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Genetically Humanized Animal Models

  • Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.

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Metadaten
Author:K. Samuelsson, Nico ScheerORCiD, I. Wilson, C.R. Wolf, C.J. Henderson
DOI:https://doi.org/10.1016/B978-0-12-409547-2.12376-5
ISBN:978-0-12-803201-5
Parent Title (English):Comprehensive Medicinal Chemistry III. 3rd Edition
Publisher:Elsevier
Place of publication:Saint Louis
Editor:Samuel Chackalamannil
Document Type:Part of a Book
Language:English
Year of Completion:2017
Date of the Publication (Server):2019/04/08
Tag:Chimeric liver-humanized mice; Drug distribution; Drug metabolism; Knockout mice; Toxicology
First Page:130
Last Page:149
Link:https://doi.org/10.1016/B978-0-12-409547-2.12376-5
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Chemie und Biotechnologie
collections:Verlag / Elsevier