TY - JOUR A1 - Schwertner, Eberhard A1 - Berndt, Heinz A1 - Gielen, Hans-Günter A1 - Zahn, Helmut T1 - Peptide 96 : Synthese einiger [2-(p-Biphenylyl)isopropyloxycarbonyl]-Aminosäurederivate JF - Justus Liebigs Annalen der Chemie N2 - Die Darstellung der N-[2-(p-Biphenylyl)isopropyloxycarbonyl]-Derivate (Bpoc-Derivate) des Cysteins unter Verwendung der Thiolschutzgruppen Tetrahydropyranyl (Thp) für 1, Diphenylmethyl (Dpm) für 2, Trityl (Trt) für 3 und S-tert.-Butyl (SBut) für 4 sowie die Synthese von aktivierten Estern der Bpoc-Derivate des Glycins (5), Isoleucins (6) und Prolins (7) werden beschrieben. An einem Beispiel wird die Möglichkeit aufgezeigt, die Bpoc-Gruppe über das Bpoc-Azid nachträglich in den Peptidverband einzuführen. Y1 - 1975 U6 - https://doi.org/10.1002/jlac.197519750318 SN - 1099-0690 VL - 75 IS - 3 SP - 581 EP - 585 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wolf, Günter A1 - Berndt, Heinz A1 - Brandenburg, Dietrich T1 - Synthese der [LysA13] Rinderinsulin-A-Kette in der Form [Lys(Tfa)A13]A(SO3H)4 und NαA1-Msc-[LysA13]A(SO3H)4 unter Verwendung des S-tert-Butylmercapto-Restes als Thiolschutzgruppe JF - Hoppe-Seyler's Zeitschrift für physiologische Chemie Y1 - 1979 U6 - https://doi.org/10.1515/bchm2.1979.360.2.1569 SN - 1437-4315 SN - 0018-4888 VL - 360 IS - 2 SP - 1569 EP - 1578 ER - TY - JOUR A1 - Hackl, Michael A1 - Buess, Eduard A1 - Kammerlohr, Sandra A1 - Nacov, Julia A1 - Staat, Manfred A1 - Leschinger, Tim A1 - Müller, Lars P. A1 - Wegmann, Kilian T1 - A "comma sign"-directed subscapularis repair in anterosuperior rotator cuff tears yields biomechanical advantages in a cadaveric model JF - The american journal of sports medicine N2 - Background: Additional stabilization of the “comma sign” in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair. Purpose: This in vitro investigation aimed to investigate the influence of a comma sign–directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair. Study Design: Controlled laboratory study. Methods: A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups. Results: The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596). Conclusion: The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading. Clinical Relevance: The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome. Y1 - 2021 U6 - https://doi.org/10.1177/03635465211031506 SN - 1552-3365 SN - 0363-5465 VL - 49 IS - 12 SP - 3212 EP - 3217 PB - Sage CY - London ER - TY - JOUR A1 - Frotscher, Ralf A1 - Muanghong, Danita A1 - Dursun, Gözde A1 - Goßmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue JF - Journal of Biomechanics N2 - We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures. KW - hiPS cardiomyocytes KW - Homogenization KW - Hodgkin–Huxley models KW - Frequency adaption KW - Electromechanical modeling KW - Drug simulation KW - Computational biomechanics KW - Cardiac tissue Y1 - 2016 U6 - https://doi.org/10.1016/j.jbiomech.2016.01.039 SN - 0021-9290 (Print) SN - 1873-2380 (Online) VL - 49 IS - 12 SP - 2428 EP - 2435 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ojovan, Michael I. A1 - Steinmetz, Hans-Jürgen T1 - Approaches to Disposal of Nuclear Waste JF - Energies N2 - We present a concise mini overview on the approaches to the disposal of nuclear waste currently used or deployed. The disposal of nuclear waste is the end point of nuclear waste management (NWM) activities and is the emplacement of waste in an appropriate facility without the intention to retrieve it. The IAEA has developed an internationally accepted classification scheme based on the end points of NWM, which is used as guidance. Retention times needed for safe isolation of waste radionuclides are estimated based on the radiotoxicity of nuclear waste. Disposal facilities usually rely on a multi-barrier defence system to isolate the waste from the biosphere, which comprises the natural geological barrier and the engineered barrier system. Disposal facilities could be of a trench type, vaults, tunnels, shafts, boreholes, or mined repositories. A graded approach relates the depth of the disposal facilities’ location with the level of hazard. Disposal practices demonstrate the reliability of nuclear waste disposal with minimal expected impacts on the environment and humans. KW - borehole disposal KW - geological disposal KW - disposal facility KW - retention time KW - nuclear waste Y1 - 2022 U6 - https://doi.org/10.3390/en15207804 SN - 1996-1073 N1 - This article belongs to the Special Issue "Treatment of Radioactive Waste and Sustainability Energy" VL - 15 IS - 20 PB - MDPI CY - Basel ER - TY - JOUR A1 - Leschinger, Tim A1 - Birgel, Stefan A1 - Hackl, Michael A1 - Staat, Manfred A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair JF - Computer Methods in Biomechanics and Biomedical Engineering Y1 - 2019 U6 - https://doi.org/10.1080/10255842.2019.1572749 IS - Early view PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Dietzel, F. A1 - Weber, Hans-Joachim A1 - Porschen, W. A1 - Feinendegen, L. E. T1 - Zur Wärmeempfindlichkeit von oxischen und hypoxischen Zellen in einem Tumor JF - Naturwissenschaften Y1 - 1976 U6 - https://doi.org/10.1007/BF00622808 SN - 0028-1042 VL - 63 IS - 12 SP - 585 EP - 586 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Timme, Michael T1 - Die Erbringung einer Leistung in der irrigen Vorstellung einer Bestellung (Zu BGH, MDR 2023, 1439) JF - Monatsschrift für Deutsches Recht Y1 - 2023 U6 - https://doi.org/10.9785/mdtr-2023-772402 SN - 2194-4202 (online) SN - 0340-1812 (print) VL - 77 IS - 24 SP - R293 EP - R296 PB - Verlag Dr. Otto Schmidt CY - Köln ER - TY - JOUR A1 - Biewendt, Marcel A1 - Blaschke, Florian A1 - Böhnert, Arno T1 - Motivational factors in organisational change JF - SocioEconomic Challenges N2 - The presented paper gives an overview of the most important and most common theories and concepts from the economic field of organisational change and is also enriched with quantitative publication data, which underlines the relevance of the topic. In particular, the topic presented is interwoven in an interdisciplinary way with economic psychological models, which are underpinned within the models with content from leading scholars in the field. The pace of change in companies is accelerating, as is technological change in our society. Adaptations of the corporate structure, but also of management techniques and tasks, are therefore indispensable. This includes not only the right approaches to employee motivation, but also the correct use of intrinsic and extrinsic motivational factors. Based on the hypothesis put forward by the scientist and researcher Rollinson in his book “Organisational behaviour and analysis” that managers believe motivational resources are available at all times, socio-economic and economic psychological theories are contrasted here in order to critically examine this statement. In addition, a fictitious company was created as a model for this work in order to illustrate the effects of motivational deficits in practice. In this context, the theories presented are applied to concrete problems within the model and conclusions are drawn about their influence and applicability. This led to the conclusion that motivation is a very individual challenge for each employee, which requires adapted and personalised approaches. On the other hand, the recommendations for action for supervisors in the case of motivation deficits also cannot be answered in a blanket manner, but can only be solved with the help of professional, expert-supported processing due to the economic-psychological realities of motivation. Identifying, analysing and remedying individual employee motivation deficits is, according to the authors, a problem and a challenge of great importance, especially in the context of rapidly changing ecosystems in modern companies, as motivation also influences other factors such as individual productivity. The authors therefore conclude that good motivation through the individual and customised promotion and further training of employees is an important point for achieving important corporate goals in order to remain competitive on the one hand and to create a productive and pleasant working environment on the other. KW - business culture KW - management KW - motivation KW - change Y1 - 2021 U6 - https://doi.org/10.21272/sec.5(3).15-27.2021 SN - 2520-6214 VL - 5 IS - 3 SP - 15 EP - 27 PB - ARMG CY - Sumy ER - TY - JOUR A1 - Hüning, Felix A1 - Heuermann, Holger A1 - Wache, Franz-Josef A1 - Jajo, Rami Audisho T1 - A new wireless sensor interface using dual-mode radio JF - Journal of Sensors and Sensor Systems : JSSS N2 - The integration of sensors is one of the major tasks in embedded, control and “internet of things” (IoT) applications. For the integration mainly digital interfaces are used, starting from rather simple pulse-width modulation (PWM) interface to more complex interfaces like CAN (Controller Area Network). Even though these interfaces are tethered by definition, a wireless realization is highly welcome in many applications to reduce cable and connector cost, increase the flexibility and realize new emerging applications like wireless control systems. Currently used wireless solutions like Bluetooth, WirelessHART or IO-Link Wireless use dedicated communication standards and corresponding higher protocol layers to realize the wireless communication. Due to the complexity of the communication and the protocol handling, additional latency and jitter are introduced to the data communication that can meet the requirements for many applications. Even though tunnelling of other bus data like CAN data is generally also possible the latency and jitter prevent the tunnelling from being transparent for the bus system. Therefore a new basic technology based on dual-mode radio is used to realize a wireless communication on the physical layer only, enabling a reliable and real-time data transfer. As this system operates on the physical layer it is independent of any higher layers of the OSI (open systems interconnection) model. Hence it can be used for several different communication systems to replace the tethered physical layer. A prototype is developed and tested for real-time wireless PWM, SENT (single-edge nibble transmission) and CAN data transfer with very low latency and jitter. Y1 - 2018 U6 - https://doi.org/10.5194/jsss-7-507-2018 VL - Volume 7 IS - 2 SP - 507 EP - 515 PB - Copernicus Publ. CY - Göttingen ER - TY - JOUR A1 - Haeger, Gerrit A1 - Jolmes, Tristan A1 - Oyen, Sven A1 - Jaeger, Karl-Erich A1 - Bongaerts, Johannes A1 - Schörken, Ulrich A1 - Siegert, Petra T1 - Novel recombinant aminoacylase from Paraburkholderia monticola capable of N-acyl-amino acid synthesis JF - Applied Microbiology and Biotechnology N2 - N-Acyl-amino acids can act as mild biobased surfactants, which are used, e.g., in baby shampoos. However, their chemical synthesis needs acyl chlorides and does not meet sustainability criteria. Thus, the identification of biocatalysts to develop greener synthesis routes is desirable. We describe a novel aminoacylase from Paraburkholderia monticola DSM 100849 (PmAcy) which was identified, cloned, and evaluated for its N-acyl-amino acid synthesis potential. Soluble protein was obtained by expression in lactose autoinduction medium and co-expression of molecular chaperones GroEL/S. Strep-tag affinity purification enriched the enzyme 16-fold and yielded 15 mg pure enzyme from 100 mL of culture. Biochemical characterization revealed that PmAcy possesses beneficial traits for industrial application like high temperature and pH-stability. A heat activation of PmAcy was observed upon incubation at temperatures up to 80 °C. Hydrolytic activity of PmAcy was detected with several N-acyl-amino acids as substrates and exhibited the highest conversion rate of 773 U/mg with N-lauroyl-L-alanine at 75 °C. The enzyme preferred long-chain acyl-amino-acids and displayed hardly any activity with acetyl-amino acids. PmAcy was also capable of N-acyl-amino acid synthesis with good conversion rates. The best synthesis results were obtained with the cationic L-amino acids L-arginine and L-lysine as well as with L-leucine and L-phenylalanine. Exemplarily, L-phenylalanine was acylated with fatty acids of chain lengths from C8 to C18 with conversion rates of up to 75%. N-lauroyl-L-phenylalanine was purified by precipitation, and the structure of the reaction product was verified by LC–MS and NMR. KW - Chaperone KW - Biocatalysis KW - Aminoacylase KW - Acylation KW - Acyl-amino acids KW - Biosurfactants Y1 - 2024 U6 - https://doi.org/10.1007/s00253-023-12868-8 SN - 1432-0614 N1 - Corresponding author: Petra Siegert IS - 108 PB - Springer CY - Berlin ER - TY - JOUR A1 - Luft, Angela A1 - Luft, Nils A1 - Arntz, Kristian T1 - A basic description logic for service-oriented architecture in factory planning and operational control in the age of industry 4.0 JF - Applied Sciences N2 - Manufacturing companies across multiple industries face an increasingly dynamic and unpredictable environment. This development can be seen on both the market and supply side. To respond to these challenges, manufacturing companies must implement smart manufacturing systems and become more flexible and agile. The flexibility in operational planning regarding the scheduling and sequencing of customer orders needs to be increased and new structures must be implemented in manufacturing systems’ fundamental design as they constitute much of the operational flexibility available. To this end, smart and more flexible solutions for production planning and control (PPC) are developed. However, scheduling or sequencing is often only considered isolated in a predefined stable environment. Moreover, their orientation on the fundamental logic of the existing IT solutions and their applicability in a dynamic environment is limited. This paper presents a conceptual model for a task-based description logic that can be applied to factory planning, technology planning, and operational control. By using service-oriented architectures, the goal is to generate smart manufacturing systems. The logic is designed to allow for easy and automated maintenance. It is compatible with the existing resource and process allocation logic across operational and strategic factory and production planning. KW - manufacturing data model KW - production planning and control KW - manufacturing flexibility KW - technology planning KW - SOA KW - service-oriented architectures KW - factory planning Y1 - 2023 U6 - https://doi.org/10.3390/app13137610 SN - 2076-3417 N1 - This article belongs to the Special Issue "Smart Industrial System" VL - 2023 IS - 13 PB - MDPI CY - Basel ER - TY - JOUR A1 - Dobbertin, Matthias A1 - Eilmann, Britta A1 - Bleuler, Peter A1 - Giuggiola, Arnaud A1 - Graf Pannatier, Elisabeth A1 - Landolt, Werner A1 - Schleppi, Patrick A1 - Rigling, Andreas T1 - Effect of irrigation on needle morphology, shoot and stem growth in a drought-exposed Pinus sylvestris forest JF - Tree Physiology N2 - In Valais, Switzerland, Scots pines (Pinus sylvestris L.) are declining, mainly following drought. To assess the impact of drought on tree growth and survival, an irrigation experiment was initiated in 2003 in a mature pine forest, approximately doubling the annual precipitation. Tree crown transparency (lack of foliage) and leaf area index (LAI) were annually assessed. Seven irrigated and six control trees were felled in 2006, and needles, stem discs and branches were taken for growth analysis. Irrigation in 2004 and 2005, both with below-average precipitation, increased needle size, area and mass, stem growth and, with a 1-year delay, shoot length. This led to a relative decrease in tree crown transparency (−14%) and to an increase in stand LAI (+20%). Irrigation increased needle length by 70%, shoot length by 100% and ring width by 120%, regardless of crown transparency. Crown transparency correlated positively with mean needle size, shoot length and ring width and negatively with specific leaf area. Trees with high crown transparency (low growth, short needles) experienced similar increases in needle mass and growth with irrigation than trees with low transparency (high growth, long needles), indicating that seemingly declining trees were able to ‘recover’ when water supply became sufficient. A simple drought index before and during the irrigation explained most of the variation found in the parameters for both irrigated and control trees. Y1 - 2010 U6 - https://doi.org/10.1093/treephys/tpp123 SN - 1758-4469 (Online) SN - 0829-318X (Print) VL - 30 IS - 3 SP - 346 EP - 360 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Hüning, Felix T1 - Nachrüstmöglichkeiten von Dieselfahrzeugen aus technischer Sicht JF - Zeitschrift für Verkehrsrecht : NZV Y1 - 2019 IS - 1 SP - 27 EP - 32 PB - C.H.Beck ER - TY - JOUR A1 - Tix, Julian A1 - Moll, Fabian A1 - Krafft, Simone A1 - Betsch, Matthias A1 - Tippkötter, Nils T1 - Hydrogen production from enzymatic pretreated organic waste with thermotoga neapolitana JF - Energies N2 - Biomass from various types of organic waste was tested for possible use in hydrogen production. The composition consisted of lignified samples, green waste, and kitchen scraps such as fruit and vegetable peels and leftover food. For this purpose, the enzymatic pretreatment of organic waste with a combination of five different hydrolytic enzymes (cellulase, amylase, glucoamylase, pectinase and xylase) was investigated to determine its ability to produce hydrogen (H2) with the hydrolyzate produced here. In course, the anaerobic rod-shaped bacterium T. neapolitana was used for H2 production. First, the enzymes were investigated using different substrates in preliminary experiments. Subsequently, hydrolyses were carried out using different types of organic waste. In the hydrolysis carried out here for 48 h, an increase in glucose concentration of 481% was measured for waste loads containing starch, corresponding to a glucose concentration at the end of hydrolysis of 7.5 g·L−1. In the subsequent set fermentation in serum bottles, a H2 yield of 1.26 mmol H2 was obtained in the overhead space when Terrific Broth Medium with glucose and yeast extract (TBGY medium) was used. When hydrolyzed organic waste was used, even a H2 yield of 1.37 mmol could be achieved in the overhead space. In addition, a dedicated reactor system for the anaerobic fermentation of T. neapolitana to produce H2 was developed. The bioreactor developed here can ferment anaerobically with a very low loss of produced gas. Here, after 24 h, a hydrogen concentration of 83% could be measured in the overhead space. KW - Biological hydrogen KW - Organic waste KW - Dark fermentation KW - Hydrolysis KW - Pretreatment Y1 - 2024 U6 - https://doi.org/10.3390/en17122938 SN - 1996-1073 N1 - Corresponding author: Nils Tippkötter VL - 17 IS - 12 PB - MDPI CY - Basel ER - TY - JOUR A1 - Heinrichs, Uwe A1 - Utting, Jane F. A1 - Frauenrath, Tobias A1 - Hezel, Fabian A1 - Krombach, Gabriele A. A1 - Hodenius, Michael A. J. A1 - Kozerke, Sebastian A1 - Niendorf, Thoralf T1 - Myocardial T2 mapping free of distortion using susceptibility-weighted fast spin-echo imaging: A feasibility study at 1.5 T and 3.0 T JF - Magnetic Resonance in Medicine N2 - This study demonstrates the feasibility of applying free-breathing, cardiac-gated, susceptibility-weighted fast spin-echo imaging together with black blood preparation and navigator-gated respiratory motion compensation for anatomically accurate T₂ mapping of the heart. First, T₂ maps are presented for oil phantoms without and with respiratory motion emulation (T₂ = (22.1 ± 1.7) ms at 1.5 T and T₂ = (22.65 ± 0.89) ms at 3.0 T). T₂ relaxometry of a ferrofluid revealed relaxivities of R2 = (477.9 ± 17) mM⁻¹s⁻¹ and R2 = (449.6 ± 13) mM⁻¹s⁻¹ for UFLARE and multiecho gradient-echo imaging at 1.5 T. For inferoseptal myocardial regions mean T₂ values of 29.9 ± 6.6 ms (1.5 T) and 22.3 ± 4.8 ms (3.0 T) were estimated. For posterior myocardial areas close to the vena cava T₂-values of 24.0 ± 6.4 ms (1.5 T) and 15.4 ± 1.8 ms (3.0 T) were observed. The merits and limitations of the proposed approach are discussed and its implications for cardiac and vascular T₂-mapping are considered. Y1 - 2009 U6 - https://doi.org/10.1002/mrm.22054 SN - 1522-2594 VL - 62 IS - 3 SP - 822 EP - 828 PB - Wiley-Liss CY - New York ER - TY - JOUR A1 - Fabo, Sabine ED - Mohr, Klaus T1 - Sisyphus wird Steiff JF - Prädikat spießig (Boxhorn ; 21) N2 - Eine Reise durch die fremde Welt eines Kaufhaus-Schaufensters. Plüschtiere mit eingebauter Bewegungstechnik - knuffig oder nur eine Ausformulierung des Ernst des Lebens? Y1 - 2010 SN - 1864-2535 VL - 2010 SP - 58 EP - 61 PB - FH Aachen, Fachbereich Gestaltung CY - Aachen ER - TY - JOUR A1 - Wolf, Martin R. A1 - Altgen, Jannik T1 - IT Service Management in der Region Aachen : White Paper Y1 - 2013 SP - 1 EP - 13 ER - TY - JOUR A1 - Anik, Sabri A1 - Tuelbentci, K. T1 - Lichtbogenschweißen : Untersuchung der Schweißschlacke und der Wirkungen auf das Entfernen der Schlacke ; Teil 3 JF - Technische Rundschau : TR ; das Schweizer Industrie-Magazin Y1 - 1974 SN - 0040-148X VL - 66 IS - 2 SP - 43 EP - 47 PB - Medtrix Group CY - Basel ER - TY - JOUR A1 - Ferrein, Alexander A1 - Meyer, Thomas T1 - A Brief Overview of Artificial Intelligence in South Africa JF - AI Magazine N2 - South Africa in recent years is the establishment of a number of research hubs involved in AI activities ranging from mobile robotics and computational intelligence, to knowledge representation and reasoning, and human language technologies. In this survey we take the reader through a quick tour of the research being conducted at these hubs, and touch on an initiative to maintain and extend the current level of interest in AI research in the country. Y1 - 2012 U6 - https://doi.org/10.1609/aimag.v33i1.2357 SN - 0738-4602 VL - 33 IS - 1 SP - 99 EP - 101 PB - AAAI CY - Menlo Park ER -