracy from ES-FEM, but also ensures that the total number of variables in the optimization problem is kept to a minimum compared with the standard finite element formulation. Numerical examples are presented to demonstrate the effectiveness of the present method. Y1 - 2014 SN - 978-94-007-6826-0 (Print) 978-94-007-6827-7 (Online) U6 - https://doi.org/10.1007/978-94-007-6827-7_5 SP - 101 EP - 117 PB - Springer CY - Dordrecht [u.a.] ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Flight style optimization in ski jumping on normal, large, and ski flying hills JF - Journal of biomechanics Y1 - 2013 SN - 1873-2380 (E-Journal); 0021-9290 (Print) N1 - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716-722] Journal of Biomechanics, 2018;71:313. VL - Vol. 47 IS - Iss. 3 SP - 716 EP - 722 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Kotliar, Konstantin T1 - Pathophysiologische Beurteilung und hämodynamische Analyse von mikrostrukturellen Veränderungen des retinalen Gefäßlängsschnittsprofils Y1 - 2012 N1 - Moskau, Habil.-Schr. ,Russ. Univ., Med. Fakultät, 2012. Originaltitel in Russisch. ER - TY - CHAP A1 - Lanzl, I. A1 - Seidova, S.-F. A1 - Dühring, C. von A1 - Kotliar, Konstantin ED - Erb, Carl T1 - Befunde der dynamischen Gefäßanalyse am Auge bei Gesunden und Glaukom-Patienten mit praxisrelevanter Bedeutung T2 - Mikrozirkulation beim Glaukom Y1 - 2009 N1 - Search on Glaucoma SP - 33 EP - 39 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Micili, Serap C. A1 - Valter, Markus A1 - Oflaz, Hakan A1 - Ozogul, Candan A1 - Linder, Peter A1 - Föckler, Nicole A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes JF - Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine Y1 - 2013 SN - 0046-2039 (Print) ; 2041-3033 (E-Journal) VL - Vol. 227 IS - No. 4 SP - 393 EP - 401 PB - Sage CY - London ER - TY - JOUR A1 - Krämer, Stefan A1 - Daab, Dominique Jonas A1 - Müller, Brigitte A1 - Wagner, Tobias A1 - Baader, Fabian A1 - Hessel, Joana A1 - Gdalewitsch, Georg A1 - Plescher, Engelbert A1 - Dachwald, Bernd A1 - Wahle, Michael A1 - Gierse, Andreas A1 - Vetter, Rudolf A1 - Pfützenreuter, Lysan T1 - Development and flight-testing of a system to isolate vibrations for microgravity experiments on sounding rockets JF - 21st ESA Symposium on Rocket and Balloon Research Y1 - 2013 SP - 1 EP - 8 ER - TY - JOUR A1 - Jiminez German, Salvador A1 - Behbahani, Mehdi A1 - Miettinen, Susanna A1 - Grijpma, Dirk W. A1 - Haimi, Suvi P. T1 - Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes JF - Macromolecular symposia Y1 - 2013 SN - 0258-0322 VL - Vol. 334 IS - Iss. 1 SP - 133 EP - 142 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Arinkin, Vladimir A1 - Digel, Ilya A1 - Porst, Dariusz A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application JF - BMC bioinformatics N2 - Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1% and reached 100% in one of the best ANN. Y1 - 2014 U6 - https://doi.org/10.1186/1471-2105-15-55 SN - 1471-2105 VL - 15 IS - 55 SP - 1 EP - 8 ER - TY - JOUR A1 - Pham, Phu Tinh A1 - Staat, Manfred T1 - FEM-based shakedown analysis of hardening structures JF - Asia Pacific journal on computational engineering N2 - This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature. Y1 - 2014 U6 - https://doi.org/10.1186/2196-1166-1-4 SN - 2196-1166 (E-Journal) IS - 1 SP - Article No. 4 PB - SpringerOpen CY - Berlin ER - TY - JOUR A1 - Fuest, Matthias A1 - Kotliar, Konstantin A1 - Walter, Peter A1 - Plange, Niklas T1 - Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry JF - Ophthalmic and physiological optics Y1 - 2014 U6 - https://doi.org/10.1111/opo.12134 SN - 1475-1313 (E-Journal); 0275-5408 (Print) N1 - Special Issue: The Ageing Visual System VL - 34 IS - 4 SP - 438 EP - 444 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Turaliyeva, M. A1 - Yeshibaev, A. A1 - Digel, Ilya A1 - Elibayeva, G. A1 - Sydykova, A. A1 - Uspabayeva, A. A1 - Dosybayeva, G. A1 - Zhylysbayeva, A. A1 - Lakhanova, K. T1 - Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L JF - Life science journal N2 - The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium – F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 % respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens. Y1 - 2014 U6 - https://doi.org/10.7537/marslsj1105s14.33 SN - 1097-8135 VL - 11 IS - Spec. iss. 5s SP - 171 EP - 175 PB - Marsland Press CY - New York ER - TY - CHAP A1 - Frotscher, Ralf A1 - Koch, Jan-Peter A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Onate, E. T1 - Evaluation of a computational model for drug action on cardiac tissue T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - CHAP A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram ED - Onate, E. T1 - Optimization of the flight style in ski jumping T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona Y1 - 2014 N1 - Das Paper wurde nach der Konferenz überarbeitet. SP - 799 EP - 810 ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Frotscher, Ralf A1 - Sora, M.-C. A1 - Staat, Manfred ED - Onate, E. T1 - A 3D finite element model of the female pelvic floor for the reconstruction of urinary incontinence T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred ED - Onate, E. T1 - Uncertain multimode failure and limit analysis of shells T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Staat, Manfred ED - Onate, E. T1 - A face-based smoothed finite element method for hyperelastic models and tissue growth T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Staat, Manfred A1 - Stavroulakis, G. E. ED - Onate, E. T1 - A multicriteria method for truss optimization T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - JOUR A1 - Mansurov, Z. A. A1 - Jandosov, J. M. A1 - Kerimkulova, A. R. A1 - Azat, S. A1 - Zhubanova, A. A. A1 - Digel, Ilya A1 - Savistkaya, I. S. A1 - Akimbekov, Nuraly S. A1 - Kistaubaeva, A. S. T1 - Nanostructured carbon materials for biomedical use JF - Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences N2 - One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials. Y1 - 2014 U6 - https://doi.org/10.18321/ectj224 SN - 1562-3920 VL - 15 (2013) IS - 3 SP - 209 EP - 217 PB - Institute of Combustion Problems CY - Almaty ER - TY - JOUR A1 - Ciobanu, Octavian A1 - Staat, Manfred A1 - Rahimi, Alireza T1 - The use of open source software in biomechanical finite element analysis JF - Buletinul Institutului Politehnic din Iaşi / Universitatea Tehnică Gh. Asachi, Iaşi Secţia 5, Construcţii de maşini = Machine construction = Bulletin of the Polytechnic Institute of Jassy = Izvestija Jasskogo Politechničeskogo Instituta Y1 - 2008 SN - 1011-2855 VL - 54 IS - 7/8 SP - 213 EP - 220 ER - TY - JOUR A1 - Seifarth, Volker A1 - Goßmann, Matthias A1 - Grosse, J. O. A1 - Becker, C. A1 - Heschel, I. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds JF - Urologia Internationalis Y1 - 2015 U6 - https://doi.org/10.1159/000368419 SN - 0042-1138 VL - 2015 IS - 95 SP - 106 EP - 113 PB - Karger CY - Basel ER - TY - JOUR A1 - Cehreli, Ruksan A1 - Akpinar, Hale A1 - Temiz Artmann, Aysegül A1 - Sagol, Ozgul T1 - Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis JF - Gastroenterology Research Y1 - 2015 U6 - https://doi.org/10.14740/gr683w SN - 1918-2813 VL - 8 IS - 5 SP - 265 EP - 273 ER - TY - CHAP A1 - Peloni, Alessandro A1 - Ceriotti, Matteo A1 - Dachwald, Bernd T1 - Solar-Sailing Trajectory Design for Close-up NEA Observations Mission T2 - 4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy Y1 - 2015 N1 - IAA-PDC-15-P-19 ER - TY - CHAP A1 - Frotscher, Ralf A1 - Duong, Minh Tuan A1 - Staat, Manfred T1 - Simulating beating cardiomyocytes with electromechanical coupling T2 - II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.) Y1 - 2015 SP - 1 EP - 2 ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues JF - Asia pacific journal on computational engineering Y1 - 2015 U6 - https://doi.org/10.1186/s40540-015-0015-x SN - 2196-1166 VL - 2 IS - 3 (December 2015) SP - 1 EP - 18 ER - TY - JOUR A1 - Goßmann, Matthias A1 - Frotscher, Ralf A1 - Linder, Peter A1 - Bayer, Robin A1 - Epple, U. A1 - Staat, Manfred A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells JF - Cellular physiology and biochemistry N2 - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential. KW - Inotropic compounds KW - Pharmacology KW - Ion channels KW - CellDrum KW - Heart tissue culture KW - Induced pluripotent stem cells KW - Cardiac myocytes Y1 - 2016 U6 - https://doi.org/10.1159/000443124 SN - 1421-9778 (Online) SN - 1015-8987 (Print) VL - 38 IS - 3 SP - 1182 EP - 1198 PB - Karger CY - Basel ER - TY - JOUR A1 - Frotscher, Ralf A1 - Muanghong, Danita A1 - Dursun, Gözde A1 - Goßmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue JF - Journal of Biomechanics N2 - We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures. KW - hiPS cardiomyocytes KW - Homogenization KW - Hodgkin–Huxley models KW - Frequency adaption KW - Electromechanical modeling KW - Drug simulation KW - Computational biomechanics KW - Cardiac tissue Y1 - 2016 U6 - https://doi.org/10.1016/j.jbiomech.2016.01.039 SN - 0021-9290 (Print) SN - 1873-2380 (Online) VL - 49 IS - 12 SP - 2428 EP - 2435 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Effect of wind on flight style optimisation in ski jumping T2 - 15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK Y1 - 2016 SP - 53 EP - 54 PB - The University of Edinburgh ; Loughborough University CY - Edinburgh ER -