TY - JOUR A1 - Attar, Mandana Hossein Zadeh A1 - Merk, Hans F. A1 - Kotliar, Konstantin A1 - Wurpts, Gerda A1 - Röseler, Stefani A1 - Moll-Slodowy, Silke A1 - Plange, Johann A1 - Baron, Jens Malte A1 - Balakirski, Galina T1 - The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria JF - European Journal of Dermatology Y1 - 2019 U6 - https://doi.org/10.1684/ejd.2019.3680 VL - 29 IS - 6 SP - 614 EP - 618 ER - TY - JOUR A1 - Pilas, Johanna A1 - Selmer, Thorsten A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Screen-printed carbon electrodes modified with graphene oxide for the design of a reagent-free NAD+-dependent biosensor array JF - Analytical Chemistry Y1 - 2019 U6 - https://doi.org/10.1021/acs.analchem.9b04481 VL - 91 IS - 23 SP - 15293 EP - 15299 PB - ACS Publications CY - Washington ER - TY - JOUR A1 - Czarnecki, Christian A1 - Bensberg, Frank A1 - Auth, Gunnar T1 - Die Rolle von Softwarerobotern für die zukünftige Arbeitswelt JF - HMD Praxis der Wirtschaftsinformatik N2 - Im Rahmen der Digitalisierung ist die zunehmende Automatisierung von bisher manuellen Prozessschritten ein Aspekt, der massive Auswirkungen auf die zukünftige Arbeitswelt haben wird. In diesem Kontext werden an den Einsatz von Softwarerobotern zur Prozessautomatisierung hohe Erwartungen geknüpft. Bei den Implementierungsansätzen wird die Diskussion aktuell insbesondere durch Robotic Process Automation (RPA) und Chatbots geprägt. Beide Ansätze verfolgen das gemeinsame Ziel einer 1:1-Automatisierung von menschlichen Handlungen und dadurch ein direktes Ersetzen von Mitarbeitern durch Maschinen. Bei RPA werden Prozesse durch Softwareroboter erlernt und automatisiert ausgeführt. Dabei emulieren RPA-Roboter die Eingaben auf der bestehenden Präsentationsschicht, so dass keine Änderungen an vorhandenen Anwendungssystemen notwendig sind. Am Markt werden bereits unterschiedliche RPA-Lösungen als Softwareprodukte angeboten. Durch Chatbots werden Ein- und Ausgaben von Anwendungssystemen über natürliche Sprache realisiert. Dadurch ist die Automatisierung von unternehmensexterner Kommunikation (z. B. mit Kunden) aber auch von unternehmensinternen Assistenztätigkeiten möglich. Der Beitrag diskutiert die Auswirkungen von Softwarerobotern auf die Arbeitswelt anhand von Anwendungsbeispielen und erläutert die unternehmensindividuelle Entscheidung über den Einsatz von Softwarerobotern anhand von Effektivitäts- und Effizienzzielen. KW - Robotic Process Automation KW - Chatbots KW - Prozessautomatisierung KW - Arbeit 4.0 KW - Digitalisierung Y1 - 2019 U6 - https://doi.org/10.1365/s40702-019-00548-z SN - 2198-2775 VL - 56 IS - 4 SP - 795 EP - 808 PB - Springer CY - Cham ER - TY - JOUR A1 - Werkhausen, Amelie A1 - Cronin, Neil J. A1 - Albracht, Kirsten A1 - Bojsen-Møller, Jens A1 - Seynnes, Olivier R. T1 - Distinct muscle-tendon interaction during running at different speeds and in different loading conditions JF - Journal of Applied Physiology Y1 - 2019 U6 - https://doi.org/10.1152/japplphysiol.00710.2018 SN - 1522-1601 VL - 127 IS - 1 SP - 246 EP - 253 ER - TY - JOUR A1 - Ermolaev, AP A1 - Erichev, VP A1 - Antonov, AA A1 - Grigoryan, GL A1 - Kotliar, Konstantin A1 - Levitsky, YV A1 - Hderi, K A1 - Mazurova, YV T1 - Assessing retinal photosensitivity in patients with central vision impairment using a portable perimeter (a preliminary report) JF - Vestnik oftalmologii Y1 - 2019 U6 - https://doi.org/10.17116/oftalma201913503146 N1 - Abstract in Englisch VL - 135 IS - 3 SP - 46 EP - 54 ER - TY - JOUR A1 - Jildeh, Zaid B. A1 - Kirchner, Patrick A1 - Baltes, Klaus A1 - Wagner, Patrick H. A1 - Schöning, Michael Josef T1 - Development of an in-line evaporation unit for the production of gas mixtures containing hydrogen peroxide – numerical modeling and experimental results JF - International Journal of Heat and Mass Transfer N2 - Hydrogen peroxide (H2O2) is a typical surface sterilization agent for packaging materials used in the pharmaceutical, food and beverage industries. We use the finite-elements method to analyze the conceptual design of an in-line thermal evaporation unit to produce a heated gas mixture of air and evaporated H2O2 solution. For the numerical model, the required phase-transition variables of pure H2O2 solution and of the aerosol mixture are acquired from vapor-liquid equilibrium (VLE) diagrams derived from vapor-pressure formulations. This work combines homogeneous single-phase turbulent flow with heat-transfer physics to describe the operation of the evaporation unit. We introduce the apparent heat-capacity concept to approximate the non-isothermal phase-transition process of the H2O2-containing aerosol. Empirical and analytical functions are defined to represent the temperature- and pressure-dependent material properties of the aqueous H2O2 solution, the aerosol and the gas mixture. To validate the numerical model, the simulation results are compared to experimental data on the heating power required to produce the gas mixture. This shows good agreement with the deviations below 10%. Experimental observations on the formation of deposits due to the evaporation of stabilized H2O2 solution fits the prediction made from simulation results. Y1 - 2019 U6 - https://doi.org/10.1016/j.ijheatmasstransfer.2019.118519 SN - 0017-9310 VL - 143 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schwarz, Alexander A1 - Gebhardt, Andreas A1 - Schleser, Markus A1 - Popoola, Patricia T1 - New Welding Joint Geometries Manufactured by Powder Bed Fusion from 316L JF - Materials Performance and Characterization 8 Y1 - 2019 U6 - https://doi.org/10.1520/MPC20180096 SN - 2379-1365 IS - in press ER - TY - JOUR A1 - Bucur, Alexandru A1 - Lazarescu, Lucian A1 - Pop, Grigore Marian A1 - Achimas, Gheorghe A1 - Gebhardt, Andreas T1 - Tribological performance of biodegradable lubricants under different surface roughness of tools JF - Academic Journal of Manufacturing Engineering Y1 - 2019 SN - 1583-7904 VL - 17 IS - 1 SP - 172 EP - 178 ER - TY - JOUR A1 - Thoma, Andreas A1 - Ravi, Sridhar T1 - Significance of parallel computing on the performance of Digital Image Correlation algorithms in MATLAB N2 - Digital Image Correlation (DIC) is a powerful tool used to evaluate displacements and deformations in a non-intrusive manner. By comparing two images, one of the undeformed reference state of a specimen and another of the deformed target state, the relative displacement between those two states is determined. DIC is well known and often used for post-processing analysis of in-plane displacements and deformation of specimen. Increasing the analysis speed to enable real-time DIC analysis will be beneficial and extend the field of use of this technique. Here we tested several combinations of the most common DIC methods in combination with different parallelization approaches in MATLAB and evaluated their performance to determine whether real-time analysis is possible with these methods. To reflect improvements in computing technology different hardware settings were also analysed. We found that implementation problems can reduce the efficiency of a theoretically superior algorithm such that it becomes practically slower than a suboptimal algorithm. The Newton-Raphson algorithm in combination with a modified Particle Swarm algorithm in parallel image computation was found to be most effective. This is contrary to theory, suggesting that the inverse-compositional Gauss-Newton algorithm is superior. As expected, the Brute Force Search algorithm is the least effective method. We also found that the correct choice of parallelization tasks is crucial to achieve improvements in computing speed. A poorly chosen parallelisation approach with high parallel overhead leads to inferior performance. Finally, irrespective of the computing mode the correct choice of combinations of integerpixel and sub-pixel search algorithms is decisive for an efficient analysis. Using currently available hardware realtime analysis at high framerates remains an aspiration. Y1 - 2019 SP - 1 EP - 17 ER - TY - JOUR A1 - Bartella, Alexander K. A1 - Kamal, Mohammad A1 - Scholl, Ingrid A1 - Schiffer, Stefan A1 - Steegmann, Julius A1 - Ketelsen, Dominik A1 - Hölzle, Frank W. A1 - Lethaus, Bernd T1 - Virtual reality in preoperative imaging in maxillofacial surgery: implementation of “the next level”? JF - British Journal of Oral and Maxillofacial Surgery Y1 - 2019 U6 - https://doi.org/10.1016/j.bjoms.2019.02.014 SN - 0266-4356 VL - 57 IS - 7 SP - 644 EP - 648 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Capri, Miriam A1 - Morsiani, Cristina A1 - Santoro, Aurelia A1 - Moriggi, Manuela A1 - Conte, Maria A1 - Martucci, Morena A1 - Bellavista, Elena A1 - Fabbri, Cristina A1 - Giampieri, Enrico A1 - Albracht, Kirsten A1 - Flück, Martin A1 - Ruoss, Severin A1 - Brocca, Lorenza A1 - Canepari, Monica A1 - Longa, Emanuela A1 - Giulio, Irene Di A1 - Bottinelli, Roberto A1 - Cerretelli, Paolo A1 - Salvioli, Stefano A1 - Gelfi, Cecilia A1 - Franceschi, Claudio A1 - Narici, Marco A1 - Rittweger, Jörn T1 - Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting JF - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology Y1 - 2019 U6 - https://doi.org/10.1096/fj.201801625R VL - 33 IS - 4 SP - 5168 EP - 5180 ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Strüder, Heiko K. T1 - Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants JF - Sports Biomechanics Y1 - 2019 U6 - https://doi.org/10.1080/14763141.2019.1593496 SN - 1752-6116 IS - Article in press PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Schmidt, Katharina A1 - Forkmann, Katarina A1 - Schultz, Heidrun A1 - Gratz, Marcel A1 - Bitz, Andreas A1 - Wiech, Katja A1 - Bingel, Ulrike T1 - Enhanced Neural Reinstatement for Evoked Facial Pain Compared With Evoked Hand Pain JF - The Journal of Pain Y1 - 2019 U6 - https://doi.org/10.1016/j.jpain.2019.03.003 SN - 1526-5900 IS - In Press, Corrected Proof PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schiffels, Johannes A1 - Selmer, Thorsten T1 - Combinatorial assembly of ferredoxin‐linked modules in Escherichia coli yields a testing platform for Rnf‐complexes JF - Biotechnology and Bioengineering Y1 - 2019 U6 - https://doi.org/10.1002/bit.27079 IS - accepted article SP - 1 EP - 36 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kopp, Alexander A1 - Schmeets, Ralf A1 - Gosau, Martin A1 - Friedrich, Reinhard E. A1 - Fuest, Sandra A1 - Behbahani, Mehdi A1 - Barbeck, Mike A1 - Rutkowski, Rico A1 - Burg, Simon A1 - Kluwe, Lan A1 - Henningsen, Anders T1 - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application JF - In Vivo Y1 - 2019 U6 - https://doi.org/10.21873/invivo.11536 SN - 1791-7549 VL - 33 IS - 3 SP - 757 EP - 762 ER - TY - JOUR A1 - Kodomskoi, Leonid A1 - Kotliar, Konstantin A1 - Schröder, Andreas A1 - Weiss, Michael A1 - Hille, Konrad T1 - Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter JF - Journal of Glaucoma Y1 - 2019 U6 - https://doi.org/10.1097/IJG.0000000000001321 SN - 1057-0829 IS - Epub ahead of print PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Noureddine, Yacine A1 - Kraff, Oliver A1 - Ladd, Mark E. A1 - Wrede, Karsten A1 - Chen, Bixia A1 - Quick, Harald H. A1 - Schaefers, Georg A1 - Bitz, Andreas T1 - Radiofrequency induced heating around aneurysm clips using a generic birdcage head coil at 7 Tesla under consideration of the minimum distance to decouple multiple aneurysm clips JF - Magnetic Resonance in Medicine Y1 - 2019 U6 - https://doi.org/10.1002/mrm.27835 SN - 1522-2594 IS - Early view SP - 1 EP - 17 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Dantism, Shahriar A1 - Röhlen, Desiree A1 - Selmer, Thorsten A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2019.111332 VL - 139 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Weber, Tobias A1 - Englhard, Markus A1 - Arent, Jan-Christoph A1 - Hausmann, Joachim T1 - An experimental characterization of wrinkling generated during prepreg autoclave manufacturing using caul plates JF - Journal of Composite Materials Y1 - 2019 U6 - https://doi.org/10.1177/0021998319846556 SN - 1530-793X VL - 53 IS - 26-27 SP - 3757 EP - 3773 ER - TY - JOUR A1 - Schiedermeier, Maximilian A1 - Rettner, Cornelius A1 - Heilmann, Marcel A1 - Schneider, Felix A1 - Marz, Martin T1 - Interference of automotive HV-DC-systems by traction voltage-source-inverters (VSI) JF - 2019 IEEE Transportation Electrification Conference (ITEC-India) Y1 - 2019 U6 - https://doi.org/10.1109/ITEC-India48457.2019.ITECINDIA2019-37 SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Gronsfeld, Richard A1 - Joachim, Klubert A1 - Malecha, Hartmut T1 - 3-D-Visualisierung von vorhandenen Staubauwerken zur holistischen Planung und Überwachung JF - Wasserwirtschaft Y1 - 2019 U6 - https://doi.org/10.1007/s35147-019-0075-x SN - 2192-8762 N1 - gedruckt in der Bereichsbibliothek Bayernallee unter der Signatur 13 Z 218 vorhanden VL - 109 IS - 5 SP - 82 EP - 85 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kunkel, Maximilian Hugo A1 - Gebhardt, Andreas A1 - Mpofu, Khumbulani A1 - Kallweit, Stephan T1 - Quality assurance in metal powder bed fusion via deep-learning-based image classification JF - Rapid Prototyping Journal Y1 - 2019 U6 - https://doi.org/10.1108/RPJ-03-2019-0066 SN - 1355-2546 VL - 26 IS - 2 SP - 259 EP - 266 ER - TY - JOUR A1 - Olbertz, Klaus T1 - Arbeitsrechtliche Akzente der Gesetzgebung und Rechtsprechung in 2018 : Ein kurzweiliger Rückblick auf das Arbeitsrecht des vergangenen Jahres JF - NWB - Steuer- und Wirtschaftsrecht Y1 - 2019 SN - 0028-3460 IS - 5 SP - 266 EP - 279 ER - TY - JOUR A1 - Olbertz, Klaus T1 - Auslandsentsendungen im arbeitsrechtlichen Zusammenhang : Ausgestaltung eines Entsendungsvertrags und mitbestimmungsrechtliche Aspekte JF - NWB - Steuer- und Wirtschaftsrecht Y1 - 2019 SN - 0028-3460 IS - 19 SP - 1400 EP - 1406 ER - TY - JOUR A1 - Olbertz, Klaus T1 - Rechtssichere Vereinbarungen von Kündigungsfristen im Arbeitsvertrag : Weitestgehende Abdingbarkeit gesetzlicher Vorgaben ermöglicht passgenaue Gestaltungen JF - NWB - Steuer- und Wirtschaftsrecht Y1 - 2019 SN - 0028-3460 IS - 23 SP - 1693 EP - 1699 ER - TY - JOUR A1 - Olbertz, Klaus T1 - Die Optionen des Arbeitgebers nach Krankmeldung des Arbeitnehmers : Ein Überblick über die Rechte und Pflichten des Arbeitgebers bei Arbeitsunfähigkeit des Mitarbeiters JF - NWB - Steuer- und Wirtschaftsrecht Y1 - 2019 SN - 0028-3460 IS - 30 SP - 2222 EP - 2229 ER - TY - JOUR A1 - Olbertz, Klaus T1 - Die arbeitsvertragliche Vereinbarung von Vertragsstrafen : Anforderungen an wirksame Vertragsstrafenabreden in Formulararbeitsverträgen beachten JF - NWB - Steuer- und Wirtschaftsrecht Y1 - 2019 SN - 0028-3460 IS - 45 SP - 3302 EP - 3308 ER - TY - JOUR A1 - Ketelhut, Maike A1 - Kolditz, Melanie A1 - Göll, Fabian A1 - Braunstein, Bjoern A1 - Albracht, Kirsten A1 - Abel, Dirk T1 - Admittance control of an industrial robot during resistance training JF - IFAC-PapersOnLine N2 - Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories. KW - Assistive technology KW - Rehabilitation engineering KW - Human-Computer interaction KW - Automatic control Y1 - 2019 U6 - https://doi.org/10.1016/j.ifacol.2019.12.102 SN - 2405-8963 N1 - 14th IFAC Symposium on Analysis, Design, and Evaluation of Human Machine Systems HMS 2019 Tallinn, Estonia, 16–91 September 2019 VL - 52 IS - 19 SP - 223 EP - 228 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Werkhausen, Amelie A1 - Cronin, Neil J. A1 - Albracht, Kirsten A1 - Paulsen, Gøran A1 - Larsen, Askild V. A1 - Bojsen-Møller, Jens A1 - Seynnes, Olivier R. T1 - Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running JF - PeerJ N2 - Background During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus. Methods Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics. Results Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training. Discussion These results show that a training-induced increase in Achilles tendon stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running. KW - Achilles tendon KW - Stiffness KW - Running KW - Tendon properties KW - Architectural gear ratio Y1 - 2019 U6 - https://doi.org/10.7717/peerj.6764 SN - 21678359 PB - Peer CY - London ER - TY - JOUR A1 - Jan Thimo, Grundmann A1 - Bauer, Waldemar A1 - Biele, Jens A1 - Boden, Ralf A1 - Ceriotti, Matteo A1 - Cordero, Federico A1 - Dachwald, Bernd A1 - Dumont, Etienne A1 - Grimm, Christian D. A1 - Hercik, David T1 - Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs JF - Acta Astronautica Y1 - 2019 U6 - https://doi.org/10.1016/j.actaastro.2018.03.019 SN - 0094-5765 VL - 156 IS - 3 SP - 330 EP - 362 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rossi, Leonardo A1 - Parisi, Davide A1 - Casari, Chiara A1 - Montanari, Luca A1 - Ruggieri, Gabriella A1 - Holtschoppen, Britta A1 - Butenweg, Christoph T1 - Empirical Data about Direct Economic Consequences of Emilia-Romagna 2012 Earthquake on Long-Span-Beam Buildings JF - Earthquake Spectra Y1 - 2019 U6 - https://doi.org/10.1193/100118EQS224DP SN - 1944-8201 VL - 35 IS - 4 SP - 1979 EP - 2001 ER - TY - JOUR A1 - Rossi, Leonardo A1 - Holtschoppen, Britta A1 - Butenweg, Christoph T1 - Official data on the economic consequences of the 2012 Emilia-Romagna earthquake: a first analysis of database SFINGE JF - Bulletin of Earthquake Engineering Y1 - 2019 U6 - https://doi.org/10.1007%2Fs10518-019-00655-8 VL - 17 IS - 9 SP - 4855 EP - 4884 PB - Springer CY - Berlin ER - TY - JOUR A1 - Rossi, Leonardo A1 - Stupazzini, Marco A1 - Parisi, Davide A1 - Holtschoppen, Britta A1 - Ruggieri, Gabriella A1 - Butenweg, Christoph T1 - Empirical fragility functions and loss curves for long-span-beam buildings based on the 2012 Emilia-Romagna earthquake official database JF - Bulletin of Earthquake Engineering N2 - The 2012 Emilia-Romagna earthquake, that mainly struck the homonymous Italian region provoking 28 casualties and damage to thousands of structures and infrastructures, is an exceptional source of information to question, investigate, and challenge the validity of seismic fragility functions and loss curves from an empirical standpoint. Among the most recent seismic events taking place in Europe, that of Emilia-Romagna is quite likely one of the best documented, not only in terms of experienced damages, but also for what concerns occurred losses and necessary reconstruction costs. In fact, in order to manage the compensations in a fair way both to citizens and business owners, soon after the seismic sequence, the regional administrative authority started (1) collecting damage and consequence-related data, (2) evaluating information sources and (3) taking care of the cross-checking of various reports. A specific database—so-called Sistema Informativo Gestione Europa (SFINGE)—was devoted to damaged business activities. As a result, 7 years after the seismic events, scientists can rely on a one-of-a-kind, vast and consistent database, containing information about (among other things): (1) buildings’ location and dimensions, (2) occurred structural damages, (3) experienced direct economic losses and (4) related reconstruction costs. The present work is focused on a specific data subset of SFINGE, whose elements are Long-Span-Beam buildings (mostly precast) deployed for business activities in industry, trade or agriculture. With the available set of data, empirical fragility functions, cost and loss ratio curves are elaborated, that may be included within existing Performance Based Earthquake Engineering assessment toolkits. KW - Empirical fragility functions KW - Empirical consequence curves KW - Precast buildings KW - Emilia-Romagna earthquake KW - PBEE Y1 - 2019 U6 - https://doi.org/10.1007/s10518-019-00759-1 SN - 1573-1456 VL - 18 SP - 1693 EP - 1721 PB - Springer Nature ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinkovic, Marko A1 - Salatic, Ratko T1 - Experimental results of reinforced concrete frames with masonry infills under combined quasi-static in-plane and out-of-plane seismic loading JF - Bulletin of Earthquake Engineering Y1 - 2019 U6 - https://doi.org/10.1007/s10518-019-00602-7 SN - 1573-1456 VL - 17 SP - 3397 EP - 3422 PB - Springer CY - Berlin ER - TY - JOUR A1 - Marinkovic, Marko A1 - Butenweg, Christoph T1 - Innovative decoupling system for the seismic protection of masonry infill walls in reinforced concrete frames JF - Engineering Structures Y1 - 2019 U6 - https://doi.org/10.1016/j.engstruct.2019.109435 SN - 0141-0296 VL - 197 IS - Article 109435 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Lyons, W. Berry A1 - Mikucki, Jill A. A1 - German, Laura A. A1 - Welch, Kathleen A. A1 - Welch, Susan A. A1 - Gardener, Christopher B. A1 - Tulaczyk, Slawek M. A1 - Pettit, Erin C. A1 - Kowalski, Julia A1 - Dachwald, Bernd T1 - The Geochemistry of Englacial Brine from Taylor Glacier, Antarctica JF - Journal of Geophysical Research: Biogeosciences Y1 - 2019 U6 - https://doi.org/10.1029/2018JG004411 SN - 2169-8961 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Turlybekuly, Amanzhol A1 - Pogrebnjak, Alexander A1 - Sukhodub, L. F. A1 - Sukhodub, Liudmyla B. A1 - Kistaubayeva, A. S. A1 - Savitskaya, Irina A1 - Shokatayeva, D. H. A1 - Bondar, Oleksandr V. A1 - Shaimardanov, Z. K. A1 - Plotnikov, Sergey V. A1 - Shaimardanova, B. H. A1 - Digel, Ilya T1 - Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix JF - Materials Science and Engineering C Y1 - 2019 U6 - https://doi.org/10.1016/j.msec.2019.109965 VL - 104 IS - Article number 109965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Götten, Falk A1 - Havermann, Marc A1 - Braun, Carsten A1 - Gomez, Francisco A1 - Bil, Cees T1 - RANS Simulation Validation of a Small Sensor Turret for UAVs JF - Journal of Aerospace Engineering N2 - Recent Unmanned Aerial Vehicle (UAV) design procedures rely on full aircraft steady-state Reynolds-Averaged-Navier-Stokes (RANS) analyses in early design stages. Small sensor turrets are included in such simulations, even though their aerodynamic properties show highly unsteady behavior. Very little is known about the effects of this approach on the simulation outcomes of small turrets. Therefore, the flow around a model turret at a Reynolds number of 47,400 is simulated with a steady-state RANS approach and compared to experimental data. Lift, drag, and surface pressure show good agreement with the experiment. The RANS model predicts the separation location too far downstream and shows a larger recirculation region aft of the body. Both characteristic arch and horseshoe vortex structures are visualized and qualitatively match the ones found by the experiment. The Reynolds number dependence of the drag coefficient follows the trend of a sphere within a distinct range. The outcomes indicate that a steady-state RANS model of a small sensor turret is able to give results that are useful for UAV engineering purposes but might not be suited for detailed insight into flow properties. Y1 - 2019 U6 - https://doi.org/10.1061/(ASCE)AS.1943-5525.0001055 SN - 1943-5525 VL - 32 IS - 5 PB - ASCE CY - New York ER - TY - JOUR A1 - Göttsche, Joachim A1 - Alexopoulos, Spiros A1 - Dümmler, Andreas A1 - Maddineni, S. K. T1 - Multi-Mirror Array Calculations With Optical Error N2 - The optical performance of a 2-axis solar concentrator was simulated with the COMSOL Multiphysics® software. The concentrator consists of a mirror array, which was created using the application builder. The mirror facets are preconfigured to form a focal point. During tracking all mirrors are moved simultaneously in a coupled mode by 2 motors in two axes, in order to keep the system in focus with the moving sun. Optical errors on each reflecting surface were implemented in combination with the solar angular cone of ± 4.65 mrad. As a result, the intercept factor of solar radiation that is available to the receiver was calculated as a function of the transversal and longitudinal angles of incidence. In addition, the intensity distribution on the receiver plane was calculated as a function of the incidence angles. KW - solar process heat KW - concentrating collector KW - raytracing KW - point-focussing system Y1 - 2019 SP - 1 EP - 6 ER - TY - JOUR A1 - Valero, D. A1 - Bung, Daniel Bernhard A1 - Crookston, B. M. T1 - Closure to “Energy Dissipation of a Type III Basin under Design and Adverse Conditions for Stepped and Smooth Spillways” JF - Journal of Hydraulic Engineering Y1 - 2019 U6 - https://doi.org/10.1061/(ASCE)HY.1943-7900.0001669 VL - 146 IS - 2 PB - ASCE CY - Reston, Va. ER - TY - JOUR A1 - Funke, Harald A1 - Beckmann, Nils A1 - Abanteriba, Sylvester T1 - An overview on dry low NOx micromix combustor development for hydrogen-rich gas turbine applications JF - International Journal of Hydrogen Energy Y1 - 2019 U6 - https://doi.org/10.1016/j.ijhydene.2019.01.161 SN - 0360-3199 VL - 44 IS - 13 SP - 6978 EP - 6990 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Finger, Felix A1 - Götten, Falk T1 - Neue Ansätze für die Entwicklung von unbemannten Fluggeräten JF - Ingenieurspiegel N2 - Wie sieht das unbemannte Flugzeug von Übermorgen aus? Dieser Frage stellen sich Forscher an der Fachhochschule Aachen. Die weltweit rasant fortschreitende Entwicklung des Marktes für unbemannte Fluggeräte (UAVs - „Unmanned Aerial Vehicles“) bietet großes Potenzial für Wachstum und Wertschöpfung. Unbemannte fliegende Systeme können – für bestimmte Anwendungsgebiete – wesentlich günstiger, kleiner und effizienter ausgelegt werden als bemannte Lösungen. Dabei sind sich viele Unternehmen über das mögliche Potential dieser Technologie noch gar nicht bewusst. Y1 - 2019 SN - 1868-5919 N1 - Project: UAV Design VL - 2019 IS - 1 SP - 67 EP - 68 ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred T1 - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue JF - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik Y1 - 2019 U6 - https://doi.org/10.1002/gamm.201900002 SN - 1522-2608 VL - 42 IS - 4 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Jessing, Max P. A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2018.11.019 SN - 0956-5663 VL - 126 SP - 510 EP - 517 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schildt, Ph. A1 - Braun, Carsten A1 - Marzocca, P. T1 - Metric evaluating potentials of condition-monitoring approaches for hybrid electric aircraft propulsion systems JF - CEAS Aeronautical Journal Y1 - 2019 U6 - https://doi.org/10.1007/s13272-019-00411-3 SN - 1869-5590 SP - 1 EP - 14 PB - Springer CY - Berlin ER - TY - JOUR A1 - Jayaraman, Chandrasekaran A1 - Mummidisetty, Chaitanya Krishna A1 - Loesch, Alexandra A1 - Kaur, Sandi A1 - Hoppe-Ludwig, Shenan A1 - Staat, Manfred A1 - Jayaraman, Arun T1 - Postural and metabolic benefits of using a forearm support walker in older adults with impairments JF - Archives of Physical Medicine and Rehabilitation Y1 - 2019 U6 - https://doi.org/10.1016/j.apmr.2018.10.001 SN - 0003-9993 VL - Volume 100 IS - Issue 4 SP - 638 EP - 647 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Linder, Peter A1 - Beckler, Matthias A1 - Doerr, Leo A1 - Stoelzle-Feix, Sonja A1 - Fertig, Niels A1 - Jung, Alexander A1 - Staat, Manfred A1 - Gossmann, Matthias T1 - A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions JF - Journal of Pharmacological and Toxicological Methods Y1 - 2019 U6 - https://doi.org/10.1016/j.vascn.2019.05.162 SN - 1056-8719 VL - 99 IS - Article number 106595 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Golland, Alexander ED - Hoeren, Thomas ED - Schneider, Jochen ED - Selmayr, Martin ED - Spies, Axel ED - Wybitul, Tim T1 - Gemeinsam einsam: Ein „Like“ für die gemeinsame Verantwortlichkeit? JF - ZD Zeitschrift für Datenschutz Y1 - 2019 SN - 2192-5593 VL - 9 IS - 9 SP - 381 EP - 382 PB - Beck CY - München ER - TY - JOUR A1 - Golland, Alexander T1 - Reichweite des “Joint Controllership”: Neue Fragen der gemeinsamen Verantwortlichkeit JF - K&R Kommunikation & Recht N2 - Kein Urteil zum Datenschutzrecht sorgte im vergangenen Jahr für mehr panische Reaktionen als die Entscheidung des EuGH in der Rechtssache “Wirtschaftsakademie Schleswig-Holstein”(C-210/16). Das Urteil warf in datenschutzrechtlicher Literatur und Öffentlichkeit zahlreiche Fragen auf: Ist jetzt jeder “gemeinsam” Verantwortlicher? Was sind die Kriterien? Der EuGH hat kürzlich in einem – dem allgemeinen Vernehmen nach aufsehenerregenden, de facto aber kaum überraschenden – Urteil für Klarheit gesorgt. Dabei hat das Gericht jedoch einige Fragen offengelassen und neue Fragen aufgeworfen. Ein Blick auf alte und neue Herausforderungen in Kooperationsszenarien. Y1 - 2019 SN - 1434-6354 N1 - Zugleich Kommentar zu EuGH, Urteil vom 29. 7. 2019 – C-40/1 VL - 22 IS - 9 SP - 533 EP - 537 PB - dfv Mediengruppe, Deutscher Fachverlag GmbH CY - Frankfurt am Main ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Tödter, Julia A1 - Niehues, Julia A1 - Telöken, Matthias A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim A1 - Schröper, Florian T1 - 3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection JF - Sensors N2 - For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated. Y1 - 2019 U6 - https://doi.org/10.3390/s19010148 SN - 1424-8220 VL - 19 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wingens, Niklas A1 - May, Jörg A1 - Pfaff, Raphael T1 - Betrieblich-technische Innovationsansätze zur Bremsprobe nach einer Prozessänderung JF - Eisenbahntechnische Rundschau : ETR ; Zeitschrift für die gesamte Eisenbahntechnik Y1 - 2019 SN - 0013-2845 IS - 5 PB - DVV Media Group CY - Hamburg ER - TY - JOUR A1 - Kapelyukh, Yury A1 - Henderson, Colin James A1 - Scheer, Nico A1 - Rode, Anja A1 - Wolf, Charles Roland T1 - Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice JF - Drug Metabolism and Disposition Y1 - 2019 U6 - https://doi.org/10.1124/dmd.119.087718 IS - Early view ER - TY - JOUR A1 - Timme, Michael T1 - Die Unwirksamkeit von auf Öffnungsklauseln in Gemeinschaftsordnungen fußenden Beschlüssen JF - Monatsschrift für deutsches Recht Y1 - 2019 U6 - https://doi.org/10.9785/mdtr-2019-731509 SN - 0340-1812 IS - 15 SP - 904 EP - 905 PB - Verlag Dr. Otto Schmidt CY - Köln ER - TY - JOUR A1 - Leschinger, Tim A1 - Birgel, Stefan A1 - Hackl, Michael A1 - Staat, Manfred A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair JF - Computer Methods in Biomechanics and Biomedical Engineering Y1 - 2019 U6 - https://doi.org/10.1080/10255842.2019.1572749 IS - Early view PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Hüning, Felix T1 - Nachrüstmöglichkeiten von Dieselfahrzeugen aus technischer Sicht JF - Zeitschrift für Verkehrsrecht : NZV Y1 - 2019 IS - 1 SP - 27 EP - 32 PB - C.H.Beck ER - TY - JOUR A1 - Herrmann, Ulf A1 - Schwarzenbart, Marc A1 - Dittmann-Gabriel, Sören A1 - May, Martin T1 - Hochtemperatur-Wärmespeicher für die Strom- und Wärmewende JF - Solarzeitalter : Politik, Kultur und Ökonomie erneuerbarer Energien Y1 - 2019 SN - 0937-3802 VL - 31 IS - 2 SP - 18 EP - 23 ER - TY - JOUR A1 - Gaigall, Daniel T1 - On a new approach to the multi-sample goodness-of-fit problem JF - Communications in Statistics - Simulation and Computation N2 - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions. KW - Goodness-of-fit test KW - Multi-sample problem KW - Parametric bootstrap Y1 - 2019 U6 - https://doi.org/10.1080/03610918.2019.1618472 SN - 1532-4141 VL - 53 IS - 10 SP - 2971 EP - 2989 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Kurz, Melanie T1 - Images of Sweden in Germany: from Sundborn and Bullerby to Ikea JF - nomad: the magazine for new design culture, business affairs and contemporary lifestyle Y1 - 2019 SN - 2513-0714 IS - 8 SP - 136 EP - 147 ER - TY - JOUR A1 - Jung, Alexander A1 - Müller, Wolfram A1 - Staat, Manfred T1 - Optimization of the flight technique in ski jumping: the influence of wind Y1 - 2019 U6 - https://doi.org/10.1016/j.jbiomech.2019.03.023 IS - Early view PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Panc, Nicolae A1 - Contiu, Glad A1 - Bocanet, Vlad A1 - Thurn, Laura A1 - Sabau, Emilia T1 - The influence of cutting technology on surface wear hardness JF - Academic Journal of Manufacturing Engineering Y1 - 2019 SN - 1583-7904 VL - 17 IS - 3 SP - 205 EP - 210 ER - TY - JOUR A1 - Stulpe, Werner T1 - Aspects of the Quantum-Classical Connection Based on Statistical Maps JF - Foundations of Physics Y1 - 2019 U6 - https://doi.org/10.1007/s10701-019-00269-9 VL - 49 IS - 6 SP - 677 EP - 692 PB - Springer CY - Berlin ER - TY - JOUR A1 - Poghossian, Arshak A1 - Geissler, Hanno A1 - Schöning, Michael Josef T1 - Rapid methods and sensors for milk quality monitoring and spoilage detection JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2019.04.040 SN - 0956-5663 VL - 140 IS - Article 111272 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Vögele, Stefan A1 - Rübbelke, Dirk A1 - Govorukha, Kristina A1 - Grajewski, Matthias T1 - Socio-technical scenarios for energy-intensive industries: the future of steel production in Germany JF - Climatic Change Y1 - 2019 U6 - https://doi.org/10.1007/s10584-019-02366-0 SN - 0165-0009 SP - 1 EP - 16 PB - Springer CY - Berlin ER - TY - JOUR A1 - Leschinger, Tim A1 - Besch, Katharina A1 - Aydin, Cansu A1 - Staat, Manfred A1 - Scaal, Martin A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Irreparable rotator cuff tears: a biomechanical comparison of superior capsuloligamentous complex reconstruction techniques and an interposition graft technique JF - The Orthopaedic Journal of Sports Medicine Y1 - 2019 U6 - https://doi.org/10.1177/2325967119864590 VL - 7 IS - 8 SP - 1 EP - 5 ER - TY - JOUR A1 - Herrmann, Ulf A1 - Schwarzenbart, Marc A1 - Dittmann-Gabriel, Sören T1 - Speicher statt Kohle. Integration thermischer Stromspeicher in vorhandene Kraftwerksstandorte JF - BWK : Das Energie-Fachmagazin Y1 - 2019 SN - 1436-4883 VL - 71 IS - 4 SP - 42 EP - 45 PB - Springer-VDI-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Rupp, Matthias A1 - Handschuh, Nils A1 - Rieke, Christian A1 - Kuperjans, Isabel T1 - Contribution of country-specific electricity mix and charging time to environmental impact of battery electric vehicles: A case study of electric buses in Germany JF - Applied Energy Y1 - 2019 U6 - https://doi.org/10.1016/j.apenergy.2019.01.059 SN - 0306-2619 VL - 237 SP - 618 EP - 634 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Orzada, Stephan A1 - Solbach, Klaus A1 - Gratz, Marcel A1 - Brunheim, Sascha A1 - Fiedler, Thomas M. A1 - Johst, Sören A1 - Bitz, Andreas A1 - Shooshtary, Samaneh A1 - Abuelhaija, Ashraf A1 - Voelker, Maximilian N. A1 - Rietsch, Stefan H. G. A1 - Kraff, Oliver A1 - Maderwald, Stefan A1 - Flöser, Martina A1 - Oehmingen, Mark A1 - Quick, Harald H. A1 - Ladd, Mark E. T1 - A 32-channel parallel transmit system add-on for 7T MRI JF - Plos one Y1 - 2019 U6 - https://doi.org/10.1371/journal.pone.0222452 ER - TY - JOUR A1 - Reger, Vitali A1 - Kuhnhenne, Markus A1 - Hachul, Helmut A1 - Döring, Bernd A1 - Blanke, Tobias A1 - Göttsche, Joachim T1 - Plusenergiegebäude 2.0 in Stahlleichtbauweise JF - Stahlbau Y1 - 2019 U6 - https://doi.org/10.1002/stab.201900034 SN - 1437-1049 (E-journal), 0038-9145 (print) VL - 88 IS - 6 SP - 522 EP - 528 PB - Ernst & Sohn CY - Berlin ER - TY - JOUR A1 - Finkenberger, Isabel Maria T1 - Bodenpolitik als Instrument strategischer Transformation JF - UrbanLab-Magazin : Fachzeitschrift für Stadt- und Quartierplanung Y1 - 2019 VL - 2019 IS - 05 SP - 18 EP - 25 ER - TY - JOUR A1 - Golland, Alexander T1 - Das 2. Datenschutz-Anpassungs- und Umsetzungsgesetz EU Änderungen und Herausforderungen für Unternehmen JF - NWB Unternehmensteuern und Bilanzen – StuB N2 - Kurz vor der parlamentarischen Sommerpause hat der Bundestag am 28.6.2019 das 2. Datenschutz-Anpassungs- und Umsetzungsgesetz EU (2. DSAnpUG-EU) beschlossen, der Bundesrat hat diesem Gesetz am 20.9.2019 zugestimmt. Das Artikelgesetz, welches im sog. Omnibusverfahren zahlreiche Gesetze auf Bundesebene ändert, soll zur Vereinheitlichung und Anpassung des Bundesrechts an die seit Mai 2018 geltende Datenschutz-Grundverordnung (DSGVO) beitragen. KW - Datenschutz KW - Datenschutzgrundverordnung Y1 - 2019 SN - 1615-8024 IS - 20 SP - 787 EP - 790 ER - TY - JOUR A1 - Özsoylu, Dua A1 - Kizildag, Sefa A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Effect of plasma treatment on the sensor properties of a light‐addressable potentiometric sensor (LAPS) JF - physica status solidi a : applications and materials sciences N2 - A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment. Y1 - 2019 U6 - https://doi.org/10.1002/pssa.201900259 SN - 1862-6319 N1 - Corresponding author: Torsten Wagner VL - 216 IS - 20 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Neuendorf, Christian A1 - Faßbender, Tobias A1 - Nölke, Greta A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim A1 - Schröper, Florian T1 - Sensitive and rapid detection of cholera toxin subunit B using magnetic frequency mixing detection JF - Plos One N2 - Cholera is a life-threatening disease caused by the cholera toxin (CT) as produced by some Vibrio cholerae serogroups. In this research we present a method which directly detects the toxin’s B subunit (CTB) in drinking water. For this purpose we performed a magnetic sandwich immunoassay inside a 3D immunofiltration column. We used two different commercially available antibodies to capture CTB and for binding to superparamagnetic beads. ELISA experiments were performed to select the antibody combination. The beads act as labels for the magnetic frequency mixing detection technique. We show that the limit of detection depends on the type of magnetic beads. A nonlinear Hill curve was fitted to the calibration measurements by means of a custom-written python software. We achieved a sensitive and rapid detection of CTB within a broad concentration range from 0.2 ng/ml to more than 700 ng/ml. Y1 - 2019 U6 - https://doi.org/10.1371/journal.pone.0219356 SN - 1932-6203 VL - 14 IS - 7 PB - Plos CY - San Francisco ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Schönenborn, Kristina A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Measurement of the magnetophoretic velocity of different superparamagnetic beads JF - Journal of Magnetism and Magnetic Materials N2 - The movement of magnetic beads due to a magnetic field gradient is of great interest in different application fields. In this report we present a technique based on a magnetic tweezers setup to measure the velocity factor of magnetically actuated individual superparamagnetic beads in a fluidic environment. Several beads can be tracked simultaneously in order to gain and improve statistics. Furthermore we show our results for different beads with hydrodynamic diameters between 200 and 1000 nm from diverse manufacturers. These measurement data can, for example, be used to determine design parameters for a magnetic separation system, like maximum flow rate and minimum separation time, or to select suitable beads for fixed experimental requirements. KW - magnetophoretic velocity KW - superparamagnetic bead KW - magnetic tweezers KW - magnetic separation KW - magnetic actuation Y1 - 2019 U6 - https://doi.org/10.1016/j.jmmm.2018.10.066 SN - 0304-8853 VL - 477 IS - 1 SP - 244 EP - 248 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Pourshahidi, Ali Mohammad A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Multiplex detection of different magnetic beads using frequency scanning in magnetic frequency mixing technique JF - Sensors N2 - In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles’ nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil’s signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements. KW - frequency mixing magnetic detection KW - magnetic sandwich immunoassay KW - multiparametric immunoassays Y1 - 2019 U6 - https://doi.org/10.3390/s19112599 SN - 1424-8220 VL - 19 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Schieren, Mark A1 - Kleinschmidt, Joris A1 - Schmutz, Axel A1 - Loop, Torsten A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Wappler, Frank A1 - Defosse, Jerome T1 - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study JF - Anaesthesia Y1 - 2019 SN - 1365-2044 U6 - https://doi.org/10.1111/anae.14815 N1 - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und "Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit. VL - 74 IS - 12 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Scheer, Nico A1 - Henderson, Colin James A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Mclaren, Aileen W. A1 - MacLeod, Alastair Kenneth A1 - Lin, De A1 - Wright, Jayne A1 - Stanley, Lesley A1 - Wolf, C. Roland T1 - An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials JF - Drug Metabolism and Disposition Y1 - 2019 U6 - https://doi.org/10.1124/dmd.119.086397 IS - Early view ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - On an asymptotic relative efficiency concept based on expected volumes of confidence regions JF - Statistics - A Journal of Theoretical and Applied Statistic N2 - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting. KW - Volume of confidence regions KW - asymptotic relative efficiency KW - likelihood ratio test KW - multivariate normal distribution KW - multinomial distribution Y1 - 2019 U6 - https://doi.org/10.1080/02331888.2019.1683560 SN - 1029-4910 VL - 53 IS - 6 SP - 1396 EP - 1436 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Claer, Mario A1 - Ferrein, Alexander A1 - Schiffer, Stefan T1 - Calibration of a Rotating or Revolving Platform with a LiDAR Sensor JF - Applied Sciences Y1 - 2019 U6 - https://doi.org/10.3390/app9112238 SN - 2076-3417 VL - Volume 9 IS - issue 11, 2238 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bung, Daniel Bernhard A1 - Erpicum, Sébastien A1 - Tullis, Blanke P. T1 - Advances in hydraulic structures engineering JF - Journal of Hydraulic Engineering Y1 - 2020 U6 - https://doi.org/10.1061/(ASCE)HY.1943-7900.0001851 SN - 0733-9429 (Druckausgabe) SN - 1943-7900 (Online-Ausgabe) VL - 147 IS - 1 PB - ASCE CY - Reston, Va. ER - TY - JOUR A1 - Michel, P. A1 - Butenweg, Christoph A1 - Klinkel, S. T1 - Einfluss der dynamischen Steifigkeit von Flach-und Pfahlgründungen auf die Dynamik von Onshore-Windenergieanlagen JF - Bauingenieur Y1 - 2020 SN - 0005-6650 VL - 95 IS - 4 SP - 139 EP - 146 PB - VDI Fachmedien CY - Düsseldorf ER - TY - JOUR A1 - Götten, Falk A1 - Havermann, Marc A1 - Braun, Carsten A1 - Marino, Matthew A1 - Bil, Cees T1 - Airfoil drag at low-to-medium reynolds numbers: A novel estimation method JF - AIAA Journal N2 - This paper presents a novel method for airfoil drag estimation at Reynolds numbers between 4×10⁵ and 4×10⁶. The novel method is based on a systematic study of 40 airfoils applying over 600 numerical simulations and considering natural transition. The influence of the airfoil thickness-to-chord ratio, camber, and freestream Reynolds number on both friction and pressure drag is analyzed in detail. Natural transition significantly affects drag characteristics and leads to distinct drag minima for different Reynolds numbers and thickness-to-chord ratios. The results of the systematic study are used to develop empirical correlations that can accurately predict an airfoil drag at low-lift conditions. The new approach estimates a transition location based on airfoil thickness-to-chord ratio, camber, and Reynolds number. It uses the transition location in a mixed laminar–turbulent skin-friction calculation, and corrects the skin-friction coefficient for separation effects. Pressure drag is estimated separately based on correlations of thickness-to-chord ratio, camber, and Reynolds number. The novel method shows excellent accuracy when compared with wind-tunnel measurements of multiple airfoils. It is easily integrable into existing aircraft design environments and is highly beneficial in the conceptual design stage. Y1 - 2020 U6 - https://doi.org/10.2514/1.J058983 SN - 1533-385X VL - 58 IS - 7 SP - 2791 EP - 2805 PB - AIAA CY - Reston, Va. ER - TY - JOUR A1 - Hein, Andreas M. A1 - Eubanks, T. Marshall A1 - Hibberd, Adam A1 - Fries, Dan A1 - Schneider, Jean A1 - Lingam, Manasvi A1 - Kennedy, Robert A1 - Perakis, Nikolaos A1 - Dachwald, Bernd A1 - Kervella, Pierre T1 - Interstellar Now! Missions to and sample returns from nearby interstellar objects N2 - The recently discovered first high velocity hyperbolic objects passing through the Solar System, 1I/'Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Interstellar objects likely formed very far from the solar system in both time and space; their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system. Y1 - 2020 SP - 1 EP - 8 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Golland, Alexander T1 - Datenschutzrechtliche Anforderungen an internationale Datentransfers JF - NJW - Neue Juristische Wochenschrift Y1 - 2020 SN - 0341-1915 N1 - Zugleich Anmerkung zu EuGH, Urteil vom 16.7.2020 (C-311/18) VL - 2020 IS - 36 SP - 2593 EP - 2596 PB - Beck CY - München ER - TY - JOUR A1 - Asante-Asamani, E.O. A1 - Kleefeld, Andreas A1 - Wade, B.A. T1 - A second-order exponential time differencing scheme for non-linear reaction-diffusion systems with dimensional splitting JF - Journal of Computational Physics N2 - A second-order L-stable exponential time-differencing (ETD) method is developed by combining an ETD scheme with approximating the matrix exponentials by rational functions having real distinct poles (RDP), together with a dimensional splitting integrating factor technique. A variety of non-linear reaction-diffusion equations in two and three dimensions with either Dirichlet, Neumann, or periodic boundary conditions are solved with this scheme and shown to outperform a variety of other second-order implicit-explicit schemes. An additional performance boost is gained through further use of basic parallelization techniques. KW - Exponential time differencing KW - Real distinct pole KW - Dimensional splitting KW - Reaction-diffusion systems KW - Matrix exponential Y1 - 2020 U6 - https://doi.org/10.1016/j.jcp.2020.109490 SN - 0021-9991 N1 - Corresponding author: Andreas Kleefeld VL - 415 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rausch, Valentin A1 - Harbrecht, Andreas A1 - Kahmann, Stephanie Lucina A1 - Fenten, Thomas A1 - Jovanovic, Nebojsa A1 - Hackl, Michael A1 - Müller, Lars P. A1 - Staat, Manfred A1 - Wegmann, Kilian T1 - Osteosynthesis of Phalangeal Fractures: Biomechanical Comparison of Kirschner Wires, Plates, and Compression Screws JF - The Journal of Hand Surgery N2 - Purpose The aim of this study was to compare several osteosynthesis techniques (intramedullary headless compression screws, T-plates, and Kirschner wires) for distal epiphyseal fractures of proximal phalanges in a human cadaveric model. Methods A total of 90 proximal phalanges from 30 specimens (index, ring, and middle fingers) were used for this study. After stripping off all soft tissue, a transverse distal epiphyseal fracture was simulated at the proximal phalanx. The 30 specimens were randomly assigned to 1 fixation technique (30 per technique), either a 3.0-mm intramedullary headless compression screw, locking plate fixation with a 2.0-mm T-plate, or 2 oblique 1.0-mm Kirschner wires. Displacement analysis (bending, distraction, and torsion) was performed using optical tracking of an applied random speckle pattern after osteosynthesis. Biomechanical testing was performed with increasing cyclic loading and with cyclic load to failure using a biaxial torsion-tension testing machine. Results Cannulated intramedullary compression screws showed significantly less displacement at the fracture site in torsional testing. Furthermore, screws were significantly more stable in bending testing. Kirschner wires were significantly less stable than plating or screw fixation in any cyclic load to failure test setup. Conclusions Intramedullary compression screws are a highly stable alternative in the treatment of transverse distal epiphyseal phalangeal fractures. Kirschner wires seem to be inferior regarding displacement properties and primary stability. Clinical relevance Fracture fixation of phalangeal fractures using plate osteosynthesis may have the advantage of a very rigid reduction, but disadvantages such as stiffness owing to the more invasive surgical approach and soft tissue irritation should be taken into account. Headless compression screws represent a minimally invasive choice for fixation with good biomechanical properties. Y1 - 2020 U6 - https://doi.org/10.1016/j.jhsa.2020.04.010 SN - 0363-5023 VL - 45 IS - 10 SP - 987.e1 EP - 987.e8 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Muschallik, Lukas A1 - Kipp, Carina Ronja A1 - Recker, Inga A1 - Bongaerts, Johannes A1 - Pohl, Martina A1 - Gelissen, Melanie A1 - Schöning, Michael Josef A1 - Selmer, Thorsten A1 - Siegert, Petra T1 - Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase JF - Journal of Biotechnology N2 - The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled. Y1 - 2020 SN - 2590-1559 U6 - https://doi.org/10.1016/j.jbiotec.2020.09.016 VL - 202 IS - Vol. 324 SP - 61 EP - 70 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Golland, Alexander T1 - EDPB: Europäische Aufsichtsbehörden mit neuen Guidelines zur datenschutzkonformen Einwilligung JF - DSB Datenschutz-Berater Y1 - 2020 SN - 0170-7256 VL - 44 IS - 6 SP - 151 EP - 153 PB - DFV Mediengruppe CY - Frankfurt a.M. ER - TY - JOUR A1 - Capitain, Charlotte A1 - Ross-Jones, Jesse A1 - Möhring, Sophie A1 - Tippkötter, Nils T1 - Differential scanning calorimetry for quantification of polymer biodegradability in compost JF - International Biodeterioration & Biodegradation N2 - The objective of this study is the establishment of a differential scanning calorimetry (DSC) based method for online analysis of the biodegradation of polymers in complex environments. Structural changes during biodegradation, such as an increase in brittleness or crystallinity, can be detected by carefully observing characteristic changes in DSC profiles. Until now, DSC profiles have not been used to draw quantitative conclusions about biodegradation. A new method is presented for quantifying the biodegradation using DSC data, whereby the results were validated using two reference methods. The proposed method is applied to evaluate the biodegradation of three polymeric biomaterials: polyhydroxybutyrate (PHB), cellulose acetate (CA) and Organosolv lignin. The method is suitable for the precise quantification of the biodegradability of PHB. For CA and lignin, conclusions regarding their biodegradation can be drawn with lower resolutions. The proposed method is also able to quantify the biodegradation of blends or composite materials, which differentiates it from commonly used degradation detection methods. Y1 - 2020 U6 - https://doi.org/10.1016/j.ibiod.2020.104914 SN - 0964-8305 VL - 149 SP - In Press, Article number 104914 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred T1 - Erratum to "Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue" [GAMM-Mitteilungen, (2019), 42, 4, 10.1002/gamm.201900002] JF - GAMM-Mitteilungen Y1 - 2020 U6 - https://doi.org/10.1002/gamm.202000011 SN - 1522-2608 N1 - Refers to: Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue. Alexander Jung, Manfred Staat. Volume 42, Issue 4. GAMM-Mitteilungen, 2019. https://doi.org/10.1002/gamm.201900002 VL - 43 IS - 4 PB - Wiley-VCH GmbH CY - Weinheim ER - TY - JOUR A1 - Rausch, Valentin A1 - Kahmann, Stephanie Lucina A1 - Baltschun, Christoph A1 - Staat, Manfred A1 - Müller, Lars P. A1 - Wegmann, Kilian T1 - Pressure distribution to the distal biceps tendon at the radial tuberosity: a biomechanical study JF - The Journal of Hand Surgery N2 - Purpose Mechanical impingement at the narrow radioulnar space of the tuberosity is believed to be an etiological factor in the injury of the distal biceps tendon. The aim of the study was to compare the pressure distribution at the proximal radioulnar space between 2 fixation techniques and the intact state. Methods Six right arms and 6 left arms from 5 female and 6 male frozen specimens were used for this study. A pressure transducer was introduced at the height of the radial tuberosity with the intact distal biceps tendon and after 2 fixation methods: the suture-anchor and the cortical button technique. The force (N), maximum pressure (kPa) applied to the radial tuberosity, and the contact area (mm²) of the radial tuberosity with the ulna were measured and differences from the intact tendon were detected from 60° supination to 60° pronation in 15° increments with the elbow in full extension and in 45° and 90° flexion of the elbow. Results With the distal biceps tendon intact, the pressures during pronation were similar regardless of extension and flexion and were the highest at 60° pronation with 90° elbow flexion (23.3 ± 53.5 kPa). After repair of the tendon, the mean peak pressure, contact area, and total force showed an increase regardless of the fixation technique. Highest peak pressures were found using the cortical button technique at 45° flexion of the elbow and 60° pronation. These differences were significantly different from the intact tendon. The contact area was significantly larger in full extension and 15°, 30°, and 60° pronation using the cortical button technique. Conclusions Pressures on the distal biceps tendon at the radial tuberosity increase during pronation, especially after repair of the tendon. Clinical relevance Mechanical impingement could play a role in both the etiology of primary distal biceps tendon ruptures and the complications occurring after fixation of the tendon using certain techniques. Y1 - 2020 U6 - https://doi.org/10.1016/j.jhsa.2020.01.006 SN - 0363-5023 VL - 45 IS - 8 SP - 776.e1 EP - 776.e9 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dachwald, Bernd A1 - Ulamec, Stephan A1 - Postberg, Frank A1 - Sohl, Frank A1 - Vera, Jean-Pierre de A1 - Christoph, Waldmann A1 - Lorenz, Ralph D. A1 - Hellard, Hugo A1 - Biele, Jens A1 - Rettberg, Petra T1 - Key technologies and instrumentation for subsurface exploration of ocean worlds JF - Space Science Reviews N2 - In this chapter, the key technologies and the instrumentation required for the subsurface exploration of ocean worlds are discussed. The focus is laid on Jupiter’s moon Europa and Saturn’s moon Enceladus because they have the highest potential for such missions in the near future. The exploration of their oceans requires landing on the surface, penetrating the thick ice shell with an ice-penetrating probe, and probably diving with an underwater vehicle through dozens of kilometers of water to the ocean floor, to have the chance to find life, if it exists. Technologically, such missions are extremely challenging. The required key technologies include power generation, communications, pressure resistance, radiation hardness, corrosion protection, navigation, miniaturization, autonomy, and sterilization and cleaning. Simpler mission concepts involve impactors and penetrators or – in the case of Enceladus – plume-fly-through missions. Y1 - 2020 U6 - https://doi.org/10.1007/s11214-020-00707-5 SN - 1572-9672 N1 - Corresponding author: Bernd Dachwald VL - 216 IS - Art. 83 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Götten, Falk A1 - Finger, Felix T1 - PhoenAIX – Die modulare Transportdrohne JF - Ingenieurspiegel N2 - Die autonome, unbemannte Luftfahrt ist einer der Schlüsselsektoren für die Zukunft der Luftfahrt. In diesem rasant wachsenden Bereich nehmen senkrecht startende und senkrecht landende Flugzeuge (Vertical Take-Off and Landing – VTOL) einen besonderen Platz ein. Ein VTOL-Flugzeug (manchmal auch „Transitionsfluggerät“ genannt) verbindet die Eigenschaft des Helikopters, überall starten und landen zu können, mit den Geschwindigkeits-, Reichweiten und Flugdauervorteilen des Starrflüglers. Grundsätzlich wird die Senkrechtstart- und -landefähigkeit sowohl von zivilen als auch von militärischen Betreibern unbemannter Fluggeräte (UAVs) gewünscht. Trotzdem bietet der Markt nur eine geringe Anzahl von VTOL-UAVs, da qualitativ hochwertige Entwürfe eine ausgesprochene Herausforderung in der Entwicklung darstellen. An der FH Aachen wird deshalb seit über 5 Jahren an der Auslegung und Analyse von solchen unbemannten VTOL Flugzeugen geforscht. Das neuste Projekt ist der Eigenentwurf einer großen, senkrechtstartenden Transportdrohne. Das „PhoenAIX“ getaufte Fluggerät wird von Falk Götten und Felix Finger im Rahmen einer EFRE-Förderung entwickelt. Y1 - 2020 SN - 1868-5919 N1 - Project: UAV Design VL - 2020 IS - 1 SP - 38 EP - 40 PB - Public Verlag CY - Bingen ER - TY - JOUR A1 - Muschallik, Lukas A1 - Molinnus, Denise A1 - Jablonski, Melanie A1 - Kipp, Carina Ronja A1 - Bongaerts, Johannes A1 - Pohl, Martina A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Selmer, Thorsten A1 - Siegert, Petra T1 - Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase JF - RSC Advances N2 - α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated. Y1 - 2020 U6 - https://doi.org/10.1039/D0RA02066D SN - 2046-2069 VL - 10 SP - 12206 EP - 12216 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Horbach, Andreas A1 - Staat, Manfred A1 - Perez-Viana, Daniel A1 - Simmen, Hans-Peter A1 - Neuhaus, Valentin A1 - Pape, Hans-Christoph A1 - Prescher, Andreas A1 - Ciritsis, Bernhard T1 - Biomechanical in vitro examination of a standardized low-volume tubular femoroplasty JF - Clinical Biomechanics N2 - Background Osteoporosis is associated with the risk of fractures near the hip. Age and comorbidities increase the perioperative risk. Due to the ageing population, fracture of the proximal femur also proves to be a socio-economic problem. Preventive surgical measures have hardly been used so far. Methods 10 pairs of human femora from fresh cadavers were divided into control and low-volume femoroplasty groups and subjected to a Hayes fall-loading fracture test. The results of the respective localization and classification of the fracture site, the Singh index determined by computed tomography (CT) examination and the parameters in terms of fracture force, work to fracture and stiffness were evaluated statistically and with the finite element method. In addition, a finite element parametric study with different position angles and variants of the tubular geometry of the femoroplasty was performed. Findings Compared to the control group, the work to fracture could be increased by 33.2%. The fracture force increased by 19.9%. The used technique and instrumentation proved to be standardized and reproducible with an average poly(methyl methacrylate) volume of 10.5 ml. The parametric study showed the best results for the selected angle and geometry. Interpretation The cadaver studies demonstrated the biomechanical efficacy of the low-volume tubular femoroplasty. The numerical calculations confirmed the optimal choice of positioning as well as the inner and outer diameter of the tube in this setting. The standardized minimally invasive technique with the instruments developed for it could be used in further comparative studies to confirm the measured biomechanical results. Y1 - 2020 U6 - https://doi.org/10.1016/j.clinbiomech.2020.105104 VL - 80 IS - Art. 105104 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Knox, Ronald A1 - Bruggemann, Andrea A1 - Gossmann, Matthias A1 - Thomas, Ulrich A1 - Horváth, András A1 - Dragicevic, Elena A1 - Stoelzle-Feix, Sonja A1 - Fertig, Niels A1 - Jung, Alexander A1 - Raman, Aravind Hariharan A1 - Staat, Manfred A1 - Linder, Peter T1 - Combining physiological relevance and throughput for in vitro cardiac contractility measurement JF - Biophysical Journal N2 - Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these. Y1 - 2020 U6 - https://doi.org/10.1016/j.bpj.2019.11.3104 SN - 0006-3495 N1 - Raman, Arayind Hariharan im Artikel unter dem Namen: Raman, Alexander H. VL - 118 IS - Issue 3, Supplement 1 SP - 570a PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dadfar, Dryed Mohammadali A1 - Camozzi, Denise A1 - Darguzyte, Milita A1 - Roemhild, Karolin A1 - Varvarà, Paola A1 - Metselaar, Josbert A1 - Banala, Srinivas A1 - Straub, Marcel A1 - Güver, Nihan A1 - Engelmann, Ulrich M. A1 - Slabu, Ioana A1 - Buhl, Miriam A1 - Leusen, Jan van A1 - Kögerler, Paul A1 - Hermanns-Sachweh, Benita A1 - Schulz, Volkmar A1 - Kiessling, Fabian A1 - Lammers, Twan T1 - Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance JF - Journal of Nanobiotechnology N2 - Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications. Y1 - 2020 U6 - https://doi.org/10.1186/s12951-020-0580-1 SN - 1477-3155 VL - 18 IS - Article number 22 SP - 1 EP - 13 PB - Nature Portfolio ER - TY - JOUR A1 - Kreyer, Jörg A1 - Müller, Marvin A1 - Esch, Thomas T1 - A Calculation Methodology for Predicting Exhaust Mass Flows and Exhaust Temperature Profiles for Heavy-Duty Vehicles JF - SAE International Journal of Commercial Vehicles N2 - The predictive control of commercial vehicle energy management systems, such as vehicle thermal management or waste heat recovery (WHR) systems, are discussed on the basis of information sources from the field of environment recognition and in combination with the determination of the vehicle system condition. In this article, a mathematical method for predicting the exhaust gas mass flow and the exhaust gas temperature is presented based on driving data of a heavy-duty vehicle. The prediction refers to the conditions of the exhaust gas at the inlet of the exhaust gas recirculation (EGR) cooler and at the outlet of the exhaust gas aftertreatment system (EAT). The heavy-duty vehicle was operated on the motorway to investigate the characteristic operational profile. In addition to the use of road gradient profile data, an evaluation of the continuously recorded distance signal, which represents the distance between the test vehicle and the road user ahead, is included in the prediction model. Using a Fourier analysis, the trajectory of the vehicle speed is determined for a defined prediction horizon. To verify the method, a holistic simulation model consisting of several hierarchically structured submodels has been developed. A map-based submodel of a combustion engine is used to determine the EGR and EAT exhaust gas mass flows and exhaust gas temperature profiles. All simulation results are validated on the basis of the recorded vehicle and environmental data. Deviations from the predicted values are analyzed and discussed. Y1 - 2020 U6 - https://doi.org/10.4271/02-13-02-0009 SN - 1946-3928 VL - 13 IS - 2 SP - 129 EP - 143 PB - SAE International CY - Warrendale, Pa. ER - TY - JOUR A1 - Henriques, A. A1 - Jurado, B. A1 - Grieser, M. A1 - Denis-Petit, D. A1 - Chiron, T. A1 - Gaudefroy, L. A1 - Glorius, J. A1 - Langer, Christoph A1 - Litvinov, Yu. A. A1 - Mathieu, L. A1 - Meot, V. A1 - Perez-Sanchez, R. A1 - Pibernat, J. A1 - Reifarth, R. A1 - Roig, O. A1 - Thomas, B. A1 - Thomas, B. A. A1 - Thomas, J. C. A1 - Tsekhanovich, I. T1 - Indirect measurements of neutron cross-secti at heavy-ion storage rings JF - Journal of Physics: Conference Series N2 - Cross sections for neutron-induced reactions of short-lived nuclei are essential for nuclear astrophysics since these reactions in the stars are responsible for the production of most heavy elements in the universe. These reactions are also key in applied domains like energy production and medicine. Nevertheless, neutron-induced cross-section measurements can be extremely challenging or even impossible to perform due to the radioactivity of the targets involved. Indirect measurements through the surrogate-reaction method can help to overcome these difficulties. The surrogate-reaction method relies on the use of an alternative reaction that will lead to the formation of the same excited nucleus as in the neutron-induced reaction of interest. The decay probabilities (for fission, neutron and gamma-ray emission) of the nucleus produced via the surrogate reaction allow one to constrain models and the prediction of the desired neutron cross sections. We propose to perform surrogate reaction measurements in inverse kinematics at heavy-ion storage rings, in particular at the CRYRING@ESR of the GSI/FAIR facility. We present the conceptual idea of the most promising setup to measure for the first time simultaneously the fission, neutron and gamma-ray emission probabilities. The results of the first simulations considering the 238U(d,d') reaction are shown, as well as new technical developments that are being carried out towards this set-up. Y1 - 2020 U6 - https://doi.org/10.1088/1742-6596/1668/1/012019 VL - 1668 IS - Art. 012019 PB - IOP CY - Bristol ER - TY - JOUR A1 - Varga, Laszlo A1 - Davinson, Thomas A1 - Glorius, Jan A1 - Jurado, Beatrix A1 - Langer, Christoph A1 - Lederer-Woods, Claudia A1 - Litvinov, Yuri A. A1 - Reifarth, Rene A1 - Slavkovska, Zuzana A1 - Stöhlker, Thomas A1 - Woods, Phil J. A1 - Xing, Yuan Ming T1 - Towards background-free studies of capture reaction in a heavy-ion storage ring JF - Journal of Physics: Conference Series N2 - Stored and cooled, highly-charged ions offer unprecedented capabilities for precision studies in the realm of atomic, nuclear structure and astrophysics[1]. After the successful investigation of the 96Ru(p,7)97Rh reaction cross section in 2009[2], the first measurement of the 124Xe(p,7)125Cs reaction cross section has been performed with decelerated, fully-ionized 124Xe ions in 2016 at the Experimental Storage Ring (ESR) of GSI[3]. Using a Double Sided Silicon Strip Detector, introduced directly into the ultra-high vacuum environment of a storage ring, the 125Cs proton-capture products have been successfully detected. The cross section has been measured at 5 different energies between 5.5AMeV and 8AMeV, on the high energy tail of the Gamow-window for hot, explosive scenarios such as supernovae and X-ray binaries. The elastic scattering on the H2 gas jet target is the major source of background to count the (p,7) events. Monte Carlo simulations show that an additional slit system in the ESR in combination with the energy information of the Si detector will enable background free measurements of the proton-capture products. The corresponding hardware is being prepared and will increase the sensitivity of the method tremendously. Y1 - 2020 VL - 1668 IS - Art 012046 PB - IOP CY - Bristol ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Albracht, Kirsten A1 - Abel, Thomas A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs JF - Journal of Electromyography and Kinesiology N2 - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA. Y1 - 2020 U6 - https://doi.org/10.1016/j.jelekin.2020.102402 SN - 1050-6411 VL - 51 IS - Article 102402 PB - Elsevier CY - Amsterdam ER -