Mechanical loading on cementoblasts: a mini review

  • Orthodontic treatments are concomitant with mechanical forces and thereby cause teeth movements. The applied forces are transmitted to the tooth root and the periodontal ligaments which is compressed on one side and tensed up on the other side. Indeed, strong forces can lead to tooth root resorption and the crown-to-tooth ratio is reduced with the potential for significant clinical impact. The cementum, which covers the tooth root, is a thin mineralized tissue of the periodontium that connects the periodontal ligament with the tooth and is build up by cementoblasts. The impact of tension and compression on these cells is investigated in several in vivo and in vitro studies demonstrating differences in protein expression and signaling pathways. In summary, osteogenic marker changes indicate that cyclic tensile forces support whereas static tension inhibits cementogenesis. Furthermore, cementogenesis experiences the same protein expression changes in static conditions as static tension, but cyclic compression leads to the exact opposite of cyclic tension. Consistent with marker expression changes, the singaling pathways of Wnt/ß-catenin and RANKL/OPG show that tissue compression leads to cementum degradation and tension forces to cementogenesis. However, the cementum, and in particular its cementoblasts, remain a research area which should be explored in more detail to understand the underlying mechanism of bone resorption and remodeling after orthodontic treatments.

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Metadaten
Author:Radermacher Chloé, Hanna Malyaran, Rogerio Bastos Craveiro, Sarah Peglow, Mehdi Behbahani, Thomas Pufe, Michael Wolf, Sabine Neuss
DOI:https://doi.org/10.1055/a-1826-0777
ISSN:1019-1291
Parent Title (English):Osteologie
Publisher:Georg Thieme Verlag
Place of publication:Stuttgart
Document Type:Article
Language:English
Year of Completion:2022
Date of the Publication (Server):2022/06/08
Tag:Cementoblast; Compression; Forces; Mechanotransduction; Tension
Volume:31
Issue:2
First Page:111
Last Page:118
Link:https://doi.org/10.1055/a-1826-0777
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering