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(Bio-)chemical Sensing and Imaging by LAPS and SPIM

  • The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.

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Metadaten
Author:Tatsuo Yoshinobu, Steffi Krause, Ko-ichiro Miyamoto, Frederik WernerORCiD, Arshak PoghossianORCiD, Torsten WagnerORCiD, Michael Josef SchöningORCiD
ISBN:978-3-319-75219-8
Opac Id:61 VZB 26
Parent Title (English):Label-free biosensing: advanced materials, devices and applications
Publisher:Springer
Place of publication:Cham
Document Type:Part of a Book
Language:English
Year of Completion:2018
Date of the Publication (Server):2018/10/24
Tag:Chemical imaging; Field-effect device; Light-addressable potentiometric sensor; Potentiometry
First Page:103
Last Page:132
Link:https://doi.org/10.1007/5346_2017_22
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / Springer