TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hanssen, Henner
A1  - Eberhardt, Karla
A1  - Vilser, Walthard
A1  - Schmaderer, Christoph
A1  - Halle, Martin
A1  - Heemann, Uwe
A1  - Baumann, M.
T1  - Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects
JF  - Microcirculation
Y1  - 2013
SN  - 1549-8719
N1  - Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
PB  - Wiley
CY  - Malden
ER  - 
TY  - JOUR
A1  - Feucht, Nikolaus
A1  - Schönbach, Etienne Michael
A1  - Lanzl, Ines
A1  - Kotliar, Konstantin
A1  - Lohmann, Chris Patrick
A1  - Maier, Mathias
T1  - Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease
JF  - Clinical Ophthalmology
Y1  - 2013
SN  - 1177-5483
VL  - 7
SP  - 173
EP  - 178
PB  - Dove Medical Press
CY  - Auckland, New Zealand
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines M.
T1  - Can vascular function be assessed by the interpretation of retinal vascular diameter changes?
JF  - Investigative Ophthalmology & Visual Science, IOVS. 52 (2011), H. 1
Y1  - 2011
SN  - 0146-0404
SP  - 635
EP  - 636
PB  - ARVO
CY  - Rockville, Md.
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Mücke, Bruno
A1  - Vilser, Walthard
A1  - Schilling, Rudolf
T1  - Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; Mücke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M.
JF  - Investigative Ophthalmology & Visual Science, IOVS. 49 (2008), H. 5
Y1  - 2008
SN  - 0146-0404
SP  - 2094
EP  - 2102
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines M.
A1  - Hanssen, Henner
A1  - Eberhardt, Karla
A1  - Vilser, Walthard
A1  - Halle, Martin
A1  - Heemann, Uwe
A1  - Schmidt-Trucksäss, Arno
A1  - Baumann, Marcus
T1  - Does increased blood pressure rather than aging influence retinal pulse wave velocity?
JF  - Investigative Ophthalmology & Visual Science, IOVS
N2  - Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself.

Methods: A total of 12 young 25.5-year-old (24.0–28.8) [median(1st quartile–3rd quartile)] and 12 senior 68.5-year-old (63.8–71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8–65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5–35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated.

Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280–500] RU/s) and in validated healthy seniors (400 [320–510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains.

Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.
Y1  - 2012
U6  - http://dx.doi.org/10.1167/iovs.11-8815
SN  - 0146-0404
VL  - 53
IS  - 4
SP  - 2119
EP  - 2126
PB  - ARVO
CY  - Rockville, Md.
ER  - 
TY  - JOUR
A1  - Hanssen, H.
A1  - Nickel, T.
A1  - Drexel, V.
A1  - Hertel, G.
A1  - Emslander, I.
A1  - Sisic, Z.
A1  - Lorang, D.
A1  - Schuster, T.
A1  - Kotliar, Konstantin
A1  - Pressler, A.
A1  - Schmidt-Trucksäss, A.
A1  - Weis, M.
A1  - Halle, M.
T1  - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity
JF  - Atherosclerosis
Y1  - 2011
SN  - 0021-9150
VL  - 216
IS  - 2
SP  - 433
EP  - 439
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlowa, O. V.
A1  - Makarov, F. N.
T1  - Biomechanical analysis of traditional and contemporary conceptions on pathogenesis of the primary open angle glaucoma / Koshitz, I. N. ; Svetlova, O. V. ; Kotliar, K. E. ; Makarov, F. N. ;  Smolnikov, B. A.
JF  - Glaukoma (2005)
Y1  - 2005
N1  - Original in Russisch
SP  - 41
EP  - 63
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Stegaev, V. A.
A1  - Parkhomov, S. D.
T1  - Biomechanical substantiation of relatively low efficiency of recurrent laser trabeculoplasty / Svetlova, O. V. ; Stagaev, V. A. ; Parkhomov, S. D. ; Kotliar, K. E. ; Makarov, F. N. ;  Smolnikov, B. A. ; Koshitz, I. N.
JF  - Glaukoma (2004)
Y1  - 2004
N1  - Original in Russisch
SP  - 29
EP  - 39
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Sourjikov, A. V.
A1  - Zaseeva, M. V.
T1  - Biomechanical peculiarities of aqueous humor production system and outflow regulation system / Svetlova, O. V. ; Sourjikov, A. V. ; Kotliar, K. E. ; Zaseeva, M. V. ; Shukhaev, S. V. ; Koshitz, I. N.
JF  - Glaukoma (2004)
Y1  - 2004
N1  - Original in Russisch
SP  - 66
EP  - 76
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Makarov, F. N.
A1  - Zaseeva, M. V.
T1  - Morfologicheskie i funktsional'nye osobennosti resnichnogo poiaska khrustalika kak kliuchevogo ispolnitel'nogo zvena v mekhanizme akkommodatsii glaza cheloveka = Morpho-functional characteristics of lens ciliary body as a key mechanism of accommodation in
JF  - Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3
Y1  - 2003
SN  - 1026-3543
N1  - Original in Russisch, English abstract
SP  - 7
EP  - 16
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Volkov, V. V.
A1  - Koshits, I. N.
A1  - Svetlova, O. V.
T1  - Biomekhanicheskie osobennosti vzaimodeĭstviia drenazhno i akkomodatsionnoĭ reguliatornykh sistem glaza v norme i pri kontuzionnom podvyvikhe khrustalika / Volkov, V. V. ; Kotliar, K. E. ; Koshits, I. n. ; Svetlova, O. V. ; Smol´nikov, B. A.
JF  - Vestnik oftalmologii. 113 (1997), H. 3
Y1  - 1997
SN  - 0042-465X
N1  - Titelübersetzung: Biomechanical characteristics of interactions between the drainage and accommodation regulatory systems of the eye in health and in contusion lens subluxation ; Original in Russisch, English abstract
SP  - 5
EP  - 7
PB  - -
ER  - 
TY  - JOUR
A1  - Mikielewicz, Marek
A1  - Kotliar, Konstantin
A1  - Barraquer, Rafael I.
A1  - Michael, Ralph
T1  - Air-pulse corneal applanation signal curve parameters for the characterisation of keratoconus
JF  - British Journal of Ophthalmology (eBJO)
Y1  - 2011
SN  - 1468-2079
VL  - 95
IS  - 6
SP  - 793
EP  - 798
PB  - BMJ Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Baumann, Marcus
A1  - Vilser, Walthard
A1  - Lanzl, Ines M.
T1  - Pulse wave velocity in retinal arteries of healthy volunteers
JF  - British Journal of Ophthalmology (eBJO)
Y1  - 2011
SN  - 1468-2079
VL  - 95
IS  - 11
SP  - 675
EP  - 679
PB  - BMJ Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines M.
A1  - Schmidt-Trucksäss, A.
A1  - Sitnikova, Diana
A1  - Ali, Mohammad
A1  - Blume, Katharina
A1  - Halle, Martin
A1  - Hansser, Henner
T1  - Dynamic retinal vessel response to flicker in obesity: A methodological approach
JF  - Microvascular Research
Y1  - 2011
SN  - 0026-2862
VL  - 81
IS  - 1
SP  - 123
EP  - 128
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dashevsky, Alexey V.
A1  - Lanzl, Ines M.
A1  - Kotliar, Konstantin
T1  - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal
JF  - Graefe's Archive for Clinical and Experimental Ophthalmology
Y1  - 2011
SN  - 0721-832x
VL  - 249
IS  - 4
SP  - 565
EP  - 573
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Schwarz, Sonja
A1  - Kotliar, Konstantin
A1  - Eynatten, Maximilian von
A1  - Trucksaess, Arno
A1  - Burckhardt, Klaus
A1  - Lutz, Jens
A1  - Heemann, Uwe
A1  - Lanzl, Ines
T1  - Non-diabetic chronic kidney disease influences retinal microvasculature
JF  - Kidney and Blood Pressure Research
Y1  - 2009
SN  - 1423-0143
VL  - 32
IS  - 6
SP  - 428
EP  - 433
PB  - -
ER  - 
TY  - JOUR
A1  - Burkhardt, Klaus
A1  - Schwarz, Sonja
A1  - Pan, Chengrui
A1  - Stelter, Felix
A1  - Kotliar, Konstantin
A1  - Eynatten, Maxilian von
A1  - Sollinger, Daniel
A1  - Lanzl, Ines
A1  - Heemann, Uwe
A1  - Baumann, Marcus
T1  - Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
JF  - Cardiovascular Diabetology
Y1  - 2009
SN  - 1475-2840
VL  - 8
IS  - 10
SP  - 1
EP  - 8
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Kozlova, Tatiana V.
A1  - Lanzl, Ines M.
T1  - Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations
JF  - Biomedizinische Technik = Biomedical Engineering
Y1  - 2009
SN  - 1862-278X
VL  - 54
IS  - 1
SP  - 14
EP  - 22
PB  - -
ER  - 
TY  - JOUR
A1  - Seidova, Seid-Fatima
A1  - Kotliar, Konstantin
A1  - Foerger, Frauke
A1  - Klopfer, Matthias
A1  - Lanzl, Ines
T1  - Functional retinal changes in Gaucher disease
JF  - Documenta Ophthalmologica
Y1  - 2009
SN  - 1573-2622
VL  - 118
IS  - 2
SP  - 151
EP  - 154
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines M.
A1  - Maier, Mathias
A1  - Feucht, Nikolaus
T1  - Intraocular pressure effects of pegaptanib (macugen) injections in patients with and without glaucoma / Lanzl, Ines M. ; Maier, Mathias ; Feucht, Nikolaus ; Lohmann, Chris P. ; Kotliar, Konstantin E.
JF  - American Journal of Ophthalmology . 145 (2008), H. 1
Y1  - 2008
SN  - 1879-1891
SP  - 185
EP  - 185
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Vilser, Walthatd
A1  - Nagel, Edgar
A1  - Lanzl, Ines M.
T1  - Retinal vessel reaction in response to chromatic flickering light / Kotliar, Konstantin E. ; Vilser, Walthard ; Nagel, Edgar ; Lanzl, Ines M.
JF  - Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5
Y1  - 2004
SN  - 1435-702X
SP  - 377
EP  - 392
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Bauer, S. M.
A1  - Zamuraev, L. A.
T1  - Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E.
JF  - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2
Y1  - 2006
SN  - 1812-5123
SP  - 41
EP  - 47
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Zinoviewa, N. V.
A1  - Krylova, I. S.
T1  - Elaboration of the conception of the biomechanical model of the aqueous intraocular outflow / Svetlova, O. V. ; Zinoviewa, N. V. ; Krylova, I. S. ; Koshitz, I. N. ; Smolnikov, B. A. ; Fedorova, E. M. ; Kotliar, K. E.
JF  - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 5 (2001), H. 3
Y1  - 2001
SN  - 1812-5123
SP  - 23
EP  - 27
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlova, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 35
EP  - 53
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlowa, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 51
EP  - 70
PB  - -
ER  - 
TY  - JOUR
A1  - Lanzl, Ines M.
A1  - Seidova, Seid-Fatima
A1  - Maier, Mathias
A1  - Schmidt-Trucksäss, Arno
A1  - Halle, Martin
A1  - Kotliar, Konstantin
T1  - Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection
JF  - Acta Ophthalmologica
Y1  - 2011
SN  - 1755-3768
VL  - 89
IS  - 5
SP  - 472
EP  - 479
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Maier, Mathias
A1  - Bauer, Svetlana
A1  - Feucht, Nikolaus
A1  - Lohmann, Chris
A1  - Lanzl, Ines
T1  - Intravitreal injection of triamcinolone acetonide and intraocular pressure: author's reply
JF  - Acta Ophthalmologica
Y1  - 2008
SN  - 1755-3768
VL  - 86
IS  - 6
SP  - 692
EP  - 693
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Nagel, Edgar
A1  - Vilser, Walthard
A1  - Lanzl, Ines M.
T1  - Functional in vivo assessment of retinal artery microirregularities in glaucoma / Kotliar, Konstantin E. ; Nagel, Edgar ; Vilser, Walthard ; Lanzl, Ines M.
JF  - Acta Ophthalmologica. 86 (2008), H. 4
Y1  - 2008
SN  - 1755-3768
SP  - 424
EP  - 433
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Maier, Mathias
A1  - Bauer, Svetlana
A1  - Feucht, Nikolaus
T1  - Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model / Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines
JF  - Acta Ophthalmologica Scandinavica. 85 (2007), H. 7
Y1  - 2007
SN  - 1755-3768
SP  - 777
EP  - 781
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Mogilevskiĭ, A. Ia.
A1  - Shilo, A. V.
A1  - Panchekha, A. P.
T1  - [Chaotic non-linear dynamics of alpha-band of the EEg and organization of the cortical activity of P300 wave] / Mogilevskiĭ, A. Ia. ; Kotliar, K. E. ; Shilo, A. V. ; Panchekha, A. P.
JF  - Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova. 58 (2008), H. 5
Y1  - 2008
SN  - 0044-4677
N1  - Original in Russisch ; English abstract
SP  - 562
EP  - 575
PB  - -
ER  - 
TY  - THES
A1  - Kotliar, Konstantin
T1  - Functional in-vivo assessment and biofluidmechanical analysis of age-related and pathological microstructural changes in retinal vessels [Elektronische Ressource]
Y1  - 2008
N1  - München, Techn. Univ., Diss., 2008
PB  - -
ER  - 
TY  - JOUR
A1  - Fuest, Matthias
A1  - Kotliar, Konstantin
A1  - Walter, Peter
A1  - Plange, Niklas
T1  - Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry
JF  - Ophthalmic and physiological optics
Y1  - 2014
U6  - http://dx.doi.org/10.1111/opo.12134
SN  - 1475-1313 (E-Journal); 0275-5408 (Print)
N1  - Special Issue: The Ageing Visual System
VL  - 34
IS  - 4
SP  - 438
EP  - 444
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Voronkova, Eva B.
A1  - Bauer, Svetlana M.
A1  - Kotliar, Konstantin
T1  - Computer simulation of the cornea-scleral shell as applied to pressure-volume relationship in the human eye
T2  - 2014 International Conference on Computer Technologies in Physical and Engineering Applications :  ICCTPEA 2014 : proceedings : June 30 2014-July 4 2014, St. Petersburg
Y1  - 2014
SN  - 978-1-4799-5315-8
SP  - 204
EP  - 205
ER  - 
TY  - JOUR
A1  - Martin-Gonzalez, Anabel
A1  - Kotliar, Konstantin
A1  - Rios-Martinez, Jorge
A1  - Lanzl, Ines
A1  - Navab, Nassir
T1  - Mediated-reality magnification for macular degeneration rehabilitation
JF  - Journal of Modern Optics
Y1  - 2014
U6  - http://dx.doi.org/10.1080/09500340.2014.936110
SN  - 1362-3044
VL  - 61
IS  - 17
SP  - 1400
EP  - 1408
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Kharoubi, A.
A1  - Schmidt-Trucksäß, A.
A1  - Halle, M.
A1  - Lanzl, I.
T1  - Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?
JF  - Acta Ophthalmologica
Y1  - 2009
SN  - 1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)
VL  - Vol. 87
IS  - Suppl. S244
SP  - 0
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Suryoputri, Nathania
A1  - Ghaderi, Aydin
A1  - Linder, Peter
A1  - Kotliar, Konstantin
A1  - Göttler, Jens
A1  - Sorg, Christian
A1  - Grimmer, Timo
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Does hemodynamic response function change in Alzheimer disease?
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 92
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lueke, Jan Niklas
A1  - Sjapic, Volha
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Sjapic, Sergej
A1  - Alpdogan, Serdan
A1  - Schneider, Toni
A1  - Schubert, Gerrit Alexander
A1  - Neumaier, Felix
T1  - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina
JF  - Current Eye Research
Y1  - 2017
U6  - http://dx.doi.org/10.1080/02713683.2017.1339807
SN  - 1460-2202
IS  - Article in press
SP  - 1
EP  - 9
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hauser, Christine
A1  - Ortner, Marion
A1  - Muggenthaler, Claudia
A1  - Diehl-Schmid, Janine
A1  - Angermann, Susanne
A1  - Hapfelmeier, Alexander
A1  - Schmaderer, Christoph
A1  - Grimmer, Timo
T1  - Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
JF  - Scientific Reports
Y1  - 2017
U6  - http://dx.doi.org/10.1038/s41598-017-13349-5
SN  - 2045-2322
N1  - Article 12906
VL  - 7
IS  - 1
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Lapitan, Denis G.
A1  - Rogatkin, Dmitrii A.
A1  - Persheyev, Sydulla K.
A1  - Kotliar, Konstantin
T1  - False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter
JF  - Biomedizinische Technik
N2  - Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise.
Y1  - 2018
U6  - http://dx.doi.org/10.1515/bmt-2017-0060
SN  - 0013-5585
VL  - 63
IS  - 4
SP  - 439
EP  - 444
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Balakirski, Galina
A1  - Kotliar, Konstantin
A1  - Pauly, Karolin J.
A1  - Krings, Laura K.
A1  - Rübben, Albert
A1  - Baron, Jens M.
A1  - Schmitt, Laurenz
T1  - Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience
JF  - Dermatologic Surgery
N2  - BACKGROUND 
Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited.

PATIENTS AND METHODS 
All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records.

RESULTS 
The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7% (19/284) of the cases. In 95% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients.

CONCLUSION 
According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients.

The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects.

Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13% to 29% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis.

To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.
Y1  - 2018
U6  - http://dx.doi.org/10.1097/DSS.0000000000001615
IS  - 44 (12)
SP  - 1525
EP  - 1536
PB  - Wolters Kluwer
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lüke, Jan Niklas
A1  - Schubert, Gerrit Alexander
A1  - Dibué-Adjei, Maxine
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Steiger, Hans-Jakob
A1  - Hänggi, Daniel
A1  - Kamp, Marcel A.
A1  - Schneider, Toni
A1  - Neumaier, Felix
T1  - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity
JF  - Molecular and Cellular Neuroscience
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.mcn.2019.03.003
SN  - 1044-7431
VL  - 96
IS  - 4
SP  - 35
EP  - 46
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Zingsheim, Jonas
A1  - Grimmer, Timo
A1  - Ortner, Marion
A1  - Schmaderer, Christoph
A1  - Hauser, Christine
A1  - Kotliar, Konstantin
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Recognition of subjects with mild cognitive impairment (MCI) by the use of retinal arterial vessels.
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 36
EP  - 37
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Blum, Yannik
A1  - Albanna, Walid
A1  - Benninghaus, Anne
A1  - Kotliar, Konstantin
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Vasomotion in retinal vessels of patients presenting post hemorrhagic hydrocephalus following subarachnoid hemorrhage
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - Clearance of blood components and fluid drainage play a crucial role in subarachnoid hemorrhage (SAH) and post hemorrhagic hydrocephalus (PHH). With the involvement of interstitial fluid (ISF) and cerebrospinal fluid (CSF), two pathways for the clearance of fluid and solutes in the brain are proposed. Starting at the level of capillaries, flow of ISF follows along the basement membranes in the walls of cerebral arteries out of the parenchyma to drain into the lymphatics and CSF [1]–[3]. Conversely, it is shown that CSF enters the parenchyma between glial and pial basement membranes of penetrating arteries [4]–[6]. Nevertheless, the involved structures and the contribution of either flow pathway to fluid balance between the subarachnoid space and interstitial space remains controversial. Low frequency oscillations in vascular tone are referred to as vasomotion and corresponding vasomotion waves are modeled as the driving force for flow of ISF out of the parenchyma [7]. Retinal vessel analysis (RVA) allows non-invasive measurement of retinal vessel vasomotion with respect to diameter changes [8]. Thus, the aim of the study is to investigate vasomotion in RVA signals of SAH and PHH patients.
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 38
EP  - 39
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Kodomskoi, Leonid
A1  - Kotliar, Konstantin
A1  - Schröder, Andreas
A1  - Weiss, Michael
A1  - Hille, Konrad
T1  - Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter
JF  - Journal of Glaucoma
Y1  - 2019
U6  - http://dx.doi.org/10.1097/IJG.0000000000001321
SN  - 1057-0829
IS  - Epub ahead of print
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Ramoshaba, Nthai E.
A1  - Huisman, Hugo W.
A1  - Lammertyn, Leandi
A1  - Kotliar, Konstantin
A1  - Schutte, Aletta E.
A1  - Smith, Wayne
T1  - Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study
JF  - Hypertension Research
N2  - Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20–30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = −0.097 (95% CI = −0.165; −0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.
Y1  - 2020
U6  - http://dx.doi.org/10.1038/s41440-020-0487-0
SN  - 1348-4214
IS  - 43
SP  - 1231
EP  - 1238
PB  - Springer Nature
CY  - Osaka
ER  - 
TY  - CHAP
A1  - Kotliar, Konstantin
ED  - Pallikaris, I.
ED  - Tsilimbaris, M. K.
ED  - Dastiridou, A. I.
T1  - Ocular rigidity: clinical approach
T2  - Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye
N2  - The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.
KW  - Coefficient of ocular rigidity
KW  - Eyeball
KW  - Corneo-scleral shell
KW  - Pressure-volume relationship
KW  - Differential tonometry
Y1  - 2021
SN  - 978-3-030-64422-2
U6  - http://dx.doi.org/10.1007/978-3-030-64422-2_2
SP  - 15
EP  - 43
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Kuerten, David
A1  - Kotliar, Konstantin
A1  - Fuest, Matthias
A1  - Walter, Peter
A1  - Hollstein, Muriel
A1  - Plange, Niklas
ED  - Neri, Piergiorgio
T1  - Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study
JF  - International Ophthalmology
N2  - Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.
KW  - Glaucoma
KW  - Visual field asymmetry
KW  - Ocular blood flow
KW  - RVA
KW  - Vascular response
Y1  - 2021
SN  - 1573-2630
U6  - http://dx.doi.org/10.1007/s10792-021-01876-0
VL  - 41
IS  - 41
SP  - 3109
EP  - 3119
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Conzen, Catharina
A1  - Weiss, Miriam
A1  - Seyfried, Katharina
A1  - Kotliar, Konstantin
A1  - Schmidt, Tobias Philip
A1  - Kuerten, David
A1  - Hescheler, Jürgen
A1  - Bruecken, Anne
A1  - Schmidt-Trucksäss, Arno
A1  - Neumaier, Felix
A1  - Wiesmann, Martin
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
T1  - Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis
JF  - Frontiers in Neurology
N2  - Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fneur.2021.690183
SN  - 1664-2295
VL  - 12
IS  - 12
SP  - 1
EP  - 15
ER  - 
TY  - JOUR
A1  - Werfel, Stanislas
A1  - Günthner, Roman
A1  - Hapfelmeier, Alexander
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
ED  - Guzik, Tomasz J.
T1  - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning
JF  - Cardiovascular Research
N2  - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.
KW  - Machine learning
KW  - Retinal vessels
KW  - Microcirculation
KW  - Haemodialysis
KW  - Myocardial infarction and cardiac death
Y1  - 2022
U6  - http://dx.doi.org/10.1093/cvr/cvab040
SN  - 0008-6363
VL  - 118
IS  - 2
SP  - 612
EP  - 621
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Malan, Leone
A1  - Hamer, Mark
A1  - Känel, Roland von
A1  - Kotliar, Konstantin
A1  - Wyk, Roelof D. van
A1  - Lambert, Gavin W.
A1  - Vilser, Walthard
A1  - Ziemssen, Tjalf
A1  - Schlaich, Markus P.
A1  - Smith, Wayne
A1  - Magnusson, Martin
A1  - Wentzel, Annemarie
A1  - Myburgh, Carlien E.
A1  - Steyn, Hendrik S.
A1  - Malan, Nico T.
T1  - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study
JF  - Cardiovascular Journal of Africa
Y1  - 2020
U6  - http://dx.doi.org/10.5830/CVJA-2020-031
SN  - 1680-0745
VL  - 26
IS  - 31
SP  - 1
EP  - 12
PB  - Clinics Cardive Publishing
CY  - Durbanville
ER  -