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A concept for a sensitive micro total analysis system for high throughput fluorescence imaging

  • This paper discusses possible methods for on-chip fluorescent imaging for integrated bio-sensors. The integration of optical and electro-optical accessories, according to suggested methods, can improve the performance of fluorescence imaging. It can boost the signal to background ratio by a few orders of magnitudes in comparison to conventional discrete setups. The methods that are present in this paper are oriented towards building reproducible arrays for high-throughput micro total analysis systems (µTAS). The first method relates to side illumination of the fluorescent material placed into microcompartments of the lab-on-chip. Its significance is in high utilization of excitation energy for low concentration of fluorescent material. The utilization of a transparent µLED chip, for the second method, allows the placement of the excitation light sources on the same optical axis with emission detector, such that the excitation and emission rays are directed controversly. The third method presents a spatial filtering of the excitation background.

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Metadaten
Author:Arthur Rabner, Yosi Shacham
URN:urn:nbn:de:hbz:a96-opus-1456
DOI:https://doi.org/10.21269/115
Document Type:Conference Proceeding
Language:English
Year of Completion:2006
Publishing Institution:Fachhochschule Aachen
Contributing Corporation:International Symposium on Sensor Science, I3S 2005 <3; 2005; Juelich, Germany>
Date of the Publication (Server):2006/05/22
Tag:Fluorescence; LED chip; biosensor; fluidic; image sensor; imaging; lab-on-chip; lenslet array
GND Keyword:Biosensor
Source:http://www.mdpi.org/sensors/papers/s6040341.pdf
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
collections:FH Aachen / International Symposium on Sensor Science, I3S 2005 <3; 2005; Ju