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Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes

  • In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.

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Author:Alexander Kopp, Laura Schunck, Martin Gosau, Ralf Smeets, Simon Burg, Sandra Fuest, Nadja Kröger, Max Zinser, Sebastian Krohn, Mehdi BehbahaniORCiD, Marius Köpf, Lisa Lauts, Rico Rutkowski
DOI:https://doi.org/10.3390/ijms21186704
ISSN:1422-0067
Parent Title (English):International Journal of Molecular Sciences
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2020
Date of the Publication (Server):2020/10/15
Volume:21
Issue:18 art. no. 6704
Note:
Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine
Link:https://doi.org/10.3390/ijms21186704
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / MDPI
Open Access / Gold
Licence (German):License LogoCreative Commons - Namensnennung