TY - CHAP A1 - Janotte, N. A1 - Feckler, G. A1 - Kötter, Jens A1 - Decker, Stefan A1 - Herrmann, Ulf A1 - Schmitz, Mark A1 - Lüpfert, E. T1 - Dynamic performance evaluation of the HelioTrough® collector demonstration loop : towards a new benchmark in parabolic trough qualification T2 - SolarPACES International Conference 2013, Las Vegas, Nevada, USA, 17 - 20 September 2013 : [proceedings]. - Pt. 1. - (Energy procedia ; 49) Y1 - 2014 SN - 978-1-63266-904-9 U6 - http://dx.doi.org/10.1016/j.egypro.2014.03.012 SN - 1876-6102 N1 - Nebent.: Power and Chemical Energy Systems concentrating solar power SP - 109 EP - 117 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Lenz, Laura L. A1 - Wolf, Martin ED - Kritz, Willy Christian T1 - Economic evaluation of serious games with the comparative assessment framework COSEGA T2 - The shift from teaching to learning : individual, collective and organizational learning through gaming simulation ; proceedings of the 45th conference of the International Simulation and Gaming Association, Dornbirn 2014 Y1 - 2014 SN - 978-3-7639-5422-3 SP - 374 EP - 386 PB - Bertelsmann CY - [Bielefeld] ER - TY - CHAP A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Glück, Olaf A1 - Thust, Marion T1 - Electrochemical composition measurement T2 - Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen Y1 - 2014 SN - 978-1-4398-4891-3 SP - 55-1 EP - 55-54 PB - CRC Pr. CY - Boca Raton, Fa. ET - 2nd ed. ER - TY - CHAP A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Glück, Olaf A1 - Thust, Marion T1 - Electrochemical methods for the determination of chemical variables in aqueous media T2 - Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement Y1 - 2014 SN - 978-1-4398-4891-3 SP - 55-1 EP - 55-54 PB - CRC Pr. CY - Boca Raton, Fla. ER - TY - JOUR A1 - Jens, Otto A1 - Kaldenhoff, E. A1 - Kirschner-Hermanns, R. A1 - Mühl, Thomas A1 - Klinge, Uwe T1 - Elongation of textile pelvic floor implants under load is related to complete loss of effective porosity, thereby favoring incorporation in scar plates JF - Journal of biomedical materials research. Part A N2 - Use of textile structures for reinforcement of pelvic floor structures has to consider mechanical forces to the implant, which are quite different to the tension free conditions of the abdominal wall. Thus, biomechanical analysis of textile devices has to include the impact of strain on stretchability and effective porosity. Prolift® and Prolift + M®, developed for tension free conditions, were tested by measuring stretchability and effective porosity applying mechanical strain. For comparison, we used Dynamesh-PR4®, which was designed for pelvic floor repair to withstand mechanical strain. Prolift® at rest showed moderate porosity with little stretchability but complete loss of effective porosity at strain of 4.9 N/cm. Prolift + M® revealed an increased porosity at rest, but at strain showed high stretchability, with subsequent loss of effective porosity at strain of 2.5 N/cm. Dynamesh PR4® preserved its high porosity even under strain, but as consequence of limited stretchability. Though in tension free conditions Prolift® and Prolift + M® can be considered as large pore class I meshes, application of mechanical strain rapidly lead to collapse of pores. The loss of porosity at mechanical stress can be prevented by constructions with high structural stability. Assessment of porosity under strain was found helpful to define requirements for pelvic floor devices. Clinical studies have to prove whether devices with high porosity as well as high structural stability can improve the patients' outcome. Y1 - 2014 U6 - http://dx.doi.org/10.1002/jbm.a.34767 SN - 1552-4965 VL - 102 IS - 4 SP - 1079 EP - 1084 PB - Wiley CY - New York ER - TY - THES A1 - Reyes Ochoa, Leonel T1 - Engineering aspects of a parabolic trough collector field with direct steam generation and an organic rankine cycle Y1 - 2014 N1 - Aachen, Fachhochsch., Masterarbeit, 2014 PB - Fachhochschule Aachen CY - Aachen ER - TY - JOUR A1 - Wagner, Patrick A1 - Doll, Theodor A1 - Schöning, Michael Josef T1 - Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Schöning (eds.) JF - Physica status solidi (A) : Applications and materials science Y1 - 2014 U6 - http://dx.doi.org/10.1002/pssa.201470241 SN - 1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print) VL - 211 IS - 6 SP - 1339 EP - 1339 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Miyamoto, K. A1 - Seki, K. A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination JF - Procedia Engineering N2 - The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.proeng.2014.11.563 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 612 EP - 615 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Tippkötter, Nils A1 - Duwe, Anna-Maria A1 - Wiesen, Sebastian A1 - Sieker, Tim A1 - Ulber, Roland T1 - Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids JF - Bioresource Technology N2 - The development of a cost-effective hydrolysis for crude cellulose is an essential part of biorefinery developments. To establish such high solid hydrolysis, a new solid state reactor with static mixing is used. However, concentrations >10% (w/w) cause a rate and yield reduction of enzymatic hydrolysis. By optimizing the synergetic activity of cellulolytic enzymes at solid concentrations of 9%, 17% and 23% (w/w) of crude Organosolv cellulose, glucose concentrations of 57, 113 and 152 g L⁻¹ are reached. However, the glucose yield decreases from 0.81 to 0.72gg⁻¹ at 17% (w/w). Optimal conditions for hydrolysis scale-up under minimal enzyme addition are identified. As result, at 23% (w/w) crude cellulose the glucose yield increases from 0.29 to 0.49gg⁻¹. As proof of its applicability, biobutanol, succinic and itaconic acid are produced with the crude hydrolysate. The potential of the substrate is proven e.g. by a high butanol yield of 0.33gg⁻¹. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.biortech.2014.06.052 VL - 167 SP - 447 EP - 455 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Bäcker, Matthias A1 - Krischer, M. A1 - Wenzel, L. A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor JF - Procedia Engineering N2 - A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers. KW - Field-effect sensor KW - enzymatic (bio)degradation KW - poly(d, l-lactic acid) KW - in-situ monitoring KW - impedance spectroscopy Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.proeng.2014.11.689 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 1314 EP - 1317 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bandodkar, Amay J. A1 - Molinnus, Denise A1 - Mirza, Omar A1 - Guinovart, Tomas A1 - Windmiller, Joshua R. A1 - Valdes-Ramirez, Gabriela A1 - Andrade, Francisco J. A1 - Schöning, Michael Josef A1 - Wang, Joseph T1 - Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring JF - Biosensors and bioelectronics N2 - This article describes the fabrication, characterization and application of an epidermal temporary-transfer tattoo-based potentiometric sensor, coupled with a miniaturized wearable wireless transceiver, for real-time monitoring of sodium in the human perspiration. Sodium excreted during perspiration is an excellent marker for electrolyte imbalance and provides valuable information regarding an individual's physical and mental wellbeing. The realization of the new skin-worn non-invasive tattoo-like sensing device has been realized by amalgamating several state-of-the-art thick film, laser printing, solid-state potentiometry, fluidics and wireless technologies. The resulting tattoo-based potentiometric sodium sensor displays a rapid near-Nernstian response with negligible carryover effects, and good resiliency against various mechanical deformations experienced by the human epidermis. On-body testing of the tattoo sensor coupled to a wireless transceiver during exercise activity demonstrated its ability to continuously monitor sweat sodium dynamics. The real-time sweat sodium concentration was transmitted wirelessly via a body-worn transceiver from the sodium tattoo sensor to a notebook while the subjects perspired on a stationary cycle. The favorable analytical performance along with the wearable nature of the wireless transceiver makes the new epidermal potentiometric sensing system attractive for continuous monitoring the sodium dynamics in human perspiration during diverse activities relevant to the healthcare, fitness, military, healthcare and skin-care domains. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.bios.2013.11.039 SN - 1873-4235 (E-Journal); 0956-5663 (Print) VL - 54 SP - 603 EP - 609 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Buniatyan, V. V. A1 - Huck, Christina A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Rustamyan, L. G. A1 - Hovnikyan, H. H. T1 - Equivalent circuit and optimization of impedance characteristics of an electrolyte conductivity sensor T2 - Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering Y1 - 2014 VL - Iss. 17 IS - No. 1 SP - 69 EP - 76 ER - TY - BOOK A1 - Bernecker, Andreas T1 - Essays in Empirical Political Economics Y1 - 2014 N1 - Mannheim, Univ., Diss., 2014. ER - TY - CHAP A1 - Frotscher, Ralf A1 - Koch, Jan-Peter A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Onate, E. T1 - Evaluation of a computational model for drug action on cardiac tissue T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - JOUR A1 - Salpati, Laurent A1 - Chu, Xiaoyan A1 - Chen, Liangfu A1 - Prasad, Bhagwat A1 - Dallas, Shannon A1 - Evers, Raymond A1 - Mamaril-Fishman, Donna A1 - Geier, Ethan G. A1 - Kehler, Jonathan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Soars, Matthew G. A1 - Unadkat, Jashvant D. A1 - van Waterschoot, Robert A.B. A1 - Yabut, Jocelyn A1 - Schinkel, Alfred H. A1 - Scheer, Nico A1 - Rode, Anja T1 - Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins JF - Drug Metabolism and Disposition N2 - Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography–tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans. Y1 - 2014 U6 - http://dx.doi.org/10.1124/dmd.114.057976 SN - 1521-009X VL - 42 IS - 8 SP - 1301 EP - 1313 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Lehnertz, Klaus A1 - Ansmann, Gerrit A1 - Bialonski, Stephan A1 - Dickten, Henning A1 - Geier, Christian A1 - Porz, Stephan T1 - Evolving networks in the human epileptic brain JF - Physica D: Nonlinear Phenomena N2 - Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.physd.2013.06.009 SN - 0167-2789 VL - 267 SP - 7 EP - 15 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Funke, Harald A1 - Dickhoff, J. A1 - Keinz, Jan A1 - Anis, H. A. A1 - Parente, A. A1 - Hendrick, P. T1 - Experimental and numerical study of the micromix combustion principle applied for hydrogen and hydrogen-rich syngas as fuel with increased energy density for industrial gas turbine applications JF - Energy procedia N2 - The Dry Low NOx (DLN) Micromix combustion principle with increased energy density is adapted for the industrial gas turbine APU GTCP 36-300 using hydrogen and hydrogen-rich syngas with a composition of 90%-Vol. hydrogen (H₂) and 10%-Vol. carbon-monoxide (CO). Experimental and numerical studies of several combustor geometries for hydrogen and syngas show the successful advance of the DLN Micromix combustion from pure hydrogen to hydrogen-rich syngas. The impact of the different fuel properties on the combustion principle and aerodynamic flame stabilization design laws, flow field, flame structure and emission characteristics is investigated by numerical analysis using a hybrid Eddy Break Up combustion model and validated against experimental results. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.egypro.2014.12.201 SN - 1876-6102 (E-Journal) IS - 61 SP - 1736 EP - 1739 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Fateri, Miranda A1 - Gebhardt, Andreas A1 - Thümmler, Stefan A1 - Thurn, Laura T1 - Experimental investigation on selective laser melting of glass JF - Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014 Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.phpro.2014.08.118 SN - 1875-3892 (E-Journal); 1875-3884 (Print) VL - 56 (2014) SP - 357 EP - 364 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. A1 - Pöttgen, Philipp ED - Lübbecke, Marco ED - Koster, Arie ED - Letmathe, Peter ED - Madlener, Reihard ED - Peis, Britta ED - Walther, Grit T1 - Experimental validation of an enhanced system synthesis approach JF - Operations Research Proceedings 2014 N2 - Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7%. Y1 - 2014 SN - 978-3-319-28695-2 U6 - http://dx.doi.org/10.1007/978-3-319-28697-6_1 PB - Springer CY - Basel ER - TY - JOUR A1 - Maas, Marnix C. A1 - Vos, Eline K. A1 - Lagemaat, Miriam W. A1 - Bitz, Andreas A1 - Orzada, Stephan A1 - Kobus, Thiele A1 - Kraff, Oliver A1 - Maderwald, Stefan A1 - Ladd, Mark E. A1 - Scheenen, Tom W. J. T1 - Feasibility of T₂-weighted turbo spin echo imaging of the human prostate at 7 tesla JF - Magnetic Resonance in Medicine N2 - Purpose To demonstrate that high quality T₂-weighted (T2w) turbo spin-echo (TSE) imaging of the complete prostate can be achieved routinely and within safety limits at 7 T, using an external transceive body array coil only. Methods Nine healthy volunteers and 12 prostate cancer patients were scanned on a 7 T whole-body system. Preparation consisted of B₀ and radiofrequency shimming and localized flip angle calibration. T₁ and T₂ relaxation times were measured and used to define the T2w-TSE protocol. T2w imaging was performed using a TSE sequence (pulse repetition time/echo time 3000–3640/71 ms) with prolonged excitation and refocusing pulses to reduce specific absorption rate. Results High quality T2w TSE imaging was performed in less than 2 min in all subjects. Tumors of patients with gold-standard tumor localization (MR-guided biopsy or prostatectomy) were well visualized on 7 T imaging (n = 3). The number of consecutive slices achievable within a 10-g averaged specific absorption rate limit of 10 W/kg was ≥28 in all subjects, sufficient for full prostate coverage with 3-mm slices in at least one direction. Conclusion High quality T2w TSE prostate imaging can be performed routinely and within specific absorption rate limits at 7 T with an external transceive body array. Y1 - 2014 U6 - http://dx.doi.org/10.1002/mrm.24818 SN - 1522-2594 VL - 71 IS - 5 SP - 1711 EP - 1719 PB - Wiley-VCH CY - Weinheim ER -