TY  - PAT
A1  - Schmitz, Susanne
A1  - Spitz, Astrid
A1  - Merkel, Marion
A1  - Siegert, Petra
T1  - Verfahren zur Bestimmung des enzymatischen Status humaner Haut in vitro [Offenlegungsschrift]
T1  - Method for determining the enzymatic status of human skin in vitro [Europäische Patentanmeldung / Australische Patentanmeldung / Internationale Patentanmeldung]
Y1  - 2004
SP  - 1
EP  - 7
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt / IP Australia / WIPO
CY  - München / Den Hague / Canberra / Genf
ER  - 
TY  - PAT
A1  - Banowski, Bernhard
A1  - Wadle, Armin
A1  - Siegert, Petra
A1  - Sättler, Andrea
T1  - Lipase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift]
T1  - Lipase inhibitors in deodorants and antiperspirants [Europäische Patentanmeldung]
Y1  - 2004
SP  - 1
EP  - 22
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt
CY  - München / Den Hague
ER  - 
TY  - PAT
A1  - Banowski, Bernhard
A1  - Waldmann-Laue, Marianne
A1  - Wadle, Armin
A1  - Siegert, Petra
A1  - Sättler, Andreas
T1  - 5-Lipoxigenase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift]
T1  - 5-Lipooxygenase inhibitors in deodorants and antiperspirants [Europäische Patentanmeldung]
Y1  - 2004
SP  - 1
EP  - 12
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt
CY  - München / Den Hague
ER  - 
TY  - JOUR
A1  - Ratke, Lorenz
A1  - Milow, Barbara
A1  - Lisinski, Susanne
A1  - Hoepfner, Sandra
T1  - On an effect of fine ceramic particles on the structure of aerogels
JF  - Microgravity science and technology
Y1  - 2014
U6  - https://doi.org/10.1007/s12217-014-9380-2
SN  - 0938-0108 ; 1875-0494
VL  - 26
SP  - 103
EP  - 110
PB  - Springer Nature
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Kleinridders, Andre
A1  - Küter-Luks, Birgit
A1  - Niehaves, Sandra
A1  - Brüning, Jens C.
A1  - Schwenk, Frieder
T1  - Reversible gene knockdown in mice using a tight, inducible shRNA expression system
JF  - Nucleic Acids Research
Y1  - 2007
U6  - https://doi.org/10.1093/nar/gkm122
SN  - 1362-4962
VL  - 35
IS  - 7
SP  - e54
ER  - 
TY  - JOUR
A1  - Plum, Leona
A1  - Ma, Xiaosong
A1  - Hampel, Brigitte
A1  - Balthasar, Nina
A1  - Coppari, Roberto
A1  - Münzberg, Heike
A1  - Shanabrough, Marya
A1  - Burdakov, Denis
A1  - Rother, Eva
A1  - Janoschek, Ruth
A1  - Alber, Jens
A1  - Belgardt, Bengt F.
A1  - Koch, Linda
A1  - Seibler, Jost
A1  - Schenk, Frieder
A1  - Fekete, Csaba
A1  - Suzuki, Akira
A1  - Mak, Tak W.
A1  - Krone, Wilhelm
A1  - Horvath, Tamas L.
A1  - Ashcroft, Frances M.
A1  - Brüning, Jens C.
T1  - Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2006
U6  - https://doi.org/10.1172/JCI27123
SN  - 1558-8238
VL  - 116
IS  - 7
SP  - 1886
EP  - 1901
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Küter-Luks, Birgit
A1  - Kern, Heidrun
A1  - Streu, Sandra
A1  - Plum, Leona
A1  - Maurer, Jan
A1  - Kühn, Ralf
A1  - Brüning, Jens C.
A1  - Schwenk, Frieder
T1  - Single copy shRNA configuration for ubiquitous gene knockdown in mice
JF  - Nucleic Acids Research
Y1  - 2005
U6  - https://doi.org/10.1093/nar/gni065
SN  - 1362-4962
VL  - 33
IS  - 7
SP  - e67
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Zevnik, Branko
A1  - Küter-Luks, Birgit
A1  - Andreas, Susanne
A1  - Kern, Heidrun
A1  - Hennek, Thomas
A1  - Rode, Anja
A1  - Heimann, Cornelia
A1  - Faust, Nicole
A1  - Kauselmann, Gunther
A1  - Schoor, Michael
A1  - Jaenisch, Rudolf
A1  - Rajewsky, Klaus
A1  - Kühn, Ralf
A1  - Schwenk, Frieder
T1  - Rapid generation of inducible mouse mutants
JF  - Nucleic Acids Research
Y1  - 2003
U6  - https://doi.org/10.1093/nar/gng012
SN  - 1362-4962
VL  - 33
IS  - 4
SP  - e12
ER  - 
TY  - JOUR
A1  - Goetze, Sandra
A1  - Baer, Alexandra
A1  - Winkelmann, Silke
A1  - Nehlsen, Kristina
A1  - Seibler, Jost
A1  - Maass, Karin
A1  - Bode, Jürgen
T1  - Performance of genomic bordering elements at predefined genomic loci
JF  - Molecular and Cellular Biology
Y1  - 2005
U6  - https://doi.org/10.1128/MCB.25.6.2260-2272.2005
SN  - 1098-5549
VL  - 25
IS  - 6
SP  - 2260
EP  - 2272
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Schneider, Benno
A1  - Erbay, E.
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
JF  - Physica status solidi (a)
N2  - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201532053
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1347
EP  - 1352
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - https://doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Raab, Monika
A1  - Kappel, Sven
A1  - Krämer, Andrea
A1  - Sanhaji, Mourad
A1  - Matthess, Yves
A1  - Kurunci-Csacsko, Elisabeth
A1  - Calzada-Wack, Julia
A1  - Rathkolb, Birgit
A1  - Rosman, Jan
A1  - Adler, Thure
A1  - Busch, Dirk H.
A1  - Esposito, Irene
A1  - Fuchs, Helmut
A1  - Gailus-Durner, Valérie
A1  - Klingenspor, Martin
A1  - Wolf, Eckhard
A1  - Sänger, Nicole
A1  - Prinz, Florian
A1  - Hrabe de Angelis, Martin
A1  - Seibler, Jost
A1  - Yuan, Juping
A1  - Bergmann, Martin
A1  - Knecht, Rainald
A1  - Kreft, Bertolt
A1  - Strebhardt, Klaus
T1  - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
JF  - Nature Communications
Y1  - 2011
U6  - https://doi.org/10.1038/ncomms1395
SN  - 2041-1723
VL  - 2
IS  - 395
SP  - 1
EP  - 11
PB  - Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Hasegawa, Maki
A1  - Kapelyukh, Yury
A1  - Tahara, Harunobu
A1  - Seibler, Jost
A1  - Rode, Anja
A1  - Krueger, Sylvia
A1  - Lee, Dongtao N.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
T1  - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
JF  - Molecular Pharmacology
Y1  - 2011
U6  - https://doi.org/10.1124/mol.111.071845
SN  - 1521-0111
VL  - 80
IS  - 33
SP  - 518
EP  - 528
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - CHAP
A1  - Seibler, Jost
A1  - Schwenk, Frieder
T1  - Transgenic RNAi Applications in the Mouse
T2  - Methods in Enzymology : Guide to Techniques in Mouse Development, Part B: Mouse Molecular Genetics. 2nd Edition
Y1  - 2010
SN  - 978-0-12-384880-2
N1  - Methods in Enzymology : Vol. 477
SP  - 367
EP  - 386
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Glaser, Stefan
A1  - Lubitz, Sandra
A1  - Loveland, Kate L.
A1  - Ohbo, Kazu
A1  - Robb, Lorraine
A1  - Schwenk, Frieder
A1  - Seibler, Jost
A1  - Roellig, Daniela
A1  - Kranz, Andrea
A1  - Anastassiadis, Konstantinos
A1  - Stewart, A. Francis
T1  - The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis
JF  - Epigenetics & Chromatin
Y1  - 2009
U6  - https://doi.org/10.1186/1756-8935-2-5
SN  - 1756-8935
VL  - 2
IS  - 5
SP  - 1
EP  - 16
ER  - 
TY  - JOUR
A1  - Kotnik, Katarina
A1  - Popova, Elena
A1  - Todiras, Mihail
A1  - Mori, Marcelo A.
A1  - Alenina, Natalia
A1  - Seibler, Jost
A1  - Bader, Michael
T1  - Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown
JF  - Plos One
Y1  - 2009
U6  - https://doi.org/10.1371/journal.pone.0005124
VL  - 4
IS  - 4
SP  - e5124
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Herold, Marco J.
A1  - Brandt, Jens van den
A1  - Seibler, Jost
A1  - Reichardt, Holger M.
T1  - Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 2008
U6  - https://doi.org/10.1073/pnas.0806213105
SN  - 1091-6490
VL  - 105
IS  - 47
SP  - 18507
EP  - 18512
ER  - 
TY  - JOUR
A1  - Koch, Linda
A1  - Wunderlich, F. Thomas
A1  - Seibler, Jost
A1  - Könner, A. Christine
A1  - Hampel, Brigitte
A1  - Irlenbusch, Sigrid
A1  - Brabant, Georg
A1  - Kahn, C. Ronald
A1  - Schwenk, Frieder
A1  - Brüning, Jens C.
T1  - Central insulin action regulates peripheral glucose and fat metabolism in mice
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2008
U6  - https://doi.org/10.1172/JCI31073
SN  - 1558-8238
VL  - 118
IS  - 6
SP  - 2132
EP  - 2147
ER  - 
TY  - JOUR
A1  - Christoph, Thomas
A1  - Bahrenberg, Gregor
A1  - Vry, Jean de
A1  - Englberger, Werner
A1  - Erdmann, Volker A.
A1  - Frech, Moritz
A1  - Kögel, Babette
A1  - Röhl, Thomas
A1  - Schiene, Klaus
A1  - Schröder, Wolfgang
A1  - Seibler, Jost
A1  - Kurreck, Jens
T1  - Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice
JF  - Molecular and Cellular Neuroscience
Y1  - 2008
U6  - https://doi.org/10.1016/j.mcn.2007.12.006
SN  - 1044-7431
VL  - 37
IS  - 3
SP  - 579
EP  - 589
ER  -