TY  - JOUR
A1  - Götten, Falk
A1  - Havermann, Marc
A1  - Braun, Carsten
A1  - Marino, Matthew
A1  - Bil, Cees
T1  - Improved Form Factor for Drag Estimation of Fuselages with Various Cross Sections
JF  - Journal of Aircraft
N2  - The paper presents an aerodynamic investigation of 70 different streamlined bodies with fineness ratios ranging from 2 to 10. The bodies are chosen to idealize both unmanned and small manned aircraft fuselages and feature cross-sectional shapes that vary from circular to quadratic. The study focuses on friction and pressure drag in dependency of the individual body’s fineness ratio and cross section. The drag forces are normalized with the respective body’s wetted area to comply with an empirical drag estimation procedure. Although the friction drag coefficient then stays rather constant for all bodies, their pressure drag coefficients decrease with an increase in fineness ratio. Referring the pressure drag coefficient to the bodies’ cross-sectional areas shows a distinct pressure drag minimum at a fineness ratio of about three. The pressure drag of bodies with a quadratic cross section is generally higher than for bodies of revolution. The results are used to derive an improved form factor that can be employed in a classic empirical drag estimation method. The improved formulation takes both the fineness ratio and cross-sectional shape into account. It shows superior accuracy in estimating streamlined body drag when compared with experimental data and other form factor formulations of the literature.
Y1  - 2020
U6  - https://doi.org/10.2514/1.C036032
SN  - 1533-3868
SP  - 1
EP  - 13
PB  - AIAA
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Reger, Vitali
A1  - Kuhnhenne, Markus
A1  - Ebbert, Thiemo
A1  - Hachul, Helmut
A1  - Blanke, Tobias
A1  - Döring, Bernd
T1  - Nutzung erneuerbarer Energien durch thermische Aktivierung von Komponenten aus Stahl
JF  - Stahlbau
N2  - Die Versorgung von Neubauten soll möglichst weitgehend unabhängig von fossilen Energieträgern erfolgen. Erneuerbare Energien spielen dafür eine gewichtige Rolle. Eine gute Möglichkeit, erneuerbare Energien ohne viel zusätzlichen Aufwand nutzbar zu machen, ist, bereits vorhandenen Komponenten im Gebäude zusätzliche Funktionen zu geben. Hier kann bspw. die Fassade oder das Dach solarthermisch aktiviert oder durch Fotovoltaikmodule ergänzt werden. Auch Tiefgründungen können neben der statischen Funktion noch eine geothermische Funktion zur Aufnahme oder Abgabe von Wärme erhalten. Neben der Erzeugung bietet sich auch für die Verteilung der Wärme oder Kälte im Gebäude die Integration in Bauteile an. Hier kann bspw. der Boden durch eine Fußbodenheizung oder die Decke durch Deckenstrahlplatten aktiviert werden.

Im Rahmen der Veröffentlichung wird auf die thermische Aktivierung von Stahlkomponenten eingegangen. Es wird eine Lösung vorgestellt, die vorgehängte hinterlüftete Stahlfassade (VHF) solarthermisch zu aktivieren. Außerdem werden zwei Möglichkeiten zur geothermischen Aktivierung von Tiefgründungen mittels Stahlpfählen gezeigt. Zuletzt wird ein System zur thermischen Aktivierung von Stahltrapezprofilen an der Decke erläutert, welches Wärme zuführen oder bei Bedarf abführen kann.
Y1  - 2020
U6  - https://doi.org/10.1002/stab.202000031
SN  - 1437-1049
VL  - 2020
IS  - Volume 89, Issue 6512-519
SP  - 512
EP  - 519
PB  - Ernst & Sohn
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wild, Dominik
A1  - Schrezenmeier, Johannes
A1  - Czupalla, Markus
A1  - Förstner, Roger
T1  - Thermal Characterization of additive manufactured Integral Structures for Phase Change Applications
JF  - 2020 International Conference on Environmental Systems
N2  - “Infused Thermal Solutions” (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, by using phase change material (PCM) in combination with lattice – both embedded into an additive manufactured integral structure. The technology is currently under development. This paper presents the results of the thermal property measurements performed on additive manufactured ITS breadboards. Within the breadboard campaigns key characteristics of the additive manufactured specimens were derived: Mechanical parameters: specimen impermeability, minimum wall thickness, lattice structure, subsequent heat treatment. Thermal properties: thermo-optical surface properties of the additive manufactured raw material, thermal conductivity and specific heat capacity measurements. As a conclusion the paper introduces an overview of potential ITS hardware applications, expected to increase the thermal performance.
Y1  - 2020
PB  - Texas Tech University
ER  - 
TY  - JOUR
A1  - Raffeis, Iris
A1  - Adjei-Kyeremeh, Frank
A1  - Vroomen, Uwe
A1  - Westhoff, Elmar
A1  - Bremen, Sebastian
A1  - Hohoi, Alexandru
A1  - Bührig-Polaczek, Andreas
T1  - Qualification of a Ni-Cu alloy for the laser powder bed fusion process (LPBF): Its microstructure and mechanical properties
JF  - Applied Sciences
N2  - As researchers continue to seek the expansion of the material base for additive manufacturing, there is a need to focus attention on the Ni–Cu group of alloys which conventionally has wide industrial applications. In this work, the G-NiCu30Nb casting alloy, a variant of the Monel family of alloys with Nb and high Si content is, for the first time, processed via the laser powder bed fusion process (LPBF). Being novel to the LPBF processes, optimum LPBF parameters were determined, and hardness and tensile tests were performed in as-built conditions and after heat treatment at 1000 °C. Microstructures of the as-cast and the as-built condition were compared. Highly dense samples (99.8% density) were achieved after varying hatch distance (80 µm and 140 µm) with scanning speed (550 mm/s–1500 mm/s). There was no significant difference in microhardness between varied hatch distance print sets. Microhardness of the as-built condition (247 HV0.2) exceeded the as-cast microhardness (179 HV0.2.). Tensile specimens built in vertical (V) and horizontal (H) orientations revealed degrees of anisotropy and were superior to conventionally reported figures. Post heat treatment increased ductility from 20% to 31% (V), as well as from 16% to 25% (H), while ultimate tensile strength (UTS) and yield strength (YS) were considerably reduced.
Y1  - 2020
U6  - https://doi.org/10.3390/app10103401
SN  - 2076-3417
N1  - Special Issue Materials Development by Additive Manufacturing Techniques
VL  - 10
IS  - Art. 3401
SP  - 1
EP  - 15
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Bayer, Robin
A1  - Temiz Artmann, Aysegül
A1  - Digel, Ilya
A1  - Falkenstein, Julia
A1  - Artmann, Gerhard
A1  - Creutz, Till
A1  - Hescheler, Jürgen
T1  - Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model
JF  - Cellular Physiology and Biochemistry
N2  - Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.
Y1  - 2020
U6  - https://doi.org/10.33594/000000225
SN  - 1421-9778
VL  - 54
SP  - 371
EP  - 383
PB  - Cell Physiol Biochem Press
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kern, Inna
A1  - Geenen, Eva-Maria
A1  - Akimbekov, Nuraly S.
T1  - Dental plaque removal by ultrasonic toothbrushes
JF  - dentistry journal
N2  - With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness.
Y1  - 2020
U6  - https://doi.org/10.3390/dj8010028
SN  - 2304-6767
VL  - 8
IS  - 28
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Akimbekov, Nuraly S.
A1  - Zhanadilovna, Abdieva G.
A1  - Ualieva, Perizat S.
A1  - Abaihanovna, Zhusipova D.
A1  - Digel, Ilya
A1  - Savitskaya, Irina S.
A1  - Zhubanova, Azhar Achmet
T1  - Functionalization of Carbon Based Wound Dressings with Antimicrobial Phytoextracts for Bioactive Treatment of Septic Wounds
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - The treatment of septic wounds with curative dressings based on biocomposites containing sage and marigold phytoextracts was effective in in vitro and in vivo experiments. These dressings caused the purification of the wound surface from purulent-necrotic masses three days earlier than in the other experimental groups. The consequence of an increase in incidents of severe course of the wound and the observed tendency to increase the number of adverse effects is the development of long-term recurrent wound processes. To treat purulent wounds, the following tactics were used: The purulent wounds of animals were covered with the examined wound dressing, and then the next day samples were taken, the procedure was performed once in 2 days. To obtain the active nanostructured sorbents such as carbonized rice husks, they are functionalized with biologically active components possessing antimicrobial, anti-inflammatory, antitoxic, immunomodulating, antiallergic and other types of properties.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-11
SP  - 211
EP  - 228
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Savitskaya, Irina S.
A1  - Kistaubayeva, Aida S.
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Shokatayeva, Dina
A1  - Zhubanova, Azhar Achmet
T1  - Prospective Use of Probiotics Immobilized on Sorbents with Nanostructured Surfaces
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - Activated carbons are known as excellent adsorbents. Their applications include the adsorptive removal of color, odor, taste, undesirable organic and inorganic pollutants from drinking and waste water; air purification in inhabited spaces; purification of many chemicals, pharmaceutical products and many others. This chapter elucidates the role of normal microflora in the maintenance of human health and presents materials on possible clinical displays of microecological infringements and ways of their correction. It presents new developments concerning new probiotics with immobilized Lactobacillus and Bacillus. The chapter considers the mechanisms of the intestine disbacteriosis correction by sorbed probiotics. It demonstrates the advantages and creation prospects of immobilized probiotics developed on the basis of carbonized rice husk. There are great prospects for the development of medical biotechnology due to use of carbon sorbents with a nanostructured surface. Microbial communities form a biocenosis of the biotope and together with the host organism create permanent or temporary ecosystems.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-12
SP  - 229
EP  - 267
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Zhubanova, Azhar A.
A1  - Mansurov, Zulkhair A.
A1  - Digel, Ilya
T1  - Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - This chapter shows that nanomaterials obtained by high-temperature carbonization of inexpensive plant raw material such as rice husk, grape seeds, and walnut shells can serve as a basis for the production of highly efficient microbial drugs, biodestructors, biosorbents, and biocatalysts, which are promising for the remediation of the ecosystem contaminated with heavy and radioactive metals, oil and oil products. A strong interest in engineering zymology is dictated by the necessity to address the issues of monitoring enzymatic processes, treatment, and diagnosis of a number of common human diseases, environmental pollution, quality control of pharmaceuticals and food. Nanomaterials obtained by high-temperature carbonization of cheap plant raw material such as-rice husks, grape seeds and walnut shells, can serve as a basis for creating of highly effective microbial preparations-biodestructors, biosorbents and biocatalysts, which are promising for the use of contaminated ecosystems, and for restoration of human intestine microecology.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-18
SP  - 353
EP  - 378
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Thoma, Andreas
A1  - Fisher, Alex
A1  - Braun, Carsten
T1  - Improving the px4 avoid algorithm by bio-inspired flight strategies
T2  - DLRK2020 - „Luft- und Raumfahrt – Verantwortung in allen Dimensionen“
Y1  - 2020
U6  - https://doi.org/10.25967/530183
N1  - Deutscher Luft- und Raumfahrtkongress 2020, 1. bis 3. September 2020 – Online, „Luft- und Raumfahrt – Verantwortung in allen Dimensionen“
ER  - 
TY  - CHAP
A1  - Eggert, Mathias
A1  - Stanke, Max-Alexander
T1  - Adoption of Integrated Voice Assistants in Health Care– Requirements and Design Guidelines
N2  - Integrated voice assistants (IVA) receive more and more attention and are widespread for entertainment use cases, such as radio hearing or web searches. At the same time, the health care segment suffers in process inefficiency and missing staff, whereas the usage of IVA has the potential to improve caring processes and patient satisfaction. By applying a design science approach and based on a qualitative study, we identify IVA requirements, barriers and design guidelines for the health care sector. The results reveal three important IVA functions: the ability to set appointments with care service staff, the documentation of health history and the communication with service staff. Integration, system stability and volume control are the most important nonfunctional requirements. Based on the interview results and project experiences, six design and implementation guidelines are derived.
Y1  - 2020
U6  - https://doi.org/10.30844/wi_2020_k2-eggert
N1  - 15. Internationale Tagung zur Wirtschaftsinformatik, 09. – 11.03.2020, Potsdam
PB  - GITO
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Finkenberger, Isabel Maria
A1  - Veil, Katja
T1  - Räumliche Transformation
JF  - RaumPlanung : Fachzeitschrift für räumliche Planung und Forschung
Y1  - 2020
SN  - 0176-7534
VL  - 205
IS  - 1
SP  - 6
EP  - 11
PB  - IfR (Informationskreis für Raumplanung)
CY  - Dortmund
ER  - 
TY  - JOUR
A1  - Götten, Falk
A1  - Havermann, Marc
A1  - Braun, Carsten
A1  - Marino, Matthew
A1  - Bil, Cees
T1  - Wind-tunnel and CFD investigations of UAV landing gears and turrets – Improvements in empirical drag estimation
JF  - Aerospace Science and Technology
N2  - This paper analyzes the drag characteristics of several landing gear and turret configurations that are representative of unmanned aircraft tricycle landing gears and sensor turrets. A variety of these components were constructed via 3D-printing and analyzed in a wind-tunnel measurement campaign. Both turrets and landing gears were attached to a modular fuselage that supported both isolated components and multiple components at a time. Selected cases were numerically investigated with a Reynolds-averaged Navier-Stokes approach that showed good accuracy when compared to wind-tunnel data. The drag of main gear struts could be significantly reduced via streamlining their cross-sectional shape and keeping load carrying capabilities similar. The attachment of wheels introduced interference effects that increased strut drag moderately but significantly increased wheel drag compared to isolated cases. Very similar behavior was identified for front landing gears. The drag of an electro-optical and infrared sensor turret was found to be much higher than compared to available data of a clean hemisphere-cylinder combination. This turret drag was merely influenced by geometrical features like sensor surfaces and the rotational mechanism. The new data of this study is used to develop simple drag estimation recommendations for main and front landing gear struts and wheels as well as sensor turrets. These recommendations take geometrical considerations and interference effects into account.
Y1  - 2020
U6  - https://doi.org/10.1016/j.ast.2020.106306
SN  - 1270-9638
VL  - 107
IS  - Art. 106306
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - BOOK
A1  - Labisch, Susanna
A1  - Wählisch, Georg
T1  - Technisches Zeichnen: Eigenständig lernen und effektiv üben
Y1  - 2020
SN  - 978-3-658-30650-2 (E-Book)
SN  - 978-3-658-30649-6 (Print)
U6  - https://doi.org/10.1007/978-3-658-30650-2
N1  - gedruckt in der Bereichsbibliothek Eupener Str. unter der Signatur 21 WBA 24(6)
PB  - Springer Vieweg
CY  - Wiesbaden
ET  - 6th ed.
ER  - 
TY  - CHAP
A1  - Marinkovic, Marko
A1  - Butenweg, Christoph
T1  - Seismic behaviour of RC frames with uncoupled masonry infills having two storeys or two bays
T2  - Brick and Block Masonry - From Historical to Sustainable Masonry. Proceedings of the 17th International Brick/Block Masonry Conference
N2  - Reinforced concrete (RC) structures with masonry infills are widely used for several types of buildings all over the world. However, it is well known that traditional masonry infills constructed with rigid contact to the surrounding RC frame performed rather poor in past earthquakes. Masonry infills showed severe in-plane damages and failed in many cases under out-of-plane seismic loading. As the undesired interactions between frames and infills changes the load transfer on building level, complete collapses of buildings were observed. A possible solution is uncoupling of masonry infills to the frame to reduce the infill contribution activated by the frame deformation under horizontal loading. The paper presents numerical simulations on RC frames equipped with the innovative decoupling system INODIS. The system was developed within the European project INSYSME and allows an effective uncoupling of frame and infill. The simulations are carried out with a micro-modelling approach, which is able to predict the complex nonlinear behaviour resulting from the different materials and their interaction. Each brick is modelled individually and connected taking into account nonlinearity of a brick mortar interface. The calibration of the model is based on small specimen tests and experimental results for one bay one storey frame are used for the validation. The validated model is further used for parametric studies on two storey and two bay infilled frames. The response and change of the structural stiffness are analysed and compared to the traditionally infilled frame. The results confirm the effectiveness of the INODIS system with less damage and relatively low contribution of the infill at high drift levels. In contrast to the uncoupled system configurations, traditionally infilled frames experienced brittle failure at rather low drift levels.
Y1  - 2020
U6  - https://doi.org/10.1201/9781003098508-72
N1  - 17th International Brick/Block Masonry Conference (17thIB2MaC 2020), July 5-8, 2020, Kraków, Poland
SP  - 1
EP  - 7
PB  - CRC Press
CY  - London
ER  - 
TY  - CHAP
A1  - Michel, Philipp
A1  - Rosin, Julia
A1  - Butenweg, Christoph
A1  - Klinkel, Sven
T1  - Soil-dependent earthquake spectra in the analysis of liquid-storage-tanks on compliant soil
T2  - Seismic design of industrial facilities 2020
N2  - A further development of the Added-Mass-Method allows the combined representation of the effects of both soil-structure-interaction and fluid-structure interaction on a liquid-filled-tank in one model. This results in a practical method for describing the dynamic fluid pressure on the tank shell during joint movement. The fluid pressure is calculated on the basis of the tank's eigenform and the earthquake acceleration and represented by additional masses on the shell. The bearing on compliant ground is represented by replacement springs, which are calculated dependent on the local soil composition. The influence of the shear modulus of the compliant soil is clearly visible in the pressure curves and the stress distribution in the shell. The acceleration spectra are also dependent on soil stiffness. According to Eurocode-8 the acceleration spectra are determined for fixed soil-classes, instead of calculating the accelerations for each site in direct dependence on the soil composition. This leads to unrealistic sudden changes in the system's response. Therefore, earthquake spectra are calculated for different soil models in direct dependence of the shear modulus. Thus, both the acceleration spectra and the replacement springs match the soil composition. This enables a reasonable and consistent calculation of the system response for the actual conditions at each site.
Y1  - 2020
SN  - 978-3-86359-729-0
N1  - 2nd International Conference on Seismic Design of Industrial Facilities (Aachen, Germany, March 4-5, 2020)
SP  - 245
EP  - 254
PB  - Apprimus Verlag
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Markinkovic, Marko
A1  - Butenweg, Christoph
A1  - Pavese, A.
A1  - Lanese, I.
A1  - Hoffmeister, B.
A1  - Pinkawa, M.
A1  - Vulcu, C.
A1  - Bursi, O.
A1  - Nardin, C.
A1  - Paolacci, F.
A1  - Quinci, G.
A1  - Fragiadakis, M.
A1  - Weber, F.
A1  - Huber, P.
A1  - Renault, P.
A1  - Gündel, M.
A1  - Dyke, S.
A1  - Ciucci, M.
A1  - Marino, A.
T1  - Investigation of the seismic behaviour of structural and nonstructural components in industrial facilities by means of shaking table tests
T2  - Seismic design of industrial facilities 2020
Y1  - 2020
SN  - 978-3-86359-729-0
N1  - 2nd International Conference on Seismic Design of Industrial Facilities (Aachen, Germany, March 4-5, 2020)
SP  - 159
EP  - 172
PB  - Apprimus Verlag
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Cacciatore, Pamela
A1  - Butenweg, Christoph
T1  - Seismic safety of cylindrical granular material steel silos under seismic loading
T2  - Seismic design of industrial facilities 2020
Y1  - 2020
SN  - 978-3-86359-729-0
N1  - 2nd International Conference on Seismic Design of Industrial Facilities (Aachen, Germany, March 4-5, 2020)
SP  - 231
EP  - 244
PB  - Apprimus Verlag
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Sherelkhan, Dinara K.
A1  - Lutfor, Afzalunnessa B.
A1  - Razzaque, Mohammed S.
T1  - Vitamin D and the Host-Gut Microbiome: A Brief Overview
JF  - Acta Histochemica et Cytochemica
N2  - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.
Y1  - 2020
U6  - https://doi.org/10.1267/ahc.20011
SN  - 1347-5800
VL  - 53
IS  - 3
SP  - 33
EP  - 42
PB  - Japan Society of Histochemistry and Cytochemistry
CY  - Osaka
ER  - 
TY  - JOUR
A1  - Köhler, Klemens
A1  - Wolf, Martin R.
T1  - Organisatorische Maßnahmen zu Erhöhung der IT Sicherheit – Empfehlungen aus der Perspektive der Konflikttheorie
N2  - Die NATO definiert den Cyberspace als die "Umgebung, die durch physische und nicht-physische Bestandteile zum Speichern, Ändern, und Austauschen von Daten mit Hilfe von Computer-Netzwerken" [NATO CCDCOE]. Darüber hinaus ist es ein Medium menschlicher Interaktion. IT Angriffe sind feindselige, nichtkooperative Interaktionen, die mittels Konflikttheorie beschrieben werden können. Durch die Anwendung dieses Gedankengebäudes auf IT Sicherheit von Organisationen können eine Reihe von Verbesserungen in Unternehmen identifiziert werden.
Y1  - 2020
IS  - Preprint
ER  -