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Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage – preliminary findings from an observational cohort study

  • Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.

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Metadaten
Author:Felix Neumaier, Miriam Weiss, Michael Veldeman, Konstantin KotliarORCiD, Martin Wiesmann, Henna Schulze-Steinen, Anke Höllig, Hans Clusmann, Gerrit Alexander Schubert, Walid Albanna
DOI:https://doi.org/10.1016/j.clineuro.2021.106870
ISSN:0303-8467
Parent Title (English):Clinical Neurology and Neurosurgery
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of Completion:2021
Date of the Publication (Server):2021/08/18
Tag:constructive alignment; examination; long-term retention; multimodal; practical learning
Volume:208
Issue:Article No.: 106870
Link:https://doi.org/10.1016/j.clineuro.2021.106870
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Elsevier