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Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications

  • Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.

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Metadaten
Author:Ulrich M. EngelmannORCiD, Eva Miriam Buhl, Sebastian Draack, Thilo Viereck, Frank, Thomas Schmitz-Rode, Ioana Slabu
DOI:https://doi.org/10.1109/LMAG.2018.2879034
ISSN:1949-307X
Parent Title (English):IEEE Magnetic Letters
Publisher:IEEE
Place of publication:New York, NY
Document Type:Article
Language:English
Year of Completion:2018
Date of the Publication (Server):2019/11/19
Volume:9
Issue:Article number 8519617
Link:https://doi.org/10.1109/LMAG.2018.2879034
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
collections:Verlag / IEEE