TY - JOUR A1 - Kern, Alexander A1 - Frentzel, Ralf A1 - Behrens, Jörg T1 - Simulation of the transient voltages in the auxiliary power network of a large power plant in case of a direct lightning strike to the high-voltage overhead transmission line N2 - Large power plants can be endangered by lightning strikes with possible consequences regarding their safety and availability. A special scenario is a lightning strike to the HV overhead transmission line close to the power plant's connection to the power grid. If then additionally a so-called shielding failure of the overhead ground wire on top of the overhead transmission line is assumed, i.e. the lightning strikes directly into a phase conductor, this is an extreme electromagnetic disturbance. The paper deals with the numerical simulation of such a lightning strike and the consequences on the components of the power plant's auxiliary power network connected to different voltage levels. KW - power generation KW - surges KW - conductors KW - arresters KW - power transmission lines KW - lightning Y1 - 2010 SN - 978-88-905519-0-1 U6 - https://doi.org/10.1109/ICLP.2010.7845756 N1 - 2010 30th International Conference on Lightning Protection (ICLP), 13-17 Sept. 2010, Cagliari, Italy SP - 749-1 EP - 749-7 PB - IEEE CY - New York ER - TY - JOUR A1 - Bouquegneau, Christian A1 - Kern, Alexander A1 - Rousseau, Alain T1 - Lightning safety guidelines N2 - This paper introduces lightning to the layman, noting the right behaviour in front of thunderstorms as well as protective measures against lightning. It also contributes to the prevention of lightning injuries and damages. This report was prepared by the authors inside the AHG1 Group for IEC TC81 (Lightning Protection). Y1 - 2010 N1 - Ground´2010 & 4th LPE, International Conference on Grounding and Earthing & 4th International Conference on Lightning Physics and Effects, Salvador - Brazil, November, 2010 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, Gamal A1 - Falk, R. A1 - Crookshank, M. T1 - Corrigendum to “Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration”. Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T. JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 1802 ER - TY - JOUR A1 - Claessen, O. A1 - Grefen, Dana A1 - Mang, Thomas A1 - Dikland, H. G. A1 - Dikland, H. G. A1 - Duin, M. van T1 - Helle Fensterprofilmaterialien : Alterungsverhalten auf Basis von peroxidisch vernetztem EPDM JF - Kautschuk, Gummi, Kunststoffe : KGK Y1 - 2010 SN - 0948-3276 VL - 63 IS - 9 SP - 350 EP - 360 PB - Hüthig CY - Heidelberg ER - TY - JOUR A1 - Weber, Tobias A1 - Arent, Jan-Christoph A1 - Steffen, Lucas A1 - Balvers, Johannes Mattheus A1 - Duhovic, Miro T1 - Thermal optimization of composite autoclave molds using the shift factor approach for boundary condition estimation JF - Journal of Composite Materials Y1 - 2017 U6 - https://doi.org/10.1177/0021998317699868 SN - 1530-793X VL - 51 IS - 12 SP - 1753 EP - 1767 PB - Sage CY - London ER - TY - JOUR A1 - Kern, Alexander A1 - Klöters, Georg A1 - Pferdemenges, Jörg T1 - Optimised protection against lightning for the signalling and safety systems of level crossings on non-electrified railway lines JF - RTR : European Rail Technology Review Y1 - 2010 SN - 0079-9548 VL - 50 IS - 2 PB - DVV Media Group CY - Hamburg ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Başkurt, Oǧuz Kerim A1 - Edremitlioglu, M. T1 - In vitro effects of in vivo activated leukocytes on red blood cell filterability and lipid peroxidation. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A. JF - Clinical Hemorheology. 14 (1994), H. 4 Y1 - 1994 SP - 591 EP - 596 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, Gamal A1 - Steffen, T. A1 - Wu, J. T1 - Parameter identification for cement infiltration of osteoporotic bone JF - Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ... Y1 - 2002 SN - 90-5809-394-8 SP - 55 EP - 58 PB - Balkema CY - Lisse [u.a.] ER - TY - JOUR A1 - Kern, Alexander A1 - Schelthoff, Christof A1 - Mathieu, Moritz T1 - Probability of lightning strikes to air-terminations of structures using the electro-geometrical model theory and the statistics of lightning current parameters N2 - Planning the air-terminations for a structure to be protected the use of the rolling-sphere method (electro-geometrical model) is the best way from the physics of lightning point-of-view. Therefore, international standards prefer this method. However, using the rolling-sphere method only results in possible point-of-strikes on a structure without giving information about the probability of strikes at the individual points compared to others. KW - atmospheric modeling KW - probability distribution KW - lightning protection KW - standards KW - planning Y1 - 2010 SN - 978-88-905519-0-1 U6 - https://doi.org/10.1109/ICLP.2010.7845757 N1 - 2010 30th International Conference on Lightning Protection (ICLP), 13-17 Sept. 2010, Cagliari, Italy SP - 750-1 EP - 750-8 PB - IEEE CY - New York ER - TY - JOUR A1 - Naujokat, Anke T1 - Ut rhetorica architectura – Leon Battista Alberti´s Technique of Architectural Collage / Leon Battista Albertis architektonische Collagetechnik JF - Candide : journal for architectural knowledge N2 - Leon Battista Alberti, probably the most innovative architect of early Renaissance Italy, has always fascinated scholars by virtue of the striking interpenetration of theory and practice manifest in his work. As an architect, Alberti was an autodidact. Without the benefit of the formative influence of a master or design education, the roots of his conception of architecture lie in his intellectual formation through humanistic rhetoric. The present study demonstrates with reference to a specific project — the Tempietto of the Holy Sepulchre in Florence — how Alberti’s humanist approach conditioned his method of architectural design. Y1 - 2010 SN - 1869-6465 VL - 2 SP - 73 EP - 100 PB - RWTH Aachen CY - Aachen ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Başkurt, Oǧuz Kerim A1 - Meiselman, H. J. T1 - Effect of superoxide anions on red blood cell rheologic properties. Baskurt, O. K.; Temiz, A.; Meiselman, H. J. JF - Free Radical Biology and Medicine. 24 (1998), H. 1 Y1 - 1998 SN - 0891-5849 SP - 102 EP - 110 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Başkurt, Oǧuz Kerim A1 - Meiselman, H. J. T1 - Red blood cell aggregation in experimental sepsis . Baskurt, O. K.; Temiz, A.; Meiselman, H. J. JF - Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2 Y1 - 1997 SN - 0022-2143 SP - 183 EP - 190 ER - TY - JOUR A1 - Kern, Alexander A1 - Schelthoff, Christof A1 - Mathieu, Moritz T1 - Die dynamische Blitzkugel : Wahrscheinlichkeitsberechnung für Blitzeinschläge in Gebäude JF - de - Fachzeitschrift für das Elektrohandwerk Y1 - 2010 SN - 2509-517X IS - 13-14 SP - 24 EP - 29 PB - Hüthig CY - Heidelberg ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Başkurt, Oǧuz Kerim A1 - Edremitlioglu, M. T1 - Effect of erythrocyte deformability on myocardial hematocrit gradient. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A. JF - American Journal of Physiology: Heart and Circulatory Physiology. 268 (1995), H. 1 Y1 - 1995 SN - 0363-6135 SP - 260 EP - 264 ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, Ko-ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging JF - Procedia Engineering N2 - Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach of read out in a light-addressable potentiometric sensor (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device which allows fast and flexible generation of light patterns. With the help of these light patterns the sensor surface of the LAPS device can be read out sequentially in a raster like scheme (scanning LAPS). The DLP approach has several advantages compared to conventional scanning LAPS set-ups, e.g., the spot size, the shape and the intensity of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of measurement. Y1 - 2010 U6 - https://doi.org/10.1016/j.proeng.2010.09.161 SN - 1877-7058 N1 - Eurosensor XXIV Conference, 5-8 September 2010, Linz, Austria VL - 5 SP - 520 EP - 523 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Pedraza, A. M. A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles JF - Procedia Engineering N2 - A new approach for a label-free electrical detection of DNA hybridization and denaturation using an array of individually addressable field-effect nanoplate SOI (silicon-on-insulator) capacitors functionalized with gold nanoparticles is presented. By using a constant-capacitance measuring setup in a differential mode, signal changes of ∼110 mV and ∼70 mV have been registered after the DNA hybridization and denaturation events, respectively. Y1 - 2010 U6 - https://doi.org/10.1016/j.proeng.2010.09.259 SN - 1877-7058 N1 - Eurosensor XXIV Conference, 5-8 September 2010, Linz, Austria VL - 5 SP - 918 EP - 921 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Esch, Thomas T1 - Trends in der Nutzfahrzeugantriebstechnik JF - Motortechnische Zeitschrift (MTZ) N2 - Umweltzonen und Fahrverbote, kletternde Dieselpreise und steigende Straßenbenutzungsgebühren setzen dem Transportgewerbe aktuell schwer zu. Nutzfahrzeughersteller und Partner finden auf diese Herausforderungen neue Antworten mit der Erfüllung der EEV-Grenzwerte (Enhanced Environmentally Friendly Vehicle) als den gegenwärtig anspruchsvollsten europäischen Abgasstandard für Lkw und Busse. Y1 - 2010 U6 - https://doi.org/10.1007/bf03225608 SN - 0024-8525 VL - 71 IS - 10 SP - 652 EP - 658 PB - Springer Nature CY - Basel ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, Torsten A1 - Wemhoff, Thomas ED - Egloffstein, Thomas T1 - Deponie auf Deponie - Technische und genehmigungsrechtliche Aspekte JF - Band 19: Abschluss und Rekultivierung von Deponien und Altlasten 2010 : Die Umsetzung der neuen Deponieverordnung - praktische Erfahrungen im Vollzug und erste Änderungsverordnung zur neuen DepV ; Beiträge zum Seminar am 13. und 14. Oktober 2010 in Karlsruhe Y1 - 2010 SN - 978-3-939662-08-2 N1 - Seminar 2010.10.13-14, Karlsruhe SP - 73 EP - 84 PB - ICP-Eigenverlag CY - Karlsruhe ER - TY - JOUR A1 - Gronsfeld, Richard A1 - Sparla, Peter A1 - Weinnhold, Wolfgang T1 - Airborne und terrestrisches Laserscanning - neue Tools für den Talsperrenbetreiber? JF - Wasserwirtschaft Y1 - 2010 U6 - https://doi.org/10.1007/BF03241621 SN - 0043-0978 VL - 100 IS - 4 SP - 80 EP - 82 PB - Springer Vieweg CY - Wiesbaden ER - TY - JOUR A1 - Thelen, Jan A1 - Paschmann, Hans A1 - Hamelmann, Dirk T1 - Zielsichere Herstellung und Anwendung von Flüssigboden JF - bi-UmweltBau Y1 - 2010 SN - 2509-2685 SP - 48 EP - 49 PB - bi-Medien-GmbH CY - Kiel ER - TY - JOUR A1 - Berretz, Frank A1 - Skorupa, Sascha A1 - Sander, Volker A1 - Belloum, Adam T1 - Towards an actor-driven workflow management system for grids JF - Proceedings of 2010 International Symposium on Collaborative Technologies and Systems N2 - Currently, most workflow management systems in Grid environments provide push-oriented job distribution strategies, where jobs are explicitly delegated to resources. In those scenarios the dedicated resources execute submitted jobs according to the request of a workflow engine or Grid wide scheduler. This approach has various limitations, particularly if human interactions should be integrated in workflow execution. To support human interactions with the benefit of enabling inter organizational computation and community approaches, this poster paper proposes the idea of a pull-based task distribution strategy. Here, heterogeneous resources, including human interaction, should actively select tasks for execution from a central repository. This leads to special demands regarding security issues like access control. In the established push-based job execution the resources are responsible for granting access to workflows and job initiators. In general this is done by access control lists, where users are explicitly mapped to local accounts according to their policies. In the pull-based approach the resources actively apply for job executions by sending requests to a central task repository. This means that every resource has to be able to authenticate against the repository to be authorized for task execution. In other words the authorization is relocated from the resources to the repository. The poster paper introduces current work regarding to the mentioned security aspects in the pull-based approach within the scope of the project “HiX4AGWS”. KW - scheduling KW - engines KW - resource management KW - grid computing KW - access control KW - distribution strategy KW - authorization KW - security KW - humans KW - workflow management software Y1 - 2010 SN - 978-1-4244-6619-1 U6 - https://doi.org/10.1109/CTS.2010.5478458 N1 - 2010 International Symposium on Collaborative Technologies and Systems, 17-21 May 2010, Chicago, IL, USA SP - 611 EP - 616 PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Emonts, Jessica A1 - Buyel, Johannes F. T1 - An overview of descriptors to capture protein properties – Tools and perspectives in the context of QSAR modeling JF - Computational and Structural Biotechnology Journal N2 - Proteins are important ingredients in food and feed, they are the active components of many pharmaceutical products, and they are necessary, in the form of enzymes, for the success of many technical processes. However, production can be challenging, especially when using heterologous host cells such as bacteria to express and assemble recombinant mammalian proteins. The manufacturability of proteins can be hindered by low solubility, a tendency to aggregate, or inefficient purification. Tools such as in silico protein engineering and models that predict separation criteria can overcome these issues but usually require the complex shape and surface properties of proteins to be represented by a small number of quantitative numeric values known as descriptors, as similarly used to capture the features of small molecules. Here, we review the current status of protein descriptors, especially for application in quantitative structure activity relationship (QSAR) models. First, we describe the complexity of proteins and the properties that descriptors must accommodate. Then we introduce descriptors of shape and surface properties that quantify the global and local features of proteins. Finally, we highlight the current limitations of protein descriptors and propose strategies for the derivation of novel protein descriptors that are more informative. KW - Prediction of molecular features KW - Protein structure complexity KW - Quantitative structure activity relationship KW - Scalar parameters KW - Shape and surface properties Y1 - 2023 U6 - https://doi.org/10.1016/j.csbj.2023.05.022 SN - 2001-0370 (Online-Ressource) IS - 21 SP - 3234 EP - 3247 PB - Research Network of Computational and Structural Biotechnology CY - Gotenburg ER - TY - JOUR A1 - Ziemons, Karl A1 - Heinrichs, U. A1 - Streun, M. A1 - Pietrzyk, Uwe T1 - Validation of GEANT3 simulation studies with a dual-head PMT ClearPET™ prototype JF - 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5 N2 - The ClearPET™ project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2nd generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET™ camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0% the simulated intrinsic resolution is about (1.41±0.11)mm compared to the measured of (1.48±0.06)mm. The simulated sensitivity profiles show a mean square deviation of 12.6% in axial direction and 3.6% in radial direction. Satisfactorily these results are representative for all designs and confirm the scanner geometry. Y1 - 2004 SN - 1082-3654 SP - 3053 EP - 3056 ER - TY - JOUR A1 - Khodaverdi, M. A1 - Chatziioannou, A. F. A1 - Weber, S. A1 - Ziemons, Karl A1 - Halling, H. A1 - Pietrzyk, Uwe T1 - Investigation of different MicroCT scanner configurations by GEANT4 simulations JF - IEEE Transactions on Nuclear Science N2 - This study has been performed to design the combination of the new ClearPET (ClearPET is a trademark of the Crystal Clear Collaboration), a small animal positron emission tomography (PET) system, with a micro-computed tomography (microCT) scanner. The properties of different microCT systems have been determined by simulations based on GEANT4. We will demonstrate the influence of the detector material and the X-ray spectrum on the obtained contrast. Four different detector materials (selenium, cadmium zinc telluride, cesium iodide and gadolinium oxysulfide) and two X-ray spectra (a molybdenum and a tungsten source) have been considered. The spectra have also been modified by aluminum filters of varying thickness. The contrast between different tissue types (water, air, brain, bone and fat) has been simulated by using a suitable phantom. The results indicate the possibility to improve the image contrast in microCT by an optimized combination of the X-ray source and detector material. Y1 - 2005 SN - 0018-9499 VL - 52 IS - 1 SP - 188 EP - 192 ER - TY - JOUR A1 - Scholl, Ingrid A1 - Schubert, Nicole A1 - Ziener, Pascal A1 - Pietrzyk, Uwe T1 - GPU-basiertes Volumenrendering von multimodalen medizinischen Bilddaten in Echtzeit JF - Bildverarbeitung für die Medizin 2010 N2 - Die vorliegende Arbeit zeichnet sich dadurch aus, dass registrierte unsegmentierte Volumina aus multimodalen Bilddatensätzen (z.B. MRT, PET) gleichzeitig in einer 3D-Rekonstruktion visualisiert werden und in Echtzeit manipuliert werden können. Ermöglicht wird die Echtzeitfähigkeit durch die Programmierung der Algorithmen zur direkten Volumenvisualisierung auf der Grafikkarte mittels der neuen CUDA-Technologie. Die Zuordnung der Farbeigenschaften wird über 1D-Transferfunktionen für jedes Volumen getrennt gesteuert. So können durch die interaktive Veränderung der 1D-Transferfunktion Detailinformationen aus den zwei Bilddatensätzen getrennt kontrolliert werden und die Vorteile der verschiedenen Bildmodalitäten in einer Visualisierung genutzt werden. Mittels dieses interaktiven Frameworks können neue Erkenntnisse insbesondere über neurodegenerativen Erkrankungen gewonnen werden. Y1 - 2010 SN - 978-3-642-11967-5 N1 - Bildverarbeitung für die Medizin 2010 - Algorithmen - Systeme - Anwendungen, Aachen, Germany, March 14-16, 2010 SP - 400 EP - 404 PB - Springer CY - Berlin ER - TY - JOUR A1 - Blome, Hans-Joachim A1 - Chicone, Carmen A1 - Hehl, Friedrich W. A1 - Mashhoon, Bahram T1 - Nonlocal modification of Newtonian gravity JF - Physical Review D N2 - The Newtonian regime of a recent nonlocal extension of general relativity is investigated. Nonlocality is introduced via a scalar “constitutive” kernel in a special case of the translational gauge theory of gravitation, namely, the teleparallel equivalent of general relativity. In this theory, the nonlocal aspect of gravity simulates dark matter. A nonlocal and nonlinear generalization of Poisson’s equation of Newtonian gravitation is presented. The implications of nonlocality for the gravitational physics in the solar system are briefly studied. Y1 - 2010 U6 - https://doi.org/10.1103/PhysRevD.81.065020 SN - 0556-2821 VL - 81 IS - 6 EP - 065020 PB - American Physical Society CY - Melville, NY ER - TY - JOUR A1 - Timme, Michael T1 - Kündigung des Mietverhältnisses wegen nicht gezahlter Kosten eines Rechtsstreits JF - Monatsschrift für deutsches Recht N2 - Der BGH hat entschieden, dass ein Vermieter einen Wohnraummietvertrag nicht deshalb kündigen kann, weil der Mieter die Prozesskosten eines früheren, auf Zahlungsverzug gestützten Räumungsprozesses nicht begleicht. Der folgende Beitrag beleuchtet die Konsequenzen dieser Entscheidung für die mietvertragliche Praxis Y1 - 2010 U6 - https://doi.org/10.9785/ovs-mdtr-2010-1089 SN - 0340-1812 VL - 64 IS - 19 SP - 1089 EP - 1091 PB - Verlag Dr. Otto Schmidt CY - Köln ER - TY - JOUR A1 - Kowollik, Silvia A1 - Schnitzler, Thomas A1 - Biselli, Manfred A1 - Krueger, R. A1 - Zang, Werner A1 - Peuscher, A. A1 - Schillberg, S. A1 - Fischer, R. T1 - Die Rolle des Respirationsquotienten in der Zellkulturfermentation JF - Chemie Ingenieur Technik N2 - In der biopharmazeutischen Industrie werden rekombinante Proteine und monoklonale Antikörper in Zellkulturfermentationen produziert, da nur humane oder tierische Zelllinien über die Fähigkeit der Glykosylierung verfügen. Um hohe Produktausbeuten in ausgezeichneter Qualität zu erzielen, ist eine funktionstüchtige Prozesskontrolle unerlässlich. Hierzu wurde in Kooperation mit der Firma Hitec Zang GmbH die HiSense� Präzisionsabgasanalytik entwickelt, die auf Basis der vollautomatischen Ermittlung des Respirationsquotienten (RQ; Verhältnis vonKohlendioxidbildungsrate (CER) zu Sauerstoffaufnahmerate (OTR)) einen Fermentationsprozess nicht-invasiv überwacht. Der RQ kann in Hybridoma- und CHO-Zellen (s. Abb.) in sowohl serumhaltigen als auch serumfreien Medien erfolgreich ermittelt werden. Hier spiegeln die CER und die OTR das Wachstumsverhalten der kultivierten CHO-Zellen wider. Der RQ nimmt dabei Werte zwischen 0,9 und 1,2 an. Dies lässt auf verschiedene Stoffwechselaktivitäten schließen. Da die momentane industrielle Prozesskontrolle auf gemessenen Sauerstoffaufnahmeraten oder entsprechende Offline-Analytiken der Metaboliten basieren, soll durch die vollautomatische RQ-Ermittlung ein neues Verfahren zur Fermentationsüberwachung etabliert werden. Bisher war diese, in bakteriellen Kultivierungen standardisierte Methode, aufgrund der schwierigen CER-Berechnung bei Zellkulturen keine adäquate Alternative. Y1 - 2010 SN - Chemie Ingenieur Tec U6 - https://doi.org/10.1002/cite.201050393 N1 - ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, 21. – 23. September 2010, Eurogress Aachen VL - 82 IS - 9 SP - 1505 EP - 1506 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Ziemons, Karl A1 - Bruyndonckx, P. A1 - Perez, J. M. A1 - Pietrzyk, Uwe A1 - Rato, P. A1 - Tavernier, S. T1 - Beyond ClearPET: Next Aims JF - 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro Symposium Proceedings ISBI 2008 N2 - The CRYSTAL CLEAR collaboration, in short CCC, is a consortium of 12 academic institutions, mainly from Europe, joining efforts in the area of developing instrumentation for nuclear medicine and medical imaging. In the framework of the CCC a high performance small animal PET system, called ClearPET, was developed by using new technologies in electronics and crystals in a phoswich arrangement combining two types of lutetium- based scintillator materials: LSO:Ce and LuYAP:Ce. Our next aim will be the development of hybrid image systems. Hybrid MR-PET imaging has many unique advantages for brain research. This has sparked a new research line within CCC for the development of novel MR-PET compatible technologies. MRI is not as sensitive as PET but PET has poorer spatial resolution than MRI. Two major advantages of PET are sensitivity and its ability to acquire metabolic information. To assess these innovations, the development of a 9.4T hybrid animal MR-PET scanner is proposed based on an existing 9.4T MR scanner that will be adapted to enable simultaneous acquisition of MR and PET data using cutting- edge technology for both MR and PET. Y1 - 2008 SN - 978-1-4244-2003-2 SP - 1421 EP - 1424 ER - TY - JOUR A1 - Khodaverdi, M. A1 - Chaziioannou, A. F. A1 - Weber, S. A1 - Ziemons, Karl A1 - Halling, H. A1 - Pietrzyk, Uwe T1 - Investigation of different microCT scanner configurations by GEANT4 simulations JF - 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 4 N2 - This study has been performed to design the combination of the new ClearPET TM (ClearPET is a trademark of the Crystal Clear Collaboration), a small animal Positron Emission Tomography (PET) system, with a microComputed Tomography (microCT) scanner. The properties of different microCT systems have been determined by simulations based on GEANT4. We demonstrate the influence of the detector material and the X-ray spectrum on the obtained contrast. Four different detector materials (selenium, cadmium zinc telluride, cesium iodide and gadolinium oxysulfide) and two X-ray spectra (a molybdenum and a tungsten source) have been considered. The spectra have also been modified by aluminum filters of varying thickness. The contrast between different tissue types (water, air, brain, bone and fat) has been simulated by using a suitable phantom. The results indicate the possibility to improve the image contrast in microCT by an optimized combination of the X-ray source and detector material. Y1 - 2004 SN - 1082-3654 SP - 2989 EP - 2993 ER - TY - JOUR A1 - Schmitt, Robert A1 - Scholl, Ingrid A1 - Cai, Yu A1 - Xia, Ji A1 - Dziwoki, Paul A1 - Harding, Martin A1 - Pavim, Alberto T1 - Machine vision system for inline inspection in carbide insert production JF - Proceedings of the 36th International MATADOR Conference N2 - In steps of the production chain of carbide inserts, such as unloading or packaging, the conformity test of the insert type is done manually, which causes a statistic increase of errors due to monotony and fatigue of the worker and the wide variety of the insert types. A machine vision system is introduced that captures digital frames of the inserts in the production line, analyses inspects automatically and measures four quality features: coating colour, edge radius, plate shape and chip-former geometry. This new method has been tested on several inserts of different types and has shown that the prevalent insert types can be inspected and robustly classified in real production environment and therefore improves the manufacturing automation. Y1 - 2010 SN - 978-1-84996-431-9 U6 - https://doi.org/10.1007/978-1-84996-432-6_77 N1 - 36th MATADOR Conference, University of Manchester, July 2010 SP - 339 EP - 342 PB - Springer CY - Berlin ER - TY - JOUR A1 - Wagner, Torsten A1 - Werner, Frederik A1 - Miyamoto, Ko-ichiro A1 - Ackermann, Hans-Josef A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces JF - Physica Status Solidi (A) N2 - The development of new interfaces for (bio-)chemical sensors requires comprehensive analyses and testing. The light-addressable potentiometric sensor (LAPS) can be used as a platform to investigate the sensitivity of a newly developed interface towards (bio-)chemical agents. LAPS measurements are spatially resolved by utilisation of focused light beams to define individual measurement spots. In this work, a new digitally modulated LAPS set-up based on an FPGA design will be introduced to increase the number of measurement spots, to shorten the measurement time and to improve the measurement accuracy. Y1 - 2010 U6 - https://doi.org/10.1002/pssa.200983320 SN - 1862-6300 N1 - Special Issue: Engineering of Functional Interfaces EnFI 2009 VL - 207 IS - 4 SP - 844 EP - 849 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Berretz, Frank A1 - Skorupa, Sascha A1 - Sander, Volker A1 - Belloum, Adam A1 - Bubak, Marian T1 - Actor-Driven Workflow Execution in Distributed Environments JF - Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.) Y1 - 2011 SN - 978-3-642-21877-4 N1 - Lecture Notes in Computer Science ; 6586 SP - 287 EP - 294 PB - Springer CY - Berlin ER - TY - JOUR A1 - Gerhards, M. A1 - Skorupa, Sascha A1 - Sander, Volker A1 - Pfeiffer, P. A1 - Belloum, Adam T1 - Towards a security framework for a WS-HumanTask processor JF - 7th International Conference on Network and Service Management (CNSM), 2011 Paris Y1 - 2011 SN - 978-3-901882-44-9 SP - 1 EP - 5 PB - IEEE CY - New York ER - TY - JOUR A1 - Bernau, C. R. A1 - Knödler, Matthias A1 - Emonts, Jessica A1 - Jäpel, Ronald Colin A1 - Buyel, Johannes Felix T1 - The use of predictive models to develop chromatography-based purification processes JF - Frontiers in Bioengineering and Biotechnology N2 - Chromatography is the workhorse of biopharmaceutical downstream processing because it can selectively enrich a target product while removing impurities from complex feed streams. This is achieved by exploiting differences in molecular properties, such as size, charge and hydrophobicity (alone or in different combinations). Accordingly, many parameters must be tested during process development in order to maximize product purity and recovery, including resin and ligand types, conductivity, pH, gradient profiles, and the sequence of separation operations. The number of possible experimental conditions quickly becomes unmanageable. Although the range of suitable conditions can be narrowed based on experience, the time and cost of the work remain high even when using high-throughput laboratory automation. In contrast, chromatography modeling using inexpensive, parallelized computer hardware can provide expert knowledge, predicting conditions that achieve high purity and efficient recovery. The prediction of suitable conditions in silico reduces the number of empirical tests required and provides in-depth process understanding, which is recommended by regulatory authorities. In this article, we discuss the benefits and specific challenges of chromatography modeling. We describe the experimental characterization of chromatography devices and settings prior to modeling, such as the determination of column porosity. We also consider the challenges that must be overcome when models are set up and calibrated, including the cross-validation and verification of data-driven and hybrid (combined data-driven and mechanistic) models. This review will therefore support researchers intending to establish a chromatography modeling workflow in their laboratory. KW - biopharmaceutical production process KW - Data-driven models KW - downstream processing design KW - experiment quality KW - hybrid model validation Y1 - 2022 U6 - https://doi.org/10.3389/fbioe.2022.1009102 SN - 2296-4185 (online-ressource) IS - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Fredebeul-Krein, Markus T1 - Die Abschaffung der Studiengebühren ist der falsche Weg! JF - Der Ordnungspolitische Kommentar Y1 - 2010 N1 - Herausgegeben vom Institut für Wirtschaftspolitik an der Universität zu Köln sowie dem Otto-Wolff-Institut für Wirtschaftsordnung ER - TY - JOUR A1 - Schlamann, M. A1 - Yoon, M.-S. A1 - Maderwald, S. A1 - Pietrzyk, Thomas A1 - Bitz, Andreas A1 - Gerwig, M. A1 - Forsting, M. A1 - Ladd, S. C. A1 - Ladd, M. E. A1 - Kastrup, O. T1 - Auswirkungen der Magnetresonanztomografie auf die Elektrophysiologie des motorischen Kortex: eine Studie mit transkranieller Magnetstimulation T1 - Effects of MRI on the electrophysiology of the motor cortex: a TMS study JF - RöFo - Fortschritte auf dem Giebiet der Röntgenstrahlen und der bildgebenden Verfahren Y1 - 2009 U6 - https://doi.org/10.1055/s-0028-1109038 SN - 1438-9029 VL - 181 IS - 3 SP - 215 EP - 219 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Gerhards, M. A1 - Skorupa, Sascha A1 - Sander, Volker A1 - Belloum, Adam A1 - Vesunin, D. A1 - Benabdelkader, A. T1 - HisT/PLIER : A Two-Fold Provenance Approach for Grid-Enabled Scientific Workflows Using WS-VLAM JF - 12th IEEE/ACM International Conference on Grid Computing (GRID), 2011 Y1 - 2011 U6 - https://doi.org/10.1109/Grid.2011.39 SP - 224 EP - 225 PB - IEEE CY - New York ER - TY - JOUR A1 - Fredebeul-Krein, Markus T1 - Wirtschaftskrise : Staatliche Förderung von glasfaserbasierten Breitbandnetzen? JF - Wirtschaftsdienst N2 - Glasfaserbasierte Breitbandnetze werden in Deutschland auch aufgrund der Wirtschaftskrise nur sehr zögerlich ausgebaut. Markus Fredebeul-Krein hält eine staatliche Subventionierung der Breitbandnetze nur bedingt für gerechtfertigt. Private Investoren benötigen jedoch dringend Planungssicherheit durch verlässliche Regulierungsvorschriften. Y1 - 2010 SN - 0043-6275 VL - 90 IS - 2 SP - 113 EP - 117 PB - ZBW CY - Berlin ER -