TY - JOUR A1 - Porschen, W. A1 - Gartzen, J. A1 - Gewehr, K. A1 - Mühlensiepen, H. A1 - Weber, Hans-Joachim A1 - [u.a.], T1 - In vivo assay of the radiation sensitivity of hypoxic tumour cells : influence of γ-rays, cyclotron neutrons, misonidazole, hyperthermia and mixed modalities JF - The British journal of cancer / Supplement N2 - Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay. With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these. Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons. Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4. These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia. Y1 - 1978 SN - 0306-9443 N1 - Section 6: Sensitization and Hypoxic Cytotoxicity: Effects of Hyperthermia and High Let IS - 3 SP - 194 EP - 197 PB - Lewis CY - London ER - TY - JOUR A1 - Matoni, Georg A1 - Berndt, Heinz T1 - Thermal synthesis of the optical pure pentapeptide derivative Z-(L)-Ala-(L)-Phe-Gly-(L)-Phe-Gly-OMe JF - Tetrahedron letters Y1 - 1980 U6 - https://doi.org/10.1016/S0040-4039(00)93618-9 SN - 0040-4039 VL - 21 IS - 1 SP - 37 EP - 40 ER - TY - CHAP A1 - Penne, Jochen A1 - Profittlich, Martin A1 - Ringbeck, Thorsten A1 - Buxbaum, Bernd ED - D, Nicola D'Apuzzo T1 - Touchless detailed 3D scan of human hand anatomy using time-of-flight cameras T2 - Proceedings of the International Conference on 3D Body Scanning Technologies : Lugano, Switzerland, 19-20 October 2010 Y1 - 2010 SN - 978-3-033-02714-5 SP - 361 EP - 369 PB - Hometrica Consulting CY - Zürich ER - TY - JOUR A1 - Eilmann, Britta A1 - Zweifel, Roman A1 - Buchmann, Nina A1 - Fonti, Patrick A1 - Rigling, Andreas T1 - Drought-induced adaptation of the xylem in Scots pine and pubescent oak JF - Tree Physiology Y1 - 2009 U6 - https://doi.org/10.1093/treephys/tpp035 SN - 0829-318X (Print) SN - 1758-4469 (Online) VL - 29 IS - 8 SP - 1011 EP - 1020 PB - Heron CY - Victoria, BC ER - TY - JOUR A1 - El Bergui, Omnia A1 - Abouabdillah, Aziz A1 - Bourioug, Mohamed A1 - Schmitz, Dominik A1 - Biel, Markus A1 - Aboudrare, Abdellah A1 - Krauss, Manuel A1 - Jomaa, Ahlem A1 - Romuli, Sebastian A1 - Müller, Joachim A1 - Fagroud, Mustapha A1 - Bouabid, Rachid T1 - Innovative solutions for drought: Evaluating hydrogel application on onion cultivation (Allium cepa) in Morocco JF - Water N2 - Throughout the last decade, and particularly in 2022, water scarcity has become a critical concern in Morocco and other Mediterranean countries. The lack of rainfall during spring was worsened by a succession of heat waves during the summer. To address this drought, innovative solutions, including the use of new technologies such as hydrogels, will be essential to transform agriculture. This paper presents the findings of a study that evaluated the impact of hydrogel application on onion (Allium cepa) cultivation in Meknes, Morocco. The treatments investigated in this study comprised two different types of hydrogel-based soil additives (Arbovit® polyacrylate and Huminsorb® polyacrylate), applied at two rates (30 and 20 kg/ha), and irrigated at two levels of water supply (100% and 50% of daily crop evapotranspiration; ETc). Two control treatments were included, without hydrogel application and with both water amounts. The experiment was conducted in an open field using a completely randomized design. The results indicated a significant impact of both hydrogel-type dose and water dose on onion plant growth, as evidenced by various vegetation parameters. Among the hydrogels tested, Huminsorb® Polyacrylate produced the most favorable outcomes, with treatment T9 (100%, HP, 30 kg/ha) yielding 70.55 t/ha; this represented an increase of 11 t/ha as compared to the 100% ETc treatment without hydrogel application. Moreover, the combination of hydrogel application with 50% ETc water stress showed promising results, with treatment T4 (HP, 30 kg, 50%) producing almost the same yield as the 100% ETc treatment without hydrogel while saving 208 mm of water. KW - water economy KW - yield KW - deficit irrigation KW - hydrogel KW - onion Y1 - 2023 U6 - https://doi.org/10.3390/w15111972 VL - 15 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel A1 - Thiele, Jan Philipp T1 - Statistical inference for L²-distances to uniformity JF - Computational Statistics N2 - The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study. KW - Integrated empirical distribution (survival) function KW - Goodness-of-fit tests for uniformity KW - Numerical inversion of Laplace transforms KW - Coverage probability KW - Equivalence test Y1 - 2018 U6 - https://doi.org/10.1007/s00180-018-0820-0 SN - 1613-9658 VL - 2018 IS - 33 SP - 1863 EP - 1896 PB - Springer CY - Berlin ER - TY - JOUR A1 - Abbas, Karim A1 - Hedwig, Lukas A1 - Balc, Nicolae A1 - Bremen, Sebastian T1 - Advanced FFF of PEEK: Infill strategies and material characteristics for rapid tooling JF - Polymers N2 - Traditional vulcanization mold manufacturing is complex, costly, and under pressure due to shorter product lifecycles and diverse variations. Additive manufacturing using Fused Filament Fabrication and high-performance polymers like PEEK offer a promising future in this industry. This study assesses the compressive strength of various infill structures (honeycomb, grid, triangle, cubic, and gyroid) when considering two distinct build directions (Z, XY) to enhance PEEK’s economic and resource efficiency in rapid tooling. A comparison with PETG samples shows the behavior of the infill strategies. Additionally, a proof of concept illustrates the application of a PEEK mold in vulcanization. A peak compressive strength of 135.6 MPa was attained in specimens that were 100% solid and subjected to thermal post-treatment. This corresponds to a 20% strength improvement in the Z direction. In terms of time and mechanical properties, the anisotropic grid and isotropic cubic infill have emerged for use in rapid tooling. Furthermore, the study highlights that reducing the layer thickness from 0.15 mm to 0.1 mm can result in a 15% strength increase. The study unveils the successful utilization of a room-temperature FFF-printed PEEK mold in vulcanization injection molding. The parameters and infill strategies identified in this research enable the resource-efficient FFF printing of PEEK without compromising its strength properties. Using PEEK in rapid tooling allows a cost reduction of up to 70% in tool production. KW - polyetheretherketone (PEEK) KW - rapid tooling KW - infill strategy KW - compression behavior KW - additive manufacturing KW - fused filament fabrication Y1 - 2023 U6 - https://doi.org/10.3390/polym15214293 N1 - This article belongs to the Special Issue "Polymer Materials and Design Processes for Additively Manufactured Products" VL - 2023 IS - 15 PB - MDPI CY - Basel ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Bronder, Thomas A1 - Wu, Chunsheng A1 - Scheja, Sabrina A1 - Jessing, Max A1 - Metzger-Boddien, Christoph A1 - Keusgen, Michael A1 - Poghossian, Arshak T1 - Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities JF - Proceedings N2 - Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed. Y1 - 2017 U6 - https://doi.org/10.3390/proceedings1080719 SN - 2504-3900 N1 - This article belongs to the Proceedings of "Proceedings of the 5th International Symposium on Sensor Science (I3S 2017)" VL - 1 IS - 8 SP - Artikel 719 PB - MDPI CY - Basel ER - TY - JOUR A1 - Gaigall, Daniel T1 - Testing marginal homogeneity of a continuous bivariate distribution with possibly incomplete paired data JF - Metrika N2 - We discuss the testing problem of homogeneity of the marginal distributions of a continuous bivariate distribution based on a paired sample with possibly missing components (missing completely at random). Applying the well-known two-sample Crámer–von-Mises distance to the remaining data, we determine the limiting null distribution of our test statistic in this situation. It is seen that a new resampling approach is appropriate for the approximation of the unknown null distribution. We prove that the resulting test asymptotically reaches the significance level and is consistent. Properties of the test under local alternatives are pointed out as well. Simulations investigate the quality of the approximation and the power of the new approach in the finite sample case. As an illustration we apply the test to real data sets. KW - Marginal homogeneity test KW - Crámer–von-Mises distance KW - Paired sample KW - Incomplete data KW - Resampling test Y1 - 2019 U6 - https://doi.org/10.1007/s00184-019-00742-5 SN - 1435-926X VL - 2020 IS - 83 SP - 437 EP - 465 PB - Springer ER - TY - JOUR A1 - Scheer, Nico A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Oswald, Stefan A1 - Busch, Diana A1 - Mclaughlin, Lesley A. A1 - Lin, De A1 - Henderson, Colin J. A1 - Wolf, C. Roland T1 - Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model JF - Drug Metabolism and Disposition Y1 - 2015 U6 - https://doi.org/10.1124/dmd.115.065656 SN - 1521-009x VL - 43 IS - 11 SP - 1679 EP - 1690 PB - ASPET CY - Bethesda ER - TY - JOUR A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Winnard, Andrew A1 - Nasser, Mona A1 - Weber, T. T1 - Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review JF - Frontiers in physiology Y1 - 2017 U6 - https://doi.org/10.3389/fphys.2017.00583 IS - 8, article 583 ER - TY - JOUR A1 - Fredebeul-Krein, Markus A1 - Steingröver, Markus T1 - Wholesale broadband access to IPTV in an NGA environment : how to deal with it from a regulatory perspective? JF - Telecommunications Policy Y1 - 2014 U6 - https://doi.org/doi:10.1016/j.telpol.2013.04.002 SN - 0308-5961 (Print) SN - 1879-3258 (Online) VL - 38 IS - 3 SP - 264 EP - 277 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Poghossian, Arshak A1 - Welden, Rene A1 - Buniatyan, Vahe V. A1 - Schöning, Michael Josef T1 - An Array of On-Chip Integrated, Individually Addressable Capacitive Field-Effect Sensors with Control Gate: Design and Modelling JF - Sensors N2 - The on-chip integration of multiple biochemical sensors based on field-effect electrolyte-insulator-semiconductor capacitors (EISCAP) is challenging due to technological difficulties in realization of electrically isolated EISCAPs on the same Si chip. In this work, we present a new simple design for an array of on-chip integrated, individually electrically addressable EISCAPs with an additional control gate (CG-EISCAP). The existence of the CG enables an addressable activation or deactivation of on-chip integrated individual CG-EISCAPs by simple electrical switching the CG of each sensor in various setups, and makes the new design capable for multianalyte detection without cross-talk effects between the sensors in the array. The new designed CG-EISCAP chip was modelled in so-called floating/short-circuited and floating/capacitively-coupled setups, and the corresponding electrical equivalent circuits were developed. In addition, the capacitance-voltage curves of the CG-EISCAP chip in different setups were simulated and compared with that of a single EISCAP sensor. Moreover, the sensitivity of the CG-EISCAP chip to surface potential changes induced by biochemical reactions was simulated and an impact of different parameters, such as gate voltage, insulator thickness and doping concentration in Si, on the sensitivity has been discussed. KW - equivalent circuit KW - multianalyte detection KW - control gate KW - on-chip integrated addressable EISCAP sensors KW - capacitive field-effect sensor Y1 - 2021 U6 - https://doi.org/10.3390/s21186161 SN - 1424-8220 N1 - This article belongs to the Special Issue "Field-Effect Sensors: From pH Sensing to Biosensing" VL - 21 IS - 18 SP - 17 PB - MDPI CY - Basel ER - TY - JOUR A1 - Vahidpour, Farnoosh A1 - Guthman, Eric A1 - Arreola, Julia A1 - Alghazali, Yousef H. M. A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Assessment of Various Process Parameters for Optimized Sterilization Conditions Using a Multi-Sensing Platform JF - Foods N2 - In this study, an online multi-sensing platform was engineered to simultaneously evaluate various process parameters of food package sterilization using gaseous hydrogen peroxide (H₂O₂). The platform enabled the validation of critical aseptic parameters. In parallel, one series of microbiological count reduction tests was performed using highly resistant spores of B. atrophaeus DSM 675 to act as the reference method for sterility validation. By means of the multi-sensing platform together with microbiological tests, we examined sterilization process parameters to define the most effective conditions with regards to the highest spore kill rate necessary for aseptic packaging. As these parameters are mutually associated, a correlation between different factors was elaborated. The resulting correlation indicated the need for specific conditions regarding the applied H₂O₂ gas temperature, the gas flow and concentration, the relative humidity and the exposure time. Finally, the novel multi-sensing platform together with the mobile electronic readout setup allowed for the online and on-site monitoring of the sterilization process, selecting the best conditions for sterility and, at the same time, reducing the use of the time-consuming and costly microbiological tests that are currently used in the food package industry. KW - spore kill rate KW - sterility KW - aseptic parameters KW - multi-sensing platform KW - gaseous hydrogen peroxide Y1 - 2022 U6 - https://doi.org/10.3390/foods11050660 SN - 2304-8158 N1 - This article belongs to the Special Issue "Sensors and Biosensors Application for Food Industries" VL - 11 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Poghossian, Arshak A1 - Karschuck, Tobias A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Field-Effect Capacitors Decorated with Ligand-Stabilized Gold Nanoparticles: Modeling and Experiments JF - Biosensors N2 - Nanoparticles are recognized as highly attractive tunable materials for designing field-effect biosensors with enhanced performance. In this work, we present a theoretical model for electrolyte-insulator-semiconductor capacitors (EISCAP) decorated with ligand-stabilized charged gold nanoparticles. The charged AuNPs are taken into account as additional, nanometer-sized local gates. The capacitance-voltage (C–V) curves and constant-capacitance (ConCap) signals of the AuNP-decorated EISCAPs have been simulated. The impact of the AuNP coverage on the shift of the C–V curves and the ConCap signals was also studied experimentally on Al–p-Si–SiO₂ EISCAPs decorated with positively charged aminooctanethiol-capped AuNPs. In addition, the surface of the EISCAPs, modified with AuNPs, was characterized by scanning electron microscopy for different immobilization times of the nanoparticles. KW - aminooctanethiol KW - nanoparticle coverage KW - capacitive model KW - gold nanoparticles KW - field-effect sensor KW - electrolyte-insulator-semiconductor capacitors Y1 - 2022 U6 - https://doi.org/10.3390/bios12050334 SN - 2079-6374 N1 - This article belongs to the Special Issue "Biosensors in Nanotechnology" VL - 12 IS - 5 PB - MDPI CY - Basel ER - TY - CHAP A1 - Berndt, Heinz A1 - Kalbe, Jochen A1 - Kuropka, Rolf A1 - Meyer-Stork, L. Sebastian A1 - Höcker, Hartwig ED - Körner, Andrea T1 - Progress and limitations of the DNA analysis in fine animal fiber identification T2 - Proceedings of the 2nd International Symposium on Specialty Animal Fibers : Aachen, October 19 - 20, 1989. - (Schriftenreihe des Deutschen Wollforschungsinstituts an der Technischen Hochschule Aachen e. V. ; 106) Y1 - 1990 SP - 259 EP - 265 PB - Dt. Wollforschungsinst. CY - Aachen ER - TY - CHAP A1 - Schwarte, Rudolf A1 - Buxbaum, Bernd A1 - Heinol, Horst-Guenther A1 - Xu, Zhanping A1 - Ringbeck, Thorsten A1 - Zang, Zhigang T1 - Novel 3D-vision systems based on layout optimized PMD-structures T2 - Proceedings / OPTO 98, Internationaler Kongress und Fachausstellung für Optische Sensorik, Messtechnik und Elektronik, 18. - 20. Mai 1998, Kongreßzentrum Erfurt Y1 - 1998 N1 - Internationaler Kongress und Fachausstellung für Optische Sensorik, Messtechnik & Elektronik <3, 1998, Erfurt> ; International Congress and Exhibition on Optoelectronics, Optical Sensors and Measuring Techniques <3, 1998, Erfurt> ; OPTO <3, 1998, Erfurt> SP - 197 EP - 202 PB - ACS Organisations GmbH CY - Wunsdorf ER - TY - JOUR A1 - Frohberg, Martin G. A1 - Anik, Sabri T1 - The calculation of component activities of binary metallic melts from their gas solubilities JF - Zeitschrift für Metallkunde Y1 - 1985 SN - 0044-3093 VL - 76 IS - 2 SP - 135 EP - 137 ER - TY - JOUR A1 - Dieringer, Matthias A. A1 - Renz, Wolfgang A1 - Lindel, Tomasz D. A1 - Seifert, Frank A1 - Frauenrath, Tobias A1 - von Knobelsdorf-Brenkenhoff, Florian A1 - Waiczies, Helmar A1 - Hoffmann, Werner A1 - Rieger, Jan A1 - Pfeiffer, Harald A1 - Ittermann, Bernd A1 - Schulz-Menger, Jeanette A1 - Niendorf, Thoralf T1 - Design and application of a four-channel transmit/receive surface coil for functional cardiac imaging at 7T JF - Journal of Magnetic Resonance Imaging N2 - Purpose To design and evaluate a four-channel cardiac transceiver coil array for functional cardiac imaging at 7T. Materials and Methods A four-element cardiac transceiver surface coil array was developed with two rectangular loops mounted on an anterior former and two rectangular loops on a posterior former. specific absorption rate (SAR) simulations were performed and a Burn:x-wiley:10531807:media:JMRI22451:tex2gif-stack-1 calibration method was applied prior to obtain 2D FLASH CINE (mSENSE, R = 2) images from nine healthy volunteers with a spatial resolution of up to 1 × 1 × 2.5 mm3. Results Tuning and matching was found to be better than 10 dB for all subjects. The decoupling (S21) was measured to be >18 dB between neighboring loops, >20 dB for opposite loops, and >30 dB for other loop combinations. SAR values were well within the limits provided by the IEC. Imaging provided clinically acceptable signal homogeneity with an excellent blood-myocardium contrast applying the Burn:x-wiley:10531807:media:JMRI22451:tex2gif-stack-2 calibration approach. Conclusion A four-channel cardiac transceiver coil array for 7T was built, allowing for cardiac imaging with clinically acceptable signal homogeneity and an excellent blood-myocardium contrast. Minor anatomic structures, such as pericardium, mitral, and tricuspid valves and their apparatus, as well as trabeculae, were accurately delineated. Y1 - 2011 U6 - https://doi.org/10.1002/jmri.22451 SN - 1522-2586 VL - 33 IS - 3 SP - 736 EP - 741 PB - Wiley-Liss CY - New York ER - TY - JOUR A1 - Fayyazi, Mojgan A1 - Sardar, Paramjotsingh A1 - Thomas, Sumit Infent A1 - Daghigh, Roonak A1 - Jamali, Ali A1 - Esch, Thomas A1 - Kemper, Hans A1 - Langari, Reza A1 - Khayyam, Hamid T1 - Artificial intelligence/machine learning in energy management systems, control, and optimization of hydrogen fuel cell vehicles N2 - Environmental emissions, global warming, and energy-related concerns have accelerated the advancements in conventional vehicles that primarily use internal combustion engines. Among the existing technologies, hydrogen fuel cell electric vehicles and fuel cell hybrid electric vehicles may have minimal contributions to greenhouse gas emissions and thus are the prime choices for environmental concerns. However, energy management in fuel cell electric vehicles and fuel cell hybrid electric vehicles is a major challenge. Appropriate control strategies should be used for effective energy management in these vehicles. On the other hand, there has been significant progress in artificial intelligence, machine learning, and designing data-driven intelligent controllers. These techniques have found much attention within the community, and state-of-the-art energy management technologies have been developed based on them. This manuscript reviews the application of machine learning and intelligent controllers for prediction, control, energy management, and vehicle to everything (V2X) in hydrogen fuel cell vehicles. The effectiveness of data-driven control and optimization systems are investigated to evolve, classify, and compare, and future trends and directions for sustainability are discussed. KW - optimization system KW - intelligent control KW - fuel cell vehicle KW - machine learning KW - artificial intelligence KW - intelligent energy management Y1 - 2023 U6 - https://doi.org/10.3390/su15065249 N1 - This article belongs to the Special Issue "Circular Economy and Artificial Intelligence" VL - 15 IS - 6 SP - 38 PB - MDPI CY - Basel ER -