TY  - CHAP
A1  - Spurmann, Jörn
A1  - Ohndorf, Andreas
A1  - Dachwald, Bernd
A1  - Seboldt, Wolfgang
A1  - Löb, Horst
A1  - Schartner, Karl-Heinz
T1  - Interplanetary trajectory optimization for a sep mission to Saturn
T2  - 60th International Astronautical Congress 2009
N2  - The recently proposed NASA and ESA missions to Saturn and Jupiter pose difficult tasks to mission designers because chemical propulsion scenarios are not capable of transferring heavy spacecraft into the outer solar system without the use of gravity assists. Thus our developed mission scenario based on the joint NASA/ESA Titan Saturn System Mission baselines solar electric propulsion to improve mission flexibility and transfer time. For the calculation of near-globally optimal low-thrust trajectories, we have used a method called Evolutionary Neurocontrol, which is implemented in the low-thrust trajectory optimization software InTrance. The studied solar electric propulsion scenario covers trajectory optimization of the interplanetary transfer including variations of the spacecraft's thrust level, the thrust unit's specific impulse and the solar power generator power level. Additionally developed software extensions enabled trajectory optimization with launcher-provided hyperbolic excess energy, a complex solar power generator model and a variable specific impulse ion engine model. For the investigated mission scenario, Evolutionary Neurocontrol yields good optimization results, which also hold valid for the more elaborate spacecraft models. Compared to Cassini/Huygens, the best found solutions have faster transfer times and a higher mission flexibility in general.
KW  - Spacecraft
KW  - Reusable Rocket Engines
KW  - Hybrid Propellants
Y1  - 2009
SN  - 9781615679089
N1  - 60th International Astronautical Congress 2009 (IAC 2009)
Held 12-16 October 2009, Daejeon, Republic of Korea.
SP  - 5234
EP  - 5248
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Aknazarov, S. K.
A1  - Mansurov, Zulkhair
A1  - Digel, Ilya
A1  - Kozhalakova, A. A.
A1  - Akimbekov, Nuraly Shardarbekovich
A1  - O'Heras, Carlos
A1  - Tazhibayeva, S.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials
N2  - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.
KW  - Kohlenstofffaser
KW  - Lipopolysaccharide
KW  - nanostrukturierte carbonisierte Pflanzenteile
KW  - lipopolysaccharides
KW  - nanostructured carbonized plant parts
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Kurulgan Demirci, Eylem
A1  - Linder, Peter
A1  - Demirci, Taylan
A1  - Gierkowski, Jessica R.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Temiz Artmann, Aysegül
T1  - rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract]
N2  - In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension.
KW  - Endothelzelle
KW  - Sepsis
KW  - kontraktile Spannung
KW  - rhAPC
KW  - contractile tension
KW  - rhAPC
KW  - celldrum technology
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Stadler, Andreas M.
A1  - Embs, Jan P.
A1  - Zaccai, Giuseppe
A1  - Büldt, Georg
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]
N2  - The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature
KW  - Hämoglobin
KW  - Erythrozyt
KW  - Körpertemperatur
Y1  - 2010
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Leimena, W.
A1  - Dachwald, Bernd
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Funke, O.
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - In-situ biological decontamination of an ice melting probe : [abstract]
N2  - The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.
KW  - Sonde
KW  - Dekontamination
KW  - Wasserstoffperoxid
KW  - Natriumhypochlorit
Y1  - 2010
ER  - 
TY  - JOUR
A1  - Ullrich, Sebastian
A1  - Grottke, Oliver
A1  - Rossaint, Rolf
A1  - Staat, Manfred
A1  - Deserno, Thomas M.
A1  - Kuhlen, Torsten
T1  - Virtual Needle Simulation with Haptics for Regional Anaesthesia
Y1  - 2010
N1  - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010
SP  - 1
EP  - 3
ER  - 
TY  - JOUR
A1  - Nguyen, N.-H.
A1  - Raatschen, Hans-Jürgen
A1  - Staat, Manfred
T1  - A hyperelastic model of biological tissue materials in tubular organs
Y1  - 2010
N1  - ECCM 2010, IV European Conference on Computational Mechanics, Paris, France, May 16-21, 2010.
SP  - 1
EP  - 12
ER  - 
TY  - JOUR
A1  - Pham, Phu Tinh
A1  - Vu, Khoi Duc
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - A primal-dual algorithm for shakedown analysis of elastic-plastic bounded linearly kinematic hardening bodies
Y1  - 2010
N1  - ECCM 2010, IV European Conference on Computational Mechanics, Paris, France, May 16-21, 2010.
SP  - 1
EP  - 7
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - Shakedown analysis of two dimensional structures by an edge-based smoothed finite element method
Y1  - 2010
N1  - ECCM 2010, IV European Conference on Computational Mechanics, Paris, France, May 16-21, 2010.
SP  - 1
EP  - 7
ER  - 
TY  - JOUR
A1  - Grottke, O.
A1  - Braunschweig, T.
A1  - Philippen, B.
A1  - Gatzweiler, Karl-Heinz
A1  - Gronloh, N.
A1  - Staat, Manfred
A1  - Rossaint, R.
A1  - Tolba, R.
T1  - A New Model for Blunt Liver Injuries in the Swine
JF  - European Surgical Research. 44 (2010), H. 2
Y1  - 2010
SN  - 1421-9921
SP  - 65
EP  - 73
ER  -