TY  - JOUR
A1  - Schwarte, Rudolf
A1  - Heinol, Horst-Guenther
A1  - Buxbaum, Bernd
A1  - Xu, Zhanping
A1  - Ringbeck, Thorsten
A1  - Zhang, Zhigang
A1  - Wei, Tai
A1  - Hartmann, K.
A1  - Kleuver, W.
A1  - Luan, Xuming
T1  - Neuartige 3D-Visionssysteme auf der Basis Layout-optimierter PMD-Strukturen
JF  - Technisches Messen : tm ; Plattform für Methoden, Systeme und Anwendungen der Messtechnik ; Organ der AMA (Fachverband für Sensorik e.V.) und der NAMUR (Interessengemeinschaft Prozessleittechnik der Chemischen und Pharmazeutischen Industrie). - 65(1998), H. 7-8
Y1  - 1998
SN  - 0340-837X
SP  - 264
EP  - 271
PB  - Oldenbourg
CY  - München
ER  - 
TY  - JOUR
A1  - Porschen, W.
A1  - Gartzen, J.
A1  - Gewehr, K.
A1  - Mühlensiepen, H.
A1  - Weber, Hans-Joachim
A1  - Feinedegen, L E.
T1  - In vivo assay of the radiation sensitivity of hypoxic tumour cells : influence of γ-rays, cyclotron neutrons, misonidazole, hyperthermia and mixed modalities
JF  - The British journal of cancer / Supplement
N2  - Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay.

With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these.

Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons.

Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4.

These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia.
Y1  - 1978
SN  - 0306-9443
N1  - Section 6: Sensitization and Hypoxic Cytotoxicity: Effects of Hyperthermia and High Let
IS  - 3
SP  - 194
EP  - 197
PB  - Lewis
CY  - London
ER  -