TY - CHAP A1 - Augenstein, Eckardt A1 - Gürzenich, D. A1 - Kuperjans, Isabel A1 - Wrobel, G. T1 - TOP-Energy : softwaregestützte Analyse und Optimierung industrieller Energieversorgungssysteme T2 - Entwicklungslinien der Energietechnik 2004 Y1 - 2004 N1 - Themengebiet Energiesysteme PB - VDI CY - Düsseldorf ET - CD-ROM-Ausg. ER - TY - CHAP A1 - Artmann, Gerhard A1 - Meruvu, Haritha A1 - Kizildag, Sefa A1 - Temiz Artmann, Aysegül ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology. Y1 - 2018 SN - 978-981-10-7904-7 U6 - https://doi.org/10.1007/978-981-10-7904-7_7 SP - 157 EP - 192 PB - Springer CY - Singapore ER - TY - CHAP A1 - Altherr, Lena A1 - Leise, Philipp A1 - Pfetsch, Marc E. A1 - Schmitt, Andreas T1 - Optimal design of resilient technical systems on the example of water supply systems T2 - Mastering Uncertainty in Mechanical Engineering Y1 - 2021 SN - 978-3-030-78356-3 N1 - Unterkapitel des Kapitels "Strategies for Mastering Uncertainty" SP - 429 EP - 433 PB - Springer CY - Cham ER - TY - CHAP A1 - Altherr, Lena A1 - Leise, Philipp T1 - Resilience as a concept for mastering uncertainty T2 - Mastering Uncertainty in Mechanical Engineering Y1 - 2021 SN - 978-3-030-78353-2 U6 - https://doi.org/10.1007/978-3-030-78354-9 N1 - Unterkapitel 6.3.1 des Kapitels "Strategies for Mastering Uncertainty" SP - 412 EP - 417 PB - Springer CY - Cham ER - TY - CHAP A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. A1 - Pöttgen, Philipp ED - Lübbecke, Marco E. ED - Koster, Arie ED - Letmathe, Peter ED - Madlener, Reihard ED - Preis, Britta ED - Walther, Grit T1 - Designing a feedback control system via mixed-integer programming T2 - Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research N2 - Pure analytical or experimental methods can only find a control strategy for technical systems with a fixed setup. In former contributions we presented an approach that simultaneously finds the optimal topology and the optimal open-loop control of a system via Mixed Integer Linear Programming (MILP). In order to extend this approach by a closed-loop control we present a Mixed Integer Program for a time discretized tank level control. This model is the basis for an extension by combinatorial decisions and thus for the variation of the network topology. Furthermore, one is able to appraise feasible solutions using the global optimality gap. KW - Optimal Topology KW - Controller Parameter KW - Level Control System KW - Technical Operation Research KW - Optimal Closed Loop Y1 - 2016 SN - 978-3-319-28695-2 U6 - https://doi.org/10.1007/978-3-319-28697-6_18 SP - 121 EP - 127 PB - Springer CY - Cham ER - TY - CHAP A1 - Altherr, Lena A1 - Dörig, Bastian A1 - Ederer, Thorsten A1 - Pelz, Peter Franz A1 - Pfetsch, Marc A1 - Wolf, Jan T1 - A mixed-integer nonlinear program for the design of gearboxes T2 - Operations Research Proceedings 2016 N2 - Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution. Y1 - 2017 SN - 978-3-319-55701-4 U6 - https://doi.org/10.1007/978-3-319-55702-1_31 SP - 227 EP - 233 PB - Springer CY - Cham ER - TY - CHAP A1 - Altay, Okyay A1 - Taddei, Francesca A1 - Butenweg, Christoph A1 - Klinkel, Sven T1 - Vibration mitigation of wind turbine towers with tuned mass dampers T2 - Wind turbine control and monitoring. (Advances in industrial control) N2 - Because of its minor environmental impact, electricity generation using wind power is getting remarkable. The further growth of the wind industry depends on technological solutions to the challenges in production and construction of the turbines. Wind turbine tower vibrations, which limit power generation efficiency and cause fatigue problems with high maintenance costs, count as one of the main structural difficulties in the wind energy sector. To mitigate tower vibrations auxiliary measures are necessary. The effectiveness of tuned mass damper is verified by means of a numeric study on a 5 MW onshore reference wind turbine. Hereby, also seismic-induced vibrations and soil–structure interaction are considered. Acquired results show that tuned mass damper can effectively reduce resonant tower vibrations and improve the fatigue life of wind turbines. This chapter is also concerned with tuned liquid column damper and a semiactive application of it. Due to its geometric versatility and low prime costs, tuned liquid column dampers are a good alternative to other damping measures, in particular for slender structures like wind turbines. Y1 - 2014 SN - 978-3-319-08412-1 (Print) ; 978-3-319-08413-8 (E-Book) U6 - https://doi.org/10.1007/978-3-319-08413-8_12 SP - 337 EP - 373 PB - Springer CY - Cham ; Heidelberg ; New York ; Dordrecht ; London ER - TY - CHAP A1 - Alt, Helmut T1 - Fußball oder Mathematik T2 - Alma Mater Aquensis : Jahresbericht Y1 - 1971 SP - 110 EP - 114 ER - TY - CHAP A1 - Alt, Helmut T1 - Analog anzeigende Digitaluhr T2 - FH-Texte ; 36 : Berichte aus dem Fachbereich Elektrotechnik Aachen Y1 - 1983 SP - 98 EP - 104 PB - Fachhochschule Aachen CY - Aachen ER - TY - CHAP A1 - Alt, Helmut T1 - Speicher speichern, Leiter leiten T2 - Generationenprojekt Energiewende : Elektroenergiepolitik im Spannungsfeld zwischen Vision und Mission / Herbert Niederhausen (Hrsg.) Y1 - 2022 SN - 9783755774389 N1 - gedruckt in der Bereichsbibliothek Eupener Str. unter der Signatur 21 ZPM 4 SP - 125 EP - 136 PB - Books on Demand CY - Norderstedt ER -