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Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts

  • The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.

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Metadaten
Author:Alexander JungORCiD, Ralf FrotscherORCiD, Manfred StaatORCiD
DOI:https://doi.org/10.21269/8394
Parent Title (English):6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK
Document Type:Conference Proceeding
Language:English
Year of Completion:2018
Publishing Institution:Fachhochschule Aachen
Date of the Publication (Server):2018/06/08
Length:11 Seiten
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Open Access / Diamond
Licence (German):License LogoCreative Commons - Namensnennung