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Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements

  • Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).

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Metadaten
Author:Aravind Hariharan RamanORCiD, Alexander JungORCiD, András Horváth, Nadine Becker, Manfred StaatORCiD
DOI:https://doi.org/10.17185/duepublico/48750
ISBN:978-3-940402-22-6
Parent Title (English):3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
Publisher:Universität Duisburg-Essen
Place of publication:Duisburg
Editor:Manfred Staat, Daniel Erni
Document Type:Conference Proceeding
Language:English
Year of Completion:2019
Creating Corporation:MedTech Symposium
Contributing Corporation:Young Researchers Academy
Date of the Publication (Server):2019/06/04
First Page:10
Last Page:11
Link:https://doi.org/10.17185/duepublico/48750
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Universität Duisburg-Essen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung