Mathematical modeling of biosensors based on an array of enzyme microreactors
- This paper presents a two-dimensional-in-space mathematical model of biosensors based on an array of enzyme microreactors immobilised on a single electrode. The modeling system acts under amperometric conditions. The microreactors were modeled by particles and by strips. The model is based on the diffusion equations containing a nonlinear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The model involves three regions: an array of enzyme microreactors where enzyme reaction as well as mass transport by diffusion takes place, a diffusion limiting region where only the diffusion takes place, and a convective region, where the analyte concentration is maintained constant. Using computer simulation, the influence of the geometry of the microreactors and of the diffusion region on the biosensor response was investigated. The digital simulation was carried out using the finite difference technique.
| Author: | Romas Baronas, Feliksas Ivanauskas, Juozas Kulys |
|---|---|
| URN: | urn:nbn:de:hbz:a96-opus-1569 |
| DOI: | https://doi.org/10.21269/126 |
| Document Type: | Conference Proceeding |
| Language: | English |
| Year of Completion: | 2006 |
| Publishing Institution: | Fachhochschule Aachen |
| Contributing Corporation: | International Symposium on Sensor Science, I3S 2005 <3; 2005; Juelich, Germany> |
| Date of the Publication (Server): | 2006/05/22 |
| Tag: | Reaction-diffusion; microreactor; modeling biosensor |
| GND Keyword: | Biosensor |
| Source: | http://www.mdpi.org/sensors/papers/s6040453.pdf |
| Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| collections: | FH Aachen / International Symposium on Sensor Science, I3S 2005 <3; 2005; Ju |
