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Influence of a freeze–thaw cycle on the stress–stretch curves of tissues of porcine abdominal organs

  • The paper investigates both fresh porcine spleen and liver and the possible decomposition of these organs under a freeze–thaw cycle. The effect of tissue preservation condition is an important factor which should be taken into account for protracted biomechanical tests. In this work, tension tests were conducted for a large number of tissue specimens from twenty pigs divided into two groups of 10. Concretely, the first group was tested in fresh state; the other one was tested after a freeze-thaw cycle which simulates the conservation conditions before biomechanical experiments. A modified Fung model for isotropic behavior was adopted for the curve fitting of each kind of tissues. Experimental results show strong effects of the realistic freeze–thaw cycle on the capsule of elastin-rich spleen but negligible effects on the liver which virtually contains no elastin. This different behavior could be explained by the autolysis of elastin by elastolytic enzymes during the warmer period after thawing. Realistic biomechanical properties of elastin-rich organs can only be expected if really fresh tissue is tested. The observations are supported by tests of intestines.

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Metadaten
Author:Nhu Huynh NguyenORCiD, Minh Tuan DuongORCiD, Thanh Ngoc TranORCiD, Phu Tinh PhamORCiD, O. Grottke, R. Tolba, Manfred StaatORCiD
DOI:https://doi.org/10.1016/j.jbiomech.2012.07.008
ISSN:1873-2380
Parent Title (English):Journal of Biomechanics
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of Completion:2012
Date of the Publication (Server):2012/12/18
Tag:Autolysis; Decomposition; Freeze–thaw process; Liver; Spleen
Volume:45
Issue:14
First Page:2382
Last Page:2386
Link:https://doi.org/10.1016/j.jbiomech.2012.07.008
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Elsevier
Licence (German):License LogoUrheberrechtlich geschützt