TY - CHAP A1 - Poghossian, Arshak A1 - Schumacher, Kerstin A1 - Kloock, Joachim P. A1 - Rosenkranz, Christian A1 - Schultze, Joachim W. A1 - Müller-Veggian, Mattea A1 - Schöning, Michael Josef T1 - Functional testing and characterisation of ISFETs on wafer level by means of a micro-droplet cell N2 - A wafer-level functionality testing and characterisation system for ISFETs (ionsensitive field-effect transistor) is realised by means of integration of a specifically designed capillary electrochemical micro-droplet cell into a commercial wafer prober-station. The developed system allows the identification and selection of “good” ISFETs at the earliest stage and to avoid expensive bonding, encapsulation and packaging processes for nonfunctioning ISFETs and thus, to decrease costs, which are wasted for bad dies. The developed system is also feasible for wafer-level characterisation of ISFETs in terms of sensitivity, hysteresis and response time. Additionally, the system might be also utilised for wafer-level testing of further electrochemical sensors. KW - Biosensor KW - Biosensorik KW - ISFET KW - Wafer KW - ISFET KW - wafer-level testing KW - capillary micro-droplet cell Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1259 ER - TY - JOUR A1 - Gasparyan, Ferdinand V. A1 - Poghossian, Arshak A1 - Vitusevich, Svetlana A. A1 - Petrychuk, Mykhaylo V. A1 - Sydoruk, Viktor A. A1 - Siqueira, José R. Jr. A1 - Oliveira, Osvaldo N. Jr. A1 - Offenhäusser, Andreas A1 - Schöning, Michael Josef T1 - Low-Frequency Noise in Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers JF - IEEE Sensors Journal. 11 (2011), H. 1 Y1 - 2011 SN - 1530-437X SP - 142 EP - 149 PB - IEEE CY - New York ER - TY - JOUR A1 - Grieger, Niklas A1 - Schwabedal, Justus T. C. A1 - Wendel, Stefanie A1 - Ritze, Yvonne A1 - Bialonski, Stephan T1 - Automated scoring of pre-REM sleep in mice with deep learning JF - Scientific Reports N2 - Reliable automation of the labor-intensive manual task of scoring animal sleep can facilitate the analysis of long-term sleep studies. In recent years, deep-learning-based systems, which learn optimal features from the data, increased scoring accuracies for the classical sleep stages of Wake, REM, and Non-REM. Meanwhile, it has been recognized that the statistics of transitional stages such as pre-REM, found between Non-REM and REM, may hold additional insight into the physiology of sleep and are now under vivid investigation. We propose a classification system based on a simple neural network architecture that scores the classical stages as well as pre-REM sleep in mice. When restricted to the classical stages, the optimized network showed state-of-the-art classification performance with an out-of-sample F1 score of 0.95 in male C57BL/6J mice. When unrestricted, the network showed lower F1 scores on pre-REM (0.5) compared to the classical stages. The result is comparable to previous attempts to score transitional stages in other species such as transition sleep in rats or N1 sleep in humans. Nevertheless, we observed that the sequence of predictions including pre-REM typically transitioned from Non-REM to REM reflecting sleep dynamics observed by human scorers. Our findings provide further evidence for the difficulty of scoring transitional sleep stages, likely because such stages of sleep are under-represented in typical data sets or show large inter-scorer variability. We further provide our source code and an online platform to run predictions with our trained network. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-91286-0 SN - 2045-2322 N1 - Corresponding author: Stephan Bialonski VL - 11 IS - Art. 12245 PB - Springer Nature CY - London ER - TY - CHAP A1 - Jablonski, Melanie A1 - Koch, Claudia A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier T2 - MDPI Proceeding Y1 - 2017 U6 - https://doi.org/10.3390/proceedings1040505 N1 - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017 VL - 1 IS - 4 ER - TY - JOUR A1 - Laack, Walter van T1 - Tennisarm - Ursachen und Behandlung JF - Apotheker-Journal . 9 (1987), H. 2 Y1 - 1987 SN - 0720-1028 SP - 42 ER - TY - CHAP A1 - Pham, Phu Tinh A1 - Nguyen, Thanh Ngoc A1 - Staat, Manfred T1 - FEM based shakedown analysis of hardening structures T2 - Proceedings International Conference on Advances in Computational Mechanics (ACOME) Y1 - 2012 N1 - International Conference on Advances in Computational Mechanics (ACOME), August 14-16, 2012, Ho Chi Minh City, Vietnam SP - 870 EP - 882 ER - TY - CHAP A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Nanomaterial-Modified Capacitive Field-Effect Biosensors T2 - Springer Series on Chemical Sensors and Biosensors (Methods and Applications) N2 - The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte–insulator–semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing. KW - Biomolecular logic gate KW - DNA KW - Enzyme biosensor KW - Field-effect sensor KW - Gold nanoparticle Y1 - 2017 U6 - https://doi.org/10.1007/5346_2017_2 SP - 1 EP - 25 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Digel, Ilya T1 - In-situ biological decontamination of an ice melting probe Y1 - 2010 N1 - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf ER - TY - JOUR A1 - Stulpe, Werner A1 - Scholz, Erhard T1 - Hilbert Space / Scholz, Erhard ; Stulpe, Werner JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 291 EP - 295 PB - Springer CY - Berlin ER - TY - JOUR A1 - Stulpe, Werner T1 - Density Operator JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 166 EP - 169 PB - Springer CY - Berlin ER - TY - JOUR A1 - Tran, Ngoc Trinh A1 - Staat, Manfred T1 - Direct plastic structural design under lognormally distributed strength by chance constrained programming JF - Optimization and Engineering N2 - We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements. Y1 - 2020 U6 - https://doi.org/10.1007/s11081-019-09437-2 SN - 1573-2924 VL - 21 IS - 1 SP - 131 EP - 157 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Gun, Jenny A1 - Gutkin, Vitaly A1 - Lev, Ovadia A1 - Boyen, Hans-Gerd A1 - Saitner, Marc A1 - Wagner, Patrick A1 - Olieslaeger, Marc D´ A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices JF - Journal of Physical Chemistry C. 115 (2011), H. 11 Y1 - 2011 SN - 1932-7455 SP - 4439 EP - 4445 PB - American Cemical Society CY - Washington, DC ER - TY - JOUR A1 - Gun, Jenny A1 - Rizkov, Dan A1 - Lev, Ovadia A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Oxygen plasma-treated gold nanoparticle-based field-effect devices as transducer structures for bio-chemical sensing JF - Microchimica Acta. 164 (2008), H. 3-4 Y1 - 2008 SN - 1436-5073 SP - 395 EP - 404 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Flow-velocity microsensors based on semiconductor field-effect structures JF - Sensors. 3 (2003), H. 7 Y1 - 2003 SN - 1424-8220 SP - 202 EP - 212 ER - TY - BOOK A1 - Laack, Walter van T1 - Wer stirbt, ist nicht tot! 2. Aufl. Y1 - 2011 SN - 978-3-936624-13-7 N1 - auch als Taschenbuch ISBN 978-3-936624-12-0 PB - van Laack CY - Aachen ER - TY - CHAP A1 - Laack, Walter van ED - Beer, André-Michael ED - Adler, Martin T1 - Elektro- und Ultraschalltherapie T2 - Leitfaden Naturheilverfahren : für die ärztliche Praxis Y1 - 2012 SN - 978-3-437-56103-0 U6 - https://doi.org/10.1016/B978-3-437-56103-0.10013-5 SP - 285 EP - 299 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Digel, Ilya A1 - Demirci, Taylan A1 - Temiz Artmann, Aysegül A1 - Nishikawa, K. T1 - Free Radical Nature of the Bactericidal Effect of Plasma-Generated Cluster Ions (PCIs) JF - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2 Y1 - 2004 SN - 0932-4666 SP - 982 EP - 983 ER - TY - CHAP A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Silicon-based chemical and biological field-effect sensors T2 - Encyclopedia of Sensors. Vol. 9 S - Sk Y1 - 2006 SN - 1-58883-065-9 SP - 463 EP - 534 PB - ASP, American Scientific Publ. CY - Stevenson Ranch, Calif. ER - TY - JOUR A1 - Poghossian, Arshak A1 - Abouzar, Maryam H. A1 - Christiaens, P. A1 - Williams, O. A. A1 - Haenen, K. A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors JF - Journal of Contemporary Physics. 43 (2008), H. 2 Y1 - 2008 SN - 1934-9378 N1 - Armenian Academy of Sciences SP - 77 EP - 81 ER - TY - JOUR A1 - Ingebrandt, S. A1 - Han, Y. A1 - Nakamura, F. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Offenhäusser, A. T1 - Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors JF - Biosensors and Bioelectronics. 22 (2007), H. 12 Y1 - 2007 SN - 0956-5663 SP - 2834 EP - 2840 ER -