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Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold

  • Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.

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Metadaten
Author:Minh Tuan DuongORCiD, Volker Seifarth, Aysegül Temiz ArtmannORCiD, Gerhard ArtmannORCiD, Manfred StaatORCiD
DOI:https://doi.org/10.1007/978-981-10-7904-7_9
ISBN:978-981-10-7904-7
Parent Title (English):Biological, Physical and Technical Basics of Cell Engineering
Publisher:Springer
Place of publication:Singapore
Editor:Gerhard Artmann, Aysegül Temiz Artmann, Azhar A. Zhubanova, Ilya Digel
Document Type:Part of a Book
Language:English
Year of Completion:2018
Date of the Publication (Server):2018/04/26
Tag:Bladder; Growth modelling; Mechanical simulation; Reconstruction; Ureter
First Page:209
Last Page:232
Link:https://doi.org/10.1007/978-981-10-7904-7_9
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Chemie und Biotechnologie
FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Springer