TY  - JOUR
A1  - Barth, Heiko
A1  - Wollert, Jörg
T1  - SMARTes Konzept - von Produkt zur Fabrik
JF  - Facility-Management : Integration, Planung, Gebäudemanagement
Y1  - 1998
SN  - 0948-0048
VL  - Bd. 4
IS  - H. August
SP  - 30
EP  - 35
ER  - 
TY  - JOUR
A1  - Schneider, Wilhelm
A1  - Schneider, Bettina
A1  - Meinhardt, Kerstin
A1  - Kinder, Stephanie
T1  - Die Fallstudie : Aufstellung eines Anlagespiegels
JF  - Das Wirtschaftsstudium : wisu ; Zeitschrift für Ausbildung, Examen, Berufseinstieg und Fortbildung
Y1  - 2015
SN  - 0340-3084
N1  - Printausgabe in der Bibliothek Eupener Str. unter der Signatur 43 Z 568
VL  - 44
IS  - 5
PB  - Lange
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Borchert, Jörg
A1  - Hasenbeck, Marc
A1  - Jungbluth, Christian
A1  - Schemm, Ralf
T1  - Bewertung und Steuerung von Gasspeichern bzw. Gasspeicherscheiben
JF  - Zeitschrift für Energiewirtschaft
N2  - In diesem Artikel werden zunächst einleitend der Gasmarkt Deutschland und der sich daraus ergebende Speicherbedarf skizziert. Folgend wird auf verschiedene Speichernutzen aus betriebswirtschaftlicher Perspektive eingegangen und die in diesem Artikel vorgestellten Bewertungsverfahren einleitend beschrieben. In diesem Artikel werden stochastische Optimierungsmethoden aufgegriffen, die sowohl eine Bewertung der Speicher gegenüber einem Spotpreis, als auch gegenüber einer gesamten Forwardcurve ermöglichen. Hierzu werden zunächst Modelle zur Beschreibung der Marktpreise vorgestellt und anhand empirischer Daten kalibriert. Dann wird eine beispielhafte Speicherscheibe zunächst auf Basis der LeastSquareMonteCarloTechnik gegenüber dem stochastischen mehrfaktoriellen Spotpreismodell bewertet. Hieran schließt sich die Vorstellung der Bewertung sowie des Hedgings gegenüber der Forwardcurve an. Abschließend erfolgt eine vergleichende Gegenüberstellung beider Verfahren.
Y1  - 2009
U6  - https://doi.org/10.1007/s12398-009-0033-x
SN  - 1866-2765
VL  - 33
IS  - 4
SP  - 279
EP  - 293
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Borchert, Jörg
A1  - Hasenbeck, Marc
T1  - Bewertung und Steuerung von Kraftwerksscheiben
JF  - Zeitschrift für Energiewirtschaft
Y1  - 2009
U6  - https://doi.org/10.1007/s12398-009-0014-0
SN  - 1866-2765
VL  - 33
IS  - 2
SP  - 115
EP  - 126
PB  - Vieweg
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Borchert, Jörg
A1  - Schemm, R.
T1  - Einsatz der Portfoliotheorie im Asset Allokations-Prozess am Beispiel eines fiktiven Anlageraumes von Windkraftstandorten
JF  - Zeitschrift für Energiewirtschaft
Y1  - 2007
SN  - 0343-5377
VL  - 31
IS  - 4
SP  - 311
ER  - 
TY  - JOUR
A1  - Jungbluth, Christian
A1  - Borchert, Jörg
T1  - Möglichkeiten der Strompreisbeeinflussung im oligopolistischen Markt
JF  - ZNER Zeitschrift für Neues Energierecht
Y1  - 2008
IS  - 4
SP  - 314
EP  - 323
ER  - 
TY  - JOUR
A1  - Borchert, Jörg
T1  - Von Beschaffern und Spekulanten
JF  - Energie & Management
Y1  - 2003
SN  - 0945-8794
IS  - 3
SP  - 16
EP  - 17
ER  - 
TY  - JOUR
A1  - Walter, G.
A1  - Borchert, Jörg
T1  - Der Einsatz von Realoptionen in der Elektrizitätswirtschaft
JF  - M & A Review
Y1  - 2002
SN  - 1616-0878
IS  - 4
SP  - 198
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Kharoubi, A.
A1  - Schmidt-Trucksäß, A.
A1  - Halle, M.
A1  - Lanzl, I.
T1  - Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?
JF  - Acta Ophthalmologica
Y1  - 2009
SN  - 1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)
VL  - Vol. 87
IS  - Suppl. S244
SP  - 0
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kappmeyer, K.
A1  - Kotliar, Konstantin
A1  - Lanzl, I. M.
T1  - Spielen von Blasinstrumenten und Augeninnendruck
JF  - Zeitschrift für praktische Augenheilkunde & augenärztliche Fortbildung : ZPA
Y1  - 2009
SN  - 1436-0322
VL  - Bd. 30
SP  - 169
EP  - 171
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Drozdova, G. A.
A1  - Shamshinova, A. M.
T1  - Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 2. Static and dynamic assessment of retinal vessel reaction to stimuli
JF  - National Journal Glaucoma
Y1  - 2007
SN  - 2078-4104
VL  - Vol. 6
IS  - No. 2
SP  - 64
EP  - 71
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Drozdova, G. A.
A1  - Shamshinova, A. M.
T1  - Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 1. Assessment of blood cell velocities and flow rates in intraocular vessels and vascular beds
JF  - Journal of Glaucoma
Y1  - 2007
SN  - 2078-4104
VL  - Vol. 6
IS  - 1
SP  - 61
EP  - 68
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Drozdova, G. A.
A1  - Shamshinova, A. M.
T1  - Ocular hemodinamics and contemporary methods of its assessment. Part II. Invasive methods of assessment of ocular blood flow
JF  - National Journal Glaucoma
Y1  - 2006
SN  - 2078-4104
VL  - Vol. 5
IS  - No. 4
SP  - 37
EP  - 49
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Wieviel Echtzeit kann Windows?
JF  - IEE : elektrische Automatisierung und Antriebstechnik
Y1  - 1997
SN  - 1434-2898
VL  - Jg. 42
IS  - Nr. 9
SP  - 30
EP  - 37
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Zeitgemäß : Echtzeit-Zusatz für Windows 3.11 und Windows 95
JF  - ELRAD : Magazin für Elektronik und technische Rechneranwendungen
Y1  - 1996
SN  - 0170-1827
IS  - H. 9
SP  - 96
EP  - 99
ER  - 
TY  - JOUR
A1  - Wollert, Jörg
T1  - Bluetooth in der Klemme
JF  - Computer & Automation : Fachmedium der Automatisierungstechnik
Y1  - 2008
SN  - 1615-8512
IS  - H. 10
SP  - 62
EP  - 67
ER  - 
TY  - JOUR
A1  - Fissabre, Anke
A1  - Kleuters, Elmar
A1  - Lohmann, Daniel
T1  - „Beweglicher und toleranter als jede alte Harmonie“ : Das Haus der Jugend von Rudolf Schwarz und Hans Schwippert in Aachen
JF  - In situ : Zeitschrift für Architekturgeschichte
Y1  - 2013
SN  - 1866-959X
VL  - 5
IS  - 2
SP  - 267
EP  - 274
PB  - Werner
CY  - Worms
ER  - 
TY  - JOUR
A1  - Fissabre, Anke
A1  - Lohmann, Daniel
T1  - Verlust einer „tragenden Wand“ : Das Haus der Jugend von Rudolf Schwarz in Aachen
JF  - Bauwelt
Y1  - 2012
SN  - 0005-6855
VL  - 103
IS  - 45
SP  - 6
EP  - 7
PB  - Bauverlag BV
CY  - Gütersloh
ER  - 
TY  - JOUR
A1  - Fissabre, Anke
T1  - Dachterrassen der Renaissance – „Cosa più maravigliosa che gl’orti pensili di Babbilonia“
JF  - Architectura : Zeitschrift für Geschichte der Baukunst
Y1  - 2011
SN  - 0044-863X
VL  - 41
IS  - 1
SP  - 27
EP  - 46
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Fissabre, Anke
T1  - Das Fach Baugeschichte : Eine Umfrage an 18 deutschsprachigen Architekturfakultäten
JF  - Bauwelt
Y1  - 2005
SN  - 0005-6855
VL  - 96
IS  - 40-41
SP  - 48
EP  - 57
ER  - 
TY  - JOUR
A1  - Warmer, Johannes
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
A1  - Kaul, Peter
T1  - Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors
JF  - Physica status solidi (a)
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201431882
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1289
EP  - 1298
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Delle, Lotta E.
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Müller, Frank
A1  - Grandthyll, Samuel
A1  - Jacobs, Karin
A1  - Lilischkis, Rainer
A1  - Vu, Xuan T.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Thoelen, Roland
A1  - Weil, Maryam
A1  - Ingebrandt, Sven
T1  - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF  - Physica status solidi (a)
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201431863
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1327
EP  - 1334
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Timme, Michael
T1  - Versagung von Pkh trotz Zulassung der Revi­sion wegen grundsätzlicher Bedeutung
JF  - Neue Juristische Wochenschrift (NJW)
Y1  - 2015
SN  - 0341-1915
IS  - 30
SP  - 2173
EP  - 2175
PB  - Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Kleinridders, Andre
A1  - Küter-Luks, Birgit
A1  - Niehaves, Sandra
A1  - Brüning, Jens C.
A1  - Schwenk, Frieder
T1  - Reversible gene knockdown in mice using a tight, inducible shRNA expression system
JF  - Nucleic Acids Research
Y1  - 2007
U6  - https://doi.org/10.1093/nar/gkm122
SN  - 1362-4962
VL  - 35
IS  - 7
SP  - e54
ER  - 
TY  - JOUR
A1  - Plum, Leona
A1  - Ma, Xiaosong
A1  - Hampel, Brigitte
A1  - Balthasar, Nina
A1  - Coppari, Roberto
A1  - Münzberg, Heike
A1  - Shanabrough, Marya
A1  - Burdakov, Denis
A1  - Rother, Eva
A1  - Janoschek, Ruth
A1  - Alber, Jens
A1  - Belgardt, Bengt F.
A1  - Koch, Linda
A1  - Seibler, Jost
A1  - Schenk, Frieder
A1  - Fekete, Csaba
A1  - Suzuki, Akira
A1  - Mak, Tak W.
A1  - Krone, Wilhelm
A1  - Horvath, Tamas L.
A1  - Ashcroft, Frances M.
A1  - Brüning, Jens C.
T1  - Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2006
U6  - https://doi.org/10.1172/JCI27123
SN  - 1558-8238
VL  - 116
IS  - 7
SP  - 1886
EP  - 1901
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Küter-Luks, Birgit
A1  - Kern, Heidrun
A1  - Streu, Sandra
A1  - Plum, Leona
A1  - Maurer, Jan
A1  - Kühn, Ralf
A1  - Brüning, Jens C.
A1  - Schwenk, Frieder
T1  - Single copy shRNA configuration for ubiquitous gene knockdown in mice
JF  - Nucleic Acids Research
Y1  - 2005
U6  - https://doi.org/10.1093/nar/gni065
SN  - 1362-4962
VL  - 33
IS  - 7
SP  - e67
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Zevnik, Branko
A1  - Küter-Luks, Birgit
A1  - Andreas, Susanne
A1  - Kern, Heidrun
A1  - Hennek, Thomas
A1  - Rode, Anja
A1  - Heimann, Cornelia
A1  - Faust, Nicole
A1  - Kauselmann, Gunther
A1  - Schoor, Michael
A1  - Jaenisch, Rudolf
A1  - Rajewsky, Klaus
A1  - Kühn, Ralf
A1  - Schwenk, Frieder
T1  - Rapid generation of inducible mouse mutants
JF  - Nucleic Acids Research
Y1  - 2003
U6  - https://doi.org/10.1093/nar/gng012
SN  - 1362-4962
VL  - 33
IS  - 4
SP  - e12
ER  - 
TY  - JOUR
A1  - Goetze, Sandra
A1  - Baer, Alexandra
A1  - Winkelmann, Silke
A1  - Nehlsen, Kristina
A1  - Seibler, Jost
A1  - Maass, Karin
A1  - Bode, Jürgen
T1  - Performance of genomic bordering elements at predefined genomic loci
JF  - Molecular and Cellular Biology
Y1  - 2005
U6  - https://doi.org/10.1128/MCB.25.6.2260-2272.2005
SN  - 1098-5549
VL  - 25
IS  - 6
SP  - 2260
EP  - 2272
ER  - 
TY  - JOUR
A1  - Yoshinobu, Tatsuo
A1  - Moritz, Werner
A1  - Finger, Friedhelm
A1  - Schöning, Michael Josef
ED  - Comini, Elisabetta
T1  - Application of thin-film amorphous silicon to chemical imaging
JF  - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.
Y1  - 2006
SN  - 9781558998711
N1  - Materials Research Society symposia proceedings; v. 915
IS  - Paper 0910-A-20-01
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Schneider, Benno
A1  - Erbay, E.
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
JF  - Physica status solidi (a)
N2  - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201532053
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1347
EP  - 1352
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - https://doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Raab, Monika
A1  - Kappel, Sven
A1  - Krämer, Andrea
A1  - Sanhaji, Mourad
A1  - Matthess, Yves
A1  - Kurunci-Csacsko, Elisabeth
A1  - Calzada-Wack, Julia
A1  - Rathkolb, Birgit
A1  - Rosman, Jan
A1  - Adler, Thure
A1  - Busch, Dirk H.
A1  - Esposito, Irene
A1  - Fuchs, Helmut
A1  - Gailus-Durner, Valérie
A1  - Klingenspor, Martin
A1  - Wolf, Eckhard
A1  - Sänger, Nicole
A1  - Prinz, Florian
A1  - Hrabe de Angelis, Martin
A1  - Seibler, Jost
A1  - Yuan, Juping
A1  - Bergmann, Martin
A1  - Knecht, Rainald
A1  - Kreft, Bertolt
A1  - Strebhardt, Klaus
T1  - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
JF  - Nature Communications
Y1  - 2011
U6  - https://doi.org/10.1038/ncomms1395
SN  - 2041-1723
VL  - 2
IS  - 395
SP  - 1
EP  - 11
PB  - Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Hasegawa, Maki
A1  - Kapelyukh, Yury
A1  - Tahara, Harunobu
A1  - Seibler, Jost
A1  - Rode, Anja
A1  - Krueger, Sylvia
A1  - Lee, Dongtao N.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
T1  - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
JF  - Molecular Pharmacology
Y1  - 2011
U6  - https://doi.org/10.1124/mol.111.071845
SN  - 1521-0111
VL  - 80
IS  - 33
SP  - 518
EP  - 528
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Glaser, Stefan
A1  - Lubitz, Sandra
A1  - Loveland, Kate L.
A1  - Ohbo, Kazu
A1  - Robb, Lorraine
A1  - Schwenk, Frieder
A1  - Seibler, Jost
A1  - Roellig, Daniela
A1  - Kranz, Andrea
A1  - Anastassiadis, Konstantinos
A1  - Stewart, A. Francis
T1  - The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis
JF  - Epigenetics & Chromatin
Y1  - 2009
U6  - https://doi.org/10.1186/1756-8935-2-5
SN  - 1756-8935
VL  - 2
IS  - 5
SP  - 1
EP  - 16
ER  - 
TY  - JOUR
A1  - Kotnik, Katarina
A1  - Popova, Elena
A1  - Todiras, Mihail
A1  - Mori, Marcelo A.
A1  - Alenina, Natalia
A1  - Seibler, Jost
A1  - Bader, Michael
T1  - Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown
JF  - Plos One
Y1  - 2009
U6  - https://doi.org/10.1371/journal.pone.0005124
VL  - 4
IS  - 4
SP  - e5124
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Herold, Marco J.
A1  - Brandt, Jens van den
A1  - Seibler, Jost
A1  - Reichardt, Holger M.
T1  - Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 2008
U6  - https://doi.org/10.1073/pnas.0806213105
SN  - 1091-6490
VL  - 105
IS  - 47
SP  - 18507
EP  - 18512
ER  - 
TY  - JOUR
A1  - Koch, Linda
A1  - Wunderlich, F. Thomas
A1  - Seibler, Jost
A1  - Könner, A. Christine
A1  - Hampel, Brigitte
A1  - Irlenbusch, Sigrid
A1  - Brabant, Georg
A1  - Kahn, C. Ronald
A1  - Schwenk, Frieder
A1  - Brüning, Jens C.
T1  - Central insulin action regulates peripheral glucose and fat metabolism in mice
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2008
U6  - https://doi.org/10.1172/JCI31073
SN  - 1558-8238
VL  - 118
IS  - 6
SP  - 2132
EP  - 2147
ER  - 
TY  - JOUR
A1  - Christoph, Thomas
A1  - Bahrenberg, Gregor
A1  - Vry, Jean de
A1  - Englberger, Werner
A1  - Erdmann, Volker A.
A1  - Frech, Moritz
A1  - Kögel, Babette
A1  - Röhl, Thomas
A1  - Schiene, Klaus
A1  - Schröder, Wolfgang
A1  - Seibler, Jost
A1  - Kurreck, Jens
T1  - Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice
JF  - Molecular and Cellular Neuroscience
Y1  - 2008
U6  - https://doi.org/10.1016/j.mcn.2007.12.006
SN  - 1044-7431
VL  - 37
IS  - 3
SP  - 579
EP  - 589
ER  - 
TY  - JOUR
A1  - Cesari, Francesca
A1  - Rennekampff, Verena
A1  - Vintersten, Kristina
A1  - Vuong, Lam Giang
A1  - Seibler, Jost
A1  - Bode, Jürgen
A1  - Wiebel, Franziska F.
A1  - Nordheim, Alfred
T1  - Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange
JF  - Genesis : The Journal of Genetics and Development
Y1  - 2004
U6  - https://doi.org/10.1002/gene.20003
SN  - 1526-968X
VL  - 38
IS  - 2
SP  - 87
EP  - 92
ER  - 
TY  - JOUR
A1  - Bode, Jürgen
A1  - Schlake, Thomas
A1  - Iber, Michaela
A1  - Schübeler, Dirk
A1  - Seibler, Jost
A1  - Snezhkov, Evgeney
A1  - Nikolaev, Lev
T1  - The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes
JF  - Biological Chemistry
Y1  - 2000
U6  - https://doi.org/10.1515/BC.2000.103
SN  - 1431-6730
VL  - 381
IS  - 9-10
SP  - 801
EP  - 813
ER  - 
TY  - JOUR
A1  - Feng, Yong-Qing
A1  - Seibler, Jost
A1  - Alami, Raouf
A1  - Eisen, Andrew
A1  - Westerman, Karen A.
A1  - Leboulch, Philippe
A1  - Fiering, Steven
A1  - Bouhassira, Eric E.
T1  - Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange
JF  - Journal of Molecular Biology
Y1  - 1999
U6  - https://doi.org/10.1006/jmbi.1999.3113
SN  - 0022-2836
VL  - 292
IS  - 4
SP  - 779
EP  - 785
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Schübeler, Dirk
A1  - Fiering, Steven
A1  - Groudine, Mark
A1  - Bode, Jürgen
T1  - DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs
JF  - Biochemistry
Y1  - 1998
U6  - https://doi.org/10.1021/bi980288t
SN  - 1520-4995
VL  - 37
IS  - 18
SP  - 6229
EP  - 6234
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Bode, Jürgen
T1  - Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay
JF  - Biochemistry
Y1  - 1997
SN  - 1520-4995
VL  - 36
IS  - 7
SP  - 1740
EP  - 1747
ER  - 
TY  - JOUR
A1  - Bode, J.
A1  - Bartsch, J.
A1  - Boulikas, T.
A1  - Iber, M.
A1  - Mielke, C.
A1  - Schübeler, D.
A1  - Seibler, Jost
A1  - Benham, C.
T1  - Transcription-promoting genomic sites in mammalia: their elucidation and architectural principles
JF  - Gene therapy & molecular biology
Y1  - 1998
SN  - 1529-9120
VL  - 1
IS  - 1
SP  - 1
EP  - 29
ER  - 
TY  - JOUR
A1  - Iber, Michaela
A1  - Schübeler, Dirk
A1  - Seibler, Jost
A1  - Höxter, Maria
A1  - Bode, Jürgen
T1  - Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions
JF  - Technical Tips Online
Y1  - 1998
U6  - https://doi.org/10.1016/S1366-2120(08)70132-6
VL  - 4
IS  - 1
SP  - 25
EP  - 29
ER  - 
TY  - JOUR
A1  - Henken, F. E.
A1  - Oosterhuis, K.
A1  - Öhlschläger, Peter
A1  - Bosch, L.
A1  - Hooijberg, E.
A1  - Haanen, J. B. A. G.
A1  - Steenbergen, R. D. M.
T1  - Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7
JF  - Vaccine
N2  - Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.
Y1  - 2012
U6  - https://doi.org/10.1016/j.vaccine.2012.04.013
SN  - 0264-410X
VL  - 30
IS  - 28
SP  - 4259
EP  - 4266
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Immel, Timo
A1  - Grützke, Martin
A1  - Späte, Anne-Katrin
A1  - Groth, Ulrich
A1  - Öhlschläger, Peter
A1  - Huhn, Thomas
T1  - Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy
JF  - Chemical Communications
N2  - Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
Y1  - 2012
U6  - https://doi.org/10.1039/C2CC31624B
SN  - 1364-548X
VL  - 48
IS  - 46
SP  - 5790
EP  - 5792
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Fellin, Wolfgang
A1  - King, Julian
A1  - Kirsch, Ansgar
A1  - Oberguggenberger, Michael
T1  - Uncertainty modelling and sensitivity analysis of tunnel face stability
JF  - Structural safety
N2  - This paper proposes an approach to the choice and evaluation of engineering models with the aid of a typical application in geotechnics. An important issue in the construction of shallow tunnels, especially in weak ground conditions, is the tunnel face stability. Various theoretical and numerical models for predicting the necessary support pressure have been put forth in the literature. In this paper, we combine laboratory experiments performed at the University of Innsbruck with current methods of uncertainty and sensitivity analysis for assessing adequacy, predictive power and robustness of the models. The major issues are the handling of the twofold uncertainty of test results and of model predictions as well as the decision about what are the influential input parameters.
Y1  - 2010
U6  - https://doi.org/10.1016/j.strusafe.2010.06.001
SN  - 0167-4730
VL  - 32
IS  - 6
SP  - 402
EP  - 410
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kirsch, Ansgar
T1  - Experimental investigation of the face stability of shallow tunnels in sand
JF  - Acta Geotechnica
N2  - Various models have been proposed for the prediction of the necessary support pressure at the face of a shallow tunnel. To assess their quality, the collapse of a tunnel face was modelled with small-scale model tests at single gravity. The development of the failure mechanism and the support force at the face in dry sand were investigated. The observed displacement patterns show a negligible influence of overburden on the extent and evolution of the failure zone. The latter is significantly influenced, though, by the initial density of the sand: in dense sand a chimney-wedge-type collapse mechanism developed, which propagated towards the soil surface. Initially, loose sand did not show any discrete collapse mechanism. The necessary support force was neither influenced by the overburden nor the initial density. A comparison with quantitative predictions by several theoretical models showed that the measured necessary support pressure is overestimated by most of the models. Those by Vermeer/Ruse and Léca/Dormieux showed the best agreement to the measurements.
Y1  - 2010
U6  - https://doi.org/10.1007/s11440-010-0110-7
SN  - 1861-1125
VL  - 5
IS  - 1
SP  - 43
EP  - 62
PB  - Springer
CY  - Berlin
ER  -