TY  - JOUR
A1  - Iken, Heiko
A1  - Ahlborn, Kristina
A1  - Gerlach, Frank
A1  - Vonau, Winfried
A1  - Zander, Wilhelm
A1  - Schubert, Jürgen P.
A1  - Schöning, Michael Josef
T1  - Development of redox glasses and subsequent processing by means of pulsed laser deposition for realizing silicon-based thin-film sensors
JF  - Electrochimica acta
Y1  - 2013
SN  - 1873-3859 (E-Journal); 0013-4686 (Print)
SP  - Available online 30.8.2013
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Vahidpour, Farnoosh
A1  - Alghazali, Yousef H. M.
A1  - Akca, Sevilay
A1  - Hommes, Gregor
A1  - Schöning, Michael Josef
T1  - An Enzyme-Based Interdigitated Electrode-Type Biosensor for Detecting Low Concentrations of H₂O₂ Vapor/Aerosol
JF  - Chemosensors
N2  - This work introduces a novel method for the detection of H₂O₂ vapor/aerosol of low concentrations, which is mainly applied in the sterilization of equipment in medical industry. Interdigitated electrode (IDE) structures have been fabricated by means of microfabrication techniques. A differential setup of IDEs was prepared, containing an active sensor element (active IDE) and a passive sensor element (passive IDE), where the former was immobilized with an enzymatic membrane of horseradish peroxidase that is selective towards H₂O₂. Changes in the IDEs’ capacitance values (active sensor element versus passive sensor element) under H₂O₂ vapor/aerosol atmosphere proved the detection in the concentration range up to 630 ppm with a fast response time (<60 s). The influence of relative humidity was also tested with regard to the sensor signal, showing no cross-sensitivity. The repeatability assessment of the IDE biosensors confirmed their stable capacitive signal in eight subsequent cycles of exposure to H₂O₂ vapor/aerosol. Room-temperature detection of H₂O₂ vapor/aerosol with such miniaturized biosensors will allow a future three-dimensional, flexible mapping of aseptic chambers and help to evaluate sterilization assurance in medical industry.
Y1  - 2022
U6  - https://doi.org/10.3390/chemosensors10060202
SN  - 2227-9040
N1  - This article belongs to the Special Issue "Bioinspired Chemical Sensors and Micro-Nano Devices"
VL  - 10
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Grinsven, Bart van
A1  - Vanden Bon, Natalie
A1  - Grieten, Lars
A1  - Murib, Mohammed Sharif
A1  - Janssen, Stoffel Dominique
A1  - Haenen, Ken
A1  - Schneider, E.
A1  - Ingebrandt, Sven
A1  - Schöning, Michael Josef
A1  - Vermeeren, Veronique
A1  - Ameloot, Marcel
A1  - Michiels, Luc
A1  - Thoelen, Ronald
A1  - De Ceuninck, Ward A.
A1  - Wagner, Patrick
T1  - Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation
JF  - Lab on a Chip
Y1  - 2011
SN  - 1473-0197
VL  - 11
IS  - 9
SP  - 1656
EP  - 1663
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Grinsven, B. van
A1  - Grieten, L.
A1  - Janssens, S. D.
A1  - Vermeeren, V.
A1  - Eersels, K.
A1  - Broeders, J.
A1  - Ameloot, Marcel
A1  - Michiels, L.
A1  - Ceuninck, W. De
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates
JF  - Physica Status Solidi (A). Vol. 210 (2013), iss. 5
Y1  - 2013
SN  - 0031-8965
SP  - 911
EP  - 917
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Eurlings, Y.
A1  - Grinsven, B. van
A1  - Boyen, H.-G.
A1  - Conings, B.
A1  - Michiels, L.
A1  - Ameloot, Marcel
A1  - Carleer, R.
A1  - Warmer, J.
A1  - Kaul, P.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Heat-transfer based characterization of DNA on synthetic sapphire chips
JF  - Sensors and Actuators B: Chemical
N2  - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.
Y1  - 2016
U6  - https://doi.org/10.1016/j.snb.2016.02.027
SN  - 0925-4005
VL  - 230
IS  - 230
SP  - 260
EP  - 271
PB  - Elsevier
CY  - Amsterdam
ER  -