TY - JOUR A1 - Ritz, Thomas T1 - Personalized information services : an electronic information commodity and its production JF - International Journal of E-Business Strategy Management Y1 - 2000 SN - 1467-0305 VL - 2 IS - 2 ER - TY - THES A1 - Steuer-Dankert, Linda T1 - Diversity in complex organizations : the triangle of diversity management, change management and organizational culture from a system-theoretical perspective N2 - Insbesondere im wirtschaftlichen Kontext wird die Diversität von Belegschaften zunehmend als ein kritischer Erfolgsfaktor gesehen. Neben dem Potenzial, welches sich laut Studien aus einem vielfältigen Team ergibt, werden jedoch ebenfalls die aus menschlicher Diversität resultierenden Herausforderungen thematisiert und wissenschaftlich untersucht. Sowohl aus dem Potenzial als auch aus den Herausforderungen ergibt sich dabei die Notwendigkeit der Implementierung eines organisationsspezifischen Diversity Managements, welches die Gewinnung neuer Mitarbeiter*innen einerseits und das Management der vorhandenen Vielfalt andererseits gleichermaßen unterstützt. In der psychologischen, sozial- und wirtschaftswissenschaftlichen Literatur gibt es unterschiedliche Definitionen von Diversität, woraus sich verschiedene Perspektiven auf das Vorgehen bei der Gestaltung und Umsetzung eines Diversity Management Ansatzes ergeben. Insbesondere vor dem Hintergrund der Komplexität des Organisationsumfeldes und der steigenden Anforderungen an die organisationsinterne Agilität besteht die Notwendigkeit, Diversität in Organisationen stärker zu reflektieren und systemspezifische Ansätze zu entwickeln. Dies erfordert die Berücksichtigung organisationsspezifischer Strukturen und Prozesse sowie die Reflexion des Wandels der Organisationskultur durch die Umsetzung eines Diversity Management Ansatzes, der die gegebene Komplexität aufgreift und bewältigen kann. Darüber hinaus sind die psychologischen Auswirkungen solcher Veränderungen auf die Mitarbeiter*innen zu berücksichtigen, um Reaktanzen zu vermeiden und eine nachhaltige Umsetzung von Diversity Management zu ermöglichen. In Ermangelung entsprechender Ansätze im Rahmen öffentlich finanzierter, komplexer Forschungsorganisationen, ist das Ziel dieser Dissertation die Entwicklung und Erprobung eines Forschungsdesigns, welches die Ansätze des Diversity- und Change Managements mit der Organisationskultur verknüpft, indem es eine systemtheoretische Perspektive einnimmt. Dabei wird das Forschungsdesign auf eine komplexe wissenschaftliche Organisation angewendet. Als Basis dient die in Teil A durchgeführte Betrachtung des aktuellen Forschungsstandes aus einer interdisziplinären Perspektive und die damit einhergehende umfassende Einführung in das Forschungsfeld. Im Zuge dessen wird detailliert auf die begriffliche Definition von Diversität eingegangen, bevor dann die psychologischen Konzepte im Diversitätskontext den Übergang zu einer differenzierten Auseinandersetzung mit dem Konzept des Diversity Managements bilden. Auf dieser Grundlage werden das Forschungsdesign sowie die daraus resultierenden Forschungsphasen abgeleitet. Teil A stellt somit die theoretische Grundlage für die in Teil B präsentierten Fachaufsätze dar. Jeder Fachaufsatz beleuchtet dabei in chronologischer Reihenfolge die unterschiedlichen Forschungsphasen. Fachaufsatz I präsentiert den sechsstufigen Forschungsansatz und beleuchtet die besonderen Rahmenbedingungen des Forschungsobjektes aus einer theoretischen Perspektive. Im Anschluss werden die Ergebnisse der Organisationsanalyse, welche zugleich Phase I und II des Forschungskonzeptes darstellen, vorgestellt. Aufbauend auf diesen Forschungsergebnissen fokussiert Forschungsaufsatz II die Darlegung der Ergebnisse aus Forschungsphase III, der Befragung der Führungsebene. Die Befragung thematisierte dabei die Wahrnehmung von Diversity und Diversity Management auf Führungsebene, die Verknüpfung von Diversität mit Innovation sowie die Reflexion des eigenen Führungsstils. Als Ergebnis der Befragung konnten sechs Typen identifiziert werden, die das Führungsverständnis im Diversitätskontext widerspiegeln und somit den Ansatzpunkt für eine top-down gerichtete Diversity Management Strategie darstellen. Darauf aufbauend wird in Forschungsphase IV die Mitarbeiter*innenebene beforscht. Im Zentrum der quantitativen Befragung standen die vorherrschenden Einstellungen zum Themenkomplex Diversity und Diversity Management, die Wahrnehmung von Diversität sowie die Untersuchung des Einflusses der Führungsebene auf die Mitarbeiter*innenebene. Forschungsaufsatz III präsentiert erste Ergebnisse dieser Untersuchung. Die Analyse weist auf eine unterschiedliche Gewichtung der verschiedenen Diversitätskategorien hinsichtlich der Verknüpfung mit Innovationen und somit der Reflexion des Kontextes zwischen Diversität und Innovationen hin. Vergleichbar mit den identifizierten Typen auf der Führungsebene, deutet die Analyse auf die Existenz unterschiedlicher Reflexionsgrade auf Mitarbeiter*innenebene hin. Auf Basis dessen wird im Rahmen von Forschungsaufsatz IV eine nähere Untersuchung des Reflexionsgrades auf Mitarbeiter*innenebene präsentiert und der Diversity Management Ansatz mit Elementen des Change Managements kombiniert. Besondere Berücksichtigung findet als Schlussfolgerung einer theoretischen Analyse die Organisationskultur als zentrales Element bei der Entwicklung und Einführung eines Diversity Management Ansatzes in eine komplexe Forschungsorganisation in Deutschland. Die Analyse zeigt, dass die Wahrnehmung von Diversität heterogen aber zunächst losgelöst vom individuellen Hintergrund ist (im Rahmen dieser Analyse lag der Fokus auf den Diversitätskategorien Gender und Herkunft). Hinsichtlich der Wertschätzung von Diversität zeigt sich dabei ebenfalls ein heterogenes Bild. In der Gesamtbetrachtung stimmen lediglich 17% der Mitarbeiter*innen zu, dass Diversitätskategorien wie Gender, Herkunft oder auch Alter einen Mehrwert darstellen können. Zugleich bewertet diese Gruppe die dem Thema beigemessene Wichtigkeit im CoE als ausreichend. Zusammengefasst lassen sich folgende Erkenntnisse im Rahmen dieser Dissertation ableiten und dienen somit als Grundlage für die Entwicklung eines Diversity Management Ansatzes: (1) Die Entwicklung eines bedarfsorientierten Diversity Management Ansatzes erfordert einen systemtheoretischen Prozess, der sowohl organisationsinterne als auch externe Einflussfaktoren berücksichtigt. Der im Rahmen des Forschungsprojektes entwickelte sechsstufige Forschungsprozess hat sich dabei als geeignetes Instrument erwiesen. (2)Im Rahmen öffentlicher Forschungseinrichtungen lassen sich dabei drei zentrale Faktoren identifizieren: die individuelle Reflexionsebene, die Organisationskultur sowie extern beeinflusste Organisationsstrukturen, Prozesse und Systeme.(3)Vergleichbar mit privatwirtschaftlichen Unternehmen hat auch in wissenschaftlichen Organisationen die Führungsebene einen maßgeblichen Einfluss auf die Wahrnehmung von Diversität und somit einen Einfluss auf die Umsetzung einer Diversity Management Strategie. Daher ist auch im wissenschaftlichen Kontext, bedingt durch die rechtlichen Rahmenbedingungen des Hochschulsystems, ein top-down Ansatz für eine nachhaltige Implementierung erforderlich. (4) Diversity Management steht in einem engen Zusammenhang mit einem organisationalen Wandel, was die Reflexion von Veränderungsprozesse aus einer psychologischen Perspektive erfordert und eine Verknüpfung von Diversity und Change Management bedingt. Aufbauend auf den im Rahmen des entwickelten Forschungskonzeptes gewonnenen zentralen Erkenntnissen wird ein Ansatz entwickelt, der die Ableitung theoretischer Implikationen sowie Implikationen für das Management ermöglicht. Insbesondere vor dem Hintergrund der Reflexion der besonderen Rahmenbedingungen öffentlich finanzierter Forschungsorganisationen werden darüber hinaus politische Implikationen abgeleitet, die auf die Veränderung struktureller Dimensionen abzielen. Y1 - 2020 U6 - https://doi.org/10.18154/RWTH-2020-11830 ER - TY - CHAP A1 - Becker, Jörg A1 - Eggert, Mathias A1 - Saat, Jan A1 - Dirding, Philipp T1 - The Influence of Regulation on Data Warehouse Engineering – Investigating an IT Consulting Case in the Financial Service Industry T2 - Proceedings of the Nineteenth Americas Conference on Information Systems, Chicago, Illinois, August 15-17, 2013. Y1 - 2013 SP - 1 EP - 8 ER - TY - THES A1 - Beckmann, Nils T1 - Characterization of the hydrogen-dry-low-Nox-micromix-combustion-principle for hydrogen-methane fuel mixtures KW - Low NOx KW - Hydrogen KW - Combustion KW - Low emission Y1 - 2019 N1 - Dissertation, RMIT University, August 2019 PB - RMIT University CY - Melbourne ER - TY - CHAP A1 - Luft, Angela A1 - Gebhardt, Andreas A1 - Balc, Nicolae T1 - Challenges of additive manufacturing in production systems T2 - Modern technologies in manufacturing (MTeM 2019) Y1 - 2019 U6 - https://doi.org/10.1051/matecconf/201929901003 N1 - MATEC Web of Conferences 299; MTeM 2019 VL - 299 IS - Article 01003 ER - TY - BOOK A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Label-free biosensing: advanced materials, devices and applications Y1 - 2018 SN - 978-3-319-75219-8 PB - Springer CY - Cham ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Savitkaya, I.S. A1 - Zhubanova, A.A. A1 - Tastambek, K.T. T1 - Investigations of LPS endotoxin elimination in the flowing column conditions with the sorbent on the basis of carbonized rice husk JF - KazNU Bulletin. Biology series Y1 - 2013 SN - 1563-0218 N1 - Original in russischer Sprache VL - 57 IS - 1 SP - 124 EP - 127 ER - TY - CHAP A1 - Schopp, Christoph A1 - Heuermann, Holger A1 - Holtrup, S. T1 - Investigation on efficacy optimization of RF-driven automotive D-lamps T2 - 44th European Microwave Conference (EuMC),2014, Rome Y1 - 2014 U6 - https://doi.org/10.1109/EuMC.2014.6986645 SP - 1154 EP - 1157 ER - TY - JOUR A1 - Gerigk, M. A1 - Bujnicki, R. A1 - Ganpo-Nkwenkwa, E. A1 - Bongaerts, Johannes A1 - Sprenger, G. A1 - Takors, Ralf T1 - Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains JF - Biotechnology and bioengineering Y1 - 2002 SN - 1097-0290 (E-Journal); 0006-3592 (Print) VL - Vol. 80 IS - Iss. 7 SP - 746 EP - 754 ER - TY - JOUR A1 - Ferrein, Alexander A1 - Jacobs, Stefan A1 - Lakemeyer, Gerhard T1 - Unreal Golog Bots / Jacobs, Stefan ; Ferrein, Alexander ; Lakemeyer, Gerhard JF - IJCAI-05 Workshop on Reasoning, Representation, and Learning in Computer Games Y1 - 2005 SP - 31 EP - 36 ER - TY - CHAP A1 - Ballmann, Josef A1 - Boucke, Alexander A1 - Braun, Carsten T1 - Aeroelastic sensitivity in the transonic regime T2 - Symposium Transsonicum IV : proceedings of the IUTAM symposium held in Göttingen, Germany, 2 - 6 September 2002 / ed. by Helmut Sobieczky. Fluid mechanics and its applications. Vol. 73 Y1 - 2003 SN - 978-94-010-3998-7 SP - 225 EP - 236 PB - Kluwer Academic CY - Dordrecht ER - TY - GEN A1 - Frauenrath, Tobias A1 - Dieringer, Matthias A1 - Patel, Nishant A1 - Zerdem, Celal A1 - Hentschel, Jan A1 - Renz, Wolfgang A1 - Niendorf, Thoralf T1 - From Artifact to Merit: Cardiac Gated MRI at 7T & 3T using Magneto-Hydrodynamic Effects for Synchronization T2 - 2011 ISMRM Annual Meeting Proceedings N2 - ECG is corrupted by magneto-hydrodynamic effects at higher magnetic field strength. Artifacts in the ECG trace and severe T-wave elevation might be mis-interpreted as R-waves. MHD being inherently sensitive to blood flow and blood velocity provides an alternative approach for cardiac gating, even in peripheral target areas far away from the commonly used upper torso positions of ECG electrodes. This feature would be very beneficial to address traveling time induced motion artifacts and trigger latency related issues raised by ECG-gated peripheral MR angiography. For all those reasons, this work proposes the use of MHD-trigger for cardiac gated MR. Y1 - 2011 SN - 1545-4428 N1 - ISMRM 19th Annual Meeting & Exhibition, 7-13 May 2011, Montreal, Quebec, Canada ER - TY - CHAP A1 - Kelly, Bruce A1 - Herrmann, Ulf A1 - Hale, M.-J. T1 - Optimization Studies for Integrated Solar Combined Cycle Systems T2 - Solar engineering 2001 : proceedings of the International Solar Energy Conference ; presented at the 2001 International Solar Energy Conference, a part of Forum 2001 - Solar energy: the power to choose, April 21 - 25, 2001, Washington, D.C. Y1 - 2001 SN - 0-7918-1670-2 N1 - International Solar Energy Conference SP - 393 EP - 398 PB - ASME CY - New York, NY ER - TY - CHAP A1 - Kleefeld, Andreas ED - Constanda, Christian T1 - Numerical calculation of interior transmission eigenvalues with mixed boundary conditions T2 - Computational and Analytic Methods in Science and Engineering N2 - Interior transmission eigenvalue problems for the Helmholtz equation play an important role in inverse wave scattering. Some distribution properties of those eigenvalues in the complex plane are reviewed. Further, a new scattering model for the interior transmission eigenvalue problem with mixed boundary conditions is described and an efficient algorithm for computing the interior transmission eigenvalues is proposed. Finally, extensive numerical results for a variety of two-dimensional scatterers are presented to show the validity of the proposed scheme. Y1 - 2020 SN - 978-3-030-48185-8 (Hardcover) U6 - https://doi.org/10.1007/978-3-030-48186-5_9 SP - 173 EP - 195 PB - Birkhäuser CY - Cham ER - TY - JOUR A1 - Heuermann, Holger A1 - Schiek, B. T1 - Results of network analyzer measurements with leakage errors-corrected with direct calibration techniques JF - IEEE transactions on instrumentation and measurement : IM / Institute of Electrical and Electronics Engineers, Instrumentation and Measurement Group. 46 (1997), H. 5 Y1 - 1997 SN - 0018-9456 SP - 1120 EP - 1127 ER - TY - JOUR A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Comparative assessment of parallel-hybrid-electric propulsion systems for four different aircraft JF - Journal of Aircraft N2 - Until electric energy storage systems are ready to allow fully electric aircraft, the combination of combustion engine and electric motor as a hybrid-electric propulsion system seems to be a promising intermediate solution. Consequently, the design space for future aircraft is expanded considerably, as serial hybrid-electric, parallel hybrid-electric, fully electric, and conventional propulsion systems must all be considered. While the best propulsion system depends on a multitude of requirements and considerations, trends can be observed for certain types of aircraft and certain types of missions. This Paper provides insight into some factors that drive a new design toward either conventional or hybrid propulsion systems. General aviation aircraft, regional transport aircraft vertical takeoff and landing air taxis, and unmanned aerial vehicles are chosen as case studies. Typical missions for each class are considered, and the aircraft are analyzed regarding their takeoff mass and primary energy consumption. For these case studies, a high-level approach is chosen, using an initial sizing methodology. Only parallel-hybrid-electric powertrains are taken into account. Aeropropulsive interaction effects are neglected. Results indicate that hybrid-electric propulsion systems should be considered if the propulsion system is sized by short-duration power constraints. However, if the propulsion system is sized by a continuous power requirement, hybrid-electric systems offer hardly any benefit. Y1 - 2020 U6 - https://doi.org/10.2514/1.C035897 SN - 1533-3868 VL - 57 IS - 5 PB - AIAA CY - Reston, Va. ER - TY - JOUR A1 - Bongaerts, Johannes A1 - Bovenberg, Roel A1 - Krämer, Marco A1 - Müller, Ulrike A1 - Raeven, Leon A1 - Wubbolts, Marcel T1 - Metabolic engineering to produce fine chemicals in Escherichia coli JF - Chemie - Ingenieur - Technik (CIT) Y1 - 2002 SN - 1522-2640 (E-Journal); 0009-286X (Print) N1 - Printausg. in der Bibliothek vorhanden: 63 ZS 022 VL - Vol. 74 IS - Iss. 5 SP - 694 ER - TY - CHAP A1 - Bung, Daniel Bernhard A1 - Oertel, Mario T1 - Wave breaking over a submerged horizontal plate: Optical Flow, LES and RANS T2 - E-proceedings of the 38th IAHR World Congress September 1-6, 2019, Panama City, Panama Y1 - 2019 U6 - https://doi.org/10.3850/38WC092019-0509 SP - 3690 EP - 3698 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Wellmer, Jörg A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis JF - Epilepsia Y1 - 2006 SN - 0013-9580 VL - 47 SP - 36 ER - TY - JOUR A1 - Ferrein, Alexander A1 - Böhnstedt, Lutz A1 - Lakemeyer, Gerhard T1 - Options in readylog reloaded -- generating decision-theoretic plan libraries in golog / Böhnstedt, Lutz ; Ferrein, Alexander ; Lakemeyer, Gerhard JF - KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabrück, Germany, September 10 - 13, 2007 ; proceedings Y1 - 2007 SN - 978-3-540-74564-8 N1 - Lecture Notes in Computer Science ; 4667 SP - 352 EP - 366 PB - Springer CY - Berlin ER - TY - CHAP A1 - Ludowicy, Jonas A1 - Rings, René A1 - Finger, Felix A1 - Braun, Carsten T1 - Sizing Studies of Light Aircraft with Serial Hybrid Propulsion Systems T2 - Luft- und Raumfahrt - Digitalisierung und Vernetzung : Deutscher Luft- und Raumfahrtkongress 2018. 4. - 6. September 2018 - Friedrichshafen Y1 - 2018 ER - TY - CHAP A1 - Neumann, Tobias A1 - Ferrein, Alexander A1 - Kallweit, Stephan A1 - Scholl, Ingrid T1 - Towards a mobile mapping robot for underground mines T2 - 7th Conference of Robotics and Mechatronics : RobMech 2014 : 27th and 28th Nov. 2014, Cape Town Y1 - 2014 SP - 1 EP - 6 ER - TY - CHAP A1 - Bung, Daniel Bernhard A1 - Tullis, Blake T1 - Hydraulic Structures - ISHS2018 in Perspective T2 - 7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May Y1 - 2018 SN - 978-0-692-13277-7 U6 - https://doi.org/10.15142/T3WH2B ER - TY - CHAP A1 - Ludowicy, Jonas A1 - Rings, René A1 - Finger, Felix A1 - Braun, Carsten T1 - Sizing Studies of Light Aircraft with Parallel Hybrid Propulsion Systems T2 - Deutscher Luft- und Raumfahrtkongress 2018 Y1 - 2018 U6 - https://doi.org/10.25967/480227 ER - TY - CHAP A1 - Thurn, Laura A1 - Gebhardt, Andreas T1 - Strategy of Education on Materials for Students T2 - Conference Proceedings: „New Perspectives in Science Education" Y1 - 2018 SN - 978-88-6292-976-9 SP - 156 EP - 161 CY - Florence, Italy ER - TY - CHAP A1 - Butenweg, Christoph A1 - Gajewski, R. A1 - Thierauf, Georg T1 - A practical approach for the optimum design of reinforced concrete structures T2 - Developments in computational mechanics with high performance computing : [papers presented at the Third Euro-Conference on Parallel and Distributed Computing for Computational Mechanics, held in Weimar, Germany between 20 - 25 March 1999] / ed. by B. H. V. Topping Y1 - 1999 SN - 0-94-8749-59-8 SP - 245 EP - 250 PB - Civil-Comp Press CY - Edinburgh ER - TY - JOUR A1 - Heuermann, Holger T1 - LZY: A Self-Calibration Approach in Competition to the LRM Method for On-Wafer Measurements Y1 - 1995 N1 - 45th ARFTG Conference digest, Spring 1995 : [conference topic: Testing and design of RFIC'S], May 19, 1995, Orange County Convention Center, Orlando, Florida / Automatic RF Techniques Group. Publications chairman: Ed Godshalk; ARFTG Conference digest ; 4 SP - 129 EP - 136 ER - TY - BOOK A1 - Laack, Walter van T1 - A better history of our world / Vol. 3. Death Y1 - 2003 SN - 978-3-936624-01-4 N1 - [Eine bessere Geschichte unserer Welt ] PB - van Laack CY - Aachen ER - TY - JOUR A1 - Wolf, Martin R. A1 - Foltz, Christian A1 - Schlick, Christopher A1 - Luczak, Holger T1 - Development and evaluation of a groupware system to support chemical design processes / Wolf, Martin ; Foltz, Christian ; Schlick, Christopher ; Luczak, Holger JF - International Journal of Human-Computer Interaction . 14 (2002), H. 2 Y1 - 2002 SN - 1044-7318 SP - 181 EP - 198 PB - - ER - TY - JOUR A1 - Bongaerts, Johannes A1 - Zoschke, Sascha A1 - Weidner, Uwe A1 - Linden, Gottfried T1 - Transcriptional regulation of the proton translocating NADH JF - Molecular microbiology Y1 - 1995 SN - 1365-2958 (E-Journal); 0950-382x (Print) VL - Vol. 16 IS - Iss. 3 SP - 521 EP - 534 ER - TY - JOUR A1 - Staat, Manfred T1 - Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability JF - Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in Jülich, 21-24 November 1994 Y1 - 1996 N1 - IAEA-TECDOC-920 ; Onlinezugriff erfolgt auf die überarb. Ausg. 2006 SP - 43 EP - 55 CY - Vienna ER - TY - JOUR A1 - Stulpe, Werner T1 - Conditional Expectations, Conditional Distributions, and A Posteriori Ensembles in Generalized Probability Theory JF - International Journal of Theoretical Physics. 27 (1988), H. 5 Y1 - 1988 SN - 1572-9575 SP - 587 EP - 611 ER - TY - JOUR A1 - Janus, Kevin Alexander A1 - Achtsnicht, Stefan A1 - Drinic, Aleksander A1 - Kopp, Alexander A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Transient magnesium-based thin-film temperature sensor on a flexible, bioabsorbable substrate for future medical applications JF - Applied Research N2 - In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C. KW - Silk fibroin KW - Polylactide acid KW - Bioabsorbable KW - Resistive temperature detector Y1 - 2023 U6 - https://doi.org/10.1002/appl.202300102 SN - 2702-4288 (Print) N1 - Corresponding author: Michael Josef Schöning IS - Accepted manuscript PB - Wiley-VCH ER - TY - JOUR A1 - Janus, Kevin Alexander A1 - Achtsnicht, Stefan A1 - Tempel, Laura A1 - Drinic, Aleksaner A1 - Kopp, Alexander A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon JF - Physica status solidi : pss. A, Applications and materials science N2 - Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5–10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior. KW - amperometric biosensors KW - biocompatible KW - biodegradabl KW - encapsulation materials KW - fibroin Y1 - 2023 U6 - https://doi.org/10.1002/pssa.202300081 SN - 1862-6300 (Print) SN - 1862-6319 (Online) N1 - Corresponding author: Michael J. Schöning VL - 220 IS - 22 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Karschuck, Tobias A1 - Poghossian, Arshak A1 - Ser, Joey A1 - Tsokolakyan, Astghik A1 - Achtsnicht, Stefan A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage JF - Sensors and Actuators B: Chemical N2 - Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed. KW - Field-effect biosensor KW - Capacitive model KW - Enzyme coverage KW - Multianalyte detection KW - Penicillin Y1 - 2024 U6 - https://doi.org/10.1016/j.snb.2024.135530 SN - 0925-4005 (Print) SN - 1873-3077 (Online) N1 - Corresponding Author: Michael J. Schöning VL - 408 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W.K. T1 - Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard JF - Talanta N2 - Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated. In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.). KW - qNMR KW - Deuterium NMR KW - Deuterated solvents KW - Standardization Y1 - 2021 SN - 0039-9140 U6 - https://doi.org/10.1016/j.talanta.2020.121504 VL - 222 IS - Article number: 121504 PB - Elsevier ER - TY - CHAP A1 - Paulsen, Svea A1 - Hoffstadt, Kevin A1 - Krafft, Simone A1 - Leite, A. A1 - Zang, J. A1 - Fonseca-Zang, W. A1 - Kuperjans, Isabel T1 - Continuous biogas production from sugarcane as sole substrate T2 - Energy Reports N2 - A German–Brazilian research project investigates sugarcane as an energy plant in anaerobic digestion for biogas production. The aim of the project is a continuous, efficient, and stable biogas process with sugarcane as the substrate. Tests are carried out in a fermenter with a volume of 10 l. In order to optimize the space–time load to achieve a stable process, a continuous process in laboratory scale has been devised. The daily feed in quantity and the harvest time of the substrate sugarcane has been varied. Analyses of the digester content were conducted twice per week to monitor the process: The ratio of inorganic carbon content to volatile organic acid content (VFA/TAC), the concentration of short-chain fatty acids, the organic dry matter, the pH value, and the total nitrogen, phosphate, and ammonium concentrations were monitored. In addition, the gas quality (the percentages of CO₂, CH₄, and H₂) and the quantity of the produced gas were analyzed. The investigations have exhibited feasible and economical production of biogas in a continuous process with energy cane as substrate. With a daily feeding rate of 1.68gᵥₛ/l*d the average specific gas formation rate was 0.5 m3/kgᵥₛ. The long-term study demonstrates a surprisingly fast metabolism of short-chain fatty acids. This indicates a stable and less susceptible process compared to other substrates. Y1 - 2020 U6 - https://doi.org/10.1016/j.egyr.2019.08.035 N1 - 6th International Conference on Energy and Environment Research, ICEER 2019, 22–25 July, University of Aveiro, Portugal VL - 6 IS - Supplement 1 SP - 153 EP - 158 PB - Elsevier ER - TY - CHAP A1 - Neth, Jannik A1 - Schuba, Marko A1 - Brodkorb, Karsten A1 - Neugebauer, Georg A1 - Höner, Tim A1 - Hack, Sacha T1 - Digital forensics triage app for android T2 - ARES '23: Proceedings of the 18th International Conference on Availability, Reliability and Security N2 - Digital forensics of smartphones is of utmost importance in many criminal cases. As modern smartphones store chats, photos, videos etc. that can be relevant for investigations and as they can have storage capacities of hundreds of gigabytes, they are a primary target for forensic investigators. However, it is exactly this large amount of data that is causing problems: extracting and examining the data from multiple phones seized in the context of a case is taking more and more time. This bears the risk of wasting a lot of time with irrelevant phones while there is not enough time left to analyze a phone which is worth examination. Forensic triage can help in this case: Such a triage is a preselection step based on a subset of data and is performed before fully extracting all the data from the smartphone. Triage can accelerate subsequent investigations and is especially useful in cases where time is essential. The aim of this paper is to determine which and how much data from an Android smartphone can be made directly accessible to the forensic investigator – without tedious investigations. For this purpose, an app has been developed that can be used with extremely limited storage of data in the handset and which outputs the extracted data immediately to the forensic workstation in a human- and machine-readable format. KW - Android KW - Digital triage KW - Triage-app Y1 - 2023 SN - 9798400707728 U6 - https://doi.org/10.1145/3600160.3605017 N1 - ARES 2023: The 18th International Conference on Availability, Reliability and Security. August 29 - September 1, 2023. Benevento, Italy. PB - ACM ER - TY - CHAP A1 - Neugebauer, Georg A1 - Brutschy, Lucas A1 - Meyer, Ulrike A1 - Wetzel, Susanne ED - Garcia-Alfaro, Joaquin ED - Lioudakis, Georgios ED - Cuppens-Boulahia, Nora ED - Foley, Simon ED - Fitzgerald, William M. T1 - Privacy-preserving multi-party reconciliation secure in the malicious model T2 - DPM 2013, SETOP 2013: Data Privacy Management and Autonomous Spontaneous Security N2 - The problem of fair and privacy-preserving ordered set reconciliation arises in a variety of applications like auctions, e-voting, and appointment reconciliation. While several multi-party protocols have been proposed that solve this problem in the semi-honest model, there are no multi-party protocols that are secure in the malicious model so far. In this paper, we close this gap. Our newly proposed protocols are shown to be secure in the malicious model based on a variety of novel non-interactive zero-knowledge-proofs. We describe the implementation of our protocols and evaluate their performance in comparison to protocols solving the problem in the semi-honest case. KW - Privacy-enhancing technologies KW - Secure multi-party computation KW - Cryptographic protocols KW - Zero-knowledge proofs KW - Malicious model Y1 - 2014 SN - 978-3-642-54567-2 (Print) SN - 978-3-642-54568-9 (Online) U6 - https://doi.org/10.1007/978-3-642-54568-9_12 N1 - 8th International Workshop, DPM 2013, and 6th International Workshop, SETOP 2013, Egham, UK, September 12-13, 2013. Part of the Lecture Notes in Computer Science book series (LNSC,volume 8247) SP - 178 EP - 193 PB - Springer CY - Berlin ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W.K. T1 - Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent JF - Journal of Pharmaceutical and Biomedical Analysis N2 - NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products. KW - NMR spectroscopy KW - Inorganic ions KW - Heparin KW - Standardization Y1 - 2022 SN - 0731-7085 U6 - https://doi.org/10.1016/j.jpba.2021.114530 VL - 209 IS - Article number: 114530 PB - Elsevier ER - TY - JOUR A1 - Block, Franziska A1 - May, Alexander A1 - Wetzel, Katharina A1 - Adels, Klaudia A1 - Elbers, Gereon A1 - Schulze, Margit A1 - Monakhova, Yulia T1 - What is the best spectroscopic method for simultaneous analysis of organic acids and (poly)saccharides in biological matrices: Example of Aloe vera extracts? JF - Talanta Open N2 - Several species of (poly)saccharides and organic acids can be found often simultaneously in various biological matrices, e.g., fruits, plant materials, and biological fluids. The analysis of such matrices sometimes represents a challenging task. Using Aloe vera (A. vera) plant materials as an example, the performance of several spectro-scopic methods (80 MHz benchtop NMR, NIR, ATR-FTIR and UV–vis) for the simultaneous analysis of quality parameters of this plant material was compared. The determined parameters include (poly)saccharides such as aloverose, fructose and glucose as well as organic acids (malic, lactic, citric, isocitric, acetic, fumaric, benzoic and sorbic acids). 500 MHz NMR and high-performance liquid chromatography (HPLC) were used as the reference methods. UV–vis data can be used only for identification of added preservatives (benzoic and sorbic acids) and drying agent (maltodextrin) and semiquantitative analysis of malic acid. NIR and MIR spectroscopies combined with multivariate regression can deliver more informative overview of A. vera extracts being able to additionally quantify glucose, aloverose, citric, isocitric, malic, lactic acids and fructose. Low-field NMR measurements can be used for the quantification of aloverose, glucose, malic, lactic, acetic, and benzoic acids. The benchtop NMR method was successfully validated in terms of robustness, stability, precision, reproducibility and limit of detection (LOD) and quantification (LOQ), respectively. All spectroscopic techniques are useful for the screening of (poly)saccharides and organic acids in plant extracts and should be applied according to its availability as well as information and confidence required for the specific analytical goal. Benchtop NMR spectroscopy seems to be the most feasible solution for quality control of A. vera products. KW - Spectroscopy KW - (Poly)saccharides KW - Organic acids KW - Aloe vera KW - qNMR Y1 - 2023 U6 - https://doi.org/10.1016/j.talo.2023.100220 SN - 2666-8319 VL - 7 IS - Art. No. 100220 SP - 1 EP - 9 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Molinnus, Denise A1 - Janus, Kevin Alexander A1 - Fang, Anyelina C. A1 - Drinic, Aleksander A1 - Achtsnicht, Stefan A1 - Köpf, Marius A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Thick-film carbon electrode deposited onto a biodegradable fibroin substrate for biosensing applications JF - Physica status solidi (a) N2 - This study addresses a proof-of-concept experiment with a biocompatible screen-printed carbon electrode deposited onto a biocompatible and biodegradable substrate, which is made of fibroin, a protein derived from silk of the Bombyx mori silkworm. To demonstrate the sensor performance, the carbon electrode is functionalized as a glucose biosensor with the enzyme glucose oxidase and encapsulated with a silicone rubber to ensure biocompatibility of the contact wires. The carbon electrode is fabricated by means of thick-film technology including a curing step to solidify the carbon paste. The influence of the curing temperature and curing time on the electrode morphology is analyzed via scanning electron microscopy. The electrochemical characterization of the glucose biosensor is performed by amperometric/voltammetric measurements of different glucose concentrations in phosphate buffer. Herein, systematic studies at applied potentials from 500 to 1200 mV to the carbon working electrode (vs the Ag/AgCl reference electrode) allow to determine the optimal working potential. Additionally, the influence of the curing parameters on the glucose sensitivity is examined over a time period of up to 361 days. The sensor shows a negligible cross-sensitivity toward ascorbic acid, noradrenaline, and adrenaline. The developed biocompatible biosensor is highly promising for future in vivo and epidermal applications. KW - biocompatible materials KW - biodegradable electronic devices KW - biosensors KW - carbon electrodes KW - glucose Y1 - 2022 U6 - https://doi.org/10.1002/pssa.202200100 SN - 1862-6319 N1 - Corresponding author: Michael J. Schöning VL - 219 IS - 23 SP - 1 EP - 9 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Özsoylu, Dua A1 - Kizildag, Sefa A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS) JF - Physics in Medicine N2 - Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO–K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO–K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images. Y1 - 2020 U6 - https://doi.org/10.1016/j.phmed.2020.100030 SN - 2352-4510 VL - 10 IS - 100030 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Sildatke, Michael A1 - Karwanni, Hendrik A1 - Kraft, Bodo A1 - Schmidts, Oliver A1 - Zündorf, Albert T1 - Automated Software Quality Monitoring in Research Collaboration Projects T2 - ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops N2 - In collaborative research projects, both researchers and practitioners work together solving business-critical challenges. These projects often deal with ETL processes, in which humans extract information from non-machine-readable documents by hand. AI-based machine learning models can help to solve this problem. Since machine learning approaches are not deterministic, their quality of output may decrease over time. This fact leads to an overall quality loss of the application which embeds machine learning models. Hence, the software qualities in development and production may differ. Machine learning models are black boxes. That makes practitioners skeptical and increases the inhibition threshold for early productive use of research prototypes. Continuous monitoring of software quality in production offers an early response capability on quality loss and encourages the use of machine learning approaches. Furthermore, experts have to ensure that they integrate possible new inputs into the model training as quickly as possible. In this paper, we introduce an architecture pattern with a reference implementation that extends the concept of Metrics Driven Research Collaboration with an automated software quality monitoring in productive use and a possibility to auto-generate new test data coming from processed documents in production. Through automated monitoring of the software quality and auto-generated test data, this approach ensures that the software quality meets and keeps requested thresholds in productive use, even during further continuous deployment and changing input data. Y1 - 2020 U6 - https://doi.org/10.1145/3387940.3391478 N1 - ICSE '20: 42nd International Conference on Software Engineering, Seoul, Republic of Korea, 27 June 2020 - 19 July 2020 SP - 603 EP - 610 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Pourshahidi, Mohammad Ali A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation JF - Journal of Magnetism and Magnetic Materials N2 - Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing. Y1 - 2022 U6 - https://doi.org/10.1016/j.jmmm.2022.169965 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Tödter, Julia A1 - Niehues, Julia A1 - Telöken, Matthias A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim A1 - Schröper, Florian T1 - 3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection JF - Sensors N2 - For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated. Y1 - 2019 U6 - https://doi.org/10.3390/s19010148 SN - 1424-8220 VL - 19 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Heuermann, Holger A1 - Sadeghfam, Arash T1 - Enhanced system architecture for rugged wide band data transmission / Sadeghfam, A. ; Heuermann, H. JF - European Radar Conference, 2009 : EuRAD 2009 ; Sept. 30 - Oct. 2 2009, Rome, Italy ; part of the European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association Y1 - 2009 SN - 978-2-87487-014-9 N1 - Proceedings of the 6th European Radar Conference SP - 347 EP - 350 PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Adels, Klaudia A1 - Elbers, Gereon A1 - Diehl, Bernd A1 - Monakhova, Yulia T1 - Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study JF - Analytical Sciences N2 - With the prevalence of glucosamine- and chondroitin-containing dietary supplements for people with osteoarthritis in the marketplace, it is important to have an accurate and reproducible analytical method for the quantitation of these compounds in finished products. NMR spectroscopic method based both on low- (80 MHz) and high- (500–600 MHz) field NMR instrumentation was established, compared and validated for the determination of chondroitin sulfate and glucosamine in dietary supplements. The proposed method was applied for analysis of 20 different dietary supplements. In the majority of cases, quantification results obtained on the low-field NMR spectrometer are similar to those obtained with high-field 500–600 MHz NMR devices. Validation results in terms of accuracy, precision, reproducibility, limit of detection and recovery demonstrated that the developed method is fit for purpose for the marketed products. The NMR method was extended to the analysis of methylsulfonylmethane, adulterant maltodextrin, acetate and inorganic ions. Low-field NMR can be a quicker and cheaper alternative to more expensive high-field NMR measurements for quality control of the investigated dietary supplements. High-field NMR instrumentation can be more favorable for samples with complex composition due to better resolution, simultaneously giving the possibility of analysis of inorganic species such as potassium and chloride. KW - Glucosamine KW - Chondroitin sulfate KW - Polysaccharides KW - Dietary supplements KW - High-field NMR Y1 - 2023 U6 - https://doi.org/10.1007/s44211-023-00433-2 SN - 1348-2246 (Online) SN - 0910-6340 (Print) N1 - Corresponding author: Yulia Monakhova VL - 2023 PB - Springer Verlag CY - Cham ER - TY - JOUR A1 - Trapp, Svenja A1 - Lammers, Tom A1 - Engudar, Gokce A1 - Hoehr, Cornelia A1 - Denkova, Antonia G. A1 - Paulßen, Elisabeth A1 - de Kruijff, Robin M. T1 - Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop JF - EJNMMI Radiopharmacy and Chemistry KW - Microfluidic solvent extraction KW - Ga-68 KW - Cyclotron production KW - Medical radionuclide production KW - Metal contaminants Y1 - 2023 U6 - https://doi.org/10.1186/s41181-023-00195-2 SN - 2365-421X VL - 2023 IS - 8, Article number: 9 SP - 1 EP - 14 PB - Springer Nature ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W. K. T1 - A step towards optimization of the qNMR workflow: proficiency testing exercise at an GxP-accredited laboratory JF - Applied Magnetic Resonance N2 - Quantitative nuclear magnetic resonance (qNMR) is considered as a powerful tool for multicomponent mixture analysis as well as for the purity determination of single compounds. Special attention is currently paid to the training of operators and study directors involved in qNMR testing. To assure that only qualified personnel are used for sample preparation at our GxP-accredited laboratory, weighing test was proposed. Sixteen participants performed six-fold weighing of the binary mixture of dibutylated hydroxytoluene (BHT) and 1,2,4,5-tetrachloro-3-nitrobenzene (TCNB). To evaluate the quality of data analysis, all spectra were evaluated manually by a qNMR expert and using in-house developed automated routine. The results revealed that mean values are comparable and both evaluation approaches are free of systematic error. However, automated evaluation resulted in an approximately 20% increase in precision. The same findings were revealed for qNMR analysis of 32 compounds used in pharmaceutical industry. Weighing test by six-fold determination in binary mixtures and automated qNMR methodology can be recommended as efficient tools for evaluating staff proficiency. The automated qNMR method significantly increases throughput and precision of qNMR for routine measurements and extends application scope of qNMR. Y1 - 2021 U6 - https://doi.org/10.1007/s00723-021-01324-3 SN - 1613-7507 N1 - Corresponding author: Yulia Monakhova VL - 52 SP - 581 EP - 593 PB - Springer Nature CY - Wien ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shalaby, Ahmed A1 - Shasha, Carolyn A1 - Krishnan, Kannan M. A1 - Krause, Hans-Joachim T1 - Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory JF - Nanomaterials N2 - Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90% of the frequency mixing magnetic response signal is generated by the largest 10% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory. KW - Magnetic nanoparticles KW - Frequency mixing magnetic detection KW - Langevin theory KW - Micromagnetic simulation KW - Nonequilibrium dynamics Y1 - 2021 SN - 2079-4991 U6 - https://doi.org/10.3390/nano11051257 N1 - This article belongs to the Special Issue Applications and Properties of Magnetic Nanoparticles VL - 11 IS - 5 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - CHAP A1 - Kurz, Melanie ED - Feijs, Loe T1 - On the benefit of moving images for the evaluation of form in virtual space : reflections in model theory T2 - Design and semantics of form and movement : DeSForM 2008 ; [Hochschule für Gestaltung Offenbach am Main, 6.-7.11.2008] Y1 - 2008 SN - 978-90-809801-2-9 SP - 31 EP - 34 PB - Philips CY - Eindhoven ER - TY - JOUR A1 - Aliazizi, Fereshteh A1 - Özsoylu, Dua A1 - Bakhshi Sichani, Soroush A1 - Khorshid, Mehran A1 - Glorieux, Christ A1 - Robbens, Johan A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures JF - Micromachines N2 - In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems. KW - chip-based sensor setup KW - aquaculture KW - microfluidics KW - impedance spectroscopy KW - thermometry KW - electrical conductivity of liquids Y1 - 2024 U6 - https://doi.org/10.3390/mi15060755 SN - 2072-666X N1 - This article belongs to the Special Issue "Multisensor Arrays" N1 - Corresponding author: Michael J. Schöning VL - 15 IS - 6 PB - MDPI CY - Basel ER - TY - CHAP A1 - Kurz, Melanie T1 - Recognition of shape in virtual visualizations T2 - Proceedings : November 15 - 17, 2006, Technische Universität Darmstadt, Darmstadt, Germany ; PACE, Partners for the advancement of collaborative engineering education Y1 - 2006 SN - 978-3-00-020161-5 N1 - International PACE Forum Collaborative Visualization ; (2006, Darmstadt) SP - 203 EP - 209 PB - Techn. Univ. CY - Darmstadt ER - TY - JOUR A1 - Zhantlessova, Sirina A1 - Savitskaya, Irina A1 - Kistaubayeva, Aida A1 - Ignatova, Ludmila A1 - Talipova, Aizhan A1 - Pogrebnjak, Alexander A1 - Digel, Ilya T1 - Correction: Zhantlessova et al. advanced “Green” prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy. Polymers 2022, 14, 3224 JF - Polymers Y1 - 2024 U6 - https://doi.org/10.3390/polym16131802 SN - 2073-4360 N1 - This article belongs to the Special Issue Cellulose Based Composites VL - 16 IS - 13 PB - MDPI CY - Basel ER -